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| 1 | Batroxobin reduces intracellular calcium concentration and inhibits proliferation of vascular smooth muscle cells显示文摘Background Batroxobin (BX),a serine protease used in defibrinogenation and thrombolysis,also has an effect on c-fos gene and growth factor. This study attempted to determine the effects of BX on the proliferation of vascular smooth muscle cells (VSMCs) and calcium metabolism. Methods VSMCs were treated with BX at concentrations of 0.1,0.3,or 1.0 mmol/L and cell numbers were determined at 0,24,48,and 72 hours. Intracellular calcium concentration ([Ca 2+ ]_i) was measured using direct fluorescence methods. Results BX was found to suppress proliferation of VSMCs in a dose-dependent fashion with inhibition rates of 18% and 31% by 48 and 72 hours,respectively. In addition,BX decreases basal [Ca 2+ ]_i significantly. The basal level in untreated cells was 162.7±33.8 nmol/L,and decreased to 131.5±27.7 nmol/L,128.3±28.5 nmol/L,and 125.6±34.3 nmol/L with the three concentrations of BX,respectively. Noradrenaline (NE)-induced [Ca 2+ ]_i stimulation was also attenuated by BX (0.1 mmol/L BX,20%±8% inhibition; 0.3 mmol/L BX,54%±11% inhibition; 1.0 mmol/L BX,62%±15% inhibition). The ability of NE to stimulate [Ca 2+ ]_i was attenuated in cultures in Ca 2+ -free medium,as was the ability of BX to blunt NE-induced stimulation. Conclusion These findings demonstrate that BX can effectively inhibit proliferation of VSMCs,probably by blocking the release and uptake of Ca 2+ ,thus influencing [Ca 2+ ]_i. | 宋清斌 魏敏杰 段志泉 张海强 LB Schwartz 辛世杰 | 2004 | Chinese Medical Journal2004，，6： | 25 |
| 2 | Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis显示文摘 | Schwartz LB Yunginger JW Miller J Bokhari R Dull D | 1989 | J Clin Invest1989，83，5： | 1 |
| 3 | Regulation of human mast cell β - tryptase: conversion of inactive monomer to active tetramer at acid pH显示文摘 | Sakai K Schwartz LB | 1998 | J Immunol1998，160，9： | 1 |
| 4 | Catheter-direc-ted thrombolysis for deep venous thrombosis显示文摘 | Baldwin ZK Comerota AJ Schwartz LB | 2004 | Vasc En-dovaseular Surg2004，38，1： | 1 |
| 5 | Elevated bron- choalveolar lavage fluid histamine levels in allergic asthmatics are associated with increased airway obstruction 显示文摘 | Jarjour NN Calhoun WJ Schwartz LB | 1991 | Am Rev Respir Dis1991，144，1： | 1 |
| 6 | The measurement of fatigue: a new instrument显示文摘 | Schwartz JE Jandorf L Krupp LB | 1993 | J Psychosom Res1993，37，7： | 1 |
| 7 | The embryo versus endometrium controversy revisited as it relates to predicting pregnancy outcome in in-vitro fertilization-embryo transfer cycles 显示文摘 | Schwartz LB Chiu AS Courtney M | 1997 | Hum Reprod1997，12，1： | 1 |
| 8 | Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics显示文摘 | Wenzel SE Schwartz LB Langmack EL | | 0，，： | 1 |
| 9 | The mesenteric circula-tion:anatomy and physiology显示文摘 | Rosenblum JD Boyle CM Schwartz LB | | 0，，02： | 1 |
| 10 | The measurement of fatigue: A new instrument显示文摘 | Schwartz JE Jandorf L Krupp LB | 1993 | J Psychosom Res1993，37，7： | 1 |
| 11 | Cell cycle activation in postmitotic neurons is essential for DNA repair显示文摘 | Schwartz EI Smilenov LB Price MA el al | 2007 | Cell Cycle2007，6，3： | 1 |
| 12 | Catheter-directedthrombolysis for deep venous thrombosis 显示文摘 | Baldwin ZK Comerota AJ Schwartz LB | 2004 | Vase EndovascularSurg2004，38，1： | 1 |
| 13 | Catheter-directed thrombolysis for deep venous thrombosis显示文摘 | Baldwin ZK Comerota A J Schwartz LB | 2004 | Vasc Endovasc Surg2004，38，1： | 1 |
| 14 | The measurement of fatigue:a new instrument显示文摘 | Schwartz JE Jandorf L Krupp LB | 1993 | Psychosomatic Research1993，37，7： | 1 |
| 15 | Diagnostic value of tryptase in anaphylaxis and mastocytosis显示文摘 | Schwartz LB | 2006 | Immunol Allergy Clin North Am2006，26，3： | 1 |
| 16 | Evaluating protein attraction and adhesion to biomaterials with the atomic force microscope显示文摘 | Wang MS Palmer LB Schwartz JD | 2004 | Langmiur2004，20，18： | 1 |
| 17 | Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis显示文摘 | Schwartz LB Metcalfe DD Miller JS | 1987 | N Engl J Med1987，316，26： | 1 |
| 18 | Combating antimicrobial resistance: policy recommendations to save lives 显示文摘 | Infectious Diseases Society of America (IDSA) Spellberg B Blaser M Guidos RJ Boucher HW Bradley JS Eisenstein BI Gerding D Lynfield R Relier LB Rex J Schwartz D Septimus E Tenover FC Gilbert DN | 2011 | Clin Infect Dis2011，52，5： | 1 |
| 19 | Clinical utility of tryptase levels in systemic mastocytosis and associated hematologic disorders显示文摘 | Schwartz LB | 2001 | Leuk Res2001，25，7： | 1 |
| 20 | Endometriosis 显示文摘 | Olive DL Schwartz LB | 1993 | N Engl J Meal1993，328，： | 1 |
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