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| 1 | 急性肺血栓栓塞症患者溶栓治疗后的远期预后分析显示文摘目的 分析急性大面积肺血栓栓塞症 (PTE)患者溶栓治疗后的远期预后。方法 对2 60例急性PTE患者进行溶栓治疗并随访 ,分析其临床资料及引起远期临床事件 [死亡、再发深静脉血栓形成、再发PTE、慢性血栓栓塞性肺动脉高压和 (或 )右心衰竭、抗凝治疗出现大出血、依赖家庭氧疗 ]的危险因素。结果 2 60例PTE患者在住院期间死亡 2 2例 (8 5 % ) ,其中 1 5例 (62 8% )死于PTE。随访 2 2 7例患者 ,为期 3 9~ 8 4年 ,死亡 72例 (31 7% ) ,其中有 2 1例患者死于再发PTE。对随访资料完整的 1 65例患者进行远期临床事件的危险因素分析 ,单因素分析显示 ,既往有血栓栓塞病史、抗凝治疗不足 6个月、植入下腔静脉滤器、溶栓后超声心动图仍显示右室功能障碍和 (或 )扩大、溶栓后超声多普勒仍测得肺动脉收缩压 >50mmHg、出院前核素肺通气 /灌注扫描显示肺血管床阻塞 >30 %与远期临床事件的发生相关 ;多变量分析显示 ,溶栓后超声心动图仍显示右室功能障碍和 (或 )扩大、溶栓后超声多普勒仍测得肺动脉收缩压 >50mmHg、出院前核素肺通气 /灌注扫描显示肺血管床阻塞 >30 %是PTE远期预后的独立危险因素。结论 通过高危因素的确立 ,可予患者更积极的治疗 。 | 刘品明 Nicolas Meneveau Franois Schiele Jean-Pierre Bassand | 2002 | 中华内科杂志2002，41，11： | 11 |
| 2 | Predictors of long-term clinical outcome of patients with acute massive pulmonary embolism after thrombolytic therapy显示文摘To assess the in-hospital clinical course and the long-term evolution of acute massive pulmonary embolism after thrombolytic therapy and to identify predictors of adverse clinical outcome Methods A total of 260 patients hospitalized from January 1989 to October 1998 were retrospectively reviewed and followed up for 3 9 to 8 4 years Baseline characteristics and variables pre- and post-thrombolysis were identified Particular attention was paid to the clinical events, including death, recurrent thromboembolism, chronic thromboembolic pulmonary hypertension, and major bleeding attributable to the use of anticoagulants Kaplan-Meier event-free survival curves were generated Univariate analysis by means of the log-rank test was used to test each candidate variable for association with clinical outcome Multivariate analysis with the Cox proportional hazard model was used to determine independent predictors of the long-term outcome Results The in-hospital mortality rate was 8 5%, with 68 2% due to pulmonary embolism itself, and the follow-up mortality rate was 31 7%, with 29 2% due to recurrent embolism Factors associated with an adverse outcome in univariate analysis were: (1) prior thromboembolic diseases; (2) duration of anticoagulant therapy <6 months; (3) inferior vena caval filter placement; (4) acute right ventricular dysfunction/dilation detected echocardiographically after thrombolysis; (5) Doppler recording of pulmonary artery systolic pressure >50 mmHg after thrombolysis; and (6) greater than 30% obstruction of pulmonary vasculature identified by pulmonary ventilation/perfusion scintigraphy before hospital discharge Multivariate analysis identified three independent predictors of poor long-term outcome for patients with acute massive pulmonary embolism after thrombolysis; which were: (1) Doppler recording of pulmonary artery systolic pressure >50 mm Hg, with relative risk of 3 78 and a 95% confidence interval of 2 70 to 4 86; (2) echocardiographic evidence of right ventricular dysfunction/dilatation (relative risk: 2 18; 95% confidence interval: 1 48 to 2 88); and (3) greater than 30% obstruction of pulmonary vasculature documented by lung scan (relative risk: 1 99; 95% confidence interval: 1 25 to 2 70) Conclusion The study showed that Doppler echocardiographic assessments after thrombolytic therapy and ventilation/perfusion scintigraphy prior to hospital discharge are valuable to establishment of new baseline characteristics, which is informative for risk stratification and prognostication of the long-term outcome for patients with acute massive pulmonary | 刘品明 Nicolas Meneveau Francois Schiele Jean Pierre Bassand | 2003 | Chinese Medical Journal2003，，4： | 10 |
| 3 | 经皮冠状动脉介入术中止血活性的早期改变及与纤溶酶原激活剂抑制物-1基因多态性的相关性显示文摘目的探讨经皮冠状动脉介入(PCI)术中冠状动脉内血浆纤溶酶原激活剂抑制物-1(PAI-1)、D-二聚体(D-D)、凝血因子Ⅶ(FⅦa)及可溶性P选择素(CD62P)活性在球囊扩张和支架植入前后的早期改变及其与PAI-1基因多态性的相关性,评估其对急性支架血栓形成的预测价值。方法选择稳定型心绞痛患者20例,按标准方法行冠状动脉造影且证实冠状动脉狭窄均在70%以上。术中冠状动脉内血样采集顺序依次为:球囊扩张前冠状动脉入口处(Ostium)用引导导管,球囊扩张15min以后及支架植入后15min通过血栓吸引器穿过病灶在病变远端采血。结果PAI-1基因多态性在本组中分布为4G/5G型最多(12例,60%),4G/4G型其次(6例,30%),5G/5G型最少(2例,10%)。4G和5G等位基因频率分别为60%和40%。具有PAI-14G/5G基因型患者冠状动脉内血浆PAI-1、D-D以及FⅦ活性在球囊扩张后较球囊扩张前明显升高且有统计学意义(P均为0.01),然而这些指标在球囊扩张前与支架植入后比较无显著性差异。结论球囊扩张较支架植入更易损伤血管内皮并导致冠状动脉内局部、早期止血活性的一过性增高,具有PAI-14G/5G基因型患者对这种反应较为敏感。PCI术前双联抗血小板药物可以有效抑制血小板活性。 | 艾力曼.马合木提 Nicolas Meneveau Francois Schiele Jean-Pierre Bassand | 2007 | 介入放射学杂志2007，16，9： | 4 |
| 4 | Value of intravascular ultrasound imaging in following up patients with replacement of the ascending aorta for acute type A aortic dissection显示文摘背景 intravascular 的价值在有为大动脉的解剖(广告)是的尖锐类型 A 的上升主动脉的代替的病人的超声( IVUS )成像这研究的 unknown.The 目的是从2002年9月在这 setting.Methods 估计 IVUS 成像的潜在的使用到2005年7月,有 9 MHz 探查的 IVUS 成像与学习为尖锐类型与上升主动脉的代替在他们中的 5 个上集中了的怀疑或建立的 AD.This 在一系列 16 个连续病人被执行 AD. | HU Wei Francois Schiele Nicolas Meneveau Marie-France Seronde Pierre Legalery Fiona Caulfield Jean-Frangois Bonneville Sidney Chocron Jean-Pierre Bassand | 2008 | Chinese Medical Journal2008，，21： | 3 |
| 5 | Safety of FFR-based treatment strategies: the Munich experience显示文摘 | Rieber J Jung P Schiele T M | 2002 | Z Kardiol2002，91，3： | 2 |
| 6 | Fractional flow reserve predicts major adverse cardiac events after coronary stent implantation显示文摘 | Rieber J Schiele T M Erdin P | 2002 | Z Kardiol2002，91，3： | 2 |
| 7 | Semantic Modeling of Natural Scenes for Content-Based Image Retrieval显示文摘 | Julia Vogel Bernt Schiele | 2007 | International Journal of Computer Vision2007，，2： | 2 |
| 8 | 药物涂层支架与金属裸支架对稳定型心绞痛患者局部冠状动脉循环组织因子水平早期影响的比较显示文摘目的比较药物涂层支架(DES)与金属裸支架(BMS)置入前后冠状动脉循环内局部血浆组织因子(TF)水平的变化,探讨DES对血浆TF水平的早期改变及其对急性支架内血栓(AST)形成的意义。方法入选稳定型心绞痛患者26例,按标准方法行冠状动脉造影证实有冠状动脉狭窄均在70%以上。其中15例置入DES(DES组),11例置入BMS(BMS组)。全部患者术前给予阿司匹林、氯吡格雷口服,支架置入前静脉给予低分子质量肝素。PCI术中冠状动脉内血样采集顺序依次为:支架置入前后冠状动脉入口处(ostium)用引导导管,支架置入后15 min通过血栓吸引器穿过病灶在病灶下方(beyond the lesion)采血。血浆TF水平检测采用酶联免疫双抗体夹心法(ELISA)。