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| 1 | 急性缺血性卒中患者早期处理指南:美国心脏协会/美国卒中协会对医疗专业人员的指南显示文摘背景和目的作者提供了关于成年急性缺血性卒中患者评估和治疗方面的现有证据和处理推荐的一份概述。目标读者为涉及急性缺血性卒中患者发病48h内诊治的院前诊疗人员、医生、综合医疗保健人员和医院管理者。该指南将取代先前的2007年版指南及其2009年更新版。方法著述委员会成员由美国卒中协会卒中委员会的科学声明监督委员会指定,代表各个领域的医疗专家。在形成共识的整个过程中,严格遵循美国心脏协会的利益冲突原则。委员会成员被分配给与其专业领域相关的内容,对卒中文献进行回顾,重点为前一版指南发表之后的文献,然后按照美国心脏协会卒中委员会的证据强度分级方案起草推荐意见。结果本指南的目的是减少卒中相关的残疾和死亡。本指南支持卒中医疗体系的全局性概念以及从患者识别、急救医疗服务激活、转送和分诊到急诊室和卒中单元内最初数小时诊治的卒中诊治细节。本指南讨论了早期卒中评估和一般治疗、缺血性卒中治疗、特殊干预措施,如再灌注策略以及脑复苏的一般生理学干预原则。结论由于许多推荐意见基于有限的证据,还迫切需要对急性缺血性卒中的治疗做进一步的研究。 | Edward C. Jauch Jeffrey L. Saver Harold P. Adams Askiel Bruno J.J. (Buddy) Connors Bart M. Demaerschalk Pooja Khatri Paul W. McMullan Jr, Adnan I. Qureshi Kenneth Rosenfield Phillip A. Scott Debbie R. Summers David Z. Wang Max Wintermark Howard Yonas 李海峰(译) 岳耀先(译) 王琦(译) 张贤军(译) 丁晓君(译) | 2013 | 国际脑血管病杂志2013，21，7： | 17 |
| 2 | Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis:a double-blind randomised multicentre trial显示文摘 | Smolen JS Kalden JR Scott DL | | 0，，： | 3 |
| 3 | A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia显示文摘This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive azoospermia.All cases at a single center between 2012 and 2016 were included.Operative approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm extraction.Blastocyst culture was exclusively utilized prior to transfer.The primary outcome was live birth rate.Secondary outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was performed.Seventy-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were analyzed.The live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,P<0.05).The euploidy rate was no different.Pregnancy rates were no different through the first transfer cycle.However,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per patient.Thus,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort. | Scott J Morin Brent M Hanson Caroline R Juneau Shelby A Neal Jessica N Landis Richard T Scott Jr James M Hotaling | 2020 | Asian Journal of Andrology2020，22，2： | 2 |
| 4 | 采用间接复位、钢板固定、不植骨的方法治疗稳定的股骨干髓内假体周围骨折显示文摘背景:间接复位技术相对于较早期的开放复位技术具有能够提高骨愈合率及减少植骨的优势,我们对以间接复位治疗股骨干假体周围骨折的结果进行了研究。
方法:连续对50例稳定的股骨干髓内假体周围骨折(Vancourvr B1型)进行治疗,根据病例记录包括切开复位、间接复位、外侧单钢板固定且不行同种异体或其他植骨。4例术后早期死亡,5例随访时间短,对其余41例(平均年龄72岁)进行了平均24个月的随访,并进行临床和影像学评估。
结果:所有骨折平均12周(7~23周)愈合,对位满意。1例有1根钢丝断裂,2例有1枚螺钉断裂,骨折最终愈合且无明显的内置物松动和对位不良。1例发生围手术期深部感染。41例中30例行走功能恢复到骨折前的状态。
结论:结果证实间接复位骨膜外侧单钢板固定且不进行植骨的方法对于稳定的股骨干髓内假体周围骨折的疗效是应该肯定的。
可信水平:治疗性研究,Ⅳ级,进一步可信度参见作者介绍。 | WILLIAM M. RICCI BRETT R. BOLHOFNER TIMOTHY LOFTUS CHRISTOPHER COX SCOTT MITCHELL JOSEPH BORRELLI JR 董强(译) 马宝通(译) | 2006 | 骨科动态2006，2，1： | 2 |
| 5 | Asymptomatic postpubertal male with equally sized normal testicles with palpable left varicocele显示文摘 | A Scott Polackwich Edmund Sabanegh Jr | 2016 | Asian Journal of Andrology2016，18，2： | 2 |
