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| 1 | Viral and host causes of fatty liver in chronic hepatitis B显示文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage. | Emin Altiparmak Seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin | 2005 | World Journal of Gastroenterology2005，11，20： | 52 |
| 2 | Effect of preoperative immunonutrition and other nutrition models on cellular immune parameters显示文摘AIM:To evaluate the effects of preoperative immunonutrition and other nutrition models on the cellular immunity parameters of patients with gastrointestinal tumors before surgical intervention.In addition,effects on postoperative complications were examined. METHODS:Patients with gastrointestinal tumors were randomized into 3 groups.The immunonutrition group received a combination of arginine,fatty acids and nucleotides.The second and third group received normal nutrition and standard enteral nutrition,respectively.Nutrition protocols were administered for 7 d prior to the operation.Nutritional parameters,in particular prealbumin levels and lymphocyte subpopulations(CD4+,CD8+,CD16+/56+,and CD69 cells)were evaluated before and after the nutrition protocols.Groups were compared in terms of postoperative complications and duration of hospital stay. RESULTS:Of the 42 patients who completed thestudy,16 received immunonutrition,13 received normal nutrition and 13 received standard enteral nutrition. prealbumin values were low in every group,but this parameter was improved after the nutritional protocol only in the immunonutrition group(13.64±8.83 vs 15.98±8.66,P=0.037).Groups were similar in terms of CD4+,CD16+/56,and CD69+prior to the nutritional protocol;whereas CD8+was higher in the standard nutrition group compared to the immunonutrition group.After nutritional protocols,none of the groups had an increase in their lymphocyte subpopulations.Also,groups did not differ in terms of postoperative complications and postoperative durations of hospital stay. CONCLUSION:Preoperative immunonutrition provided a significant increase in prealbumin levels,while it did not significantly alter T lymphocyte subpopulation counts,the rate of postoperative complications and the duration of hospital stay. | Yusuf Gunerhan Neset Koksal Umit Yasar Sahin Mehmet Ali Uzun Emel Ek■ioglu-Demiralp | 2009 | World Journal of Gastroenterology2009，15，4： | 21 |
| 3 | Endoscopic retrograde cholangiopancreatography during pregnancy without radiation显示文摘AIM: To present our experience with pregnant patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) without using radiation, and to evaluate the acceptability of this alternative therapeutic pathway for ERCP during pregnancy. METHODS: Between 2000 and 2008, six pregnant women underwent seven ERCP procedures. ERCP was performed under mild sedoanalgesia induced with pethidine HCl and midazolam. The bile duct was cannulated with a guidewire through the papilla. A catheter was slid over the guidewire and bile aspiration and/or visualization of the bile oozing around the guidewire was used to confirm correct cannulation. Following sphincterotomy, the bile duct was cleared by balloon sweeping. When indicated, stents were placed. Confirmation of successful biliary cannulation and stone extraction was made by laboratory, radiological and clinical improvement. Neither fluoroscopy nor spot radiography was used during the procedure. RESULTS: The mean age of the patients was 28 years (range, 21-33 years). The mean gestational age for the fetus was 23 wk (range, 14-34 wk). Five patients underwent ERCP because of choledocholithiasis and/orcholedocholithiasis-induced acute cholangitis. In one case, a stone was extracted after precut papillotomy with a needle-knife, since the stone was impacted. One patient had ERCP because of persistent biliary fistula after hepatic hydatid disease surgery. Following sphincterotomy, scoleces were removed from the common bile duct. Two weeks later, because of the absence of fistula closure, repeat ERCP was performed and a stent was placed. The fistula was closed after stent placement. Neither post-ERCP complications nor premature birth or abortion was seen. CONCLUSION: Non-radiation ERCP in experienced hands can be performed during pregnancy. Stent placement should be considered in cases for which complete common bile duct clearance is dubious because of a lack of visualization of the biliary tree. | Adem Akcakaya Orhan Veli Ozkan Ismail Okan Orhan Kocaman Mustafa Sahin | 2009 | World Journal of Gastroenterology2009，15，29： | 17 |