结果PCI术前26例患者在冠状动脉入口处与病灶下方冠状动脉循环内的TF基线水平比较差异无统计学意义(31.50±7.05 ng/L比31.40±7.30 ng/L,P=0.748),但高于正常参考值3倍;支架置入后15min在冠状动脉入口处(29.60±6.96 ng/L比31.50±7.05 ng/L,P=0.135)与病灶下方(30.70±7.70 ng/L比31.40±6.30 ng/L,P=0.230)冠状动脉循环内的TF水平与术前比较,差异亦无统计学意义。术后15min,DES组和BMS组冠状动脉入口处(31.20±4.37 ng/L比30.70±5.39 ng/L,P=0.674)及病灶下方(31.60±5.39 ng/L比29.00±7.96 ng/L,P=0.789)TF水平差异均无统计学意义。结论稳定型心绞痛患者冠状动脉循环血内存在大量的TF。DES和BMS两种支架均不引起冠状动脉内局部、早期血浆TF水平的改变。 | 艾力曼·马合木提 Nicolas Meneveau 刘品明 Francois Schiele Jean-Pierre Bassand | 2008 | 中国介入心脏病学杂志2008，16，3： | 2 |
| 9 | Arboreal nesting an anti-predator adaptation by Savanna chimpanzees (Pan troglodyres verus ) in Souutheastern Senegal显示文摘 | Pruetz JD Schiel M Waller M | 2008 | Am J Primatol2008，70，： | 1 |
| 10 | Diabetes knowledge and risk of severe hypoglycaemiaone and four years after participation in a 5-day structured treatmentand teaching programme for intensified insulin therapy显示文摘 | Schiel R | 1998 | Quality ofdiabetes care1998，24，6： | 1 |
| 11 | Supplier innova- tiveness and supplier pricing: the role of preferred cus- tomer status 显示文摘 | Schiele H Veldman J Htittinger L | 2011 | International Journal of Innovation Management2011，15，1： | 1 |
| 12 | Surface-enhanced Raman scattering based approach for quantitative determination of creatinine in human serum显示文摘 | STOSCH R HENRION A SCHIEL D | | 0，，22： | 1 |
| 13 | Pedestrian detection: an evaluation of the state of the art 显示文摘 | DOLLAR P WOJEK C SCHIELE B | 2012 | Institute of Electrical and Electronics Engineer Transactions on Information Forensics and Se- curity2012，34，4： | 1 |
| 14 | Pedestrian detection: an evaluation of the state of the art显示文摘 | Dollar P Wojek C Schiele B | 2012 | IEEE Transactions on Pat- tern Analvsis and Machine Intelligence2012，34，4： | 1 |
| 15 | Pedestrian detection:an evaluation of the state of the art显示文摘 | DOLLR P WOJEK C SCHIELE B | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，4： | 1 |
| 16 | A specific antidote for dabigatran: functional and structural characterization 显示文摘 | Schiele F van Ryn J Canada K | 2013 | Blood2013，121，18： | 1 |
| 17 | Activated platelets release two types of membrane vesicles:microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alphagranules显示文摘 | Heijacn HF Schiel AE Fijnheer R | 1999 | Blood1999，94，11： | 1 |
| 18 | When do industries cluster? a proposal on how to assess an industry' s propensity to concentrate at a single region or nation显示文摘 | Steinle C Schiele H | 2002 | Research Policy2002，，31： | 1 |
| 19 | Introducing a weighted non-negative matrix factorization for image classification 显示文摘 | GUILLAMET D VITRIA J SCHIELE B | 2003 | Pattern Recognition Letters2003，24，14： | 1 |
| 20 | Comparison of clinical benef its of clopidogrel therapy in patients with a- cute coronary syndromes taking at orvas tatin versus oth- ers tatin therapies显示文摘 | Weinbergen H Gitt AK Schiele R | 2010 | Am J Cardiol2010，92，3： | 1 |
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