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| 1 | Prediction of atrial fibrillation development and progression:current perspectives显示文摘Atrial fibrillation(AF) is the most common arrhythmia in clinical practice. Several conventional and novel predictors of AF development and progression(from paroxysmal to persistent and permanent types) have been reported. The most important predictor of AF progression is possibly the arrhythmia itself. The electrical, mechanical and structural remodeling determines the perpetuation of AF and the progression from paroxysmal to persistent and permanent forms. Common clinical scores such as the hypertension, age ≥ 75 years, transient ischemic attack or stroke, chronic obstructive pulmonary disease, and heart failure and the congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category scores as well as biomarkers related to inflammation may also add important information on this topic. There is now increasing evidence that even in patients with so-called lone or idiopathic AF, the arrhythmia is the manifestation of a structural atrial disease which has recently been defined and described as fibrotic atrial cardiomyopathy. Fibrosis results from a broad range of factors related to AF inducing pathologies such as cell stretch, neurohumoral activation, and oxidative stress. The extent of fibrosis as detected either by late gadolinium enhancement-magnetic resonance imaging or electroanatomic voltage mapping may guide the therapeutic approach based on the arrhythmia substrate. The knowledge of these risk factors may not only delay arrhythmia progression, but also reduce the arrhythmia burden in patients with first detected AF. The present review highlights on the conventional and novel risk factors of development and progression of AF. | Konstantinos Vlachos Konstantinos P Letsas Panagiotis Korantzopoulos Tong Liu Stamatis Georgopoulos Athanasios Bakalakos Nikolaos Karamichalakis Sotirios Xydonas Michael Efremidis Antonios Sideris | 2016 | World Journal of Cardiology2016，8，3： | 16 |
| 2 | Alternative Transcription Initiation and the AUG Context Configuration Control Dual-Organellar Targeting and Functional Competence of Arabidopsis Lon 1 Protease显示文摘细胞的动态平衡包括女伴和朊酶依靠蛋白质质量控制的部件。在细菌和 eukaryoticorganelles, Lon 朊酶在移开不能挽回地损坏的蛋白质并且从而阻止 accumulationof 起一个关键作用有害降级抵抗的总数。基因表示,实时房间的成像, immunobiochemical,和功能的 complementationapproaches 为对叶绿体和线粒体双指向的 Lon1 提供最后的证据。Dual-organellar depositionof Lon1 isoforms 经由漏的核糖体 scanningfrom 取决于 transcriptional 规定和其他的翻译开始从最佳 Kozak 一致广泛地背离的第一 8 月顺序上下文。在 Arabidopsis lon1-1 异种的部分互补的细胞器特定的 Lon1 targetingresults,而完整的互补被指向的 dual-organellar 完全完成。两最佳并且 non-optimalAUG 顺序上下文在酵母是功能的并且便于漏的核糖体扫描当 mitochondrial presequence 被使用时,补充 pim1 显型。生物信息的搜索与 Lon1 类型双指向的顺序组织识别了一小部分 Arabidopsis 基因。Lon4, Lon1 的 paralog,模糊 presequence 多半从祖先的象 Lon1 一样基因的成双的 presequences 演变,产生单个双目标的蛋白质 isoform。我们要求那 Lon1 和它的 subfunctional paralog Lon4 发展了 transcriptional 和 posttranscriptional 的互补子集对为 dual-organellar targeting.Key 词的 environmentalcues 应答的规章的部件: | Gerasimos Daras Stamatis Rigas Dikran Tsitsekian Hadas Zur Tamir Tuller Polydefkis Hatzopoulos | 2014 | Molecular Plant2014，7，6： | 4 |