| 4 | Etiology and portal vein thrombosis in Budd-Chiari syndrome显示文摘AIM: To research the etiology, portal vein thrombosis and other features of Budd-Chiari syndrome (BCS) patients prospectively. METHODS: A total of 75 patients (40 female, 35 male) who were diagnosed between January 2002 and July 2004 as having BCS were studied prospectively. Findings from on physical examination, ultrasonography, duplex ultrasonography and venography were analyzed. Hemogram and blood chemistry were studied at the time of diagnosis and on each hospital visit. Bone marrow examination and immune phenotyping were performed by a hematologist when necessary. Protein C, S, antithrombin Ⅲ, activated protein C resistance, and anticardiolipin antibodies, antinuclear antibodies, and anti ds-DNA were studied twice. The presence of ascite, esophageal varices, and portal thrombosis were evaluated at admission and on every visit. RESULTS: At least one etiological factor was determined in 54 (72%) of the patients. The etiology could not be defined in 21 (28%) patients. One etiological factor was found in 39, 2 factors in 14 and 3 factors in 1 patient. The most common cause was the web (16%), the second was Hydatid disease (11%), the third was Behcet’s disease (9%). Portal vein thrombosis was present in 11 patients and at least one etiology was identified in 9 of them (82%). CONCLUSION: Behcet’s disease and hydatid disease are more prominent etiological factors in Turkey than in other countries. Patients with web have an excellent response to treatment without signs of portal veinthrombosis while patients having thrombofilic factors more than one are prone to develop portal vein thrombosis with worse clinical outcome. | Oguz Uskudar Meral Akdogan Nurgul Sasmaz Sevinc Yilmaz Muharrem Tola Burhan Sahin | 2008 | World Journal of Gastroenterology2008，14，18： | 14 |
| 5 | Three-dimensional MR and axial CT colonography versus conventional colonoscopy for detection of colon pathologies显示文摘瞄准:在检测冒号损害评估先生 colonography (MRC ) 和 CT 性能的敏感和特性,并且把他们的敏感和特性与常规结肠镜检查的作比较。方法:怀疑有结肠的损害的 42 个病人因为直肠的流血,积极烘便的潜血测试结果或改变的肠习惯,经历了考试。在一个直肠的试管的插入以后,冒号充满 9 g/L NaCl 答案, 0.5 mmol/L gadopentetate dimeglumine 的 15-20 mL 和 iodinized 对比材料的 100 mL 的混合物的 1000-1500 mL。为先生 colonography 和互补先生图象的从前结肠的扩张被完成的、三维的坡度回响(3D-GRE ) 序列在所有情况中被拿。立即在先生 colonography 以后,腹的 CT 图象被螺线 CT 拿在里面轴并且背卧位。然后,所有病人被常规结肠镜检查(CC ) 检查。结果:为冒号病理的 MRC 的敏感和特性是 96.4% 并且 100% 分别地。由 MRC 的正确诊断的百分比是 97.6% 。百分之百,为冒号病理的 CT 的敏感和特性分别地是 92.8% 。由 CT 的正确诊断的百分比是 95.2% 。结论:在检测冒号损害, MRC 完成了类似于 CC 的诊断精确性。然而, MRC 是最低限度地侵略的,没有对在调查期间的镇静或止痛剂的需要。有穿孔风险的一个更低的百分比,并且所有冒号片断能由于多部分的成像可获得性被评估;结肠的损害,转移和任何另外的损害的内部、额外肠的部件能容易被评估。MRC 和 CT colonography 是答应在颜色的察觉高度敏感的新放射学的技术表面的集体、煽动性的肠损害。 | Rahime Haykir Serdar Karakose Aydin Karabacakoglu Mustafa Sahin Ertugrul Kayacetin | 2006 | World Journal of Gastroenterology2006，12，15： | 12 |
| 6 | Coexistence of Mirizzi syndrome with adenomyomatosis in the gallbladder:report of a case显示文摘BACKGROUND:Mirizzi syndrome is a rare complication of cholelithiasis. Adenomyomatosis is a common tumor-like lesion of the gallbladder. METHODS:A 52-year-old man was admitted to our hospital complaining of right hypochondriac pain and jaundice. Ultrasonography and computed tomography revealed stones in the gallbladder and dilation of the intrahepatic bile ducts. Magnetic resonance cholangiopancreatography revealed narrowing of the common bile duct caused by compression of the gallbladder. Laparotomy revealed type Ⅱ Mirizzi syndrome. RESULTS:Partial cholecystectomy with a Roux-en-Y hepaticojejunostomy reconstruction was performed. Histologically,Rokitansky-Aschoff sinus proliferation,hypertrophy of smooth muscles,and fibrosis were seen in the gallbladder. A segmental type of adenomyomatosis of the gallbladder was diagnosed. CONCLUSIONS:The pathogenic link between the two peculiar entities is unclear. A possible explanation is considered that the pathogenesis of Mirizzi syndrome is resulted from chronic inflammation due to adenomyomatosis. | Abdulkadir Bedirli Mustafa Kerem Hasan Bostanci Tarkan Karakan T. Tolga Sahin Nalan Akyurek | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，4： | 10 |
