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| 1 | Taurine protects against retinal and optic nerve damage induced by endothelin-1 in rats via antioxidant effects显示文摘Endothelin-1(ET-1), a potent vasoconstrictor, is involved in retinal vascular dysregulation and oxidative stress in glaucomatous eyes. Taurine(TAU), a naturally occurring free amino acid, is known for its neuroprotective and antioxidant properties. Hence, we evaluated its neuroprotective properties against ET-1 induced retinal and optic nerve damage. ET-1 was administered intravitreally to Sprague-Dawley rats and TAU was injected as pre-, co-or post-treatment. Animals were euthanized seven days post TAU injection. Retinae and optic nerve were examined for morphology, and were also processed for caspase-3 immunostaining. Retinal redox status was estimated by measuring retinal superoxide dismutase, catalase, glutathione, and malondialdehyde levels using enzyme-linked immuosorbent assay. Histopathological examination showed significantly improved retinal and optic nerve morphology in TAU-treated groups. Morphometric examination showed that TAU pre-treatment provided marked protection against ET-1 induced damage to retina and optic nerve. In accordance with the morphological observations, immunostaining for caspase showed a significantly lesser number of apoptotic retinal cells in the TAU pre-treatment group. The retinal oxidative stress was reduced in all TAU-treated groups, and particularly in the pre-treatment group. The findings suggest that treatment with TAU, particularly pre-treatment, prevents apoptosis of retinal cells induced by ET-1 and hence prevents the changes in the morphology of retina and optic nerve. The protective effect of TAU against ET-1 induced retinal and optic nerve damage is associated with reduced retinal oxidative stress. | Natasha Najwa Nor Arfuzir Renu Agarwal Igor Iezhitsa Puneet Agarwal Sabrilhakim Sidek Nafeeza Mohd Ismail | 2018 | Neural Regeneration Research2018，13，11： | 3 |
| 2 | A review of vibration-based MEMS piezoelec- tric energy harvesters 显示文摘 | Saadon S Sidek O | 2011 | Energy Conversion and Management2011，52，： | 1 |
| 3 | Knowledge-based expert system for stormwater management in Malaysia 显示文摘 | Al-Ani I A R Sidek D Mohamed M N | 2012 | Journal of Envi- ronmental Science And Technology2012，5，5： | 1 |
| 4 | A fault syndromes simulator for random access memories显示文摘 | Hasan W Z W Halin I A Sidek R | 2008 | European Journal of Scientific Research2008，23，1： | 1 |
| 5 | Parameter estimation of multieomponent transient signals using deconvolution and ARMA modeling techniques 显示文摘 | Salami M J E Sidek S N | 2003 | Mechanical System and Signal Processing2003，17，6： | 1 |
| 6 | Design of a micro-UART for SOC application显示文摘 | ALI L SIDEK R ARIS I | 2004 | Computers and Electrical Engineering2004，30，4： | 1 |
| 7 | A review of vibration-based MEMS piezoelectric energy harvesters显示文摘 | Saadon S Sidek O | 2011 | Energy Conversion and Management2011，52，1： | 1 |
| 8 | A review of vibration-based MEMS piezoelectric energy harvesters 显示文摘 | SAADON S SIDEK O | 2011 | Energy Convers Manage2011，52，： | 1 |
| 9 | A review of vibration-based MEMS piezoelectric energy harvesters显示文摘 | SAADON S SIDEK O | 2011 | Energy Conversion and Management2011，52，： | 1 |
| 10 | Design of micro-UART for SoC application 显示文摘 | Ali L Sidek R Aris I | 2004 | Computers and Electrical Engineering2004，30，4： | 1 |
| 11 | A review of vibration-based MEMS piezoelectric energy harvesters 显示文摘 | Saadon S Sidek O | 2011 | Energy Conversion and Management2011，52，： | 1 |
| 12 | A low complexity selected mapping scheme for peak to aver- age power ratio reduction with digital predistortion in OFDM systems 显示文摘 | MOHAMMADY S SIDEK R M VARAHRAM P | 2013 | International Journal of Communica- tion Systems2013，26，4： | 1 |
| 13 | Effect of bisphosphonates treatment on cytokine imbalance between TH 17 and Treg in osteoporosis显示文摘 | Talaat RM? Sidek A Mosalem A | 2015 | Inflammopharmacology2015，23，23： | 1 |
| 14 | Development of heterogeneous multi- sensor data fusion system to improve evaluation of concrete structures显示文摘 | Quadri S A Sidek O | 2014 | International Journal of Image & Data Fu- sion2014，5，2： | 1 |
| 15 | Analytical and simulation evaluation for diaphragm' s deflection and its applications to touch mode mems capacitive pressure sensors 显示文摘 | HEZARJARIBI Y HAMIDON M N SIDEK R M | 2009 | Journal of Baaic and Applied Sciences2009，3，4： | 1 |
| 16 | Screening of dental staff nurses for noise induced hearing loss显示文摘 | Daud MK Noh NF Sidek DS | 2011 | B-ENT2011，7，4： | 1 |
| 17 | Vibra-tional properties of samarium phosphate glasses显示文摘 | MIERZEJEWSKI A SAUNDERS G A SIDEK H A A | 1988 | J Non–Cryst Sol-ids1988，104，32： | 1 |
| 18 | A review of vibration-based MEMS piezoelectric energy harvesters显示文摘 | SAADON S SIDEK O | 2011 | Energy Conversion and Management2011，52，： | 1 |
| 19 | Parameter Estimation of Multicomponent Transient Signals Using Deconvolution and ARMA Modeling Techniques显示文摘 | Salami M J E Sidek S N | 2003 | Mechanical Systems and Signal Processing2003，17，6： | 1 |
| 20 | Effect of bisphosphonates treatment on cytokine imbalance between Th17 and Treg in osteoporosis 显示文摘 | TALAAT RM SIDEK A MOSALEM A | 2015 | Inflammo pharmacol2015，23，2： | 1 |
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