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| 1 | Protective effect of ginger volatile oil against acetic acid-induced colitis in rats: a light microscopic evaluation显示文摘OBJECTIVE: Ulcerative colitis is a chronically recurrent infl ammatory bowel disease of unknown origin. In the present study, the effect of ginger(rhizome of Zing iber officinale Roscoe) volatile oil on a rat model of colitis was evaluated. METHODS: Volatile oil of ginger with doses of 100, 200, and 400 mg/kg, prednisolone(4 mg/kg), or vehicle were administered orally to groups of male Wistar rats(n = 6) for 5 d. Animals were randomly divided into 6 groups, each group consisting of 6 rats. Colitis was induced by intracolonic instillation of 2 mL of 4%(v/v) acetic acid solution. All rats were sacrificed 24 h later and the tissue injuries were assessed macroscopically and histopathologically. RESULTS: Ginger volatile oil with all doses reduced colon weight/length ratio(P < 0.01) and the effects were similar to the reference drugs. Higher oral doses of volatile oil(200 and 400 mg/kg) reduced ulcer severity(P < 0.05 and P < 0.01), ulcer area(P < 0.01) and ulcer index(P < 0.01). On the other hand, evaluation of microscopic scores showed that the dose of 400 mg/kg of volatile oil was effective to reduce infl ammation severity(P < 0.01) and infl ammation extent(P < 0.05) compared to the control group.CONCLUSION: It is concluded that ginger volatile oil could effectively reduce symptoms of experimental colitis in a dose-dependent manner. | Amir Rashidian Saeed Mehrzadi Ali Reza Ghannadi Parvin Mahzooni Samira Sadr Mohsen Minaiyan | 2014 | Journal of Integrative Medicine2014，12，2： | 7 |
| 2 | In vitro anti-leishmanial activity of methanolic extracts of Calendula officinalis flowers, Datura stramonium seeds, and Salvia officinalis leaves显示文摘AIM: The anti-leishmanial activity of methanolic extracts of Calendula officinalis flowers, Datura stramonium seeds, and Salvia officinalis leaves against extracellular(promastigote) and intracellular(amastigote) forms of Leishmania major were evaluated in this study. METHOD: In the first stage, promastigote forms of L. major, were treated with different doses of the plant extracts in a 96-well tissue-culture microplate and IC50 values for each extract were measured with colorimetric MTT assay. In the second stage, macrophage cells were infected with L. major promastigotes. Infected macrophages were treated with plant extracts. Then the macrophages were stained with Gimsa and the number of infected macrophages and amastigotes were counted with a light microscope. RESULTS: The results indicated that the plant extracts inhibited the growth of promastigotes and amastigotes of L. major. Inhibitory concentrations(IC50) for promastigote assay were 108.19, 155.15, and 184.32 μg·mL-1 for C. officinalis flowers, D. stramonium seeds and S. officinalis, respectively. The extracts also reduced the number of amastigotes in macrophage cells from 264 for control group to 88, 97, and 102 for test groups. Although the anti-leishmanial activity of the extracts were not comparable with the standard drug, miltefosine; but they showed significant efficiency in reducing the number of amastigotes in macrophages, in comparison with the control group(P < 0.001). These plant extracts had lower toxicity compared with miltefosine. CONCLUSION: This study demonstrates the potential efficacy of the methanolic extracts of C. officinalis flowers, D. stramonium seeds, and S. officinalis leaves to control of cutaneous leishmaniasis. | Banafsheh Nikmehr Habib Ghaznavi Amir Rahbar Samira Sadr Saeed Mehrzadi | 2014 | Chinese Journal of Natural Medicines2014，12，6： | 2 |
| 3 | Hereditary risk factors for the development of gastric cancer in younger patients显示文摘 | Yaghoobi M Rakhshani N Sadr F | 2004 | BMC gastroenterology2004，4，1： | 1 |
| 4 | Adaptation After- effects in the Perception of Gender from Biological Motion显示文摘 | Troje N F Sadr J Geyer H | 2006 | Journal of Vision2006，6，8： | 1 |
| 5 | Fitting world-wide web request traces with the EM-algorithm显示文摘 | Khayari R E Sadre R Haverkort B R | 2003 | Performance Evaluation2003，52，23： | 1 |
| 6 | lodometric method for determination of persulfates显示文摘 | Wabba N Asmar M F E Sadr MME | 1959 | Analytical Chemistry1959，31，11： | 1 |
| 7 | Effects of a perioperative smoking cessation intervention on postoperative complications:a randomized trial显示文摘 | Lindstrm D Sadr Azodi O Wladis A | 2008 | Ann Surg2008，248，5： | 1 |
| 8 | Prevention and management of dysphonia during anterior cervical spine surgery显示文摘 | Razfar A Sadr - Hosseini S M Rosen C A | 2012 | The Laryngoscope2012，122，10： | 1 |
| 9 | Serum uric acid levels and its association with cardiovascular risk factors 显示文摘 | SADR S M NAMAYANDEH S M MOADARES M M | 2009 | Ranian J Publ Health2009，1，38： | 1 |
| 10 | Flow whitelisting in SCADA networks显示文摘 | Barbosa R R R Sadre R Pras A | 2013 | International Journal of Critical Infrastructure Protection2013，6，34： | 1 |
| 11 | Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker显示文摘 | Sadr Nabavi A Ramser J Volkmann J | 2009 | Int J Cancer2009，124，7： | 1 |
| 12 | Nanoindentation hardness of intertubular dentin in sound, demineralized and natural caries- affected dentin 显示文摘 | Joves GJ Inoue G Sadr A | 2014 | J Mech Behav Biomed Mater2014，，32： | 1 |
| 13 | The multifaceted proprotein convertases : their unique, redundant, complementary, and opposite functions显示文摘 | Seidah NG Sadr MS Chrtien M | 2013 | J Biol Chem2013，288，21： | 1 |
| 14 | Gum containing calcium fluoride reinforces enamel subsurface lesions in situ显示文摘 | Kitasako Y Sadr A Hamba H | 2012 | Journal of dental research2012，91，4： | 1 |
| 15 | Radio resource allocation algorithms for the downlink of multiuser OFDM com- munication systems显示文摘 | Sadr S Anpalagan A and Raahemifar K | 2009 | IEEE Communications Surveys & Tutorials2009，11，3： | 1 |
| 16 | The role of eyebrows in face recognition 显示文摘 | SADR J JARUDI I SINHA P | 2003 | Perception2003，32，2： | 1 |
| 17 | Acid resistance of dentin after erbium: yttrium-alumi- num-garnet laser irradiation 显示文摘 | Zhengdi He Masayuki Otsuki Alireza Sadr and Junii Taga- mi | 2009 | Lasers Med Sci2009，24，4： | 1 |
| 18 | An experimental study of electro-osmotic flow in rectangular microchannels显示文摘 | SADR R YODA M | 2004 | Journal of Fluid Mechanics2004，506，： | 1 |
| 19 | Production rate control for stochastic remanufacturing systems 显示文摘 | GHARBI A PELLERIN R SADR J | 2008 | International Journal of Production Economics2008，112，1： | 1 |
| 20 | Radio resource allocation algorithms for the downlink of muhiuser OFDM communication systems显示文摘 | Sadr S Anpalagan A Raahemifar K | 2009 | IEEE Communications Surveys and Tutorials2009，11，3： | 1 |
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