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| 1 | Neuroendocrine carcinoma of the ampulla of Vater:a clinicopathologic evaluation显示文摘BACKGROUND:Only 105 cases of neuroendocrine tumor(NET)of the ampulla of Vater have been described, mostly as single case reports.The incidence of NET is rising.The changes in incidence may result from changes in detection.This study was to determine the relative incidence and clinicopathological characteristics of high- grade neuroendocrine carcinoma(small cell carcinoma and large cell carcinoma)of the ampulla of Vater at a single institution. METHODS:Sections from paraffin blocks of tumors of the ampulla of Vater taken from 45 patients who underwent Whipple's procedure and 6 patients who underwent palliative bypass between September 2003 and January 2007 were subjected to immunohistochemical analysis.The clinical and pathological data from 5 patients diagnosed with NET of the ampulla of Vater were analyzed. RESULTS:The patients were 3 men and 2 women,ranging in age from 39 to 47 years(mean 44 years).Operative procedures included Whipple's procedure in 4 patients and palliative bypass in 1 patient.Histopathological examination revealed large-cell neuroendocrine carcinoma in 2 patients,small cell carcinoma in 2,and carcinoid in 1.Three patients with high-grade neuroendocrine carcinoma who had undergone Whipple's procedure died at postoperatively 7,11,and 13 months.The patient who had undergone palliative triple bypass died 3 months after surgery.CONCLUSIONS:The relative incidence of high-grade neuroendocrine carcinomas of the ampulla of Vater is higher than that generally expected.The tumors behave aggressively and have a dismal prognosis despite aggressive treatment. | Eswaran Selvakumar Shanmugasundaram Rajendran Tirupporur Govindaswamy Balachandar Devy Gounder Kannan Satyanesan Jeswanth Palaniappan Ravichandran Rajagopal Surendran | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 7 |
| 2 | Long-term outcome of gastric access loop in hepaticojejunostomy显示文摘BACKGROUND:The incidence of hepaticojejunostomy stricture is 4%-10% in experienced centres. Many access loops have been designed and used to facilitate endoscopic intervention for this complication of hepaticojejunostomy. In this study, we investigated the effectiveness and safety of gastric access loop. METHODS:A retrospective analysis was conducted on 13 patients who had undergone hepaticojejunostomy with gastric access loop between June 1999 and September 2003. Eleven patients were followed up for a mean period of 51 months (range 20-81 months). Two patients were lost to follow up. RESULTS:On follow-up, 8 patients had patent jejuno- gastrostomy (end to side anastomosis between Roux loop of jejunum and stomach) and hepaticojejunostomy. Three patients developed stricture of jejunogastrostomy at 41 months, 63 months and 81 months of follow-up. Among these 3 patients, one also had hepaticojejunostomy stricture. In the patient with hepaticojejunostomy stricture, dilatation of jejunogastrostomy stricture was attempted but failed. None of the patients had any evidence of bile gastritis/cholangitis. There was no procedure related morbidity/mortality. CONCLUSIONS:Further studies involving large numbers of patients are required before wide application of gastric access loop in hepaticojejunostomy though it is a safer option than percutaneous transhepatic manipulations or revision surgery. | Eswaran Selvakumar Shanmugasundaram Rajendran Tirupporur G. Balachandar Devy Gounder Kannan Satyanesan Jeswanth Palaniappan Ravichandran Rajagopal Surendran | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，2： | 6 |
