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	题名	作者	年代	出处	被引量
1	p16 promoter hypermethylation:A useful serum marker for early detection of gastric cancer显示文摘AIM: To determine p16 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on p16-protein expression, and correlation with clinical and histological features. METHODS: Samples were obtained from 52 histologically confirmed cases of gastric adenocarcinoma. Gastric tissue and serum of 50 age- and sex-matched individuals with normal gastroscopy and biopsy were obtained as control samples. Methylation-specific polymerase chain reaction (MSP) was used to evaluate methylation status of p16 promoter. p16-protein expression was analyzed by immunohistochemical staining on paraffin-embedded sections. RESULTS: Methylation was detected in 44.2% (23/52) of tumoral tissues. 60.9% of them were also methylated in serum, i.e., 26.9% of all patients (14/52). Methylation was not detected in tissue and sera of control samples. p16-protein expression was decreased in 61.5% of cases (32/52), and was significantly associated with promoter hypermethylation (P < 0.001). Methylation was significantly more frequent in higher pathological grades (P < 0.05). Methylation was not associated with other clinicopathological features and environmental factors including H pylori infection and smoking. CONCLUSION: p16 promoter hypermethylation is an important event in gastric carcinogenesis. It is the principle mechanism of p16 gene silencing. It is related to malignant tumor behavior. Detection of DNA methylation in serum may be a biomarker for early detection of gastric cancer.	Mohammad Reza Abbaszadegan Omeed Moaven Hamid Reza Sima Kamran Ghafarzadegan Azadeh A'rabi Mohammad Naser Forghani Hamid Reza Raziee Ali Mashhadinejad Mostafa Jafarzadeh Ehsan Esmaili-Shandiz Ezzat Dadkhah	2008	World Journal of Gastroenterology2008，14，13：	50
2	Short hairpin RNA targeting c-FLIP sensitizes human cervical adenocarcinoma Hela cells to chemotherapy adnd radiotherapy显示文摘	Luo A Wang W Sima N	2008	Cancer Lett2008，271，2：	1
3	Cationic liposomes for gene delivery显示文摘	Simaes S Filipe A Faneca H Mano M Penacho N Dtizgiines N	2005	Expert Opin Drug Deliv2005，2，：	1
4	Experimental diabetic neuropathy:an update显示文摘	Sima A A Sugimoto K	1999	Diabetologia1999，42，7：	1
5	Statins:mechanism of action and effects显示文摘	Stancu C Sima A	2001	J Cell Mol Med2001，5，4：	1
6	Aldose reductase in the BB rat: isolation, immunological identification and localization in the retina and peripheral nerve 显示文摘	Chakrabarti S Sima A A Nakajima T	1987	Diabetologia1987，30，4：	1
7	Coronary artery disease is associated with the ratio of apolipeprotein A-I/B and serum concentration of apolipopro- rein B, but not with paraoxonase enzyme activity in Iranian subjects 显示文摘	Maziar R Farbod R Sima A	2002	Ath- erosclerosis2002，162，2：	1
8	Endothelin-1 and endothelin-3-like immunoreactivity in the eyes of diabetic and non-diabetic BB/W rats显示文摘	CHAKRABARTI S SIMA A A	1997	Diabetes Res Clin Pract1997，37，2：	1
9	Vascular endothelium in atherosclerosis显示文摘	Sima A V Stancu C S Simionescu M	2009	Cell Tissue Res2009，335，1：	1
10	Pathobiochemistry combined diabetes and atherosclerosis studied on novel animal:The hyperlipemic-hyperglycemia hamster显示文摘	Simionescu M Popov D Sima A	1996	Am J Pathol1996，148，：	1
11	Proinsulin Cpeptide replacement in type 1 diabetic BB/Wor-rats prevents deficits in nerve fiber regeneration显示文摘	Pierson C R Zhang W Sima A A	2003	J Neuropathol Exp Neurol2003，62，：	1
12	The CC chemokine RANTES in breast carcinoma progression:regulation of expression and potential mechanisms of promalignant activity显示文摘	Elina A Galia L Sima S	2002	Cancer Res2002，62，4：	1
13	Complication: Neuropathy, Pathogenetic considerations 显示文摘	Sima A A F Stevens M J	1992	Diabetes Care1992，15，：	1
14	Diabetic neuropathy and oxidative stress显示文摘	Pop-Busui R Sima A Stevens M	2006	Diabetes Metab Res Rev2006，22，：	1
15	The Younger Dryas an intrinsic feature of late Pleistocene climate change at millennial times cales显示文摘	Sima A Paul A Schulz M	2004	Earth and Planetary Science Letters2004，222，：	1
16	The Younger Dryas-an intrinsic feature of late Pleistocene climate change at millennial timescales显示文摘	Sima A Paul A Schulz M	2004	Earth and Planetary Science Letters2004，222，：	1
17	Diabetic neuropathy and oxidative stress显示文摘	Pop-Busui R Sima A Stevens M	2006	Diabetes Metab Res Rev2006，22，4：	1
18	Diabetic neuropathy in type 1 and type 2 diabetes and the effects of C-peptide显示文摘	SIMA A A		J Neurol Sei0，220，12：	1
19	Impaired visual evoked potential and primary axonopathy of the optic nerve in the diabetic BB/W-rat显示文摘	Sima A A Zhang W X Cherian P V etal	1992	Diabetologia1992，35，7：	1
20	C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes 显示文摘	KAMIYA H ZHANG W SIMA A A	2004	Ann Neurol2004，56，6：	1

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