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| 1 | -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia显示文摘AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia. | Carina Pereira Hugo Sousa Paula Ferreira Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，34： | 16 |
| 2 | Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review显示文摘BACKGROUND Despite the advent of biological drugs, conventional therapy continues to be used in moderate to severe inflammatory bowel disease(MS-IBD). This study hypothesized that as a standard of treatment and the primary alternative to biologics, conventional therapy should present robust effectiveness results in IBD outcomes.AIM To investigate the effectiveness of conventional therapy for MS-IBD.METHODS A systematic review with no time limit was conducted in July 2017 through the Cochrane Collaboration, MEDLINE, and LILACS databases. The inclusion criteria encompassed meta-analyses, systematic reviews, randomized clinical trials, observational and case-control studies concerning conventional therapy in adult patients with MS-IBD, including Crohn's disease(CD) and ulcerative colitis(UC). Corticosteroids(prednisone, hydrocortisone, budesonide, prednisolone,dexamethasone), 5-aminosalicylic acid(5-ASA) derivatives(mesalazine and sulfasalazine) and immunosuppressants [azathioprine(AZA), methotrexate(MTX), mycophenolate, cyclosporine, tacrolimus, 6-mercaptopurine(6-MP)] were considered conventional therapy. The exclusion criteria were sample size below50; narrative reviews; specific subpopulations(e.g., pregnant women,comorbidities); studies on postoperative IBD; and languages other than English,Spanish, French or Portuguese. The primary outcome measures were clinical remission(induction or maintenance), clinical response and mucosal healing. As secondary outcomes, fecal calprotectin, hospitalization, death, and surgeries were analyzed. The quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation criteria.RESULTS The search strategy identified 1995 citations, of which 27 were considered eligible(7 meta-analyses, 20 individual studies). For induction of clinical remission, four meta-analyses were selected(AZA and 6-MP showed no advantage over placebo,MTX or 5-ASA in CD; MTX showed no statistically significant difference versus placebo, 6-MP, or 5-ASA in UC; tacrolimus was superior to placebo for UC in two meta-analyses). Only one meta-analysis evaluated clinical remission maintenance, showing no statistically significant difference between MTX and placebo, 5-ASA, or 6-MP in UC. AZA and 6-MP had no advantage over placebo in induction of clinical response in CD. Three meta-analyses showed the superiority of tacrolimus vs placebo for induction of clinical response in UC. The clinical response rates for cyclosporine were 41.7% in randomized controlled trials(RCTs) and 55.4% in non-RCTs for UC. For induction of mucosal healing,one meta-analysis showed a favorable rate with tacrolimus versus placebo for UC. For secondary outcomes, no meta-analyses specifically evaluated fecal calprotectin, hospitalization or death. Two meta-analyses were retrieved evaluating colectomy rates for tacrolimus and cyclosporine in UC. Most