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| 1 | Glycogenic hepatopathy显示文摘Background: Glycogenic hepatopathy(GH) is a disorder associated with uncontrolled diabetes mellitus,most commonly type 1, expressed as right upper quadrant abdominal pain, hepatomegaly and increased liver enzymes. The diagnosis may be difficult, because laboratory and imaging tests are not pathognomonic. Although GH may be suggested based on clinical presentation and imaging studies, the gold standard for diagnosis is a liver biopsy, showing a significant accumulation of glycogen within the hepatocytes. GH may be diagnosed also after elevated liver enzymes in routine blood tests. GH usually regresses after tight glycemic control. Progression to end-stage liver disease has never been reported. This review aims to increase the awareness to this disease, to suggest a pathway for investigation that may reduce the use of unnecessary tests, especially invasive ones.Data sources: A Pub Med database search(up to July 1, 2017) was done with the words 'glycogenic hepatopathy', 'hepatic glycogenosis', 'liver glycogenosis' and 'diabetes mellitus-associated glycogen storage hepatopathy'. Articles in which diabetes mellitus-associated liver glycogen accumulation was described were included in this review.Results: A total of 47 articles were found, describing 126 patients with GH. Hepatocellular disturbance was more profound than cholestatic disturbance. No synthetic failure was reported.Conclusions: GH may be diagnosed conservatively, based on corroborating medical history, physical examination, laboratory tests, imaging studies and response to treatment, even without liver biopsy. In case of doubt about the diagnosis or lack of clinical response to treatment, a liver biopsy may be considered.There is no role for noninvasive tests like fibroscan or fibrotest for the diagnosis of GH or for differentiation of this situation from nonalcoholic fatty liver disease. | Johad Khoury Yaniv Zohar Naim Shehadeh Tarek Saadi | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，2： | 5 |
| 2 | Hypoglycemia in diabetes:An update on pathophysiology,treatment,and prevention显示文摘Hypoglycemia is a common complication in patients with diabetes,mainly in those treated with insulin,sulfonylurea,or glinide.Impairments in counterregulatory responses and hypoglycemia unawareness constitute the main risk factors for severe hypoglycemia.Episodes of hypoglycemia are associated with physical and psychological morbidity.The fear of hypoglycemia constitutes a barrier that impairs the patient’s ability to reach good glycemic control.To prevent hypoglycemia,much effort must be invested in patient education regarding risk factors,warning signs,and treatment of hypoglycemia at an early stage,together with setting personalized goals for glycemic control.In this review,we present a comprehensive update on the treatment and prevention of hypoglycemia in type 1 and type 2 diabetic patients. | Afif Nakhleh Naim Shehadeh | 2021 | World Journal of Diabetes2021，12，12： | 2 |
| 3 | Oral insulin supple menation attenuates atherosclerosis progression in apolipoprotein Edeficient mice显示文摘 | Shamir R Shehadeh N Rosenblat M | 2003 | Arterioscler Thromb Vasc Biol2003，23，1： | 1 |
| 4 | Heterogeneity in SDF-1 expression defines the vasculogenic potential of adult cardiac progenitor cells显示文摘 | Rodrigues CO Shehadeh LA Hoosien M | 2011 | Plos one2011，6，24： | 1 |
| 5 | Expression of lewy body protein septin 4 in postmortem brain of Parkinson 's disease and control subjects 显示文摘 | Shehadeh L Mitsi G Adi N | 2009 | Mov Disord2009，24，2： | 1 |
| 6 | Study of Sacrificial Cathodic Protec- tion on Marine Structures in Sea and Fresh Water in Relation to Flow Conditions显示文摘 | Shehadeh M Hassan et I | 2013 | Ships and Offshore Structures2013，8，1： | 1 |
| 7 | MieroRNA - 20a con- strains p300 - driven myocardial angiogenic transcription by direct targeting of p300显示文摘 | Shehadeh LA Sharma S Pessanha M | 2013 | PLoS One2013，8，79： | 1 |
| 8 | Myocyte deficiency as a target in the treatment of cardiomyopathy 显示文摘 | Rodrigues CO Shehadeh LA Webster KA | 2007 | Prog Pediatr Cardiol2007，24，： | 1 |
| 9 | A survey on secret key generation mechanisms on the physical layer in wireless networks 显示文摘 | SHEHADEH Y E H HOGREFE D | 2015 | Security and Communication Networks2015，8，2： | 1 |
| 10 | Abdominal fat and sleep apnea:the chicken or the egg?显示文摘 | Shehadeh N | 2008 | Diabetes Care2008，2，： | 1 |
| 11 | Oral insulin enhances intestinal regrowth following massive small bowel resection in rat 显示文摘 | Igor Sukhotnik Naim Shehadeh Shamir R | 2005 | Dig Dis Sci2005，50，12： | 1 |
| 12 | Multiscale dislocation dynamics simulations of shock-induced plasticity in small volumes显示文摘 | MutasemA. Shehadeh | 2012 | Philosophical Magazine2012，，10： | 1 |
| 13 | Self and Other initiated Modified Output During Task-based Interaction显示文摘 | Shehadeh A | 2001 | TESOL Quarterly2001，，35： | 1 |
| 14 | Striatal neuronal apoptosis is preferentiallyenhanced by NMDA receptor activation in YAC transgenicmouse model of Huntington disease显示文摘 | Shehadeh Jacqueline Fernandes Herman B Zeron MullinsMelinda M | 2006 | Neurobiol Dis2006，21，2： | 1 |
| 15 | Self- and other-initiated modified output during task-basod interaction 显示文摘 | Shehadeh A | 2001 | TESOL Quarterly2001，35，： | 1 |
| 16 | Cardiac consequence of diabetes mellitus 显示文摘 | Shehadeh A Regan T2 | 1995 | Clin Cardiol1995，18，1： | 1 |
| 17 | Non-native speakers production of modified comprehensible output and second language learning显示文摘 | A | 1999 | Language learning1999，49，4： | 1 |
| 18 | Cardiac consequences of diabetes mellitus显示文摘 | Shehadeh A Regan TJ | 1995 | Clin Cardiol1995，18，6： | 1 |
| 19 | Comprehensible Output,from Occurrence to Acquisition:an Agenda for Acquisitional Research显示文摘 | Shehadeh A | | 0，，3： | 1 |
| 20 | Abdominal fat and sleep apnea: the chicken or the egg? 显示文摘 | PILLAR G SHEHADEH N | 2008 | Diabetes Care2008，312，： | 1 |
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