| 3 | Evaluation of antipyretic activity of ethyl acetate extract of Adenema hyssopifolium G.Don in a rat model显示文摘Objective:To evaluate the effect of ethyl acetate extract of Adenema hyssopifolium(AHEAE) on normal body temperature and brewer’s yeast-induced pyrexia rats.Methods:Preliminary phytochemical tests,acute toxicity tests and antipyretic evaluation were carried out in ethyl acetate extract of Adenoma hyssopifolium,.Two doses of the extract(300 or 600 mg/kg orally) and standard antipyretic agent,paracetamol at a dose of 150 mg/kg were administered to various group of the rats.Mean rectal temperature before and after treatment was noted.Results:The phytochemical analysis of AHEAE revealed the presence of flavonoid and iridoid glycosides as major phytoconstituents.The administration of AHEAE at a dose of 300 or 600 mg/kg produced significant reduction(P<0.001 and P<0.01) of the body temperature in normal and pyrexia rats on a dose dependent manner.The antipyretic influence of AHEAE was comparable to that of standard antipyretic agent,paracetamol(150 mg/kg),and onset of action and reduction in pyrexia towards normal body temperature was delayed when compared to paracetamol treatment.At dose of 600 mg/kg,AHEAE reduced pyrexia to normal body temperature at 4 h after its administration compared to reduction of pyrexia to normal body temperature at 2 h by standard drug.The reduction of fever was consistent in paracetamol group from 2 to 4 h after its administration to normal body temperature compared to AHEAE treatments.Conclusions:Our present results corroborate with the traditional notion of Adenema hyssopifolium G.DON that is being used as an effective cure of fever and add authenticity to claim of indigenous healers that the taxon is a potential antipyretic agent. | Aiyalu Rajasekaran Ramasamy Arivukkarasu Shanmugasundaram Murugesh | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 3 |
| 4 | Is bactibilia a predictor of poor outcome of pancreaticoduodenectomy?显示文摘BACKGROUND:Although bile infection has been proposed to increase infective complications following pancreaticoduodenectomy,its association with infective complications and non-infective complications like pancreatic fistula is still controversial.METHODS:Seventy-six patients who had undergone pancreaticoduodenectomy between July 2007 and December 2008 were included in a prospective database and their data analyzed.In all patients intraoperative bile from the bile duct was cultured.Preoperative,intra-operative,and post-operative variables were recorded and analyzed.RESULTS:Bile culture showed positive growth in 35 patients and negative growth in 41.Twenty patients in the positive group underwent ERCP and stenting.The patients with a positive bile culture had a higher incidence of infective complications including intra-abdominal abscess (n=8),wound infection (n=27),bacteremia (n=10),and renal insufficiency (n=9).There was no increase in the rate of non-infective complications of pancreaticoduodenectomy including pancreatic fistula (n=7),delayed gastric emptying (n=9),and post-operative hemorrhage (n=3).The hospital stay was significantly prolonged in the patients with a positive bile culture (P=0.0002).CONCLUSIONS:Pre-operative biliary drainage is significantly associated with bile infection,and bile infection increases the overall rates of infective complications and renal insufficiency.Because of the high incidence of complications is associated with infected bile,routine intra-operative bile culture is recommended in patients undergoing pancreaticoduodenectomy.Pre-operative prophylaxis is dependent on sensitivity of cases to perioperative antibiotics and intraoperative bile culture report.Because of its significant association with infected bile,biliary stenting should be used in strictly selected cases. | Sivanpillay Mahadevan Sivaraj Velayutham Vimalraj Palanichamy Saravanaboopathy Shanmugasundaram Rajendran Sathyanesan Jeswanth Palaniappan Ravichandran Rosy Vennilla Rajagopalan Surendran | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 2 |
