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| 1 | Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice显示文摘The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various stressors.The foremost among these is the threat posed by oxidative stress,which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids,proteins,and nucleic acids.In mice,the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5(GPX5)as a major luminal scavenger in the proximal caput epididymidal segment.Accordingly,the loss of GPX5^-/-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx57 mice.To explore the underlying mechanism,we have conducted transcriptomic analysis of caput epididymidal epithelial cells from aged(13 months old)Gpx5^-/-m mice.This analysis revealed the dysregulation of several thousand epididymal mRNA transcripts,in eluding the downregulation of a subgroup of piRNA pathway gen es,in aged Gpx5^-/-mice.In agreeme nt with these fin dings,we also observed the loss of piRNAs,which potentially bind to the P-element-induced wimpy testis(PlWI)-like proteins PIWIL1 and PIWIL2.The absence of these piRNAs was correlated with the elevated mRNA levels of their putative gene targets in the caput epididymidis of Gpx5^-/-mice.Importantly,the oxidative stress response genes tend to have more targeting piRNAs,and many of them were among the top increased genes upon the loss of GPX5^-/-.Taken together,our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible invoIvement in the aging and oxidative stress-mediated responses. | Chen Chu Lu Yu Joelle Henry-Berger Yan-Fei Ru Ayhan Kocer Alexandre Champroux Zhi-Tong Li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-Li Guo Zhao-Liang Fei Lan-Tao Gou Qiang Liu Samanta Sharma Yu Zhou Mo-Fang Liu Charlie Degui Chen Andrew L Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-Lian Zhang | 2020 | Asian Journal of Andrology2020，22，6： | 2 |
| 2 | Ferroelectric characterization studies on barium calcium titanate single crystals显示文摘 | Varatharajan R Samanta S B Jayavel R | 2000 | Materials Characterization2000，45，2： | 2 |
| 3 | Polycyclic aromatic hydrocarbons: environmental pollution and bioremediation 显示文摘 | SAMANTA S K SINGH O V JAIN R K | 2002 | Trends Biotechnol2002，20，6： | 1 |
| 4 | Decomposition and/or hydrogenation of hydrogen peroxide over Pd/Al2O3 catalyst in aqueous medium: Factors affecting the rate of H2O2 destruction in presence of hydrogen显示文摘 | CHOUDARY V R SAMANTA C JANA P | 2007 | Applied Catalysis A: General2007，332，1： | 1 |
| 5 | Artificial neural networks and genetic algorithm for nearing fault detection 显示文摘 | Samanta B Al-BalushiK R Al-Araimi S A | 2006 | Soft Computing2006，10，3： | 1 |
| 6 | Three-dimensional plasma particle-in-cell calculations of ion thruster backflow contamination显示文摘 | Samanta Roy R L Hastings D E Taylor S | 1996 | Journal of Computational Physics1996，128，1： | 1 |
| 7 | Gradation of openness显示文摘 | Chattopadhyay K C Hazra R N Samanta S K | 1992 | Fuzzy topology:FSS1992，，49： | 1 |
| 8 | Plasma glucose responses to glucose, sucrose, and honey in patients with diabetes mellitus: an analysis of glycaemic and peak incremental indices 显示文摘 | Samanta A Burden A C Jones G R | 1985 | Diabetic Medicine1985，2，5： | 1 |
| 9 | Polycyclic aromatic hydrocarbons:environmental pollution and bioremediation显示文摘 | Samanta S K Singh O V Jain R K | 2002 | Trends in Biotechnology2002，20，6： | 1 |
| 10 | Polycyclic aromatic hydrocarbons: environmental pollution and bioremediation 显示文摘 | Samanta S K Singh O V Jain R K | 2002 | Trends Biotechnol2002，20，6： | 1 |
| 11 | Multi-objective parameter estimation for simulating canopy transpiration in forested watersheds 显示文摘 | MACKAY D S SAMANTA S NEMANI R R | 2003 | J Hydrol2003，277，： | 1 |
| 12 | Degradation of phenanthrene by different bacteria: evidence for novel transformation sequences involving the formation of 1-naphthol显示文摘 | Chakraborti A K Jain R K | 1999 | J Appl Microbiol Biotechnol1999，53，： | 1 |
| 13 | C2-Symmetric Bisprolinamide as a Highly Efficient Catalyst for Direct Aldol Reaction显示文摘 | Liu J Y Dodda R | 2005 | Org Lett2005，7，23： | 1 |
| 14 | Polycyclic aromatic hydrocarbons:Environmental pollution and bioremediation显示文摘 | SAMANTA S K SINGH O V JAIN R K | 2002 | Trends in Biotechnology2002，20，： | 1 |
| 15 | Artificial Neural Networks and Support Vector Machines with Genetic Algorithm for Bearing Fault Detection显示文摘 | Samanta B Al-Balushi K R Al-Araimi S A | 2003 | Engineering Applications of Artificial Intelligence2003，16，7： | 1 |
| 16 | Systems Analysis of Electrodynamic Tethers 显示文摘 | Samanta Roy R I Hastings D E Ahedo E | 1992 | Journal of Spacecraft and Rockets1992，29，3： | 1 |
| 17 | Exact analysis for static analysis of intelligent structures显示文摘 | Ray M C Bhattacharya R Samanta B | 1993 | American Institute of Aeronautics and Astronautics Journal1993，31，： | 1 |
| 18 | slam encodes a developmental regulator of polarized membrane growth during cleavage of the Drosophila embryo显示文摘 | Lecuit T Samanta R Wieschaus E | | 0，，04： | 1 |
| 19 | Effectiveness of beta blockers in primary prophylaxis of variceal bleeding in children with portal hypertension 显示文摘 | Samanta T Purkait R Sarkar M | 2011 | Trop Gastroenterol2011，32，4： | 1 |
| 20 | Antigenic and mutational analyses of herpes simplex virus glycoprotein B reveal four functional regions显示文摘 | Bender F C Samanta M Heldwein E E de Leon M P Bilman E Lou H Whitbeck J C Eisenberg R J Cohen G H | 2007 | J Virol2007，81，8： | 1 |
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