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| 1 | Results of National Colorectal Cancer Screening Program in Croatia(2007-2011)显示文摘AIM:To study the epidemiologic indicators of uptake and characteristic colonoscopic findings in the Croatian National Colorectal Cancer Screening Program.METHODS:Colorectal cancer(CRC) was the second leading cause of cancer mortality in men(n = 1063,49.77/100 000),as well as women(n = 803,34.89/100 000) in Croatia in 2009.The Croatian National CRC Screening Program was established by the Ministry of Health and Social Welfare,and its implementation started in September,2007.The coordinators were recruited in each county institute of public health with an obligation to provide fecal occult blood testing(FOBT) to the participants,followed by colonoscopy in all positive cases.The FOBT was performed by hypersensitive guaiac-based Hemognost card test(Biognost,Zagreb).The test and short questionnaire were delivered to the home addresses of all citizens aged 50-74 years consecutively during a 3-year period.Each participant was required to complete the questionnaire and send it together with the stool specimen on three test cards back to the institute for further analysis.About 4% FOBT positive cases are expected in normal risk populations.A descriptive analysis was performed.RESULTS:A total of 1 056 694 individuals(born between 1933-1945 and 1952-1957) were invited to screening by the end of September 2011.In total,210 239(19.9%) persons returned the envelope with a completed questionnaire,and 181 102 of them returned it with a correctly placed stool specimen on FOBT cards.Until now,12 477(6.9%),FOBT-positive patients have been found,which is at the upper limit of the expected values in European Guidelines for Quality Assurance in CRC Screening and Diagnosis [European Union(EU) Guidelines].Colonoscopy was performed in 8541 cases(uptake 66%).Screening has identified CRC in 472 patients(5.5% of colonoscopied,3.8% of FOBT-positive,and 0.26% of all screened individuals).This is also in the expected range according to EU Guidelines.Polyps were found and removed in 3329(39% of colonoscopied) patients.The largest number of polyps were found in the left half of the colon:64%(19%,37% and 8% in the rectum,sigma,and descendens,respectively).The other 36% were detected in the proximal part(17% in the transverse colon and 19% in ceco-ascending colon).Small polyps in the rectum(5-10 mm in diameter),sigmoid and descending colon were histologically found to be tubular adenomas in 60% of cases,with a low degree of dysplasia,and 40% were classified as hyperplastic.Polyps of this size in the transverse or ceco-ascending colon in almost 20% had a histologically villous component,but still had a low degree of dysplasia.Polyps sized 10-20 mm in diameter were in 43% cases tubulovillous,and among them,32% had areas with a high degree of dysplasia,especially those polyps in the cecoascending or transverse part.The characteristics of the Croatian CRC Screening National Program in the first 3 years were as follows:relatively low percentage of returned FOBT,higher number of FOBT-positive persons but still in the range for population-based programs,and higher number of pathologic findings(polyps and cancers).CONCLUSION:These results suggest a need for intervention strategies that include organizational changes and educational activities to improve awareness of CRC screening usefulness and increase participation rates. | Miroslava Katii Nataa Antoljak Milan Kujundzi Valerija Stameni Dunja Skoko Poljak Danica Kramari Davor timac Marija Strnad Peikan Mirko amija Zdravko Ebling | 2012 | World Journal of Gastroenterology2012，18，32： | 2 |