| 6 | Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer’s disease显示文摘Aging is by far the most prominent risk factor for Alzheimer’s disease(AD),and both aging and AD are associated with apparent metabolic alterations.As developing effective therapeutic interventions to treat AD is clearly in urgent need,the impact of modulating whole-body and intracellular metabolism in preclinical models and in human patients,on disease pathogenesis,have been explored.There is also an increasing awareness of differential risk and potential targeting strategies related to biological sex,microbiome,and circadian regulation.As a major part of intracellular metabolism,mitochondrial bioenergetics,mitochondrial quality-control mechanisms,and mitochondria-linked inflammatory responses have been considered for AD therapeutic interventions.This review summarizes and highlights these efforts. | Steven N.Austad Scott Ballinger Thomas W.Buford Christy S.Carter Daniel L.Smith Jr Victor Darley-Usmar Jianhua Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 7 | Pulmonary hamartoma CT findings显示文摘 | Siegelman SS Khouri NF Scott WW Jr | 1996 | Radiology1996，160，2： | 1 |
| 8 | Accurate computation of the radiation from simple antennas using the finite- difference time- domain method显示文摘 | Maloney J G Smith G S Scott W R JR | 1990 | IEEE Trans Antennas and Propagat1990，38，7： | 1 |
| 9 | Type Ⅰ fracture of the odontoid process: implication for atlano-occiptal instability显示文摘 | Scott EW Haid RW Jr Peacee D | 1990 | J Neurosurg1990，72，3： | 1 |
| 10 | Women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B before a rise in day 3 follicle-stimulating hormone显示文摘 | Seifer DB Scott RT Jr Bergh PA | 1999 | Fertil Steril1999，72，1： | 1 |
| 11 | Fluid-fluid levels in injured knees: do they always represent lipohemarthrosis?显示文摘 | Lugo-Olivieri CH Scott WW Jr Zerhouni EA | 1996 | Radiology1996，198，2： | 1 |
| 12 | Immunologic aspects of recurrent abortion and fetal death显示文摘 | Rote NS Branch DW | 1987 | ObstetGynec1987，70，： | 1 |
| 13 | Masked confirmation of linkage between type 1 congenital vitreous anomaly and COL 2A1 in Stickler syndrome显示文摘 | Snead MP Yates JR Pope FM Temple IK Scott JD | 1996 | Graefe Arch Clin Exp Ophthalmol1996，234，： | 1 |
| 14 | Acute-onset endophthal- mitis after cataract surgery(2000-2004):incidence, clinical set- tings,and visual acuity outcomes after treatment显示文摘 | Miller JJ Scott IU Flynn HW Jr | 2005 | Am J Oph-thalmol2005，139，： | 1 |
| 15 | Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis:a double-blind,randomised,multicentre trial显示文摘 | Smolen JS Kalden JR Scott DL | 1999 | Lancet1999，353，23： | 1 |
| 16 | Immunotherapy for recurrent miscar- riage 显示文摘 | Wong LF Porter TF Scott JR | 2014 | Cochrane Database Syst Rev2014，10，00： | 1 |
| 17 | Intravitreal triamcinolone acetonid for idiopathic cystoid macular edema显示文摘 | Scott IU Flynn HW Jr Rosenfeld PJ | 2003 | Am J Ophthalmol2003，136，4： | 1 |
| 18 | Immunotherapy for recur- rent miscarriage显示文摘 | Porter TF LaCoursiere Y Scott JR | 2006 | Cochrane Database Syst Rev2006，，00： | 1 |
| 19 | Uterine rupture with attempted vaginal birth after cesarean delivery:decision-todelivery time and neonatal outcome显示文摘 | Holmgren C Scott JR Porter TF | 2012 | Obstet Gynecol2012，119，4： | 1 |
| 20 | Elastic waves interacting with buried land mines: A study using the FDTD method显示文摘 | Scott W Jr Larson G D | 2002 | IEEE Transactions on Geoscience and Remote Sensing2002，40，： | 1 |
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