| 5 | Occurrence of Clostridium perfringens contamination in poultry feed ingredients:Isolation, identification and its antibiotic sensitivity pattern显示文摘This work has been undertaken to study the occurrence of Clostridium perfringens contamination in the poultry feed ingredients and find out its in-vitro antibiotic sensitivity pattern to various antimicrobial drugs. Two hundred and ninety-eight poultry feed ingredient samples received at Poultry Disease Diagnosis and Surveillance Laboratory, Namakkal, Tamil Nadu in South India were screened for the presence of C. perfringens. The organisms were isolated in Perfringens agar under anaerobic condition and subjected to standard biochemical tests for confirmation. In vitro antibiogram assay has been carried out to determine the sensitivity pattern of the isolates to various antimicrobial drugs. One hundred and one isolates of C. perfringens were obtained from a total of 298 poultry feed ingredient samples. Overall positivity of 33.89% could be made from the poultry feed ingredients. Highest level of C. perfringens contamination was detected in fish meal followed by bone meal, meat and bone meal and dry fish.Antibiogram assay indicated that the organisms are highly sensitive to gentamicin(100%), chlortetracycline(96.67%), gatifloxacin(93.33%), ciprofloxacin(86.67%), ofloxacin(86.67%) and lincomycin(86.67%). All the isolates were resistant to penicillin-G. Feed ingredients rich in animal proteins are the major source of C. perfringens contamination. | Shanmugasundaram Udhayavel Gopalakrishnamurthy Thippichettypalayam Ramasamy Vasudevan Gowthaman Shanmugasamy Malmarugan Kandasamy Senthilvel | 2017 | Animal Nutrition2017，，3： | 2 |
| 6 | Prediction of the angle of gibbus deformity in tuberculosis of the spine显示文摘 | Rajasekaran S Shanmugasundaram TK | 1987 | J Bone Joint Surg Am1987，69，： | 1 |
| 7 | Analytical and experimental studies on the gust response of a 52m tall steel lattice tower under wind loading显示文摘 | Harikrishna P Shanmugasundaram J Gomathinayagam S | 1999 | Computers and Structures1999，70，： | 1 |
| 8 | Optimization of machining parameters using gentic algorithm and experimental val-idation for end-milling operations显示文摘 | Palanisamy Rajendran I Shanmugasundaram S | | 0，，32： | 1 |
| 9 | In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn显示文摘 | Adhirajan N Ravi Kumar T Shanmugasundaram N | 2003 | J Ethnopharmacol2003，88，23： | 1 |
| 10 | Synthesis and laser properties of 9-alkyl-3,3,6,6-tetramethyl-1, 2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione derivatives显示文摘 | Murugan P Shanmugasundaram P Ramakrishnan V T | 1998 | J Chem Soc Perkin Trans 21998，4，： | 1 |
| 11 | NOX4 mediates renal cell carcinoma cell invasion through hypoxia- induced interleukin 6- and 8- production 显示文摘 | FITZGERALD J P NAYAK B SHANMUGASUNDARAM K | 2012 | PLoS One2012，7，30： | 1 |
| 12 | In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn 显示文摘 | Kumar TR Shanmugasundaram N | 2003 | Journal of Ethnopharmacology2003，88，23： | 1 |
| 13 | Hyperthermia induced NFkappaB mediated apoptosis in normal human mono-cytes显示文摘 | Aravindan N Shanmugasundaram K Natarajan M | | 0，，1： | 1 |
| 14 | Acute coronary syndrome in the elderly显示文摘 | Shanmugasundaram M Alpert JS | 2009 | ClinCardiol2009，32，11： | 1 |
| 15 | Develop- ment of morulae from the oocytes of cultured sheep preantral follicles显示文摘 | Arunakumari G Shanmugasundaram N Rao V H | 2010 | Theriogenology2010，74，5： | 1 |
| 16 | Effect of yeast cell product (CitriStim) supplementation on broiler performance and intestinal immune cell parameters during an experimental coccidial infection显示文摘 | SHANMUGASUNDARAM R SIFRI M SELVARAJ R K | 2013 | Poultry Science2013，92，： | 1 |
| 17 | Dynam- ic effects of wind loads on offshore deck structures-A criticat eval- uation of provisions and practices显示文摘 | S Gomathinayagam C P Vendhan J Shanmugasundaram | 2000 | Journal of Wind Engineering and Industrial Aerodynamics2000，84，： | 1 |
| 18 | Vegetable soybean显示文摘 | Shanmugasundaram S Yan M R | 2010 | Soybean Botany Production & Uses2010，，： | 1 |
| 19 | Progression of kyphosis in tuberculosis of the spine treated by anterio- rarthrodesis显示文摘 | Rajasekaran S Shanmugasundaram TK | 1989 | J Bone Joint Surg1989，71，9： | 1 |
| 20 | Percutaneous coronary intervention in elderly patients:is it beneficial显示文摘 | Shanmugasundaram M | | 0，，： | 1 |
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