of the twenty individual studies retrieved contained a low or very low quality of evidence.CONCLUSION High-quality evidence assessing conventional therapy in MS-IBD treatment is scarce, especially for remission maintenance, mucosal healing and fecal calprotectin. | Adérson Omar Mourao Cintra Damiao Matheus Freitas Cardoso de Azevedo Alexandre de Sousa Carlos Marcela Yumi Wada Taciana Valéria Marcolino Silva Flávio de Castro Feitosa | 2019 | World Journal of Gastroenterology2019，25，9： | 13 |
| 3 | Land Surface Displacement Geohazards Monitoring Using Multi-temporal InSAR Techniques显示文摘China has been affected by some of the world’s most serious geological disasters and experiences high economic damage every year.Geohazards occur not only in remote areas but also in highly populated cities.In the framework of the Dragon-432365 Project,this paper presents the main results and the major conclusions derived from an extensive exploitation of Sentinel-1,ALOS-2(Advanced Land Observing Satellite 2),GF-3(Gao Fen Satellite 3),and latest launched SAR(Synthetic Aperture Radar),together with methods that allow the evaluation of their importance for various geohazards.Therefore,in the scope of this project,the great benefits of recent remote sensing data(wide spatial and temporal coverage)that allow a detailed reconstruction of past displacement events and to monitor currently occurring phenomena are exploited to study different areas and geohazards problems,including:surface deformation of mountain slopes;identification and monitoring of ground movements and subsidence;landslides;ground fissure;and building inclination studies.Suspicious movements detected in the different study areas were cross validated with different SAR sensors and truth data. | Guang LIU Perski ZBIGNIEW Salvi STEFANO Thiebes BENNI Lixin WU Jinghui FAN Shibiao BAI Lianhuan WEI Shiyong YAN Rui SONG Bignami CHRISTIAN Tolomei CRISTIANO Stefan SCHNEIDERBAUER Joao Sousa JOAQUIM 无 | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 13 |
| 4 | Major regulatory mechanisms involved in sperm motility显示文摘涉及鞭子部件以及在 flagellar 运动的规定的汇编和函数的基因库和分子的机制充分没被理解,特别在人。为精子无法移动,一些能被避免并且改正有几个原因,而其它与基因缺点有关并且值得完整的调查把诊断给病人。这评论在科学的联机数据库 PubMed, ScienceDirect,和网上在广泛的文学搜索以后被执行。这里,我们考察为精子活动性负责的规章的小径的参与,显示为精子无法移动的可能的原因。这些包括了钙小径,营地依赖者蛋白质 kinase 小径, kinases 和磷酸酶的重要性,反应的氧种类的功能,并且房间体积和 osmolarity 的规定怎么也是基本部件。我们然后讨论与特定的词法畸形联系的主要基因缺点。最后,我们稍微讨论某预防措施和治疗途径避免与未特别指出的精子无法移动被联系的条件的开发。我们在不久的将来相信那,与更强大的技术,精子无法移动的基因原因和活动性将是的精子的规章的机制的发展更好理解,因此启用执行完整的诊断并且揭开新治疗。 | Rute Pereira Rosalia Sa Alberto Barros Mario Sousa | 2017 | Asian Journal of Andrology2017，19，1： | 12 |
| 5 | Thalidomide induces mucosal healing in Crohn's disease: Case report显示文摘Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract that is defi ned by relapsing and remitting episodes. Tumor necrosis factor alpha (TNF-α) appears to play a central role in the pathophysiology of the disease. Standard therapies for inflammatory bowel disease fail to induce remission in about 30% of patients. Biological therapies have been associated with an increased incidence of infections, especially infection by Mycobacterium tuberculosis (Mtb). Thalidomide is an oral immunomodulatory agent with