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| 1 | Acute pancreatitis at the beginning of the 21st century: The state of the art显示文摘Acute pancreatitis is an acute inflammatory disease of the pancreas which can lead to a systemic inflammatory response syndrome with significant morbidity and mortality in 20% of patients. Gallstones and alcohol consumption are the most frequent causes of pancreatitis in adults. The treatment of mild acute pancreatitis is conservative and supportive; however severe episodes characterized by necrosis of the pancreatic tissue may require surgical intervention. Advanced understanding of the pathology, and increased interest in assessment of disease severity are the cornerstones of future management strategies of this complex and heterogeneous disease in the 21st century. | Alfredo F Tonsi Matilde Bacchion Stefano Crippa Giuseppe Malleo Claudio Bassi | 2009 | World Journal of Gastroenterology2009，15，24： | 54 |
| 2 | Helicobacter pylori infection and extragastric disorders in children: A critical update显示文摘Helicobacter pylori(H. pylori) is a highly prevalent, serious and chronic infection that has been associated causally with a diverse spectrum of extragastric disorders including iron deficiency anemia, chronic idiopathic thrombocytopenic purpura, growth retardation, and diabetes mellitus. The inverse relation of H. pylori prevalence and the increase in allergies, as reported from epidemiological studies, has stimulated research for elucidating potential underlying pathophysiological mechanisms. Although H. pylori is most frequently acquired during childhood in both developed and developing countries, clinicians are less familiar with the pediatric literature in the field. A better understanding of the H. pylori disease spectrum in childhood should lead to clearer recommendations about testing for and treating H. pylori infection in children who are more likely to develop clinical sequelae. A further clinical challenge is whether the progressive decrease of H. pylori in thelast decades, abetted by modern clinical practices, may have other health consequences. | Lucia Pacifico John F Osborn Valeria Tromba Sara Romaggioli Stefano Bascetta Claudio Chiesa | 2014 | World Journal of Gastroenterology2014，20，6： | 18 |
| 3 | Endoscopic ultrasound-guided ethanol ablation ofpancreatic neuroendocrine tumours:A case study andliterature review显示文摘Here we offer a review of the literature regarding endoscopic ultrasound-guided ethanol ablation for pancreatic neuroendocrine tumours and describe the case of a cystic tumour completely ablated after a multisession procedure. A total of 35 PubM ed indexed cases of treated functioning and non-functioning pancreatic neuroendocrine tumours resulted from our search, 29 of which are well-documented and summarised. Endoscopic ultrasound-guided ethanol ablation appears as a local, minimally invasive treatment of pancreatic neuroendocrine tumours, suitable for selected patients. This technique appears feasible, relatively safe and efficient, especially when applied to symptom relief in functioning tumours, aiming at loss of endocrine secretion. For non-functioning tumours, where the goal is complete tissue ablation, eus guided ethanol ablation can provide good results for patients who are unfit for surgery or for those who refuse surgical resection. Its role in 'fit for surgery' patients requires assessment through further studies. | Elia Armellini Stefano F Crinò Marco Ballarè Socrate Pallio Pietro Occhipinti | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，3： | 3 |
| 4 | Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23–01): a phase 3 randomised controlled trial显示文摘 | Viviana Galimberti Bernard F Cole Stefano Zurrida Giuseppe Viale Alberto Luini Paolo Veronesi Paola Baratella Camelia Chifu Manuela Sargenti Mattia Intra Oreste Gentilini Mauro G Mastropasqua Giovanni Mazzarol Samuele Massarut Jean-Rémi Garbay Janez Zgajn | 2013 | Lancet Oncology2013，，4： | 2 |
| 5 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 6 | Diffusion-weighted MR imaging in the evaluation of renal tumours显示文摘 | Squillaci E Manenti G Di Stefano F | 2004 | J Exp Clin Cancer Res2004，23，1： | 1 |
| 7 | Dental disease and risk of coronary heart disease and mortality 显示文摘 | de Stefano F Anda R F Kahn H S | 1993 | Br Med J1993，306，6879： | 1 |
| 8 | ZNCC-based template matching using bounded partial correlation 显示文摘 | STEFANO L D MATTOCC I S TOMBAR I F | 2005 | Pat- tern Recognition Letters2005，，14： | 1 |
| 9 | Electroluminescence of silicon nanocrystals in MOS structures显示文摘 | Franzò G Irrera A Moreira E C Miritello M Iacona F Sanfilippo D Di Stefano G Fallica P G Priolo F | | 0，，： | 1 |
| 10 | Chaotic sequences to improve the performance of evolutionary algorithms 显示文摘 | RICCARDO C LUIGI F STEFANO F | 2003 | IEEE Trans on Evolutionary Computation2003，7，3： | 1 |
| 11 | Remote sensing image fusion using the curvelet transform显示文摘 | Nencini F Andrea G Stefano B | 2007 | Information Fusion2007，，8： | 1 |
| 12 | The neural correlates of verb and noun processing: A PET study 显示文摘 | DANIELA PERANI STEFANO F CAPPA | 1999 | Brain1999，122，12： | 1 |
| 13 | Angiogenesis as risk factor for plaque vulnerability显示文摘 | Di Stefano R Feiice F Balbarini A | 2009 | Curr Pharm Des2009，15，10： | 1 |
| 14 | Oxidative stress in response to high glucose levels in endothelial cells and in endothelial progenitor cells: evidence for differential glutathione peroxidase-1 expression 显示文摘 | Felice F Lueehesi D di Stefano R | 2010 | Microvasc Res2010，80，3： | 1 |
| 15 | Modulation of expression and polymerization of hemoglobin polytaur, a potential blood substitute显示文摘 | SERENA F STEFANO B LUCA R | 2011 | Arch Biochem Biophys2011，505，1： | 1 |
| 16 | The role of prefrontal cortex in verbal episodic memory: rTMS evidence显示文摘 | Marco S Stefano F C Simone R | 2003 | Journal of Cognitive Neuroscienee2003，15，6： | 1 |
| 17 | Cellular and molecular mechanisms in chronic obstructive pulmonary disease 显示文摘 | Di Stefano A Caramori G Ricciardolo F L | 2004 | Clin Exp Allergy2004，34，8： | 1 |
| 18 | Post-traumaticlipoma of the parotid gland: case report 显示文摘 | ] Dispenza F De Stefano A Romano G | 2008 | Acta Otorhinolaryngol Ital2008，28，2： | 1 |
| 19 | Thepopliteal ryst显示文摘 | Daniel F Jean F Stefano B | 2006 | Knee Surg Sports TraumatoiArthrosn2006，14，7： | 1 |
| 20 | Comparison of the usefulness of cardiac resynchronization therapy in three age-groups (<65, 65-74 and ≥75 Years) (from the InSync/InSync ICD Italian Registry)显示文摘 | Stefano F Sergio V Giuseppe B | 2011 | Am J Cardiol2011，107，10： | 1 |
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