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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | C-reactive protein levels during a relapse of Crohn’s disease are associated with the clinical course of the disease显示文摘AIM: To explore if C-reactive protein (CRP) levels might serve as a prognostic factor with respect to the clinical course of Crohn's disease and might be useful for classification.METHODS: In this retrospective cohort study we enrolled 94 patients from the inflammatory bowel disease (IBD) database of the University Medical Centre Utrecht. CRP levels during relapse were correlated with the number of relapses per year. Severity of relapses was based on endoscopic reports and prednisone use. Furthermore, patients were categorized in a low or high CRP group based on their CRP response during relapse and demographic and clinical features were compared.RESULTS: Overall, a positive correlation between CRP levels, number of relapses, and severity of relapse was found (respectively rs = 0.31, P < 0.01 and rs = 0.50, P < 0.001). Employing a cut-off level of 15 mg/L, the index CRP level was found to discriminate patients with respect to the number of relapses per year, as well as for severity of relapses (respectively 0.25 ± 0.16 vs 0.36 ± 0.24, P < 0.05 and 4.4 ± 1.2 vs 3.2 ± 1.1 on a 10-point visual analogue scale, P < 0.001 for the high CRP and low CRP groups respectively). In addition, the high CRP group showed more cumulative days of prednisone use per year (107 ± 95 vs 58 ± 48, P < 0.05), as well as a better response to infliximab (93 % vs 33 %, P = 0.06).CONCLUSION: A higher CRP level during relapse seems to be associated with a more severe clinical course of disease. | Chantal L Koelewijn Matthijs P Schwartz Melvin Samsom Bas Oldenburg | 2008 | World Journal of Gastroenterology2008，14，1： | 4 |
| 3 | 子宫颈癌累及泌尿生殖道:潜在的诊断困境显示文摘Schwartz L E, Khani F, Bishop J A, et al. Carcinoma of the u- terine cervix involving the genitourinary tract: a potential diag- nostic dilemma. Am J Surg Pathol, 2016,40(1) :27 -35.有关子宫颈癌继发累及泌尿生殖道的记载非常少见。由于形态学上这些肿瘤可以类似于尿路上皮癌,也可以与膀胱的原发性鳞状细胞癌和原发性腺癌非常相似,故诊断具有极大的挑战性。作者收集了约翰霍普金斯医院从1984年至今的泌尿生殖器咨询案例,主要包括原发性膀胱癌与子宫颈癌继发性累及膀胱的鉴别诊断病例。作者确定了10例满足这些标准的病例。 | Schwartz L E Khani F Bishop J A 魏建国 许春伟 | 2016 | 临床与实验病理学杂志2016，32，2： | 3 |
| 4 | Cardiovascular physiology in the older adults显示文摘 | Xuming Dai Scott L Hummel Jorge B Salazar George E Taffet Susan Zieman Janice B Schwartz | 2015 | Journal of Geriatric Cardiology2015，12，3： | 2 |
| 5 | intrahepatic cholangiocarcinoma 的胰腺的复发: 案例报告和文学的评论显示文摘 Intrahepatic cholangiocarcinomas(ICC)are malignant tumors arising from the intrahepatic bile ducts that frequently recur after resection.The main sites of recurrence are the remnant liver,lymph nodes and lungs.Metastasis to the pancreas has never been reported.This case describes a 24-year-old woman who underwent a hepatic lobectomy in 2008 for an ICC.Almost 4years after her surgery she presented with a pancreatic mass and lung nodules.An endoscopic ultrasound guided fine needle aspiration of the pancreatic mass and a video-assisted thoracoscopic surgery resection for the lung nodules were performed for diagnostic purposes.Pathological analyses of specimens revealed recurrence of her primary ICC in both pancreas and lungs.Subsequently,the patient received systemic chemotherapy.The patient is currently off chemotherapy and remains well.Moreover,she is pregnant.This is the first report of an ICC with pancreatic metastasis. | Isma?l Labgaa Gonzalo Carrasco-Avino Maria Isabel Fiel Myron Eliot Schwartz | 2014 | World Journal of Gastrointestinal Surgery2014，6，4： | 2 |
| 6 | A greedy algorithm for aligning DNA sequences 显示文摘 | Zhang Z Schwartz S Wagner L | 2000 | Journal of Computational Biology2000，7，： | 1 |
| 7 | Chlamydia pneumoniae, herpes simplex virus type 1, and Cytomegalovirus and incident myocardial infarction and coronary heart disease death in older adults: the Cardiovascular Health Study 显示文摘 | Siscovick DS Schwartz SM Corey L el al | 2000 | Circulation2000，102，19： | 1 |
| 8 | Lead-induced anemia: doseresponse relationships and evidence for a threshold 显示文摘 | Schwartz J Landrigan P J Baker E L | 1990 | American Journal Public Health1990，80，： | 1 |
| 9 | Pluripotency of mesenchymal stem cells derived from adult marrow显示文摘 | Jiang Y Jahagirdar B N Reinhardt R L Schwartz R E Keene C D Ortiz Gonzalez X R | 2002 | Nature2002，418，： | 1 |
| 10 | HPLC separation of Cis-trans carotene Isomers in fresh and processed fruits and vegetables显示文摘 | L A Chandler S J Schwartz | 1987 | J Food Science1987，52，3： | 1 |
| 11 | Taxotere-induced inhibition of human endothelial cell migration is a result of heat shock protein 90 degradation 显示文摘 | Murtagh J Lu H Schwartz E L | 2006 | Cancer Res2006，66，16： | 1 |
| 12 | The vesical calculi 显示文摘 | Bradley F Schwartz Marshall L Stoller | 2000 | Urol Clin North Am2000，2，3： | 1 |
| 13 | Comma hairs: a dermatoscopic marker for tinea capitis: a rapid diagnostic method 显示文摘 | Slowinska M Rudnicka L Schwartz RA | 2008 | J Am Acad Dermatol2008，59，5： | 1 |
| 14 | Ruboxistaurin mesilate hydrate for diabetic retinopathy 显示文摘 | Schwartz S G Flynn H W Aiello L P | 2009 | Drugs Today2009，45，4： | 1 |
| 15 | MR imaging of the breast with rotating delivery of excition off resonance clinical experience with pathologic correlation显示文摘 | Morris E A Schwartz L H Dershaw D D | 1993 | Radiology1993，187，2： | 1 |
| 16 | Phase I trial and pharmaeokinetic study of high-dose elofarabine and busulfan and allogeneic stem cell transplantation in adults with high-risk and refractory acute leukemia 显示文摘 | FARAG S S WOOD L L SCHWARTZ J E | 2011 | Leukemia2011，25，4： | 1 |
| 17 | Detection of macrolide resistance in Mycoplasma pneumoniae by real - time PCR and high - resolution melt analysis 显示文摘 | Wolff B J Thacker W L Schwartz S B | 2008 | Antimicrob AgentsChemother2008，52，10： | 1 |
| 18 | The Jervell and Lange-Nielsen syndrome: natural history, molecular basis, and clinical outcome显示文摘 | Schwartz PJ Spazzolini C Crotti L | 2006 | Circulation2006，113，6： | 1 |
| 19 | A model to predict peach phenology and maturity using meteorolgical variables显示文摘 | Schwartz M D Carbone G J Reighard G L | | 0，，02： | 1 |
| 20 | Urinary TWEAK and the activity of lupus nephritis显示文摘 | Schwartz N Su L Burkly LC | 2006 | J Autoimmun2006，27，4： | 1 |
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