| 7 | Associating liver partition and portal vein ligation for staged hepatectomy for extensive alveolar echinococcosis:First case report in the literature显示文摘Alveolar echinococcosis(AE) is a zoonotic disease that is caused by Echinococcus multilocularis that affects liver and a variety of organs and tissues. It differs from other echinococcal disease because it shows tumor like behavior in the affected organ and tissues. The treatment of choice is concomitant medical therapy and resection with negative margins. Nevertheless, resection with the intent of negative margins(R0) may lead to serious complications such as liver failure. In the present case report, we used Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy(ALPPS) procedure, which was defined in 2012 by Schnitzbauer et al, in a 28-year-old male patient to avoid complications of major liver resection in order to treat alveolar echinococcosis. Until now, we have not encountered any study using ALPPS procedure for the treatment of alveolar echinococcosis. In the present case report we aimed to show that ALPPS procedure can be safely performed for marginnegative resection of primary or recurrent AE that shows a tumor like behavior. It is our opinion that this procedure should be performed in centers that have expertise and sufficient technical capacity to perform liver transplantation and advanced liver surgery. | Sami Akbulut Egemen Cicek Mehmet Kolu Tevfik Tolga Sahin Sezai Yilmaz | 2018 | World Journal of Gastrointestinal Surgery2018，10，1： | 10 |
| 8 | Unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis显示文摘AIM: To investigate the prevalence and implications of unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis. METHODS: The demographic and histopathological data of 1621 patients (≥ 16 years-old) who underwent appendectomy to treat an initial diagnosis of acute appendicitis between January 1999 and November 2011 were retrospectively assessed. Microscopic findings were used to classify the patients under six categories: appendix vermiformis, phlegmonous appendicitis, gan- grenous appendicitis, perforated appendicitis, supurative appendicitis, and unusual histopathologic findings. The demographic and clinicopathologic characteristics of patients with unusual histopathologic findings were evaluated in detail, and re-analysis of archived resected appendix specimens was carried out. RESULTS: A total of 912 males and 709 females, from16 to 94 years old, were included in the study and comprised 789 cases of suppurative appendicitis, 370 cases of appendix vermiformis, 243 cases of perforated gangrenous appendicitis, 53 cases of flegmaneous appendicitis, 32 cases of gangrenous appendicitis, and 134 (8.3%) cases of unusual histopathological findings. The unusual histopathological findings included fibrous obliteration (n = 62), enterobius vermicularis (n = 31), eosinophilic infiltration (n = 10), mucinous cystadenoma (n = 8), carcinoid tumor (n = 6), granulomatous inflammation (n = 5), adenocarcinoma (n = 4; one of them mucinous), and mucocele (n = 3), adenomatous polyp (n = 1), taenia sup (n = 1), ascaris lumbricoides (n = 1), appendiceal diverticula (n = 1), and B cell non-hodgkin lymphoma (n = 1). None of the 11 patients with subsequent diagnosis of tumor were suspected of cancer prior to the appendectomy. CONCLUSION: Even when the macroscopic appearance of appendectomy specimens is normal, histopathological assessment will allow early diagnosis of many unusual diseases. | Mehmet Yilmaz Sami Akbulut Koray Kutluturk Nurhan Sahin Ebru Arabaci Cengiz Ara Sezai Yilmaz | 2013 | World Journal of Gastroenterology2013，19，25： | 9 |
