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| 1 | Skin toxicity predicts efficacy to sorafenib in patients with advanced hepatocellular carcinoma显示文摘AIM:To study the relationship between adverse events(AEs),efficacy,and nursing intervention for sorafenibtherapy in patients with hepatocellular carcinoma(HCC).METHODS:We enrolled 37 consecutive patients withadvanced HCC who received sorafenib therapy.Relationships among baseline characteristics as well as AEoccurrence and tumor response,overall survival(OS),and treatment duration were analyzed.The nursingintervention program consisted of education regardingself-monitoring and AEs management,and telephoneRESULTS:A total of 37 patients were enrolled in the study,comprising 30 males(81%) with a median age of 71 years.The disease control rate at 3 mo was 41%,and the median OS and treatment duration were 259 and 108 d,respectively.Nursing intervention was given to 24 patients(65%).Every patient exhibited some kinds of AEs,but no patients experienced G4 AEs.Frequently observed AEs > G2 included anorexia(57%),skin toxicity(57%),and fatigue(54%).Factors significantly associated with longer OS in multivariate analysis demonstrated that age ≤ 70 years,presence of > G2 skin toxicity,and absence of > G2 hypoalbuminemia.The disease control rate in patients with > G2 skin toxicity was 13/20(65%),which was significantly higher compared with that in patients with no or G1 skin toxicity.Multivariate analysis revealed that nursing intervention and > G2 skin toxicity were independent significant predictors for longer treatment duration.CONCLUSION:Skin toxicity was associated with favorable outcomes with sorafenib therapy for advanced HCC.Nursing intervention contributed to better adher-ence,which may improve the efficacy of sorafenib. | Masako Shomura Tatehiro Kagawa Koichi Shiraishi Shunji Hirose Yoshitaka Arase Tetsuya Mine Jun Koizumi | 2014 | World Journal of Hepatology2014，6，9： | 6 |
| 2 | Effects of pulsed electromagnetic field (PEMF)stimulation on bone tissue like formation are dependent on the maturation stages of the osteoblasts 显示文摘 | Diniz P Shomura K Soejima K | 2002 | Bioelectromagnetics2002，23，5： | 1 |
| 3 | Comparison of the Carpentier and Duran prosthetic ring used in mitral reconstruction显示文摘 | Okada Y Shomura T Yamaura Y I | | 0，，： | 1 |
| 4 | A high-density rice genetic linkage map with 2775 markers using a single F_2 population显示文摘 | Harushima Y Yano M Shomura A | 1998 | Genetics1998，148，1： | 1 |
| 5 | Molecular chaperones of the HspllO family act as nucleotide exchange factors of Hsp70s 显示文摘 | Dragovic Z Broadley SA Shomura Y | 2006 | EMBO J2006，25，： | 1 |
| 6 | Expressed sequence tags for genes:a review显示文摘 | Hatey F Yano M Shomura A | 1998 | Genet Select Evol1998，30，6： | 1 |
| 7 | Chylous ascites as a rarecomplication after abdominal aortic aneurysm surgery显示文摘 | Fukunaga N Shomura Y Nasu M | 2011 | South Med J2011，104，5： | 1 |
| 8 | A high-density rice genetic linkage map with2275 markers using a single F2 population显示文摘 | Harushima Y Yano M Shomura A Sato M | 1998 | Genetics1998，148，： | 1 |
| 9 | Toll-like receptor 4 mediates lung ischemia-reperfusion injury显示文摘 | Shimamoto A Pohlman TH Shomura S | 2006 | Ann Thorac Surg2006，82，6： | 1 |
| 10 | A high-density rice genetic linkage map with 2275 markers using a single F2 population显示文摘 | Harushima Y Yano M Shomura A | 1998 | Genetics1998，148，： | 1 |
| 11 | Hd6,a rice quantitative trait locus involved in photoperiod sensitivity,encodes the a subunit of protein kinase CK2显示文摘 | TAKAHASHI Y SHOMURA A SASAKI T | 2001 | PNAS2001，98，14： | 1 |
| 12 | Hd6,a ricequantitative trait locus involved in photoperiods sensitivity,encodes the a subunit of protein kinase CK2显示文摘 | Takahashi Y Shomura A Sasaki T | 2001 | Proc Natl Acad Sci USA2001，98，： | 1 |
| 13 | A high-density rice genetic linkage map with 2275 markers using a single F2 population显示文摘 | HARUSHIMA Y YANO M SHOMURA A | 1998 | Genetics1998，148，： | 1 |
| 14 | Hd6, a rice quantitative trait locus involved in photoperiod sensitivity, encodes the a subunit of protein kinase CK2 显示文摘 | Takahashi Y Shomura A Sasaki T | 2001 | Proc Natl Acad Sci USA2001，98，79： | 1 |
| 15 | Deletion in a gene associated with grain size increased yields during rice domestication显示文摘 | Shomura A Shomura A Izawa T | 2008 | Nature Genetics2008，40，8： | 1 |
| 16 | Deletion in a gene associated with grain size increased yields during rice do- mestication显示文摘 | Shomura A Izawa T Ebana K | 2008 | Nat Genet2008，40，： | 1 |
| 17 | Toll-- like receptor 4 mediates lung ischemia--reperfusion injury显示文摘 | Shimamoto A Pohlman T H Shomura S | 2006 | Ann Thorac Surg2006，82，6： | 1 |
| 18 | Effects of pulsed electromagnetic field (PEMF) stimulation on bone tissue like formation are dependent on the maturation stages of the osteoblasts显示文摘 | Diniz P Shomura K Soejima K | 2002 | Bioelectromagnetics2002，23，5： | 1 |
| 19 | Hd 6, a rice quantitative trait locus involved in photoperiod sensitivity, encodes the alpha subunit of protein kinase CK2显示文摘 | TAKAHASHI Y SHOMURA A SASAKI T | 2001 | Proc Natl Acad Sei USA2001，98，14： | 1 |
| 20 | A four-dimensional study of the aortic root dynamics显示文摘 | Lansac E Lim HS Shomura Y | 2002 | Eur J Cardiothorac Surg2002，22，4： | 1 |
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