anti-TNF-α properties. Recent studies have suggested that thalidomide is effective in refractory luminal and fistulizing Crohn's disease. Thalidomide costimulates T lymphocytes, with greater effect on CD8+ than on CD4+ T cells, which contributes to the protective immune response to Mtb infection. We present a case of Crohn's disease with gastric, ileal, colon and rectum involvement as well as steroid dependency, which progressed with loss of response to infliximabafter three years of therapy. The thorax computed tomography scan demonstrated a pulmonary nodule suspected to be Mtb infection. The patient was started on thalidomide therapy and exhibited an excellent response. | Márcio Rios Leite Sandra Sousa Santos André Castro Lyra Jaciane Mota Genoile Oliveira Santana | 2011 | World Journal of Gastroenterology2011，17，45： | 9 |
| 6 | Update on hepatitis B and C virus diagnosis显示文摘Viral hepatitis B and C virus(HBV and HCV) are responsible for the most of chronic liver disease worldwide and are transmitted by parenteral route, sexual and vertical transmission. One important measure to reduce the burden of these infections is the diagnosis of acute and chronic cases of HBV and HCV. In order to provide an effective diagnosis and monitoring of antiviral treatment, it is important to choose sensitive, rapid, inexpensive, and robust analytical methods. Primary diagnosis of HBV and HCV infection is made by using serological tests for detecting antigens and antibodies against these viruses. In order to confirm primary diagnosis, to quantify viral load, to determine genotypes and resistance mutants for antiviral treatment, qualitative and quantitative molecular tests are used. In this manuscript, we review the current serological and molecular methods for the diagnosis of hepatitis B and C. | Livia Melo Villar Helena Medina Cruz Jakeline Ribeiro Barbosa Cristianne Sousa Bezerra Moyra Machado Portilho Letícia de Paula Scalioni | 2015 | World Journal of Virology2015，4，4： | 9 |
| 7 | Clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal显示文摘AIM To determine the prevalence of epstein-barr virus(eb V)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics. METHODS We have performed a retrospective study including a total of 179 consecutive patients with gastric cancer(GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification. Tumour tissues were collected from the institutional tumour bank. eb V was detected by in situ hybridization for the detection of eb V-encoded small RNAs(ebe Rs) and eb V latent proteins(LMP1 and LMP2 A) were detected by immunohistochemistry.RESULTS The analysis showed that eb V-associated gastric carcinomas(eb Va GC) represents 8.4%(15/179) of all GC cases, with a significant differential distribution among histological types(P < 0.001): 100%(3/3) of medullary carcinomas, 100%(1/1) of adenosquamous carcinoma, 8.7%(8/92) of tubular adenocarcinomas, 8.0%(2/25) of mixed carcinomas and 2%(1/51) in poorly cohesive carcinomas. The analysis revealed a higher predominance of eb Va GC in the upper third and middle(cardia, fundus and body) of the stomach(P = 0.041), a significant lower number of regional lymph nodes invasion(P = 0.025) and a tendency