| 9 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 10 | H pylori:Treatment for the patient only or the whole family?显示文摘AIM:To compare the effects of treatment of H pylori-infected individuals with the effects of treatment of individuals as well as all H pylori-infected family members. METHODS:H pylori-positive patients with similar demographic specifications were prospectively randomized with respect to treatment, with a triple regimen of either patients and all H pylori-positive family members living together (groupⅠ) or patients only (group Ⅱ). Nine months after treatment, all patients were assessed for H pylori positivity. RESULTS:There were 70 H pylori-positive patients in each group;patients in groupsⅠand Ⅱ lived with 175 and 190 H pylori-positive relatives, respectively. Age, sex and H pylori positivity rate were similar in both groups of relatives. Nine months after 14 d standard triple therapy, H pylori positivity was 7.1% in groupⅠpatients and 38.6% in group Ⅱ patients [P < 0.01, OR = 8.61 95% confidence interval (CI):2.91-22.84]. CONCLUSION:The present results indicate bad environmental hygienic conditions and close intra-familial relationships are important in H pylori contamination. These findings indicate all family members of H pylori-positive individuals should be assessed for H pylori positivity, particularly in developing countries where H pylori prevalence is high;they also suggest patients, their spouses and all H pylori-positive family members of H pylori-positive individuals should be treated for H pylori infection. | Yavuz Selim Sari Didem Can Vahit Tunali Orhan Sahin Oguz Koc Omer Bender | 2008 | World Journal of Gastroenterology2008，14，8： | 7 |
| 11 | Determining Crop and Pan Coefficients for Cauliflower and Red Cabbage Crops Under Cool Season Semiarid Climatic Conditions显示文摘The aim of this study was to estimate the evapotranspiration of cauliflower and red cabbage crops grown under cool season semiarid climatic conditions from Class A pan evaporation. Actual evapotranspiration (ETc) of cauliflower and red cabbage crops was calculated according to the water balance approach. Reference evapotranspiration (ETo) was calculated with FAO Penman-Monteith equation. Pan evaporation (Epan) was measured by using Class A pan. Seasonal ETc was determined as 475 mm for cauliflower and 556 mm for red cabbage. Seasonal pan coefficient (kp = ETo/Epan) was determined as 0.82, and the seasonal crop coefficient (kc = ETc/ETo) was determined as 0.84 for cauliflower and 0.83 for red cabbage. So the evapotranspiration of cauliflower and red cabbage crops was estimated as 70% Class A pan evaporation. | Ustun Sahin Yasemin Kuslu Talip Tunc Fatih Mehmet Kiziloglu | 2009 | Agricultural Sciences in China2009，8，2： | 7 |
| 12 | Surface-enhanced Raman scattering on dielectric microspheres with whispering gallery mode resonance显示文摘Conventionally, metallic nanostructures are used for surface-enhanced Raman spectroscopy(SERS), but recently there has been increasing interest in the enhancement of Raman scattering from dielectric substrates due to their improved stability and biocompatibility compared with metallic substrates. Here, we report the observation of enhanced Raman scattering from rhodamine 6 G molecules coated on silica microspheres. We excite the whispering gallery modes(WGMs) supported in the microspheres with a tapered fiber coupler for efficient WGM excitation, and the Raman enhancement can be attributed to the WGM mechanism. Strong resonance enhancement in pump laser intensity and modified Raman emission from the Purcell effect in the microsphere resonator are observed from the experiment and compared with theoretical results. A total Raman enhancement factor of 1.4 × 10~4 is observed, with contribution mostly from the enhancement in pump laser intensity. Our results show that, with an efficient pumping scheme, dielectric microspheres are a viable alternative to metallic SERS substrates. | STEVEN H.HUANG XUEFENG JIANG Bo PENG COREY JANISCH ALEXANDER COCKING SAHIN KAYA OZDEMIR ZHIWEN LIU LAN YANG | 2018 | Photonics Research2018，6，5： | 7 |
