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| 1 | Widespread use of gastric acid inhibitors in infants:Are they needed? Are they safe?显示文摘Gastroesophageal reflux is a common phenomenon in infants,but the differentiation between gastro-esophageal reflux and gastroesophageal reflux disease can be difficult.Symptoms are non-specific and there is increasing evidence that the majority of symptoms may not be acid-related.Despite this,gastric acid inhibitors such as proton pump inhibitors are widely and increasingly used,often without objective evidence or investigations to guide treatment.Several studies have shown that these medications are ineffective at treating symptoms associated with reflux in the absence of endoscopically proven oesophagitis.With a lack of evidence for efficacy,attention is now being turned to the potential risks of gastric acid suppression.Previously assumed safety of these medications is being challenged with evidence of potential side effects including GI and respiratory infections,bacterial overgrowth,adverse bone health,food allergy and drug interactions. | Mark Safe Wei H Chan Steven T Leach Lee Sutton Kei Lui Usha Krishnan | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 2 | Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure显示文摘 | St John Sutton MG Plappert T Abraham WT | 2003 | Circulation2003，107，15： | 1 |
| 3 | Pacing in heart failure : patientand pacing mode selection 显示文摘 | Salukhe T V Henein M Y Sutton R | 2003 | Eur Heart J2003，24，： | 1 |
| 4 | Oxygen transport and cardiovascular function at extreme altitude: lessons from Operation Everest II 显示文摘 | SUTTON J R REEVES J T GROVES B M | 1992 | Int J Sports Med1992，13，1： | 1 |
| 5 | Etiology of apple sooty blotch disease in North Carolina显示文摘 | Johnson E M Sutton T B Hodges C S | 1997 | Phytopathology1997，87，： | 1 |
| 6 | Craniometric and Velopharyngeal Assessment of Infants With and Without Cleft Palate显示文摘 | Jamie L Perry David P Kuehn T Bradley P Sutton | | 0，，： | 1 |
| 7 | The association of bone mineral density measures with incident cardiovascular disease in older adults 显示文摘 | FARHAT G N NEWMAN A B SUTTON T K | 2007 | Osteoporosis Int2007，18，： | 1 |
| 8 | Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure显示文摘 | St John Sutton MG Plappert T Abraham WT | 2003 | Circulation2003，107，15： | 1 |
| 9 | Peltaster fructicola:A new species in the complex of fungi causing apple sooty blotch显示文摘 | Johnson E M Sutton T B Hodges C S | 1996 | Mycologia1996，88，： | 1 |
| 10 | Electrotonic cancellation oftransmural electrical gradients in the left ventricle in man显示文摘 | Taggart P Sutton P Opthof T | 2003 | ProgBiophys Mol Biol2003，82，13： | 1 |
| 11 | Surgical versus nonsurgieal treatment of acute minimally displaced and undisplaced scaphoid waist fractures:pairwise and net- work meta-analyses of randomized controlled trials显示文摘 | Ibrahim T Oureshi A Sutton AJ | 2011 | J Hand Surg Am2011，36，11： | 1 |
| 12 | Building and evaluating models to estimate ambient population density显示文摘 | SUTTON P C ELVIDGE C OBREMSKI T | 2003 | Photogrammetric Engineering and Remote Sensing2003，69，3： | 1 |
| 13 | Applica- tions of Digital-image-correlation Techniques to Ex- perimental Mechanics 显示文摘 | CHU T C RANSON W F SUTTON M A | 1985 | Experimental Mechanics1985，25，3： | 1 |
| 14 | Applications of digitalimage-correlation techniques to experimental mechanics显示文摘 | Chu T C Ranson W F Sutton M A | 1985 | Experimental Mechanics1985，25，3： | 1 |
| 15 | Production and dispersal of ascospores and conidia byphysalospora obtusa and Botryosphaeria dothidae in apple orchards显示文摘 | SUTTON B T | 1981 | Phytopathology1981，71，： | 1 |
| 16 | Endothelial injury and dysfunction:role in the extension phase of acute renal failure显示文摘 | Molitoris B A Sutton T A | 2004 | Kidney Int2004，66，： | 1 |
| 17 | Left ventricular reverse remodeling with biventricular versus right ventricular pacing in patients with atrioventricular block and heart failure in the BLOCK HF trial 显示文摘 | St John Sutton M Plappert T Adamson PB | 2015 | Circ Heart Fail2015，8，3： | 1 |
| 18 | A global poverty map derived from satellite data显示文摘 | ELVIDGE C D SUTTON P C GHOSH T | 2009 | Computers & Geosciences2009，35，8： | 1 |
| 19 | 成人2型糖尿病不同筛查及预防策略成本效益分析显示文摘目的 比较针对2型糖尿病预防及治疗的4种筛查策略及随后予以的干预措施:(a)筛查2型糖尿病患者使其能接受早期检查及治疗,(b)筛查2型糖尿病和糖耐量受损患者,对糖耐量受损的人群予以生活方式干预以延缓或预防糖尿病的发生,(c)同(b)但予以药物干预措施,(d)不筛查。
设计 成本效益决策分析建立在对概率的发展和评估基础上,是从筛查到死亡的综合性经济决策分析模型。
研究对象 一组假设人群,筛查时年龄45岁,高于平均糖尿病风险水平。
数据来源 电子书目数据库收录的已发表的临床试验和流行病学研究;补充数据分别来自英国和威尔士健康统计署、风险筛查(STAR)研究和ADDITION研究的Leicester部分。
方法 建立一种决策树/Markov混合模型,以模拟每一种筛查策略的长期效用,包括临床和成本效益终点。该模型假设水平跨度为50年时间,其成本效益折损率为3.5%。采用敏感度分析以验证模型假设及确定哪种模型数据输入对结果的影响最大。
结果 与不筛查策略比较,筛查2型糖尿病、筛查糖尿病和糖耐量受损并予以生活方式干预、筛查糖尿病和糖耐量受损并予以药物干预治疗3种策略,每获得一个质量调整生命年(QALY)估计所需成本分别为(每年成本效益贴现率为3.5%)14150英镑(17560欧元;27860美元)、6242英镑和7023英镑。在支付意愿阈值为20000英镑时,各主动筛查策略通过干预产生的成本效益概率分别为49%,93%和85%。
结论 对年龄45岁、高于平均风险水平的人群进行2型糖尿病和糖耐量受损的筛查,并对糖耐量受损人群予以适当的干预似乎具有很好的成本效益。单独筛查糖尿病而不对糖耐量受损人群予以干预的策略具有的成本效益仍不确定,需要进一步研究确定早期检测糖尿病的作用。 | Clare L Gillies Paul C Lambert Keith R Abrams Alex J Sutton Nicola J Cooper Ron T Hsu Melanie J Davies Kamlesh Khunti 张晓梅(译) 纪立农(校) | 2008 | 英国医学杂志中文版2008，11，5： | 1 |
| 20 | Synthesis of a Stable Compound with Fivefold Bonding between Two Chromium(I) Centers 显示文摘 | NGUYEN T SUTTON A D BRYNDA M | 2005 | Science2005，310，： | 1 |
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