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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | 星形胶质细胞通过分泌IL-23促进黑色素瘤脑转移显示文摘黑色素瘤是最主要皮肤致死性恶性肿瘤,黑色素瘤患者死亡的主要原因是远处转移,常为脑转移。微环境在肿瘤的发生和转移中起着关键的作用,为了治疗或预防转移,必须阐明播散的肿瘤细胞与转移性器官微环境之间的相互作用。然而,大脑间质细胞在促进转移性生长中的作用却知之甚少。星形胶质细胞的主要功能是大脑损伤后修复和形成胶质瘢痕,部分因为通过介导神经炎症,但是星形胶质细胞在黑色素瘤脑转移中的作用却不清楚。 | Klein A Schwartz H Sagi-Assif O 陈达阳 王行富 | 2015 | 临床与实验病理学杂志2015，31，11： | 4 |
| 3 | Contribution of technical materials to the mobile fraction of metals in urban soils in Marrakech (Morocco) 显示文摘 | Khalil H E Schwartz C Elhamiani O | 2008 | Journal of Soils and Sediments2008，8，1： | 1 |
| 4 | 13C andl5N natural abundance of the soil microbial biomass显示文摘 | Dijkstra P Ishizu A Doucett R Hart S C Schwartz E Menyailo O V Hungate B A | 2006 | Soil Biology & Biochemistry2006，38，： | 1 |
| 5 | Pulp and perio- dontal healing, root development and root resorption subsequent to transplantation anc显示文摘 | Paulsen HU Andreasen JO Schwartz O | 1995 | Am J Orthod Dentofacial Orthop1995，108，6： | 1 |
| 6 | Dual regula-tion of phosphorylation and dephosphorylation of C/EBPbeta modulate its transcriptional activation and DNA binding in re-sponse to growth hormone显示文摘 | Piwien-Pilipuk G MacDougald O Schwartz J | 2002 | J Biol Chem2002，277，44： | 1 |
| 7 | Microglial phenotype: is the commitment reversible? 显示文摘 | Schwartz M Butovsky O Bruck W etal | 2006 | Trends Neurosci2006，29，2： | 1 |
| 8 | Hyperbaric oxygen therapy as a treatment for stage-1 avascular necrosis of the femoral head显示文摘 | Reis ND Schwartz O Militianu D | 2003 | J Bone Joint Surg Br2003，85，3： | 1 |
| 9 | Hyperbaric oxygen therapy as a treatment for stage-1 avascular necrosis of the femoral head 显示文摘 | Reis ND Schwartz O Militianu D | 2003 | J Bone Joint Surg Br2003，85，3： | 1 |
| 10 | Stimulation of 5-fluorouracil metabolic activation by interferon-alpha in human colon carcinoma cells显示文摘 | Schwartz EL Hoffman M O'Connor CJ | 1992 | Bioch Biophys Res Commu1992，182，： | 1 |
| 11 | Microglia activated by IL-4 or INF gamma differentially induce neurogenesis and oligodendro genesis from adult stem/ progenitor cells 显示文摘 | Butovsky O Ziv Y Schwartz A | 2006 | Mol Cell Neurosci2006，31，1： | 1 |
| 12 | Intrahepatic Cholangiocarcinoma: Rising Frequency, Improved Survival, and Determinants of Outcome After Resection显示文摘 | Itaru Endo Mithat Gonen Adam C. Yopp Kimberly M. Dalal Qin Zhou David Klimstra Michael D?Angelica Ronald P. DeMatteo Yuman Fong Lawrence Schwartz Nancy Kemeny Eileen O?Reilly Ghassan K. Abou-Alfa Hiroshi Shimada Leslie H. Blumgart William R. Jarnagin | 2008 | Annals of Surgery2008，，1： | 1 |
| 13 | Hyperbaric oxygen therapy as a treatment for stage-Ⅰ avascular necrosis of the femoral head显示文摘 | Reis ND Schwartz O Militianu D | 2003 | J Bone Joint Surg Br2003，85，3： | 1 |
| 14 | Positive assoliation of the beta fibrinogen H1/H2 gene variation to basal fibrinogen levels and to the increase in fibrinogen concentration during acute phase reaction but not to coronary artery disease and myocardial infarction显示文摘 | Gardemann A Schwartz O Haberbosch W | 1997 | Thromb Haemost1997，77，6： | 1 |
| 15 | Vitamin D-mediated induction of innate immunity in gingival epithelial cells显示文摘 | McMahon L Schwartz K Yilmaz O | 2011 | Infect immun2011，79，6： | 1 |
| 16 | Radiosurgery with unflattened 6 MV photon beams 显示文摘 | O'BRIEN P F GILLIES B A SCHWARTZ M | 1991 | Med Phys1991，18，3： | 1 |
| 17 | Chemical etching of ion track in LiF crystals显示文摘 | Trautrnann C Schwartz K Geiss O | 1983 | J Chem Phys1983，79，： | 1 |
| 18 | Cadmium in zinc deposits:Economicgeology of apolluting element显示文摘 | Schwartz M O | 2000 | International Geology Review2000，42，： | 1 |
| 19 | Efficient dye-sensitized charge separation in a wide-band-gap p-n heterojunction显示文摘 | O'REGAN B SCHWARTZ D T | 1996 | Appl Phys1996，80，8： | 1 |
| 20 | Uncertainty in climate change caused by aerosol 显示文摘 | Schwartz S E Andreae M O | 1996 | Science1996，272，24： | 1 |
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