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| 1 | Hepatic encephalopathy: Ever closer to its big bang显示文摘Hepatic encephalopathy(HE) is a neuropsychiatric disorder that commonly complicates the course of patients with liver disease. Despite the fact that the syndrome was probably first recognized hundreds of years ago, the exact pathogenesis still remains unclear. Minimal hepatic encephalopathy(MHE) is the earliest form of HE and is estimated to affect more that 75% of patients with liver cirrhosis. It is characterized by cognitive impairment predominantly attention, reactiveness and integrative function with very subtle clinical manifestations. The development of MHE is associated with worsen in driving skills, daily activities and the increase of overall mortality. Skeletal muscle has the ability to shift from ammonia producer to ammonia detoxifying organ. Due to its large size, becomes the main ammonia detoxifying organ in case of chronic liver failure and muscular glutaminesynthase becomes important due to the failing liver and brain metabolic activity. Gut is the major glutamine consumer and ammonia producer organ in the body. Hepatocellular dysfunction due to liver disease, results in an impaired clearance of ammonium and in its interorgan trafficking. Intestinal bacteria, can also represent an extra source of ammonia production and in cirrhosis, small intestinal bacterial overgrowth and symbiosis can be observed. In the study of HE, to get close to MHE is to get closer to its big bang; and from here, to travel less transited roads such as skeletal muscle and intestine, is to go even closer. The aim of this editorial is to expose this road for further and deeper work. | Pablo A Souto Ariel R Marcotegui Lisandro Orbea Juan Skerl Juan Carlos Perazzo | 2016 | World Journal of Gastroenterology2016，22，42： | 6 |
| 2 | Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines显示文摘 | Jácomo R H Melo R A Souto F R | 2007 | Haematologica2007，92，10： | 1 |
| 3 | Dyeing mechanism and optimization of polyamide 6,6 functionalized with double barrier discharge (DBD) plasma in air显示文摘 | Oliveira F R Zille A Souto A P | 2014 | Applied Sur- face Science2014，293，： | 1 |
| 4 | Analytical matched filter hound for M- QAM hierarchical constellations with diversity lception in multipath rayleigh fading channels 显示文摘 | Souto N Dinis R Silva J C | 2010 | IEEE Trans on Communications2010，58，3： | 1 |
| 5 | Actinomyces species, streptococci, and Enterococcus faecdis in primary root canal in- fections显示文摘 | Siqueira JF Jr R6~as IN Souto R | 2002 | J Endod2002，28，3： | 1 |
| 6 | Prevalence of Enterococcus faecalis in subgingival biofilm and saliva of subjects with chronic periodontal infection显示文摘 | Souto R Colombo A P | | 0，，2： | 1 |
| 7 | A doubleline sequential injection system for the spectrophotometric determination of copper, iron, manganese, and zinc in waters 显示文摘 | Morais I P Souto M R Rangel A O | 2002 | Anal Bioanal Chem2002，373，12： | 1 |
| 8 | A Pre-regularization Scheme for the Reconstruction of a Spatial Dependent Scattering Albedo Using a Hybrid Ant Colony Optimization Implementation显示文摘 | Stephany S Becceneri J C Souto R P | 2010 | Applied Mathematical Modelling2010，34，3： | 1 |
| 9 | Clinical features and outcomes of 134 Brazilians with acute promyelocytie leukemia who received ATRA and anthracyclines 显示文摘 | JACOMO R H MELO R A SOUTO F R | 2007 | Haematologica2007，92，10： | 1 |
| 10 | Spectrophoto- metric flow system using vanadomolybdophosphate detection chemistry and a liquid waveguide capillary cell for the determination of phosphate with improved sensitivity in surface and ground water samples显示文摘 | Neves M S A C Souto M R S | 2008 | Talanta2008，77，： | 1 |
| 11 | Solid lipid nanoparticles and nanostructured lipid carriers for topical delivery of ketoconazole 显示文摘 | SOUTO E B MULLER R H | 2005 | J Microencapsul2005，22，5： | 1 |
| 12 | Checker-board DNA-DNA hybridization analysis of endodontic infections显示文摘 | Siqueira JF Rocas IN Souto R | 2000 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2000，89，： | 1 |
| 13 | Antibiotic resistance profile of the subgingival microbiota following systemic or local tetracycline therapy显示文摘 | Rodrigues RM Goncalves C Souto R | 2004 | J Clin Periodontol2004，31，6： | 1 |
| 14 | The use of SLN and NLC as topical particulate carriers for imidazole antifungal agents 显示文摘 | SOUTO E B MULLER R H | 2006 | Pharmazie2006，61，5： | 1 |
| 15 | Prevalence of Enterococcus faecalis in sub- gingival biofilm and saliva of subjects with chronic periodontal in- fection显示文摘 | Souto R Colombo AP | 2008 | Arch Oral Biol2008，53，2： | 1 |
| 16 | Investigating corrosion processes in the micrometric range: A SVET study of the galvanic corrosion of zinc coupled with iron显示文摘 | Souto R M Gonzalez-Garcia Y Bastos A C | 2007 | Corrosion Science2007，49，： | 1 |
| 17 | SECM imaging of interfacial processes in defective organic coatings applied on me- tallic substrates using oxygen as redox mediator 显示文摘 | Souto R M Femndez-M6rida L Oonzlez S | 2009 | Electroanal2009，21，24： | 1 |
| 18 | Endodontic therapy associated with calcium hydroxide as an intracanal dressing: microbiologic evalu- ation by the checkerboard DNA-DNA hybridization technique 显示文摘 | De Souza CA Teles RP Souto R | 2005 | J Endod2005，31，2： | 1 |
| 19 | Electrochemical and structural properties of a polyurethane coating on steel substrates for corrosion protection 显示文摘 | Gonztilez- Garcia Y Gonzalez S Souto R M | 2007 | Corros Sci2007，49，： | 1 |
| 20 | Micro- wave Fast Sintering of Ceramic Materials显示文摘 | Menezes RR Souto PM Kiminami R H G A | 2007 | Journal of Materials Processing Technology2007，190，： | 1 |
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