| 13 | Same-day colonoscopy preparation with Senna alkaloids and bisacodyl tablets:A pilot study显示文摘AIM:To evaluate the efficacy of same-day bowel preparation with Senna alkaloids combined with bisacodyl tablets in routine colonoscopy procedures.METHODS:Between March and June 2013,a sameday bowel preparation was implemented in our endoscopy unit.The preparation consisted of a semi-liquid,fiber-free diet one day prior to the procedure,with two bisacodyl tablets after lunch and dinner,and 250 mL of Senna alkaloid with 1.5 L of drinking water at 6 am the day of the procedure.The quality control parameters of colonoscopy were evaluated and implemented according to the guidelines of the American Society for Gastrointestinal Endoscopy.The pre-procedure,duringprocedure and post-procedure patient data were collected and analyzed:(1) pre-procedure(age,gender,comorbid diseases,colonoscopy indications,complete lack of compliance with the bowel preparation protocol);(2) during-procedure(sedation dose,duration of colonoscopy,withdrawal time,cecal intubation rate,polyp detection rate,Boston Bowel Preparation Scores and presence of foam and clear liquid); and(3) postprocedure(visual analogue scale score,pain during the procedure,patient satisfaction and premature withdrawal due to the insufficient bowel preparation).RESULTS:A total of 75 patients were included in this study with a mean age of 54.64 ± 13.29 years; 53.3%(40/75) were female and 46.7%(35/75) were male.A complete lack of compliance with the bowel preparation protocol was seen in 6.7% of patients(5/75).The mean total duration of colonoscopy was 16.12 ± 6.51 min,and the mean withdrawal time was 8.89 ± 4.07 min.The cecal intubation rate was 93.8%(61/64) and the polyp detection rate was 40%(30/75).The mean Boston Bowel Preparation Score was 7.38 ± 1.81,with the following distribution:right colon,2.34 ± 0.89; transverse colon,2.52 ± 0.67; left colon,2.52 ± 0.63.The mean visual analogue scale score was 4.59 ± 1.57.Due to insufficient bowel preparation,seven patients(7/75; 9.3%) were asked to repeat the procedure.Of these,five patients had poor or modest compliance with the protocol,and two patients reported constipation.Premature withdrawal due to insufficient bowel preparation was 2.7%(2/75).The overall satisfaction with the protocol was 86.7%(65/75),with patients reporting they would prefer the same protocol in a repeat procedure.CONCLUSION:The same-day administration of Senna alkaloids appears to be a safe and effective bowel cleansing protocol for colonoscopy procedures. | Erdinc Yenidogan Ismail Okan Huseyin Ayhan Kayaoglu Gokhan Giray Akgul Mufit Sansal Servet Tali Zeki Ozsoy Mustafa Sahin | 2014 | World Journal of Gastroenterology2014，20，41： | 7 |
| 14 | Raman lasing and Fano lineshapes in a packaged fiber-coupled whispering-gallery-mode microresonator显示文摘We report Raman lasing and the optical analog of electromagnetically-induced-transparency(EIT) in a whispering-gallery-mode(WGM) microtoroid resonator embedded in a low refractive index polymer matrix together with a tapered fiber coupler. The microtoroid resonator supports both single mode and multimode Raman lasing with low power thresholds. Observations of Fano and EIT-like phenomena in a packaged microresonator will enable high resolution sensors and can be used in networks where slow-light effect is needed. These results will open up new possibilities for portable, robust, and stable WGM microlasers and resonator-based sensors for applications in various environments. | Guangming Zhao Sahin Kaya Ozdemir Tao Wang Linhua Xu Eshan King Gui-Lu Long Lan Yang | 2017 | Science Bulletin2017，62，12： | 6 |
| 15 | Manometric findings in patients with isolated distal gastroesophageal reflux显示文摘AIM:To analyze manometric abnormalities in patients with isolated distal reflux and compare these findings in patients with erosive and non-erosive disease. METHODS:Five hundred and fifty patients who presented to the outpatient clinic of Turkiye Yuksek Ihtisas Hospital with gastroesophageal reflux disease-like symptoms were enrolled.Each individual was evaluated with esophageal manometry,24-h ambulatory pH monitoring,and upper gastrointestinal endoscopy. Manometric findings for the patients with isolated distal reflux were compared to findings in controls who were free of reflux disorders or hypersensitive esopha- gus.Findings for isolated distal reflux patients with and without erosive reflux disease were also compared. RESULTS:Of the 550 subjects enrolled,97(17.6%, mean age 48 years)had isolated distal reflux and 100 had no abnormalities on ambulatory pH monitoring (control group,mean age 45 years).There were no significant differences between the isolated distal reflux group and control