| 3 | USE OF CONSTRUCTION AND DEMOLITION WASTESAS RAW MATERIALS IN CEMENT CLINKER PRODUCTION显示文摘The aim of the present paper was to investigate the possibility of utilizing Construction and Demolition (C&D) wastes as substitutes of Portland cement raw meal. The C&D wastes that were so used, were the Recycled Concrete Aggregates (RCA) and the Recycled Masonry Aggregates (RMA) derived from demolished buildings in Attica region, Greece. RCA and RMA samples were selected because of their calcareous and siliceous origin respectively, which conformed the composition of the ordinary Portland cement raw meal. For that reason, six samples of cement raw meals were prepared: one with ordinary raw materials, as a reference sample, and five by mixing the reference sample with RCA and RMA in appropriate proportions. The effect on the reactivity of the generated mixtures, was evaluated on the basis of the free lime content (fCaO) in the mixtures sintered at 1350°C, 1400°C and 1450°C. Test showed that the added recycled aggregates improved the burnability of the cement raw meal without affecting negatively the cement clinker properties. Moreover, the formation of the major components (C3S, C2S, C3A and C4AF) of the produced clinkers (sintered at 1450°C) was corroborated by X-Ray Diffraction (XRD). | Christos-Triantafyllos Galbenis Stamatis Tsimas | 2006 | China Particuology2006，4，2： | 4 |
| 4 | Impact of SGLT2 inhibitors on major clinical events and safety outcomes in heart failure patients:a meta-analysis of randomized clinical trials显示文摘BACKGROUND Sodium-glucose co-transporter-2 inhibitors(SGLT2i)significantly reduce the risk of cardiovascular(CV)and renal adverse events in patients with diabetes mellitus,heart failure(HF)and/or chronic kidney disease.We performed a meta-analysis to explore the impact of several different SGLT2i on all-cause mortality,CV mortality,HF hospitalizations and the combined outcome CV death/HF hospitalization in HF patients across the spectrum of left ventricular ejection fraction(LVEF)phenotypes.METHODS A systematic search in MEDLINE database and Cochrane library through March 2021 was performed without limitations.Randomized clinical trials that provided data about the impact of SGLT2i on all-cause mortality,CV mortality,HF hospitalizations or the combined outcome of CV death/HF hospitalization in HF patients were included.A random effects model was used for calculating the effect estimates.RESULTS Nine studies(n=16,723 patients,mean age:65.9 years,males:70.7%)were included in the quantitative synthesis.Compared to placebo,SGLT2i use was associated with 14%lower risk of all-cause mortality[hazard ratio(HR)=0.86,95%CI:0.78−0.94,I^(2)=0,P=0.0008],32%lower risk of HF hospitalizations(HR=0.68,95%CI:0.62−0.74,I^(2)=0,P<0.001),14%lower risk of CV mortality(HR=0.86,95%CI:0.77−0.95,I^(2)=0,P=0.003)and 26%lower risk of CV death/HF hospitalization(HR=0.74,95%CI:0.68−0.80,I^(2)=0,P<0.001).Regarding the safety outcomes,our data revealed no significant differences between SGLT2i and placebo groups in drug related discontinuations,amputations,severe hypoglycemia,hypotension,volume depletion,ketoacidosis and genital infections.By contrast,a protective role of SGLT2i against placebo was found for serious adverse events and acute kidney injury.CONCLUSIONS In patients with HF,regardless of LVEF phenotype,all SGLT2i had an excellent safety profile and significantly reduced the risk of all-cause mortality,CV mortality,HF hospitalizations and CV deaths/HF hospitalizations compared to placebo. | George Bazoukis Stamatis S.Papadatos Costas Thomopoulos Gary Tse Stefanos Cheilidis Konstantinos Tsioufis Dimitrios Farmakis | 2021 | Journal of Geriatric Cardiology2021，18，10： | 3 |