for better prognosis(P = 0.222). eb V latent protein expression revealed that all eb Va GC cases were LMP1-negative, nevertheless 6 cases(40%) expressed LPM2 A, which reveals that these cases show a distinct eb V-Latency profile(latency II-like).CONCLUSION eb Va GC represents 8.4% of all GC in the North Region of Portugal. The eb V-infected patients have specific clinic-pathological features that should be further explored to develop new strategies of management and treatment. | Joana Ribeiro Andreia Oliveira Mariana Malta Claudia Oliveira Fernanda Silva Ana Galaghar Luís Pedro Afonso Maria Cassiano Neves Rui Medeiros Pedro Pimentel-Nunes Hugo Sousa | 2017 | World Journal of Gastroenterology2017，23，40： | 9 |
| 8 | 1型糖尿病患者的血糖控制,心脏自身免疫和心血管病的长期风险显示文摘血糖控制不佳与1型糖尿病(type 1diabetes mellitus,T1DM)患者的心血管病风险增加有关;然而,对T1DM的特异性机制知之甚少。在T1DM中,心肌损伤可诱发持续的心脏自身免疫。慢性高血糖症引起心肌损伤,高血糖诱导的心脏自身免疫可能导致长期心血管病并发症的可能性。 | Sousa GR Pober D Galderisi A Lv H Yu L Pereira AC Doria A Kosiborod M Lipes MA 刘莉 叶鹏 | 2019 | 中华高血压杂志2019，27，1： | 8 |
| 9 | Mechanisms of neuroplasticity and brain degeneration: strategies for protection during the aging process显示文摘Aging is a dynamic and progressive process that begins at conception and continues until death.This process leads to a decrease in homeostasis and morphological,biochemical and psychological changes,increasing the individual’s vulnerability to various diseases.The growth in the number of aging populations has increased the prevalence of chronic degenerative diseases,impairment of the central nervous system and dementias,such as Alzheimer’s disease,whose main risk factor is age,leading to an increase of the number of individuals who need daily support for life activities.Some theories about aging suggest it is caused by an increase of cellular senescence and reactive oxygen species,which leads to inflammation,oxidation,cell membrane damage and consequently neuronal death.Also,mitochondrial mutations,which are generated throughout the aging process,can lead to changes in energy production,deficiencies in electron transport and apoptosis induction that can result in decreased function.Additionally,increasing cellular senescence and the release of proinflammatory cytokines can cause irreversible damage to neuronal cells.Recent reports point to the importance of changing lifestyle by increasing physical exercise,improving nutrition and environmental enrichment to activate neuroprotective defense mechanisms.Therefore,this review aims to address the latest information about the different mechanisms related to neuroplasticity and neuronal death and to provide strategies that can improve neuroprotection and decrease the neurodegeneration caused by aging and environmental stressors. | Mariana Toricelli Arthur Antonio Ruiz Pereira Guilherme Souza Abrao Helena Nascimento Malerba Julia Maia Hudson Sousa Buck Tania Araujo Viel | 2021 | Neural Regeneration Research2021，16，1： | 8 |