group with respect to age,body mass index,and esophageal body contraction amplitude (EBCA).Mean lower esophageal sphincter pressure was significantly higher in the control group(12.7±10.3 mmHg vs 9.6±7.4 mmHg,P=0.01).Fifty-five(56.7%) of the 97 patients with isolated distal reflux had erosive reflux disease.There were no statistical differences be- tween the erosive reflux disease and non-erosive reflux disease subgroups with respect to mean EBCA,lower esophageal sphincter pressure,or DeMeester score.However,13%of patients with gastroesophageal reflux disease had distal wave amplitudes≤30 mmHg, whereas none of the patients with non-erosive reflux disease had distal wave amplitudes in this low category. CONCLUSION:Patients with erosive and non-erosive disease present with similar manometric abnormalities. The only striking difference is the observation of very low EBCA exclusively in patients with erosive disease. | Yasemin Ozin Ulku Dagli Sedef Kuran Burhan Sahin | 2009 | World Journal of Gastroenterology2009，15，43： | 6 |
| 16 | 吸烟,血清抗氧化维生素水平和老年性黄斑变性之间的关系(英文)显示文摘目的:研究老年性黄斑变性(AMD)等级、血清抗氧化维生素水平(维生素A、C和E)和吸烟的关系。方法:对84例患者行黄斑彩色眼底成像,根据AMD损伤率和损伤程度将其分为五组(等级I^V)。应用高效液相色谱法(HPLC)测量血清抗氧化维生素水平。根据吸烟状况分不吸烟者、已戒烟者和吸烟者三组,并统计吸烟者每年的吸烟总量。结果:对照组中,维生素A、E、C水平分别为0.874±0.326mg/L,10.739±4.874mg/L和1.737±0.447mg/L,AMD组中分别为0.880±0.305mg/L,9.487±6.060mg/L和1.870±2.191mg/L,无显著差异(P>0.05)。AMD不同等级分组间维生素A(P=0.881)和E(P=0.293)水平差异无统计学意义,维生素C水平(P=0.044)随AMD程度的加深而增加。根据吸烟状况,AMD组与对照组之间无显著差异。根据每年的吸烟总量,两组之间有显著差异(P=0.02)。AMD越严重,年吸烟总量越高(P=0.007)。结论:研究结果显示AMD与维生素A、E血清水平无关,但和维生素C的血清水平相关,并与吸烟量有关。 | Sezen Akkaya Cakir Ozlem Sahin Haluk Kazokoglu Feyza Tekeli Goncagul Haklar Yelda Ozkurt | 2014 | 国际眼科杂志2014，14，5： | 5 |
| 17 | Fruit Yield and Quality, and Irrigation Water Use Efficiency of Summer Squash Drip-Irrigated with Different Irrigation Quantities in a Semi-Arid Agricultural Area显示文摘Fruit yield, yield components, fruit mineral content, total p henolic content, antioxidant activity and irrigation water use efficiency(IWUE) of summer squash responses to different irrigation quantities were evaluated with a field study. Irrigations were done when the total evaporated water from a Class A pan was about 30 mm. Different irrigation quantities were adjusted using three different plant-pan coefficients(Kcp, 100%(Kcp1), 85%(Kcp2) and 70%(Kcp3)). Results indicated that lower irrigation quantities provided statistically lower yield and yield components. The highest seasonal fruit yield(80.0 t ha-1) was determined in the Kcp1 treatment, which applied the highest volume of irrigation water(452.9 mm). The highest early fruit yield, average fruit weight and fruit diameter, length and number per plant were also determined in the Kcp1 treatment, with values of 7.25 t ha-1, 264.1 g, 5.49 cm, 19.95 cm and 10.92, respectively. Although the IWUE value was the highest in the Kcp1 treatment(176.6 kg ha-1 mm-1), it was statistically similar to the value for Kcp3 treatment(157.1 kg ha-1 mm-1). Total phenolic content and antioxidant activity of fruits was higher in the Kcp1(44.27 μg gallic acid equivalents(GAE) mg-1 fresh sample) and in the Kcp2(84.75%) treatments, respectively. Major(Na, N, P, K, Ca, Mg and S) and trace(Fe, Cu, Mn, Zn and B) mineral contents of squash fruits were the highest in the Kcp2 treatment, with the exception of P, Ca and Cu. Mineral contents and total phenolic content were significantly affected by irrigation quantities, but antioxidant activity was not affected. It can be concluded that the Kcp1 treatment was the most suitable for achieving higher yield and IWUE. However, the Kcp2 treatment will be the most suitable due to the high fruit quality and relatively high yield in water shortage conditions. | Yasemin Kuslu Ustun Sahin Fatih M Kiziloglu Selcuk Memis | 2014 | Journal of Integrative Agriculture2014，13，11： | 5 |
