|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Contribution of TLR signaling to the pathogenesis of colitisassociated cancer in inflammatory bowel disease显示文摘In the intestine a balance between proinflammatory and repair signals of the immune system is essential for the maintenance of intestinal homeostasis. The innate immunity ensures a primary host response to microbial invasion, which induces an inflammatory process to localize the infection and prevent systemic dissemination of pathogens. The key elements of this process are the germline encoded pattern recognition receptors inclu-ding Toll-like receptors(TLRs). If pathogens cannot be eliminated, they may elicit chronic inflammation, which may be partly mediated via TLRs. Additionally, chronic inflammation has long been suggested to trigger tissue tumorous transformation. Inflammation, the seventh hallmark of cancer, may affect all phases of tumor development, and evade the immune system. Inflammation acts as a cellular stressor and may trigger DNA damage or genetic instability. Furthermore, chronic inflammation can provoke genetic mutations and epigenetic mechanisms that promote malignant cell transformation. Colorectal cancers in inflammatory bowel disease patients are considered typical examples of inflammation-related cancers. Although data regarding the role of TLRs in the pathomechanism of cancer-as-sociated colitis are rather conflicting, functionally these molecules can be classified as 'largely antitumorigenic' and 'largely pro-tumorigenic' with the caveat that the underlying signaling pathways are mainly context(i.e., organ-, tissue-, cell-) and ligand-dependent. | Ferenc Sipos István Fri Miklós Constantinovits Zsolt Tulassay Gyrgyi Mzes | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 3 | Nitrate removal form synthetic wastewater with the mixed bacterial culture 显示文摘 | Foglar L Briski F Sipos L | 2005 | Bioresour Technol2005，96，： | 1 |
| 4 | Evaluation of malignant and benign gastric biopsy specimens by mRNA expression profile and multivariate statistical methods 显示文摘 | Galamb O Sipos F Molnar B | 2007 | Cytometry B Clinical Cytometry2007，72，5： | 1 |
| 5 | Isolation of epsilon-haemoglobin-chain positive fetal cells with micromanipulation for prenatal diagnosis显示文摘 | Nagy GR Bán Z Sipos F | 2005 | Prenat Diagn2005，25，14： | 1 |
| 6 | Nitrate removalfrom synthetic wastewater with the mixed bacterialculture 显示文摘 | Foglar L Briski F Sipos L | 2005 | Bioresource Technology2005，96，8： | 1 |
| 7 | Detection of methylated SEPT9 in plasma is a reliable screening method for both left- and right-sided colon cancers 显示文摘 | T6th K Sipos F KalmOr A | 2012 | PLoS One2012，7，46： | 1 |
| 8 | The Behavior of Matrix metallo- proteinase - 9 in lymphocytic colitis, collagenous colitis and ulcer - ative eolitis显示文摘 | Lakatos G Sipos F Miheller P | 2011 | Pathol Oncol Res2011，7，16： | 1 |
| 9 | Detection of methylated SEPT9 in plasma is a reliable screening method for both left- and right-sided colon cancers显示文摘 | Toth K Sipos F Kalmar A | 2012 | PLoS One2012，7，46： | 1 |
| 10 | First attempts of detecting fetal ceils in the maternal circulation显示文摘 | Nagy GR Ban Z Sipos F | 2004 | Orv Hetil2004，145，11： | 1 |
| 11 | Promoter hypermethylation- related reduced somatostatin production promotes uncontrolled cell proliferation in colorectal cancer 显示文摘 | Leiszter K Sipos F Galamb O | 2015 | PLoS One2015，10，01： | 1 |
| 12 | Matrix metalloproteinase-9 expression in the normal mucosa-adenoma-dysplasia-adenocarcinoma sequence of the colon 显示文摘 | Herszenyi L Sipos F Galamb O | 2005 | Pathol Oncol Res2005，14，1： | 1 |
| 13 | Systemic cytokine profile in feeder pigs suffering from natural postweaning multisystemic wasting syndrome (PMWS) as determined by semiquantitative RTPCR and flow cytometric intracellular cytokine detection 显示文摘 | Sipos W Duvigneau J C Willheim M F | 2004 | Veterinary Immunology and Immunopathology2004，99，： | 1 |
| 14 | Functional mRNA expression analysis and classification of colonic biopsy samples using overall cDNA microarray technique显示文摘 | Galamb O Sipos F Dinya E | 2008 | Orv Hetil2008，149，5： | 1 |
| 15 | Elevated L1CAM expression in precursor lesions and primary and metastastic tissues of pancreatic duetal adenocarcinoma 显示文摘 | Bergmann F Wandschneider F Sipos BA | 2010 | Oncol Rep2010，24，4： | 1 |
| 16 | The role of the bone marrow derived mesenchymal stem cells in colonic epithelial regeneration显示文摘 | Valcz G Krenács T Sipos F | | 0，，01： | 1 |
| 17 | Elevated osteopontin expression and proliferative/apoptotic ratio in the coloreetal adenoma-dysplasia- carcinoma sequence 显示文摘 | Valcz G Sipos F KrenOcs T | 2010 | Pathol Oncol Res2010，16，4： | 1 |
| 18 | Detection of methylated SEPT9 in plasma is a reliable screening method for both left- and right-sided co- lon cancers显示文摘 | Toth K Sipos F Kalmar A | 2012 | PLoS One2012，7，46： | 1 |
| 19 | Importance of carcinoma-associated fibroblast-derived proteins in clinical oncology显示文摘 | Valcz G Sipos F Tulassay Z | 2014 | J Clin Pathol2014，67，12： | 1 |
| 20 | Molecular pathogenesis of Helicobacter pylori infection:the role of bacterial virulence factors显示文摘 | Molnar B Galamb O Sipos F et a1 | 2010 | Dig Dis2010，28，45： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员