| 10 | “徒手针刺影响健康人和中风后遗症患者肱二头肌功能的即时效果的平行随机对照试验”的研究方案(英文)显示文摘背景:中风作为一种疾病,中医早在2 000多年前即有诸多经典著作对其进行描述。然而,大部分有关针刺对中风后遗症患者功能恢复的疗效的临床对照试验未能得出针刺具有长期疗效的结论。并且,很多试验以表面肌电图测量患者骨骼肌的电活动以评定针刺刺激的即时疗效的结论也不一致。这些研究结果对针刺在神经肌肉水平的作用提出了质疑。本研究旨在比较徒手针刺影响健康人和中风后肌张力亢进患者的肱二头肌功能及力量的即时效果。方法与设计:本研究拟开展含有4个平行对照组的随机单盲临床试验。分别针刺健康受试者及中风后遗症痉挛性轻瘫患者的曲池(LI11)及天泉(PC2)2个穴位。表面肌电图测量针刺对于肌肉功能的即时疗效及肱二头肌的等长张力作为主要结局指标。次要结局指标包括每组中医证候的出现频率及频率分布。讨论:本研究的临床试验设计在方法学上较之前的类似试验有些改善。预计这一研究能够证实针刺刺激对健康人及中风后遗症患者的神经肌肉的作用。临床试验注册:巴西临床试验注册(www.ensaiosclinicos.gov.br,注册号为RBR-5g7xqh). | Ana Paula de Sousa Fragoso Arthur de Sá Ferreira | 2012 | 中西医结合学报2012，10，3： | 8 |
| 11 | In vitro antibacterial effect of aqueous and ethanolic Moringa leaf extracts显示文摘Objective:To evaluate the antibacterial effect of aqueous and ethanolic moringa leaf extracts (Moringa oleifera) on the growth of gram-positive and negative bacteria.Methods:Paper disks were soaked with 100,200,300 and 400μL of extract at 20 g/180mL and 10 g/190 mL.All extracts were tested against Escherichia coli(ATCC25922),Staphylococcus aureus(ATCC25923),Vibrio parahaemolyticus,Enterococcus faecalis(ATCC29212),Pseudomonas aeruginosa(ATCC27853), Salmonella enteritidis(IH) and Aeromonas caviae.The susceptibility tests were performed using the modified disk diffusion method.Results:The strains E.coli,P.aeruginosa and S.enteritidis (IH) were resistant to all treatments.In general,disks with 400μL extract were the most efficient against S.aureus,V.parahaemolyticus,E.faecalis and A.caviae.Conclusions:The study indicates a promising potential for aqueous and ethanolic Moringa leaf extracts as alternative treatment of infections caused by the tested strains. | Jackson Rafael Oliveira Peixoto Giselle Cristina Silva Renata Albuquerque Costa Joseires Lira de Sousa Fontenelle Gustavo Hitzschky Fernandes Vieira Antonio Adauto Fonteles Filho Regine Helena Silva dos Fernandes Vieira | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，3： | 7 |
| 12 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 13 | Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants显示文摘瞄准:在胃蛋白酶原 C (PGC ) 基因学习插入 / 删除多型性的角色,为胃粘膜的终端区别的一个有效标记,在到胃的损害的开发的危险性。方法:没有肿瘤的疾病的证据,学习与已知的胃的损害的 99 件样品和 127 件样品被执行。PCR 被采用, 6 多态的等位基因被放大:等位基因 1 (510 bp ) ,等位基因 2 (480 bp ) ,等位基因 3/4 (450/460 bp ) ,等位基因 5 (400 bp ) 并且等位基因 6 (310 bp ) 。结果:我们的结果表明等位基因 6 搬运人似乎对任何胃的损害的发展有保护(或 = 0.34;P<0.001 ) ,与象萎缩或肠的组织变形那样的胃的腺癌联系的 non-dysplastic 损害(或 = 0.28;P<0.001 ) 或侵略 GC (或 = 0.39;P = 0.004 ) 。结论:我们的学习表明等位基因 6 搬运人地位在胃的损害的发展有一个保护的角色,可能由于它有 PGC 的更高的表示的协会。而且,在控制组的等位基因 6 搬运人的频率比在亚洲人口获得了高是远的,它可能代表在白种人和亚洲人口之间的基因差距。 | Ana L Pinto-Correia Hugo Sousa Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，31： | 6 |
| 14 | 以用户为中心的新兴电力市场模式显示文摘随着可再生能源在现代能源产业中的占比不断提高,其对现行电力系统和电力市场的运行机制所带来的影响也日趋明显;同时,通过与数字信息产业深度结合,分布式能量管理手段也处于飞速发展阶段。在这二者的驱动下,一种以用户为中心的新兴电力市场模式正以不同的表现形式出现在世界各地。文章以高度概括的方式介绍了这一新兴电力市场模式,浅析了其在不同表现形式下的机理和特征。基于这一新兴电力市场模式在短期内所取得的发展成就,有理由相信此类新兴电力市场模式将逐步成为未来电力市场中的重要组成部分。 | Pierre Pinson Thomas Baroche Fabio Moret Tiago Sousa Etienne Sorin Shi You | 2017 | 供用电2017，34，12： | 6 |
| 15 | The Use of Data Mining Techniques in Rockburst Risk Assessment显示文摘目前在世界范围内的很多地下矿山,岩爆已经成为一个与矿山采矿生产密切相关的重要现象。深入理解这类现象,不仅有助于岩爆管理,而且还有可能节约采矿成本,减少人身伤亡事故。其中,实验室实验是深入研究岩爆机理的一个重要途径。在本文作者前期的研究中,已经建立了实验室岩爆实验数据库。与此同时,借助于数字采矿技术,也建立了岩爆最大应力和岩爆风险指数的预测模型。为实现基于矿山地质条件和矿山井巷建筑结构特性对岩爆类型即岩爆强度等级的准确预测,本文的重点是,基于对岩爆实例的分析来建立岩爆影响矩阵,明确岩爆现象的诱发因子,并厘清这些影响因子之间的相互关系。运用人工神经网络(ANN)和初始贝叶斯分类器等数字矿山技术,对矿山岩爆数据库进行了更深入的研究。最后给出了研究得出的各项结论。 | Luis Ribeiro e Sousa Tiago Miranda Rita Leal e Sousa Joaquim Tinoco | 2017 | Engineering2017，3，4： | 6 |