| 18 | Mechanical lithotripsy and/or stenting in management of difficult common bile duct stones显示文摘BACKGROUND:Mechanical lithotripsy and/or stent insertion is the alternative therapeutic approach in difficult endoscopic retrograde cholangiopancreatography (ERCP)case.This study was designed to investigate the appropriate treatment for extraction of bile duct stones in difficult cases of ERCP. METHODS:Between 2000 and 2008,744 ERCP procedures were performed in 592 patients with choledocholithiasis in our endoscopy unit.The demographic features,and clinical and laboratory findings were collected from a prospectively held database.Bile duct calculi were extracted by basket and/or balloon catheter following ERCP and sphincterotomy.Patients with retained stones were regarded as difficult cases.These patients were treated with mechanical lithotripsy and those with incomplete clearance of stones underwent stent placement. RESULTS:Two hundred and forty-five patients(41%) were male and 347(59%)were female with a mean age of 58 years(range 19-95 years).Stones were impacted in 27 patients(5%).Stone extraction was performed by basket and/or balloon catheter in 610 ERCP procedures,and lithotripsy was performed in 70 ERCP procedures.Forty- four patients underwent stent insertion,and 20 underwent stent replacement.Morbidity occurred in 39 patients (5%),with no mortality associated with the procedure.Hemorrhage occurred in 9 patients and basket impaction in 4.Mild pancreatitis and cholangitis developed in 12 and 11 patients,respectively. CONCLUSION:Difficult cases of bile duct stones can be treated successfully with lithotripsy,and a stent should be applied when the common bile duct cannot be cleared completely. | Adem Akcakaya Orhan Veli Ozkan Gurhan Bas Atilla Karakelleoglu Orhan Kocaman Ismail Okan Mustafa Sahin | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，5： | 5 |
| 19 | Dysentery caused by Balantidium coliin a patient with non-Hodgkin's lymphoma from Turkey显示文摘Balantidium coli is the only parasitic ciliate of man. It is a flattened oval organism covered with cilia, and a gullet at the anterior end. It is infrequently pathogenic for man,although epidemic buds in tropical zones have been described. The infection fundamentally affects the colon and causes variable clinic pictures, from asymptomatic to serious dysenteric forms. We present a case of parasitologically diagnosed as causes of diarrhea in a patient with non Hodgkin's lymphoma from Turkey.In order to find out the causative etiologic agent of diarrhea,stool samples were examined by native,lugol and flotation methods and we detected moving trophozoites, which were approximately 60μm long and 35μm wide.These bodies were diagnosed as Balantidium coli This case underlines that Balantidium coli should also be considered as a possible pathogen in immunocompromised patients with diarrhea. | Süleyman Yazar Fevzi Altuntas Izzet Sahin Metin Atambay | 2004 | World Journal of Gastroenterology2004，10，3： | 4 |
| 20 | Relation of coronary collateral circulation with epicardial fat volume in patients with stable coronary artery disease显示文摘OBJECTIVE: To investigated the relationship between epicardial fat volume (EFV) and coronary collateral circulation (CCC) in patients with stable coronary artery disease (CAD)。 METHODS: The study population consisted of 152 consecutive patients with CAD who underwent coronary angiography and were found to have at least 95% significiant lesion in at least one major coronary artery。 EFV was assessed utilizing 64-multislice computed tomography。 The patients were classifield into impaired CCC group (Group 1, Rentrop grades0-1, n =58), or adequate CCC (Group 2, Rentrop grades 2-3, n = 94)。 RESULTS: The EFV values were significantly higher in paitients with adequate CCC than in those with impaired CCC。 In multivariate logistic regression analysis, EFV (OR = 1.059;95% CI: 1.035-1.085; P = 0.001); and presence of angina were independent predictors of adequate CCC。 In receiver-operating characteristic curve analysis, the EFV value > 106.5 mL yielded an area under the curve value of 0.84, with the test sensitivity of 49.3%, and with 98.3% specifity。 CONCLUSIONS: High EFV, and the presence of angina independently predict adequate CCC in patients with stable coronary artery disease。 This association offers new diagnostic opportinities to assess collateral flow by conventional ultrasound techniques。 | Aslm Enhos Irfan Sahin Mehmet Mustafa Can Ibrahim Biter Mustafa Hakan Dinckal Victor Serebruany | 2013 | Journal of Geriatric Cardiology2013，10，4： | 4 |
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