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| 1 | Emerging treatments for complex perianal fistula in Crohn's disease显示文摘Complex perianal fistulas have a negative impact on the quality of life of sufferers and should be treated.Correct diagnosis,characterization and classification of the fistulas are essential to optimize treatment.Nevertheless, in the case of patients whose fistulas are associated with Crohn's disease,complete closure is particularly difficult to achieve.Systemic medical treatments(antibiotics, thiopurines and other immunomodulatory agents,and, more recently,anti-tumor necrosis factor-αagents such as infliximab)have been tried with varying degrees of success.Combined medical(including infliximab)and less aggressive surgical therapy(drainage and seton placement)offer the best outcomes in complex Crohn's fistulas while more aggressive surgical procedures such as fistulotomy or fistulectomy may increase the risk of incontinence.This review will focus on emerging novel treatments for perianal disease in Crohn's patients. These include locally applied infliximab or tacrolimus, fistula plugs,instillation of fibrin glue and the use of adult expanded adipose-derived stem cell injection.More welldesigned controlled studies are required to confirm the effectiveness of these emerging treatments. | Carlos Taxonera David A Schwartz Damián García-Olmo | 2009 | World Journal of Gastroenterology2009，15，34： | 6 |
| 2 | 新生儿心电图判读指南(二)显示文摘 | 魏丽 周同甫 Schwartz PJ Garson A Jr Paul T | 2009 | 中华妇幼临床医学杂志(电子版)2009，5，1： | 4 |
| 3 | Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease显示文摘AIM: To identify pathologic features associated with this 'ulcerative colitis(UC)-like' subgroup of Crohn's disease(CD).METHODS: Seventeen subjects diagnosed as having UC who underwent proctocolectomy(RPC) from 2003-2007 and subsequently developed CD of the ileal pouch were identified. UC was diagnosed based on preoperative clinical, endoscopic, and pathologic studies. Eighteen patients who underwent RPC for UC within the same time period without subsequently developing CD were randomly selected and used as controls. Pathology reports and histological slides were reviewed for a wide range of gross and microscopic pathological features, as well as extent of disease. The demographics, gross description and histopathology of the resection specimens were reviewed and compared between the two groups. RESULTS: Patients with 'UC-like' CD were on average 13 years younger than those with 'true' UC(P < 0.01). More severe disease in the proximal involved region and active ileitis with/without architectural distortion were observed in 6 of 17(35%) and 7 of 17(41%) 'UC-like' CD cases, respectively, but in none of the 'true' UC cases(P < 0.05). Active appendicitis occurred in 8 of 16(50%) 'UC-like' CD cases but in only two(11%) 'true' UC cases(P < 0.05). Conspicuous lamina propria neutrophils were more specific for 'UClike' CD(76% vs 22%, P < 0.05). In addition, prominent lymphoid aggregates tended to be more common in 'UC-like' CD(P = 0.07). The 'true' UC group contained a greater number of cases with severe activity(78% vs 47%). Therefore, the features more commonly seen in 'UC-like' CD were not due to a more severe disease process. Crohn's granulomas and transmural inflammation in non-ulcerated areas were absent in both groups.CONCLUSION: More severe disease in the proximal involved region, terminal ileum involvement, active appendicitis, and prominent lamina propria neutrophils may be morphological factors associated with 'UC-like' CD. | Samuel D James Paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 4 | 星形胶质细胞通过分泌IL-23促进黑色素瘤脑转移显示文摘黑色素瘤是最主要皮肤致死性恶性肿瘤,黑色素瘤患者死亡的主要原因是远处转移,常为脑转移。微环境在肿瘤的发生和转移中起着关键的作用,为了治疗或预防转移,必须阐明播散的肿瘤细胞与转移性器官微环境之间的相互作用。然而,大脑间质细胞在促进转移性生长中的作用却知之甚少。星形胶质细胞的主要功能是大脑损伤后修复和形成胶质瘢痕,部分因为通过介导神经炎症,但是星形胶质细胞在黑色素瘤脑转移中的作用却不清楚。 | Klein A Schwartz H Sagi-Assif O 陈达阳 王行富 | 2015 | 临床与实验病理学杂志2015，31，11： | 4 |