| 5 | 与 transarterial chemoembolization 对待的 Hepatocellular 癌: 有参量的提高对比的 ultrasonography 的评估显示文摘 AIM:To evaluate the response of hepatocellular carcinoma(HCC) to transarterial chemoembolization(TACE) using a simplified protocol of parametric contrastenhanced ultrasound(pCEUS).METHODS:Eighteen patients with HCC(18 target tumors,diameter:2.8-12 cm) were evaluated before,and 20 d after TACE.The distribution and morphology of TACE-induced necrosis in these tumors precluded accurate evaluation by visual assessment or by simple measurements.For pCEUS,a 4.8 mL bolus of SonoVue(Bracco,Milan,Italy) was intravenously administered and analysis of tumor perfusion during the initial phase of enhancement(0-30 s post injection) was performed with dedicated software(Qontrast,Bracco,Milan,Italy).Time-intensity curves were plotted and three parameters were calculated:peak intensity(PI,in percentage %),time to peak(TTP in seconds,s) and area under the curve during wash-in(AUC-WI,in arbitrary units,a.u).Magnetic resonance imaging was the standard imaging modality for post-treatment evaluation.Changes in tumor size were recorded and response was assessed according to response evaluation criteria in solid tumors criteria.RESULTS:A statistically significant decrease in PI and AUC-WI was observed in the treated tumors post TACE;PIpre:21.5% ± 8.7%(mean ± SD),PIpost:12.7% ± 6.7%,P < 0.001,AUC-WI pre:17493 ± 9563 a.u,AUCWI post:9585 ± 5494 a.u,P < 0.001.A slight increase in TTP was noted post TACE,but this was not statistically significant;TTP pre:13.1 ± 4.3 s,TTP post:13.6 ± 4.2 s,P = 0.058).The changes in the aforementioned parameters were not accompanied by significant tumor shrinkage.CONCLUSION:pCEUS,even when limited to the study of the arterial phase of tumoral enhancement,can detect and quantify early perfusional changes in HCC post TACE. | Hippocrates Moschouris Katerina Malagari Athanasios Marinis Ioannis Kornezos Konstantinos Stamatiou Georgios Nikas Marina Georgiou Papadaki Panagiotis Gkoutzios | 2012 | World Journal of Radiology2012，4，8： | 3 |
| 6 | Efficacy and safety of novel anticoagulants in the elderly显示文摘Atrial 纤维性颤动和静脉的 thromboembolism (VTE ) 是与有害 thrombotic 事件联系的普通混乱,特别地在老病人。Polypharmacy,合作病态,和改变的 pharmacokinetics,在这些病人经常在场,使抗凝剂的使用变为相当挑战性。新奇口头的抗凝剂(NOAC ) 最近作为维生素 K 对手(VKA ) 的选择出现了并且主要因为他们的更少药和食物相互作用和容易使用,逐渐地正在增加他们的流行。他们的有效性和安全在一般人口是生长得很好的但是在利益和伤害在之间的平衡老仍然是不清楚的。在这些病人的平淡的使用是不平常的。积累的数据证明了 NOAC 的利益在所有年龄组之中是一致的,展示在阻止 thrombotic 事件的相等或更大的功效。过量流血与与 VKA 相比的 NOAC 是更低的,但是为模式放血在他们之中并且面对面是迥异的比较不是可得到的。在老人口的新奇抗凝剂的功效和安全上的现在的评论热点。 | Nikolaos Karamichalakis Stamatis Georgopoulos Konstantinos Vlachos Ioarmis Liatakis Michael Efremidis Antonios Sideris Konstantinos P Letsas | 2016 | Journal of Geriatric Cardiology2016，13，8： | 3 |
| 7 | What will the future hold for artificial organs in the service of assisted reproduction: prospects and considerations显示文摘Assisted reproduction provides a wide spectrum of treatments and strategies addressing infertility.However,distinct groups of infertile patients with unexplained infertility,congenital disorders,and other complex cases pose a challenge in in vitro fertilization(IVF)practices.This special cohort of patients is associated with futile attempts,IVF overuse,and dead ends in management.Cutting edge research on animal models introduced this concept,along with the development of artificial organs with the aim to mimic the respective physiological functions in reproduction.Extrapolation on clinical application leads to the future use of infertility management in humans.To date,the successful clinical application of artificial reproductive organs in humans is not feasible because further animal