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| 1 | Therapeutic targets and delivery challenges for Alzheimer's disease显示文摘Dementia,including Alzheimer’s disease,the 21st Centuryepidemic,is one of the most significant social and health crises which has currently afflicted nearly 44 million patients worldwide and about new 7.7 million cases are reported every year.This portrays the unmet need towards better understanding of Alzheimer’s disease pathomechanisms and related research towards more effective treatment strategies.The review thus comprehensively addresses Alzheimer’s disease pathophysiology with an insight of underlying multicascade pathway and elaborates possible therapeutic targets-particularly anti-amyloid approaches,anti-tau approaches,acetylcholinesterase inhibitors,glutamatergic system modifiers,immunotherapy,antiinflammatory targets,antioxidants,3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors and insulin.In spite of extensive research leading to identification of newer targets and potent drugs,complete cure of Alzheimer’s disease appears to be an unreached holy grail.This can be attributed to their ineffective delivery across blood brain barrier and ultimately to the brain.With this understanding,researchers are now focusing on development of drug delivery systems to be delivered via suitable route that can circumvent blood brain barrier effectively with enhanced patient compliance.In this context,we have summarized current drug delivery strategies by oral,transdermal,intravenous,intranasal and other miscellaneous routes and have accentuated the future standpoint towards promising therapy ultimately leading to Alzheimer’s disease cure. | Preshita Desai Harshad Shete Rahul Adnaik John Disouza Vandana Patravale | 2015 | World Journal of Pharmacology2015，4，3： | 4 |
| 2 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 3 | sA review on peripheral blood CD4 + T lymphocyte counts in healthy adult Indians显示文摘 | Shete A Thakar M Abraham PR | 2010 | Indian J Med Res2010，132，： | 1 |
| 4 | Serosurvey of crimean-congohemorrhagic Fever virus in domestic animals,gujarat,India,2013显示文摘 | Mourya DT Yadav PD Shete A | 2014 | Vector Borne Zoonotic Dis2014，14，9： | 1 |
| 5 | HER 2 gene amplification can be acquired as breast cancer progresses显示文摘 | Meng S D Tripathy D Shete S | 2004 | Proc Natl Acad Sci U S A2004，101，25： | 1 |
| 6 | Polymorphisms ofLIG4, BTBD2,HMGA2, and RTEL1 genes involvedin the double-strand break repair pathway predictglioblastoma survival 显示文摘 | Liu Y Shete S Etzel CJ | 2010 | J Clin Oncol2010，28，14： | 1 |
| 7 | Anticonvulsant actibity of glycyr- rhizic acid in mice显示文摘 | Kale S S Shete R V Kore K J | 2010 | Int J Pharm Res and Devel2010，2，10： | 1 |
| 8 | Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk显示文摘 | Liu YH Shete S Wang LE | 2010 | Carcinogene- sis2010，31，10： | 1 |
| 9 | On estimating the heterozygosity and polymorphic information content value显示文摘 | Shete S Tiwari H Elston R C | 2000 | Theor Popul Biol2000，57，3： | 1 |
| 10 | HER 2 gene amplification can be acquired as breast cancer progresses显示文摘 | Meng S Tripathy D Shete S | 2004 | Proc Natl Acad Sci U S A2004，101，25： | 1 |
| 11 | Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene显示文摘 | Reyes-Gibby CC Shete S Rakvag T | 2007 | Pain2007，130，12： | 1 |
| 12 | Serum retinol-hinding pro- tein 4 ( RBP4 ) and retinol in a cohort of borderline obese women with and without gestational diabetes 显示文摘 | Tepper B J Kim YK Shete V | 2010 | Clin Biochem2010，43，3： | 1 |
| 13 | Endoscopic anatomy of the sphenopalatine and posterior nasal arteries:implications for the endoscopic management of epistaxis 显示文摘 | Schwartzbaur HR Shete M Tami TA | 2003 | Am J Rhinol2003，17，1： | 1 |
| 14 | Association of single nu- cleotide gene polymorphism at interleukin-lbeta +3954,-511, and - 31 in chronic periodontitis and aggressive periodontitis in Dravidian ethnicity显示文摘 | Shete AR Joseph R Vijayan NN | 2010 | J Periodontal2010，81，： | 1 |
| 15 | Experimental and computational investigation of coupled resonator–cavity systems显示文摘 | S. Unnikrishnan Nair C.D. Shete A. Subramoniam K.L. Handoo C. Padmanabhan | 2009 | Applied Acoustics2009，，1： | 1 |
| 16 | Exploring joint ef- fects of genes and the clinical efficacy of morphine for cancer pain:OPRMl and COMT gene显示文摘 | Reyes-Gibby CC Shete S Rakvag T | 2007 | Pain2007，130，12： | 1 |
| 17 | A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer显示文摘 | GU J CHEN M SHETE S | 2011 | Cancer Prev Res (Phila)2011，4，4： | 1 |
| 18 | Organochlorine pesticides in Avicennia marina from the Mumbai mangroves, India 显示文摘 | Shete A Gunale V R Pandit G G | 2009 | Chemosphere2009，76，11： | 1 |
| 19 | Water dispersible oleic acid-coated Fea 04 nanoparticles for biomedical applica- tions 显示文摘 | Shete P B Patil R M Tiwale B M | 2015 | J Magn Magn Mater2015，130，10： | 1 |
| 20 | Ecidence for a continuum of decreased vancomycin susceptibility in unselected Staphylococcus aureus clinical isolates显示文摘 | Hussain FM Boyle-Vavra S Shete PB | 2002 | J Infect Dis2002，186，5： | 1 |
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