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| 1 | Risk stratification for ST segment elevation myocardial infarction in the era of primary percutaneous coronary intervention显示文摘Acute coronary syndromes presenting with ST elevation are usually treated with emergency reperfusion/revascularisation therapy. In contrast current evidence and national guidelines recommend risk stratification for non ST segment elevation myocardial infarction(NSTEMI) with the decision on revascularisation dependent on perceived clinical risk. Risk stratification for STEMI has no recommendation. Statistical risk scoring techniques in NSTEMI have been demonstrated to improve outcomes however their uptake has been poor perhaps due to questions over their discrimination and concern for application to individuals who may not have been adequately represented in clinical trials. STEMI is perceived to carry sufficient risk to warrant emergency coronary intervention [by primary percutaneous coronary intervention(PPCI)] even if this results in a delay to reperfusion with immediate thrombolysis. Immediate thrombolysis may be as effective in patients presenting early, or at low risk, but physicians are poor at assessing clinical and procedural risks and currently are not required to consider this. Inadequate data on risk stratification in STEMI inhibits the option of immediate fibrinolysis, which may be cost-effective. Currently the mode of reperfusion for STEMI defaults to emergency angiography and percutaneous coronary intervention ignoring alternative strategies. This review article examines the current risk scores and evidence base for risk stratification for STEMI patients. The requirements for an ideal STEMI risk score are discussed. | Richard A Brogan Christopher J Malkin Philip D Batin Alexander D Simms James M McLenachan Christopher P Gale | 2014 | World Journal of Cardiology2014，6，8： | 6 |
| 2 | Towards a global One Health index: a potential assessment tool for One Health performance显示文摘Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge. | Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou | 2022 | Infectious Diseases of Poverty2022，11，3： | 3 |
| 3 | Microradiographic characterization oflaser fusion pellets显示文摘 | Henderson TM Cielaszyk D E Simms R J | 1977 | Rev Sci Instrum1977，48，7： | 2 |
| 4 | A new graft polymer pigment dispersant synthesis 显示文摘 | SIMMS J A | 1999 | Progress in Organic Coatings1999，35，14： | 1 |
| 5 | Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic setting:parallel pathways of tumorigenesis显示文摘 | Young J Simms LA Biden KG | 2001 | Am J Pathol2001，159，6： | 1 |
| 6 | Uniquely extensive seismites from the latest Triassic of the United Kingdom: evidence for bolide impact 显示文摘 | Michael J Simms | 2003 | Geology2003，31，： | 1 |
| 7 | Nephronophthisis: a genetically diverse ciliopathy 显示文摘 | SIMMS R J HYNES A M ELEY L | 2011 | Int J Nephrol2011，2011，52： | 1 |
| 8 | Varenicline, an alpha 4 beta 2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking显示文摘 | Steensland P Simms JA Holgate J | 2007 | Proc Natl Acad Sci USA2007，104，12： | 1 |
| 9 | How to drive business success and your own ca- reer 显示文摘 | Simms J | 2003 | Marketing2003，18，9： | 1 |
| 10 | Abdominal compartment syndrome:clinical manifestation and predictive factors显示文摘 | McNelis J Marini CP Simms HH | 2003 | Curr Opin Crit Care2003，9，2： | 1 |
| 11 | Recent developments of in- frared fiber optics 显示文摘 | Kapany N S Simms R J | 1965 | Infrared Physics1965，5，2： | 1 |
| 12 | Smart overlay coatings-concept and practice 显示文摘 | Nicholls J R Simms A J Chan W Y | 2002 | Surface and Coatings Technology2002，296，： | 1 |
| 13 | ATG16L1 T300A shows strong associations with disease subgroups in a large Australian IBD population: further support for significant disease heterogeneity显示文摘 | Fowler EV Doecke J Simms LA | 2008 | Am J Gastroenterol2008，103，10： | 1 |
| 14 | Measurement of THM and precursor concentrations revisited: the effect of bromide ion 显示文摘 | Simons J M Kranser S W Simms L A | 1993 | Journal of American Water Works Association1993，85，： | 1 |
| 15 | HPP1 : a transmembrane protein - encoding gene commonly methylated in colorectal polyps and cancers显示文摘 | YOUNG J BIDEN K G SIMMS L A | 2001 | Proc Nail Acad2001，98，1： | 1 |
| 16 | Non-linearcams for weft-knitting machines 显示文摘 | OLDHAM K BURNS N D SIMMS G J | 1985 | Journal of theTextile Institute1985，，1： | 1 |
| 17 | Features of colorectal cancers with high - level microsatellite instability occurring in familial and sporadic settings : parallel pathways of tumorigenesis 显示文摘 | Young J Simms LA Biden KG | 2001 | Am J Pathol2001，159，： | 1 |
| 18 | Bulgecin A: a novel inhibitor of binuclear metallo-beta-lactamases 显示文摘 | Simm AM Loveridge EJ Crosby J | 2005 | Biochem J2005，387，3： | 1 |
| 19 | Reduced alpha-defensinexpression is associated with inflammation and not NOD2 mutationstatus in ileal Crohn’s disease显示文摘 | Simms L A Doecke J D Walsh M D | 2008 | Gut2008，57，7： | 1 |
| 20 | An Experimental Investigation on the Structural Performance of Steel Columns Subjected to Elevated Temperatures 显示文摘 | Simms W I O' Connor D J Ali F | 1995 | Journal of Applied Fire Science1995，5，4： | 1 |
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