model studies are required prior to clinical trials.The application of these artificial organs could provide a solution to infertility cases with no other options.This manuscript presents an overview on the current status,future prospects,and considerations on the potential clinical application of artificial ovary,uterus,and gametes in humans.This paper presents how the IVF practice landscape may be shaped and challenged in the future,along with the subsequent concerns in assisted reproductive treatments. | Mara Simopoulou Konstantinos Sfakianoudis Petroula Tsioulou Anna Rapani Polina Giannelou Nikolaos Kiriakopoulos Agni Pantou Nikolaos Vlahos George Anifandis Stamatis Bolaris Konstantinos Pantos Michael Koutsilieri | 2019 | Frontiers of Medicine2019，13，6： | 2 |
| 8 | The treatment and functional outcome of typeⅣ coronal shear fractures of the distal humerus:a retrospective review of five cases显示文摘 | Stamatis E Paxinos O | 2003 | J Orthop Trauma2003，17，4： | 1 |
| 9 | Construction of a human cardiovascular cDNA microarray:portrait of the failing heart显示文摘 | Barrans J D Stamatiou D Liew C | 2001 | Biochem Biophys Res Commun2001，280，： | 1 |
| 10 | Azithromycin has an antiproliferative and autophagic effect on airway smooth muscle cells显示文摘 | Stamatiou R Paraskeva E Boukas K | | 0，，03： | 1 |
| 11 | Groundwater pollution by heavy metals in historical mining area of Lavrio, Attica, Greece 显示文摘 | Stamatis G Voudouris K Karefilakis F | 2001 | Water Air Soil Pollut2001，128，12： | 1 |
| 12 | Channel diversity in random wireless networks显示文摘 | Stamatiou K Proakis J G Zeidler J R | 2010 | IEEE Transactions on Wireless Communications2010，9，22： | 1 |
| 13 | A novel lipolytic activity of Rhodotorula glutinis cells: Production, partial characterization and application in the synthesis of esters显示文摘 | Dimitris G. Hatzinikolaou Ekaterini Kourentzi Haralambos Stamatis Paul Christakopoulos Fragiskos N. Kolisis Dimitris Kekos Basil J. Macris | 1999 | Journal of Bioscience and Bioengineering1999，，1： | 1 |
| 14 | Current concepts in delayed bone union and non-union显示文摘 | Polyzois VD'Papakostas I Stamatis ED ef al | 2006 | Clin Podiatr Med Surgy2006，23，2： | 1 |
| 15 | Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray 显示文摘 | Barrans JD Allen PD Stamatiou D | 2002 | Am J Pathol2002，160，： | 1 |
| 16 | Effect of surgical lung volume reduction on respiratory muscle function in pulmonary emphysema显示文摘 | Teschler H Stamatis G el-Raouf Farhat AA | 1996 | Eur Respir J1996，9，9： | 1 |
| 17 | Random Access Poisson Networks: Stability and Delay显示文摘 | Stamatiou K Haenggi M | 2010 | IEE[Communications Letters2010，14，11： | 1 |
| 18 | The effect of iron overload in the hearts of patients with beta‐thalassemia显示文摘 | Stella V.Brili Stamatis S.Castelanos Constadina J.Aggeli Costas A.Tentolouris Christos E.Pitsavos Pavlos K.Toutouzas Anastasia I.Tzonou | 2009 | Clin Cardiol2009，，6： | 1 |
| 19 | Mutagenesis of varicella-zoster virus glycoprotein I (gI) identifies a cysteine residue critical for gE/gI heterodimer formation, gI structure, and virulence in skin cells 显示文摘 | Oliver SL Sommer MH Reichelt M Rajamani J Vlaycheva-Beisheim L Stamatis S Cheng J Jones C Zehnder J Arvin AM | 2011 | J Virol2011，85，9： | 1 |
| 20 | Prognostically orientatedmultimodality treatment including surgery for selected patients of small-cell lung cancer patients stages ⅠB to ⅢB:long-term results of a phase Ⅱ trial显示文摘 | Eberhardt W Stamatis G Stuschke M | | 0，，07： | 1 |
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