|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Treatability studies of naphthalene in soil,water and air with persulfate activated by iron(Ⅱ)显示文摘Chemical oxidation was applied to an artificially contaminated soil with naphthalene(NAP).Evaluation of NAP distribution and mass reduction in soil,water and air phases was carried out through mass balance.Evaluation of NAP distribution and mass reduction in soil,water and air phases was carried out through mass balance.The importance of the air phase analysis was emphasized by demonstrating how NAP behaves in a sealed system over a 4 hr reaction period.Design of Experiments method was applied to the following variables:sodium persulfate concentration[SP],ferrous sulfate concentration[FeS04],and pH.The system operated with a prefixed solid to liquid ratio of 1:2.The following conditions resulted in optimum NAP removal[SP]=18.37 g/L,[FeSO4]=4.25 g/L and pH=3.00.At the end of the 4 hr reaction,62%of NAP was degraded.In the soil phase,the chemical oxidation reduced the NAP concentration thus achieving levels which comply with Brazilian and USA environmental legislations.Besides the NAP partitioning view,the monitoring of each phase allowed the variabilities assessment over the process,refining the knowledge of mass reduction.Based on NAP distribution in the system,this study demonstrates the importance of evaluating the presence of semi-volatile and volatile organic compounds in the air phase during remediation,so that there is greater control of the system as to the distribution and presence of the contaminant in the environment.The results highlight the importance of treating the contaminant in all its phases at the contaminated site. | Gabriela P.Mendes Vivian M.A.Magalhaes Lélia C·R·Soares Rayanne M.Aranha Claudio A.O.Nascimento Marilda M.G.R.Vianna Osvaldo Chiavone-Filho | 2020 | Journal of Environmental Sciences2020，32，4： | 4 |
| 3 | Abeliovich a denitrification in laboratory sandy columms: Carbon regime, gas accumulation and hydraulic prodraulic properties显示文摘 | Soares M I M Braester C Belkin S | 1991 | Water Research1991，25，3： | 2 |
| 4 | Reliability of maintained,corrosion protected plates subjected to non-liner corrosion and compressive loads显示文摘 | Guedes Soares C Garbatov Y | 1999 | Marine Structures1999，12，6： | 2 |
| 5 | Finite element dynamic analysis of practical disc 显示文摘 | Mota Soares C A Petyt M | 1978 | J Sound Vibr1978，61，： | 2 |
| 6 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 7 | An open trial of mirtazapine in menopausal women with depression unresponsive to estrogen replacement therapy显示文摘 | Joffe H Groninger H Soares C | 2001 | J Womens Health Gend Based Med2001，10，： | 1 |
| 8 | An experimental study of ultimate torsional strength of a ship-type hull girder with a large deck opening 显示文摘 | SUN Hai-hong SOARES C G | 2003 | Marine Structures2003，16，1： | 1 |
| 9 | Reliability of maintained ship hulls subjected to corrosion 显示文摘 | Guedes Soares C Garbatov Y | 1996 | Journalof Ship Research1996，40，3： | 1 |
| 10 | Dinamica-a stochastic cellular automata model designed to simulate the landscape dynamics in an Amazonian colonization frontier显示文摘 | Soares B S Cerqueira G C Pennachin C L | 2002 | Ecological Modelling2002，154，3： | 1 |
| 11 | A graphical user interface for variable selection employing the successive projections algorithm显示文摘 | PAIVA H M SOARES S F C GALVAO R K H | 2012 | Chemometrics and Intelligent Laboratory Systems2012，118，15： | 1 |
| 12 | Modeling waves in open coastal ar- eas and harbours with phase-resolving and phase-averaged models显示文摘 | RUSU E SOARES C G | 2013 | Journal of Coastal Research2013，29，1： | 1 |
| 13 | Contact indentation of marine composites显示文摘 | Sutherland L S Soares C G | 2005 | Composite Structures2005，70，3： | 1 |
| 14 | Pyranoxanthones:Synthesis,growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models显示文摘 | AZEVEDO C M G AFONSO C M M SOARES J X | | 0，，11： | 1 |
| 15 | Deficiencies of proteins C,S and antithrombin and factor V Leiden and the risk of ischemic strokes显示文摘 | Soare AM Popa C | | 0，，3： | 1 |
| 16 | Corrosion resistant of a Zn-Ni electrodeposited alloy obtained with a controlled flow and gelatin additive 显示文摘 | SOARES M N SOUZA C A C KURI S E | 2006 | Surf Coat Technol2006，201，： | 1 |
| 17 | Optimal design for active damping in sandwich structures using the Direct MultiSearch method 显示文摘 | Araujo A L Madeira J F A Mota Soares C M | 2013 | Composite Structures2013，105，： | 1 |
| 18 | The role of throm- bophilia and thyroid autoimmunity in unexplained infertil- ity,implantation failure and recurrent spontaneous abor- tion显示文摘 | Bellver J Soares SR Alvarez C | 2008 | Hum Reprod (Oxford England)2008，23，2： | 1 |
| 19 | Cyclooxygenase-2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer显示文摘 | Costa C Soares R Reis-Filho JS | 2002 | Clin Pathol2002，55，： | 1 |
| 20 | Plastic analysis of laterally loaded circular tubes显示文摘 | Soares C G Soreide T H | 1983 | Journal of Structural Engineering1983，109，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员