| 2 | Opimum distribution of seismic observation point Ⅱ 显示文摘 | Sato Y Skoko D | 1965 | Bull of earthquake Res Inst Tokyo Univ1965，，43： | 1 |
| 3 | Nonspecific B and T cell-stimulatory activity mediated by mast cells is associated with exosomes显示文摘 | Skokos D Le-Panse S Villa I | 2001 | Int Arch Allergy Immunol2001，124，1： | 1 |
| 4 | Design and development of fuzzy logic control strategies for wind turbine generator显示文摘 | SKOKOS G D MACHIAS A V | 1995 | Wind Eng1995，19，5： | 1 |
| 5 | Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes 显示文摘 | Skokos D Le Panse S Villa I | 2001 | J hnmunol2001，166，2： | 1 |
| 6 | Mast cell derived exosomes induce phenotypic and functional maturation of den- dritic cells and elicit specific immune responses in vivo 显示文摘 | Skokos D Botros H G Demeure C | 2003 | J Immunol2003，170，： | 1 |
| 7 | Nonspecific B and T cell-stimulatory activity mediated by mast cells is associated with exosomes显示文摘 | Skokos D Le Panse S Villa I | 2001 | Int Arch Allergy Immunol2001，124，1： | 1 |
| 8 | The influence of Zn-dopant on the precipitation of α-FcOOH in highly alkaline media显示文摘 | Krehula S Music S Skoko Z | 2006 | J Alloy Compd2006，420，12： | 1 |
| 9 | Nonspecific B and T cell-stimulatory activity mediated by mast cells is associated with exosomes显示文摘 | Skokos D Le Panse S Villa I | 2001 | Int Arch Allergy Immunol2001，124，13： | 1 |
| 10 | Enhanced an- giogenesis and reduced contraction in thrombospondin-2- null wounds is associated with increased levels of matrix metalloproteinases-2 and -9, and soluble VEGF显示文摘 | Maclauchlan S Skokos EA Agah A | 2009 | J His- tochem Cytochem2009，57，4： | 1 |
| 11 | Enhanced angiogenesis and reduced contraction in thrombospondin-2-null wounds is associated with increased levels of matrix metalloproteinases-2 and -9, and soluble VEGF显示文摘 | Maclauehlan S Skokos EA Agah A | 2009 | J Histochem Cytochem2009，57，4： | 1 |
| 12 | Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes显示文摘 | Skokos D Le Panse S Villa I | 2001 | J Immunol2001，166，2： | 1 |
| 13 | Mast Cell-derived Exosomes in Duces Phenotypic and Functional Maturation of Dendritic Cells and Elicit Specific Immune Responses in Vivo显示文摘 | Skokos D Botros H G Demeure C | 2003 | Immunol2003，170，： | 1 |
| 14 | Application of simple fed-batch technique to high-level secretory production of insulin precursor using Pichia pastoris with subsequent purification and conversion to human insulin显示文摘 | Gurramkonda C Polez S Skoko N | | 0，，： | 1 |
| 15 | Micromechanical analysis of the binding of DNA-bending proteins HMGB1,NHP6A,and HU reveals their ability to form highly stable DNA-protein complexes显示文摘 | Skoko D Wong B Johnson RC | | 0，，： | 1 |
| 16 | Mast celi- derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo显示文摘 | SKOKOS D BOTROS H G DEMEURE C | 2003 | J Immunol2003，170，6： | 1 |
| 17 | Effect of grain size on the N6el temperature of nanocrystalline nickel ferrite 显示文摘 | RAGHAVENDER A T ZADRO K PAJIC D SKOKO Z BILI~KOV N | 2010 | Materials Letters2010，64，： | 1 |
| 18 | CD8-DCs induce IL-12-independent Th1 differentiation through Delta 4 Notchhke ligand in response to bacterial LPS显示文摘 | SKOKOS D NUSSENZWEIG M C | 2007 | J Exp Med2007，204，7： | 1 |
| 19 | The level of serum pro-matrix metaUoproteinase-2 as a prognostic factor in patients with invasive ductal breast cancer显示文摘 | Vucemilo T Skoko M Sareevi B | 2014 | Coil Antropol2014，38，1： | 1 |
| 20 | Mast cell-derived exo-somes induce phenotypic and functional maturalion of dendritic cells and elicit specific immune responses in vivo 显示文摘 | Skokos D Botros HG Demeure C | 2003 | J Immunol2003，170，6： | 1 |
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