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| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | Using an objective structured clinical examination (OSCE) to assess multiple physician competencies in postgraduate training 显示文摘 | Jefferies A Simmons B Tabak D | 2007 | Mcd Teach2007，29，23： | 1 |
| 3 | Genetic risk factors associated with lipid-lowering drug-induced myopathies显示文摘 | Vladutiu G D Simmons Z Isackson P J | 2006 | Muscle Nerve2006，34，： | 1 |
| 4 | Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9显示文摘 | Simmons D P Canaday D H Liu Y | 2010 | J Immunol2010，185，4： | 1 |
| 5 | The relationship between petroleum emplacement and carbonate reservoir quality: Examples from Abu Dhabi and the Amu Darya Basin显示文摘 | Neilson J E Oxtoby N H Simmons M D | 1998 | Marine and Petroleum Geology1998，15，1： | 1 |
| 6 | Functional oxytocin receptors discovered in human osteoblasts显示文摘 | Copland J A Ives K L Simmons D J | 1999 | Endocrinology1999，140，9： | 1 |
| 7 | Energy use associated with different travel choices 显示文摘 | Becken S Simmons D Frampton C | 2003 | Tourism Management2003，24，3： | 1 |
| 8 | The effects of high-air velocity on broiler performance 显示文摘 | SIMMONS J D LOTT B D MILES D M | 2003 | Poultry Science2003，82，2： | 1 |
| 9 | Ameloblastin gene (AMBN) maps within the critical region for autosomal dominant amelogenesis imperfecta at chromosome 4q21 显示文摘 | DuPont BR Simmons D | 1997 | Genomics1997，41，： | 1 |
| 10 | Pathogenesis of paralytic ileus, intestinal manipulation opens a transient pathway between the intestinal lumen and the ieukocytic infiltrate of the jejunal musculaeis显示文摘 | Schwartz NT Beer-stolz D Simmons RL etal | 2002 | Ann Surg2002，235，1： | 1 |
| 11 | Apolipoprotein E epsilon4 allele affects the relationship between stress and depres- sion in caregivers of patients with Alzheimer' s disease显示文摘 | Gallagher-Thompson D O'Hara R Simmons A | 2001 | J Geriatr Psychiatry Neurol2001，14，： | 1 |
| 12 | Expression of a large family of POU-domain regulatory genes in mammalian brain development显示文摘 | HE X TREACY M N SIMMONS D M | 1989 | Nature1989，340，6228： | 1 |
| 13 | Energy consumption patterns in the accommodation sector:The New Zealand case显示文摘 | Becken S Frampton C Simmons D | 2001 | Ecological Economics2001，39，3： | 1 |
| 14 | Understanding energy consumption pa- tterns of tourist attractions and activities in New Zealand显示文摘 | Becken S Simmons D | 2002 | Tourism Management2002，23，4： | 1 |
| 15 | Characteristics and genesis of epithermal gold deposits 显示文摘 | Cooke D R Simmons S F | 2000 | Reviews in Economic Geology2000，13，2： | 1 |
| 16 | Metformin therapy and diabetes in pregnancy 显示文摘 | Simmons D Waiters BN Rowan JA | 2004 | Med J Aust2004，180，： | 1 |
| 17 | Community participation in tourism planning 显示文摘 | Simmons D G | 1994 | Tourism Management1994，15，： | 1 |
| 18 | Hemolysis from ABO Incompatibili- ty显示文摘 | Simmons D P Savage W J | 2015 | Hematol Oncol Clin North Am2015，29，3： | 1 |
| 19 | Surgical treatment of patients with lumbar spinal stenosis with associated scoliosis显示文摘 | Simmons E D | 2001 | Clin Orthop Relat Res2001，，384： | 1 |
| 20 | A field study of macropore flow under saturated conditions using a bromide tracer显示文摘 | Jabro J D Loste E G Simmons K E | 1991 | Journal of Soil & Water Conservation1991，46，5： | 1 |
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