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| 1 | Emerging treatments for complex perianal fistula in Crohn's disease显示文摘Complex perianal fistulas have a negative impact on the quality of life of sufferers and should be treated.Correct diagnosis,characterization and classification of the fistulas are essential to optimize treatment.Nevertheless, in the case of patients whose fistulas are associated with Crohn's disease,complete closure is particularly difficult to achieve.Systemic medical treatments(antibiotics, thiopurines and other immunomodulatory agents,and, more recently,anti-tumor necrosis factor-αagents such as infliximab)have been tried with varying degrees of success.Combined medical(including infliximab)and less aggressive surgical therapy(drainage and seton placement)offer the best outcomes in complex Crohn's fistulas while more aggressive surgical procedures such as fistulotomy or fistulectomy may increase the risk of incontinence.This review will focus on emerging novel treatments for perianal disease in Crohn's patients. These include locally applied infliximab or tacrolimus, fistula plugs,instillation of fibrin glue and the use of adult expanded adipose-derived stem cell injection.More welldesigned controlled studies are required to confirm the effectiveness of these emerging treatments. | Carlos Taxonera David A Schwartz Damián García-Olmo | 2009 | World Journal of Gastroenterology2009，15，34： | 6 |
| 2 | 肝的周期性的巨大的 hemangiomas : 有文学评论的二个稀罕案例的报告显示文摘 Most hepatic hemangiomas(HHs) are small,asymptomatic and do not require clinical intervention.Surgical resection is only indicated for symptomatic hemangiomas.We report here cases of recurrent HHs in 2 women of 37 and 40 years old,who initially presented with abdominal pain and mass.Radiological examination of each tumor revealed a solitary tumor of 14 and 20 cm in diameter,respectively.Surgical liver segmental resections were performed in both,and the diagnosis of cavernous hemangioma was confirmed.Both patients had recurrent tumor on subsequent radiological examination 4-5 years after the initial surgery.In the first patient,a 15 cm recurrent hemangioma was resected,but multiple hemangiomas were again detected 8 years later occupying the other hepatic lobe,which was not amendable for resection.In the second patient,a 16 cm hemangioma was seen on radiogram,and because the lesion was not symptomatic,conservative observation was offered.Recurrence after liver resection of giant hemangioma is extremely rare.The pathogenesis of tumor progression and recurrence is unknown,as is the management of these patients with recurrent hemangioma,particularly when it is extensive and unresectable. | Hongfa Zhu Khaled Obeidat Jie Ouyang Sasan Roayaie Myron E Schwartz Swan N Thung | 2012 | World Journal of Gastrointestinal Surgery2012，4，11： | 5 |
| 3 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 4 | Chemoradiation with 5-fluorouracil and mitomycin C in the treatment of vulvar squamous cell carcinoma显示文摘 | Mulayim N Foster Silver D Schwartz P E | 2004 | Gynecol Oncol2004，93，3： | 2 |
| 5 | Robust Transient Signal Detection Using the Oversampled Gabor Representation显示文摘 | Lee N Schwartz S C | 1995 | IEEE Transactions on Signal Processing1995，43，6： | 1 |
| 6 | Pluripotency of mesenchymal stem cells derived from adult marrow显示文摘 | Jiang Y Jahagirdar B N Reinhardt R L Schwartz R E Keene C D Ortiz Gonzalez X R | 2002 | Nature2002，418，： | 1 |
| 7 | Adverse effects of recombinant human insulin -like growth factor I in obese insulin -resistant type Ⅱ diabetic patients显示文摘 | Jabri N Schalch DS Schwartz SL | 1994 | Diabetes1994，43，3： | 1 |
| 8 | Novel 3-dimensional placental measurements in early pregnancy as predictors of adverse pregnancy outcomes 显示文摘 | Schwartz N Coletta J Pessel C | 2010 | J Ultrasound Med2010，29，8： | 1 |
| 9 | A coarse grain modet for DNA显示文摘 | Knotts IV T A Rathore N Schwartz 9 C | 2007 | The Journal of chemical physics2007，126，08： | 1 |
| 10 | Urinary TWEAK and the activity of lupus nephritis显示文摘 | Schwartz N Su L Burkly LC | 2006 | J Autoimmun2006，27，4： | 1 |
| 11 | American Socie- ty o Clinical Oncology / College o显示文摘 | Wolff A C Hammond M E Schwartz J N | 2007 | Arch Pathol Lab Med2007，131，1： | 1 |
| 12 | The utility of F- 18 fluorodeoxyglucose whole body PET imaging for determining malignancy in cystic lesions of the pancreas 显示文摘 | Mansour JC Schwartz L Pandit-Taskar N | 2006 | J Gastrointest Surg2006，10，10： | 1 |
| 13 | Seven-day therapy for helicobacter pylori in the United States显示文摘 | Vaki N Lanza F Schwartz H | 2004 | Aliment Pharmacol Ther2004，20，： | 1 |
| 14 | Thymidine phosphorylase mediates the sensitivity of human colon-carcinoma cells to 5-fluorouracil显示文摘 | Schwartz EL Baptiste N Wadler S | 1995 | J Biol Chem1995，270，19： | 1 |
| 15 | Risk factors forsubtrochanteric and diaphyseal fractures:the study ofosteoporotic fractures显示文摘 | Napoli N Schwartz AV Palermi L | 2013 | J Clin Endocrinol Metab2013，98，2： | 1 |
| 16 | Effect of Oxiplex films(PEO/CMC) on adhesion formation and reformation in rabbit models and on peritoneal infection in a rat model显示文摘 | Rodgcrs KE Schwartz HE Roda N | 2000 | Fertil Steril2000，73，4： | 1 |
| 17 | Lipocalin-2, TWEAK,and other cytokines as urinary biomarkers for lupus nephritis 显示文摘 | Schwartz N Michaelson J S Putterman C | 2007 | Ann N Y Acad Sci2007，1202，11： | 1 |
| 18 | American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer显示文摘 | Wolff A C Hammond M E Schwartz J N | 2007 | J Clin Oncol2007，25，1： | 1 |
| 19 | Performance ofp!6/Ki-67 iramunostaining to detect cervical cancer pre-cursors in a colposcopy referral population 显示文摘 | Wentzensen N Schwartz L Zuna RE | 2012 | Clinical Can-cer Research2012，18，15： | 1 |
| 20 | Potential rivalry, monopoly profits and the pace of inventive activity 显示文摘 | Kamien M I Schwartz N L | 1978 | The Re- view of Economic Studies1978，45，3： | 1 |
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