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136篇 您的检索式:作者名="ST LEGER"
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1Genome survey uncovers the secrets of sex and lifestyle in caterpillar fungus显示文摘The caterpillar fungus Ophiocordyceps sinensis (best known as Cordyceps sinensis) mummifies ghost moth larvae exclusively in Tibetan Plateau alpine ecosystems. Touted as 'Himalayan Viagra', the fungus is highly prized due to its medical benefits and dwindling supplies. Attempts to culture the sexual fruiting-body have failed and the huge market demand has led to severe devastation of local ecosystems and to the fungus heading towards extinction. By genome sequencing, we establish that unlike related insect pathogens O. sinensis contains two compatible mating-type genes in its genome and is self-fertile, i.e. homothallic. However, sexual processes are only initiated under native environmental conditions. O. sinensis resembles biotrophic plant pathogens in having a genome shaped by retrotransposon-driven expansions. The resulting changes in gene content suggest that O. sinensis has a biphasic pathogenic mechanism beginning with stealth pathogenesis in early host instars. O. sinensis is the first psychrophilic fungus sequenced and is adapted to extreme cold with putative antifreeze proteins and mechanisms for increasing lipid accumulation and fatty acid unsaturation. We hypothesize that for the inbreeding O. sinensis the massive proliferation of retrotransposons provides a tradeoff between the advantages of increased genetic variation independent of sexual recombination and deletion of genes dispensable for its specialized pathogenic lifestyle.HU Xiao ZHANG YongJie XIAO GuoHua ZHENG Peng XIA YongLiang ZHANG XingYu ST LEGER Raymond J LIU XingZhong WANG ChengShu 2013Chinese Science Bulletin2013,58,23:26
2Differential gene expression by Metarhizium anisopliae growing in root exudate and host(Manduca sexta)cuticle or hemolymph reveals mechanisms of physiological adaptation显示文摘Wang C S Hu G St Leger R J 2005Fungal Genetics and Biology2005,42,:1
3Engineering improved mycoinsecticides显示文摘St Leger R J Roberts D W 1997Trends in Biotechnology1997,15,:1
4The Metarbizium anisopliae Perilipin homolog MPL1 regulates lipid metabolism, appressorial turgor pressure, and vintlence显示文摘Wang Chengshu St Leger R J 2007J Biol Chem2007,282,21:1
5A scorpion neurotoxin increases the potency of a fungal insecticide显示文摘Wang C St Leger R 2007Nature Biotechnology2007,25,12:1
6Biochemical characterization and ul'trastructural localization of two extracellular trypsins produced by Metarhizium anisopliae in infected insect cuticles 显示文摘St Leger R J Joshi L Bidochka M J 1996Applied and Environmental Microbiology1996,4,:1
7Clostridium perfrin- gens septicemia in a long-beaked common dolphin Delphinus capensis: an etiology of gas bubble accumulation in cetaceans 显示文摘Danil K St Leger JA Dennison S 2014Diseases of Aquatic Organisms2014,111,3:1
8Characterization of cuticle degrading proteases produced by the entomopathogen Metarhizium anisolliae 显示文摘St Leger R J Charnley A K Cooper R M 1987Arch Biochem Biophys1987,253,1:1
9Ambient pH is a major de-terminant in the expression of cuticle-degrading enzymes and hydrophobin by Metarhizium anisopliae显示文摘St Leger R J Oshi L Roberts D 1998Applied and En-vironment Microbiology1998,64,4:1
10The entomopathogenic fungus Metarhizium anisopliae alters ambient pH, allowing extracellular proteases production and activity 显示文摘St Leger R J Nelson J O Screen S E 1999Microbiology1999,145,10:1
11Construction of an improved mycoinsecticide overexpressing a toxic protease 显示文摘ST LEGER R J JOSHI L BIDOCHKA M J 1996Proc Natl Acad Sci USA1996,,93:1
12Production of cuticle-degrading enzymes by the entomopathogen Metarhizium anisopliae during infection of cuticles from Calliphora vomitoria and Manduca sexta显示文摘St Leger R J Charnley A K Cooper R M 1987J Geu Microbiol1987,133,:1
13Schools, health literacy and public health: pos- sibilities and challenges显示文摘St Leger L 2001Health Promotion International2001,16,2:1
14Molecular cloning and regulatory analysis of the cuticle-degrading-protease structural gene from the entomopathogenic fungus Metarhizum anisoplia显示文摘ST LEGER R J FRANK D C ROBERTS D W 1992Eur J Biochem1992,204,:1
15Emergence of fatal avian influenza in New England harbor seals显示文摘ANTHONY S J ST LEGER J A PUGLIARES K 2012MBio2012,3,4:1
16Engineering improved mycoinsecticides 显示文摘ST LEGER R J ROBERTS D W 1997Trends in Biotechnology1997,,15:1
17Pharmaco- kinetics of enfloxacin in fingerling rainbow trout(Oncorhyn-chus mykiss)显示文摘Bowser P R Wooster G A St Leger J 1992J Vet PharmacolTherap1992,15,1:1
18Entomopathogen- ie Isolates of Metarhizium anisopliae, Beauveria bassiana and Aspergillus flavus Produce Multiple Extracellular Chitinase Isozymes显示文摘St Leger R J Staples R C Roberts D W 1993Journal of Invertebrat( Patholo gy1993,81,1:1
19The role of extracellular chymoelastase in virulence of Metarhizium anisopliae for Manduca sexta 显示文摘St Leger R J 1988J Invertebr Pathol1988,52,:1
20Molecular cloning and regulatory analysis of the cuticle-degradingprotease structural gene from the entornopathogenic fungus Metarhizium anisopliae 显示文摘St Leger R J Frank D C Roberts D W 1992Eur J Biochem1992,204,:1
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