|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Long-term survival of a case with multiple liver metastases from duodenal gastrointestinal stromal tumor drastically reduced by the treatment with imatinib and hepatectomy显示文摘工具包受体酷氨酸激酶的组成的激活是在胃肠的基质肿瘤(大意) 的致病的一个关键因素。但是几乎没有 imatinib mesylate (IM ) 和外科疗法的联合是否能与 unresectable 在情况中延长幸存的很少信息多重肝转移。我们报导酷氨酸激酶禁止者 IM 和外科疗法对待的大意的手术后的复发的一个案例。对处理的起始的完全的反应(CR ) 为 18 瞬间继续,但是单个肝转移在 IM 处理期间在左肝的脑叶显示出生长。在再发性瘤的部分切除术以后,手术后的路线是平静的,没有复发,病人为 24 瞬间幸存。当前, imatinib 是为 non-resectable 大意的首要的治疗,但是单个代理人治疗经常导致肿瘤抵抗。就算到 imatinib 的忍耐发生, imatinib 和外科疗法的联合能在这里报导了的一些情况中延长幸存。然而,周期性的大意的很多案例上的进一步的研究是必要的评估治疗与外科相结合的 IM 的有效性。 | Chouhei Sakakura Akeo Hagiwara Koji Soga Koji Miyagawa Susumu Nakashima Tetsuji Yoshikawa Shuichi Kin Yuenn Nakase Nobuki Yamaoka Yoshihiko Sagara Hisakazu Yamagishi | 2006 | World Journal of Gastroenterology2006，12，17： | 5 |
| 2 | Cytapheresis re-induces high-rate steroid-free remission in patients with steroid-dependent and steroid-refractory ulcerative colitis显示文摘BACKGROUND It is a crucial issue for patients with refractory ulcerative colitis(UC),including steroid-dependent and steroid-refractory patients,to achieve and maintain steroid-free remission.However,clinical studies focused on the achievement of steroid-free remission in refractory UC patients are insufficient.Cytapheresis(CAP)is a non-pharmacological extracorporeal therapy that is effective for active UC with fewer adverse effects.This study comprised UC patients treated with CAP and suggested the efficacy of CAP for refractory UC patients.AIM To clarify the efficacy of CAP in achieving steroid-free remission in refractory UC patients.METHODS We retrospectively reviewed the collected data from 55 patients with refractory UC treated with CAP.We analyzed the following points:(1)Efficacy of the first course of CAP;(2)Efficacy of the second,third,and fourth courses of CAP in patients who experienced relapses during the observation period;(3)Efficacy of CAP in colonic mucosa;and(4)Long-term efficacy of CAP.Clinical efficacy was evaluated using Lichtiger’s clinical activity index or Sutherland index(disease activity index).Mucosal healing was evaluated using Mayo endoscopic subscore.The primary and secondary endpoints were the rate of achievement of steroidfree remission and the rate of sustained steroid-free remission,respectively.Statistical analysis was performed using the paired t-test and chi-squared test.RESULTS The rates of clinical remission,steroid-free remission,and poor effectiveness after CAP were 69.1%,45.5%,and 30.9%,respectively.There were no significant differences in rate of steroid-free remission between patients with steroiddependent and steroid-refractory UC.The mean disease activity index and Lichtiger’s clinical activity index scores were significantly decreased after CAP(P<0.0001).The rates of steroid-free remission after the second,third,and fourth courses of CAP in patients who achieved steroid-free remission after the first course of CAP were 83.3%,83.3%,and 60%,respectively.Mucosal healing was observed in all patients who achieved steroid-free remission after the first course of CAP.The rates of sustained steroid-free remission were 68.0%,60.0%,and 56.0%at 12,24,and 36 mo after the CAP.Nine patients(36%)had maintained steroid-free remission throughout the observation period.CONCLUSION Our results suggest that CAP effectively induces and maintains steroid-free remission in refractory UC and re-induces steroid-free remission in patients achieving steroid-free remission after the first course of CAP. | Masahiro Iizuka Takeshi Etou Yosuke Shimodaira Takashi Hatakeyama Shiho Sagara | 2021 | World Journal of Gastroenterology2021，27，12： | 2 |
| 3 | Acute respiratory distress syndrome associated with severe ulcerative colitis显示文摘Various extraintestinal manifestations including pulmonary abnormalities have been reported in patients with ulcerative colitis. Acute respiratory distress syndrome (ARDS) is a serious and fatal pulmonary manifestation. We have experienced a 67-year-old male patient with ARDS associated with a severe type of ulcerative colitis (UC). Severe dyspnea symptoms occurred during the treatment of UC in a previous hospital and the patient was transferred to our hospital on June 27, 2007. Both blood and sputa cultures for bacteria and fungi were negative. Cytomega-lovirus antigenemia was also not detected. From the clinical and radiological [Chest X-ray, computed tomography (CT)] findings, the patient was diagnosed with ARDS on the basis of the def inition of ARDS developed by the European-American Consensus Conference on ARDS. Both colonic inflammations and ARDS symptoms of the patient were resistant to any medical treatment includingcorticosteroids and antibiotics. However, ARDS symptoms were dramatically improved after surgical colectomy. We believe that severe colonic inflammation from UC was closely associated with the onset of ARDS of the patient. Our case report suggests that a severe type of ulcerative colitis might be taken into consideration as one of the predisposing factors of ARDS. | Shiho Sagara Yasuo Horie Yumiko Anezaki Hideaki Miyazawa Masahiro Iizuka | 2010 | World Journal of Gastroenterology2010，16，19： | 2 |