| 16 | Y-chromosome microdeletions in nonobstructive azoospermia and severe oligozoospermia显示文摘现在的工作的目的是介绍病人的结果, Y 染色体 microdeletions 由 intracytoplasmic 精子注射(ICSI ) 对待,任何一个用新鲜(TESE ) 或结冰融化(TESE-C ) 阴囊的精子和呼喊的精子(EJAC ) 。这个工作的创见居住在在 Y-microdeletions (AZFa, AZFb,和 AZFc ) 和治疗的不同类型之间的比较,与详细说明人口统计,刺激,胚胎学、临床、新生(NB ) 结果。有 Y-microdeletions 的 125 个病人, 33 个病人介绍了严重 oligozoospermia (有呼喊的精子的 18 执行 ICSI ) 和 92 能分泌的精子缺乏(65 与 40 去了 TESE 有成功的精子检索并且执行了 ICSI ) 。有 51 个 TESE 治疗周期和 43 个 TESE-C 治疗周期,与 19 NB 的出生(2 在 AZFa/TESE-C, 12 在 AZFc/TESE,并且 5 在 AZFc/TESE-C ) 。29 个 EJAC 周期,有 8 NB 的出生(在 AZFc ) 。在 TESE 和 EJAC 周期,在胚胎学、临床的参数没有重要差别。在 TESE-C 周期,在 AZFc 有重要更低的卵母细胞成熟率和更低的授精率。在结论,尽管有 AZFc microdeletions 的病人介绍了高阴囊的精子恢复率和可接受的临床的结果,有 AZFa 和 AZFb microdeletions 的盒子介绍了差的预后。由于 microdeletions 的报导遗传,病人们应该在 NB 和使用 preimplantation 的可能性上关于不肥沃的后果被通知为女性的基因诊断选择。 | Carolina Goncalves Mariana Cunha Eduardo Rocha Susana Fernandess, Joaquina Silva Luis Ferraz Cristiano Oliveira Alberto Barros Mairio Sousa | 2017 | Asian Journal of Andrology2017，19，3： | 5 |
| 17 | Risk assessment of CO_2 injection processes and storage in carboniferous formations:a review显示文摘Over the last decades,people from almost all over the world have realized that it is necessary to quickly develop strategies for the control and reduction of greenhouse gases (GHG) emissions.Among various GHGs,carbon dioxide (CO2) is the most abundant GHG.Its underground storage involves less risk and lower levels of dangerousness.The paper briefly describes the most effective technologies available in the market for background processes to storage (capture and transport) CO2,as well as the more secure solutions for its storage,in particular for the geological storage in carboniferous formations.This paper also outlines the methodologies for the risk assessment involved in storage of CO2,with a particular focus on cases where the injection is made into unminable coal seams and in abandoned coalmines.Methodologies used for risk analysis are described in detail with particular emphasis on Bayesian network (BN).Some applications regarding the risk assessment of CO2 injection processes and CO2 storage in carboniferous formations and contamination of aquifers are presented and analyzed.Finally,based on the applications of BN,several conclusions are drawn. | Sousa Luis Sousa Rita Gomes Ana Vargas Jr.Eurípedes | 2011 | Journal of Rock Mechanics and Geotechnical Engineering2011，3，1： | 5 |
| 18 | Intranasal delivery of nanostructured lipid carriers,solid lipid nanoparticles and nanoemulsions:A current overview of in vivo studies显示文摘The management of the central nervous system(CNS)disorders is challenging,due to the need of drugs to cross the blood-brain barrier(BBB)and reach the brain.Among the various strategies that have been studied to circumvent this challenge,the use of the intranasal route to transport drugs from the nose directly to the brain has been showing promising results.In addition,the encapsulation of the drugs in lipid-based nanocarriers,such as solid lipid nanoparticles(SLNs),nanostructured lipid carriers(NLCs)or nanoemulsions(NEs),can improve nose-to-brain transport by increasing the bioavailability