|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A current perspective of autophagosome biogenesis显示文摘Autophagy 是象滋养的饥饿那样的细胞的压力导致的一个体积降级系统。它的功能依靠泡把 autophagosomes 称为的双膜的形成。不同于看起来稳定地在房间存在的另外的细胞器, autophagosomes 在需求上被形成,并且一旦他们的形成被开始,它很快令人惊讶地继续。这动态 autophagosome 形成怎么并且在哪儿发生在 1990 年代的 Atg 蛋白质的一个长期的问题,而是发现显著地被加速了我们理解 autophagosome 生物的续生说。在这评论,我们将简短介绍每 Atg 在与 autophagosome 生物的续生说的关系的功能的单位,然后与处理这个问题的选择最近的研究的介绍讨论 autophagosomal 膜的起源。 | Shusaku T Shibutani | 2014 | Cell Research2014，24，1： | 41 |
| 2 | Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer显示文摘AIM:To evaluate the prognostic significance of the lymphocyte to monocyte ratio(LMR) in patients with unresectable metastatic colorectal cancer who received palliative chemotherapy.METHODS:A total of 104 patients with unresectable metastatic colorectal cancer who underwent palliative chemotherapy were enrolled. The LMR was calculated from blood samples by dividing the absolute lymphocyte count by the absolute monocyte count. Pretreatment LMR values were measured within one week before the initiation of chemotherapy,while posttreatment LMR values were measured eight weeks after the initiation of chemotherapy.RESULTS:The median pre-treatment LMR was 4.16(range:0.58-14.06). We set 3.38 as the cut-off level based on the receiver operating characteristic curve. Based on the cut-off level of 3.38,66 patients were classified into the high pre-treatment LMR group and 38 patients were classified into the low pretreatment LMR group. The low pre-treatment LMR group had a significantly worse overall survival rate(P = 0.0011). Moreover,patients who demonstrated low pre-treatment LMR and normalization after treatmentexhibited a better overall survival rate than the patients with low pre-treatment and post-treatment LMR values.CONCLUSION:The lymphocyte to monocyte ratio is a useful prognostic marker in patients with unresectable metastatic colorectal cancer who receive palliative chemotherapy. | Masatsune Shibutani Kiyoshi Maeda Hisashi Nagahara Hiroshi Ohtani Katsunobu Sakurai Sadaaki Yamazoe Kenjiro Kimura Takahiro Toyokawa Ryosuke Amano Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa | 2015 | World Journal of Gastroenterology2015，21，34： | 19 |
| 3 | Inflammation-based factors and prognosis in patients with colorectal cancer显示文摘Several parameters for predicting survival in patients with colorectal cancer have been identified, including the performance status, age, gender and tumor-nodemetastasis(TNM) stage. Although the TNM stage is important and useful for predicting the prognosis and determining the appropriate treatment, it is well known that the survival time varies widely, even in patients with the same stage of disease. Therefore, the identification of new parameters capable of more precisely predicting patient survival is needed to help select the optimal treatment, especially in patients in the advanced stage of disease. Although the TNM stage reflects the tumor characteristics, cancer progression and survival are not determined solely based on the local characteristics of the tumor, but also the host systemic immune/inflammatory response. Therefore, using a combination of parameters that reflect both tumor characteristics and the host systemic inflammatory status is thought to be important for accurately predicting patient survival. | Kiyoshi Maeda Masatusne Shibutani Hiroshi Otani Hisashi Nagahara Tetsuro Ikeya Yasuhito Iseki Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa | 2015 | World Journal of Gastrointestinal Oncology2015，7，8： | 12 |
| 4 | Improvement in strength and electrical conductivity of Cu–Ni–Si alloys by aging and cold rolling显示文摘 | S. Suzuki N. Shibutani K. Mimura M. Isshiki Y. Waseda | 2005 | Journal of Alloys and Compounds2005，，1： | 3 |