| 5 | 子宫颈癌累及泌尿生殖道:潜在的诊断困境显示文摘Schwartz L E, Khani F, Bishop J A, et al. Carcinoma of the u- terine cervix involving the genitourinary tract: a potential diag- nostic dilemma. Am J Surg Pathol, 2016,40(1) :27 -35.有关子宫颈癌继发累及泌尿生殖道的记载非常少见。由于形态学上这些肿瘤可以类似于尿路上皮癌,也可以与膀胱的原发性鳞状细胞癌和原发性腺癌非常相似,故诊断具有极大的挑战性。作者收集了约翰霍普金斯医院从1984年至今的泌尿生殖器咨询案例,主要包括原发性膀胱癌与子宫颈癌继发性累及膀胱的鉴别诊断病例。作者确定了10例满足这些标准的病例。 | Schwartz L E Khani F Bishop J A 魏建国 许春伟 | 2016 | 临床与实验病理学杂志2016，32，2： | 3 |
| 6 | Cyclodextrin-enhanced degradation of toluene and p-toluic acid by pseudomonas putida显示文摘 | Schwartz A Bar R | 1995 | Applied Microbiology and Biotechnology1995，61，7： | 2 |
| 7 | 新生儿心电图判读指南(一)显示文摘 | Schwartz PJ Garson A Jr Paul T 魏丽 周同甫 | 2008 | 中华妇幼临床医学杂志(电子版)2008，4，6： | 2 |
| 8 | Patients with chronic obstructive pulmonary disease are at increased risk of death associated with urban particle air pollution: a case-crossover analysis 显示文摘 | Sunyer J Schwartz J Tobias A | 2000 | Am J Epidemiol2000，151，： | 2 |
| 9 | Correlation of expression of BP1,a homeobox gene,with estrogen receptor status in breast cancer 显示文摘 | Fu SW Schwartz A Stevenson H | 2003 | Breast Cancer Res2003，5，4： | 1 |
| 10 | Intrathecal fluorescein in endoscopic skull base surgery 显示文摘 | Tabaee A Placantonakis DG Schwartz TH | 2007 | Otolaryngol Head Neck Surg2007，137，2： | 1 |
| 11 | Genetic variants of platelet glycoprotein receptors and risk of stroke in young women 显示文摘 | Reiner A P Kumar P M Schwartz S M | 2000 | Stroke2000，31，7： | 1 |
| 12 | 13C andl5N natural abundance of the soil microbial biomass显示文摘 | Dijkstra P Ishizu A Doucett R Hart S C Schwartz E Menyailo O V Hungate B A | 2006 | Soil Biology & Biochemistry2006，38，： | 1 |
| 13 | HPLC separation of Cis-trans carotene Isomers in fresh and processed fruits and vegetables显示文摘 | L A Chandler S J Schwartz | 1987 | J Food Science1987，52，3： | 1 |
| 14 | MR imaging of the breast with rotating delivery of excition off resonance clinical experience with pathologic correlation显示文摘 | Morris E A Schwartz L H Dershaw D D | 1993 | Radiology1993，187，2： | 1 |
| 15 | Left cardiac sympathetic denervation in the therapy of congenital long QT syndrome:A worldwide report显示文摘 | SCHWARTZ P J LOCATI E H MOSS A J | 1991 | Circulation1991，84，2： | 1 |
| 16 | Cognitive representationsof hand posture in ideomotor apraxia 显示文摘 | Buxbaum LJ Sirigu A Schwartz MF | 2003 | Neuropsychologia2003，41，8： | 1 |
| 17 | P- harmacokinetics and pharmacodynamics of vecuronium in the obese surgical patient 显示文摘 | SCHWARTZ A E MATrEO R S ORNSTEIN E | 1992 | Anaesth Analg1992，74，4： | 1 |
| 18 | Alternate estrogen re- ceptors promote invasion of inflammatory breast cancer cells via non- genomic signaling显示文摘 | Ohshiro K Schwartz A M Levine P H | 2012 | PLoS One2012，7，30： | 1 |
| 19 | A coarse grain modet for DNA显示文摘 | Knotts IV T A Rathore N Schwartz 9 C | 2007 | The Journal of chemical physics2007，126，08： | 1 |
| 20 | Extracellular BCL2 proteins are danger - associated molecular patterns that re- duce tissue damage in routine models of ischemia - reperfusion injury显示文摘 | Iwata A Morgan - Stevenson V Schwartz B | 2010 | PLoS One2010，5，2： | 1 |
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