and site-specifc delivery.This review provides the state-of-the-art of in vivo studies with lipid-based nanocarriers(SLNs,NLCs and NEs)for nose-to-brain delivery.Based on the literature available from the past two years,we present an insight into the different mechanisms that drugs can follow to reach the brain after intranasal administration.The results of pharmacokinetic and pharmacodynamics studies are reported and a critical analysis of the differences between the anatomy of the nasal cavity of the different animal species used in in vivo studies is carried out.Although the exact mechanism of drug transport from the nose to the brain is not fully understood and its effectiveness in humans is unclear,it appears that the intranasal route together with the use of NLCs,SLNs or NEs is advantageous for targeting drugs to the brain.These systems have been shown to be more effective for nose-to-brain delivery than other routes or formulations with non-encapsulated drugs,so they are expected to be approved by regulatory authorities in the coming years. | Cláudia Pina Costa Joao Nuno Moreira JoséManuel Sousa Lobo Ana Catarina Silva | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 5 |
| 19 | Pediatric primary urolithiasis: Symptoms, medical management and prevention strategies显示文摘In the past few decades pediatric urolithiasis has become more frequent. The reason for this increase is not completely clear but has been attributed to changes in climate, nutritional habits and possibly other environmental factors. Although less frequent than adult stone disease, urolithiasis in the pediatric age group is also related to significant morbidity, particularly since stones tend to recur, and, thus, should not be underestimated. Most children with idiopathic stone disease have an underlying metabolic abnormality substantiating the importance of metabolic evaluation already following initial diagnosis of urolithiasis. Identification of the metabolic abnormality allows for more specific prescription of non pharmacological and pharmacological interventions aimed at preventing recurrent stone formation. A better understanding of the causes of kidney stone disease will provide better strategies for stone prevention in children. | Maria Goretti Moreira Guimar?es Penido Marcelo de Sousa Tavares | 2015 | World Journal of Nephrology2015，4，4： | 4 |
| 20 | 西藏多龙矿集区热构造演化历史——来自磷灰石(U-Th)/He的证据显示文摘西藏多龙矿集区是西藏最重要的斑岩-浅成低温热液型矿集区。多龙矿集区经历了多期次的构造抬升-剥蚀事件,成矿后的埋藏-剥蚀历史对矿体的保存至关重要。本文运用磷灰石(U-Th)/He数据对多龙矿集区的低温热年代学进行研究。磷灰石(U-Th)/He年龄平均值分布在85. 1±4. 0Ma到37. 9±2. 5Ma,记录了晚白垩世到古新世、始新世、渐新世的热-构造事件。热历史模拟显示,多龙矿集区主要经历4次冷却事件:Ⅰ) 100~75Ma,冷却速率约为4℃/Myr,剥速率约为0. 16km/Myr,与班公湖-怒江洋的闭合以及拉萨-羌塘地块的碰撞事件有关;Ⅱ) 75~45Ma,冷却速率约为0. 3℃/Myr,剥蚀速率约为0. 01km/Myr,与拉萨-羌塘地块的继续碰撞事件以及由碰撞作用引起的逆冲推覆构造事件有关;Ⅲ) 45~30Ma,冷却速率约为2℃/Myr,剥蚀速率约为0. 08km/Myr,与印度-欧亚大陆的碰撞抬升事件有关;Ⅳ) 30Ma至今,冷却速率约为1℃/Myr,剥蚀速率约为0. 04km/Myr,与渐新世以来印度-欧亚大陆的持续碰撞作用以及渐新世以来青藏高原发育的频繁构造事件有关。多龙矿集区斑岩-浅成低温热液型矿床形成后在强烈的隆升-剥蚀的环境下保存下来,得益于早白垩世美日切错组火山岩的覆盖,由拉萨-羌塘地块碰撞作用引起的逆冲推覆构造引起的上部地层加厚,以及印度-欧亚大陆碰撞事件在多龙矿集区产生的相对较弱的破坏效应。拉萨-羌塘地块碰撞作用引起的地层加厚对多龙矿集区矿床起主要的保护作用。 | 杨欢欢 宋扬 DILLES John H SOUSA Francis DANI?íK Martin 杨超 | 2019 | 岩石学报2019，35，3： | 4 |
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