| 5 | Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss显示文摘Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors.Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases.Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride(Na F) on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. Na F strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin(IL)-1β, matrix metalloproteinase 9(MMP9), and tartrate-resistant acid phosphatase,which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect,Na F inhibited osteoclast formation caused by the differentiation factor RANKL(receptor activator of nuclear factor kB ligand)and macrophage colony-stimulating factor(M-CSF). The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells(NFAT) c1 was also abrogated by Na F. Taken together, our data demonstrate that Na F inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATc1, ultimately leading to the suppressed expression of cathepsin K and MMP9.The in vivo effect of Na F on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of Na F for treating periodontal diseases. | Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh Shibutani | 2015 | International Journal of Oral Science2015，7，4： | 3 |
| 6 | Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy显示文摘 | Moriwaki Y Yamamoto T Shibutani Y | 2003 | Metabolism2003，52，5： | 1 |
| 7 | Down - regulation of GAT - 1 mRNA expression in the microdissected hypothalamic medial preoptic area of rat offspring exposed maternally to ethinylestradiol 显示文摘 | Shibutani M Masutomi N Uneyama C | 2005 | Toxico- logy2005，208，1： | 1 |
| 8 | Bell pepper fruit fatty acid hydroperoxide lyase is a cytochrome P450(CYP74B)显示文摘 | Matsui K Shibutani M Hase T | 1996 | FEBS Letters1996，394，： | 1 |
| 9 | Differences in erythrocyte sedimentation rates using the Westergren method and a centrifu- gationmethod 显示文摘 | Shelat SG Chacosky D Shibutani S | 2008 | AmJClinPathol2008，130，1： | 1 |
| 10 | Significance of preoperative neutrophil-to-lymphocyte ratio as a predictor of prognosis in patients with stage IV colorectal cancer显示文摘 | Shibutani M Maeda K Nagahara H | 2013 | Gall To Kagaku Ryoho2013，40，： | 1 |
| 11 | A high preoperative neutrophil-to-lymphocyte ratio is associated with poor survival in patients with colorectal cancer 显示文摘 | Shibutani M Maeda K Nagahara H | 2013 | Anticancer Res2013，33，8： | 1 |
| 12 | Action of mitochondrial DNA polymerase gamma at sites of base loss of oxidative damage显示文摘 | Pinz KG Shibutani S Bogenhagen DF | 1995 | J Biol Chem1995，270，16： | 1 |
| 13 | Selective toxicity of aristolochic acids I and II 显示文摘 | Shibutani S Dong H Suzuki N | 2007 | Drug Metab Dispos2007，35，： | 1 |
| 14 | Pertussis toxin sensitive Gproteins as mediators of the signal transduction on pathways activated by megalovirus infection of smooth muscle cells显示文摘 | Shibutani T Yu ZX Ferrans VJ | 1997 | J Clin Invest1997，100，： | 1 |
| 15 | Tamoxifen-DNA adducts detected in theendometrium of women treated with tamoxifen显示文摘 | Shibutani S Suzuki N Terashima I Sugarman SM Groll-man AP Pearl ML | 1999 | Chem ResToxicol1999，12，7： | 1 |
| 16 | 查看详情显示文摘 | Shibutani Y Yoshinaga H Yakabe K | | 0，，： | 1 |
| 17 | Calculation of ocular single-pass modulation transfer function and retinal image simulation from measurements of the polarized double-pass ocular point spread function显示文摘 | Kabayashi K Shibutani M Takeuchi G | 2004 | J Biomed Opt2004，9，1： | 1 |
| 18 | Selective toxicity of aris toloehic acids I and II 显示文摘 | Shibutani S Dong H Suzuki N | 2007 | Drug MetabDispos2007，35，7： | 1 |
| 19 | Pore structural properties of bamboo charcoals显示文摘 | Abe I Hasegawa T Shibutani Y | 2004 | TANSO2004，，215： | 1 |
| 20 | Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus:relationship with diabetic nephropathy显示文摘 | MORIWAKI Y YAMAMOTO T SHIBUTANI Y | 2003 | Metabolism2003，52，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员