| 4 | Angiotension converting enzyme inhibitors suppress production of tumor necrosis factor- alpha in vitro and in vivo 显示文摘 | Fucuzawa M Saton J Sagara M | 1997 | Immunophamacology1997，36，1： | 2 |
| 5 | Typical gastroduodenal endoscopic findings in a Crohn's disease patient in remission stage显示文摘A 39-year-old patient with Crohn's disease (CD) was referred to our hospital for maintenance treatment of CD.He was diagnosed as having CD of the small and large intestines at 32 years old.He underwent partial resection of the ileum at 35 years old because of ileal perforation.He had received enteral nutritional supplement (1200 kcal/d) and metronidazole preparation (500 mg/d),and was in remission Crohn's disease activity index 73.We performed a routine gastroduodenal endoscopic examination,which revealed the representative endoscopic findings of gastroduodenal lesions in CD,namely,bamboo-joint-like appearance of the gastric body and cardia and a notched sign in the duodenum.These findings were clearly observed by using indigo carmine dye spraying.In our patient,typical gastroduodenal findings were observed even in the remission stage,suggesting that these findings would contribute to the early diagnosis of CD not only in the active stage but also during remission. | Masahiro Iizuka Taku Harada Hiro-o Yamano Takeshi Etou Shiho Sagara | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，3： | 2 |
| 6 | Specific inhibitors of intracellular transport ATPases 显示文摘 | Sagara Y | 1994 | J Membrane Biology1994，141，： | 1 |
| 7 | The activition of dopamine D4 receptor inhibits oxidative stress-induced nerve cell death显示文摘 | Ishige K Chen Q Sagara Y | 2001 | J Neurosci2001，21，16： | 1 |
| 8 | Simple calibration Algorithm for high–distortion-lens camera显示文摘 | Nomura Y Sagara M Naruse H | 1992 | IEEE Trans Pattarn Anal Machine Intell1992，14，： | 1 |
| 9 | Clinically mild encephalitis/encephalopathy with a reversible splenial lesion caused by methicillin-sensitive Staphylococcus aureus bacteremia with toxic shock syndrome: a case report显示文摘 | Kosaim K Kenzaka T Sagara Y | 2016 | BMC Infect Dis2016，16，1： | 1 |
| 10 | Gold alloys for resin bongding including small amount base metal-struvtural changes of alloy surface by tne high-temperature oxidation显示文摘 | Sagara M Ohno H | 1999 | Dent Mater J1999，18，4： | 1 |
| 11 | A bimodal maxwellian distribution as the equilibrium solution of the two-particle regime显示文摘 | Sagara K Tsuge S | 1982 | Physics of Fluids1982，25，11： | 1 |
| 12 | Functions of milk protein in gene 5-flanking region on human growth hormone gene显示文摘 | Ninomiya T Hirabayashi M Sagara J | 1994 | Mol Reprod Dev1994，37，： | 1 |
| 13 | Basic and clinical studies of pazufloxacin on infectious enteritis research group of T-3761 on infectious enteritis 显示文摘 | Sagara H Yoshikawa K Tomizawa I | 1996 | Kansenshogaku Zasshi (in Japanese)1996，70，1： | 1 |
| 14 | Preparation and adsorption properties of λ-MnO2-celluse hybird-yype ion-exchanger for lithium ion,application to the enrichment of lithium ion from seawater显示文摘 | Wang baoning Isao yoshida | 1989 | Separation Sclence and Technology1989，24，14： | 1 |
| 15 | The effects of early occlusal loading on one-stage titanium alloy implants in beagle dogs:a pilot study显示文摘 | Sagara M Akagawa Y Nikai H | 1993 | J Prosthet Dent1993，69，： | 1 |
| 16 | CD105 is a more appropri- ate marker for evaluating angiogenesis in urothelial cancer of the upper urinary tract than CD31 or CD34 显示文摘 | Miyata Y Sagara Y Watanabe S | 2013 | Virchows Arch2013，463，5： | 1 |
| 17 | Ultracentrifugation deforms unfixed influenza A virions显示文摘 | SUGITA Y NODA T SAGARA H | 2011 | J Gen Virol2011，92，11： | 1 |
| 18 | In vitro synthesis of monoamine oxidase of rat liver outer mitochondrial membrane显示文摘 | Sagara Y Ito A | 1982 | Biochem Biophys Res Commun1982，109，： | 1 |
| 19 | Kinetic theory of turbulent compressible flows and comparison with classical theory显示文摘 | Tsuge S Sagara K | 1976 | Physics of Fluids1976，19，10： | 1 |
| 20 | Basic and clinical studies of pazufloxacin on infectious enterities research group of T-3761 on infectious enterities 显示文摘 | Sagara H Yoshikawa K Tomizawa I | 1996 | Kansenshogaku Zasshi1996，70，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员