|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antihyperglycemic and antioxidant effects of Solanum xanthocarpum leaves(field grown & in vitro raised) extracts on alloxan induced diabetic rats显示文摘Objective:To investigate antidiabetic efficacy of the extract of field grown and in vitro raised leaves of Solanum xanthocarpum(S.xanthocarpum) against alloxan induced diabetic rats. Methods:The antidiabetic activity of the crude methanol extracts of the field grown and in vitro raised leaves of S.xanthocarpum at different concentrations(100-200 mg/kg bw) was tested against alloxan induced diabetic rats.The antidiabetic efficacy was validated through various biochemical parameters and the antioxidant effect was also determined.The phytochemical analyses of field grown S.xanthocarpum and in vitro rasied 5.xanthocarpum leaves were done by estimating their chlorophyll,carotenoids,total sugar,protein,amino acid and minerals contents. Results:The results revealed that the methanol extracts of both the leaves(field grown and in vitro raised) of S.xanthocarpum was efficient anti hyperglycemic agents at a concentration of 200 mg/kg bw and posses potent antioxidant activity.However,the extracts of in vitro rasied S.xanthocarpum raised leaves exhibit higher efficacy than the field grown leaves in all tested concentrations.Proximal composition and mineral analysis of S.xanthocarpum revealed higher concentration of contents in in vitro rasied S.xanthocarpum than field grown S.xanthocarpum. Conclusions:From the results it can be concluded that the leaves extracts of S.xanthocarpum can be a potential candidate in treating the hyperglycemic conditions and suits to be an agent to reduce oxidative stress. | K Poongothai P Ponmurugan K Syed Zameer Ahmed B Senthil Kumar SA Sheriff | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 9 |
| 2 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Cyclophotocoagulation: a report by the American Academy of Ophthalmology 显示文摘 | Paster SA Singh K Lee Da | 2001 | Ophthalmologica2001，108，11： | 2 |
| 5 | Comparison of three commercially available peptide-based immunoglobulin G (IgG) and IgA assays to microimmunofluorescence assay for detection of Chlamydia trachomatis antibodies显示文摘 | Munk C Persson K | 2002 | J Clin Microbiol2002，40，2： | 1 |
| 6 | Value of the new hone classification system in pediatric renal osteodystrophy显示文摘 | Bakkaloglu SA Wesseling Perry K Pereira RC | 2010 | Clin J Am Soc Nephrol2010，5，10： | 1 |
| 7 | Biomechanical comparison of posterior pelvic ring fixation显示文摘 | Yinger K Scalse J Olson SA | 2003 | Orthop Trauma2003，17，7： | 1 |
| 8 | A rapid real-time quantitative polymerase chain reaction for hepatitis B virus显示文摘 | Brechtbuehl K Whalley SA Dusheiko GM | 2001 | J Virol Methods2001，93，： | 1 |
| 9 | Amplification of an invA gene sequence of Salmonella typhimurium by polymerase chain reaction as a specific method of detection of Salmonella显示文摘 | Rahn K De Grandis SA Clarke RC McEwen SA Galan JE Ginocchio C | 1992 | Mol Cell Probes1992，6，4： | 1 |
| 10 | Dysfunctional mitochondria contain endogenous high-affinity human Toll like receptor 4 (TLR4) ligands and induce TLR4 mediated in flammatory reactions 显示文摘 | Nicholas SA Coughlan K Yasinska I | 2011 | Int J Bioehem Cell Biol2011，43，4： | 1 |
| 11 | MyD88 drives the IFN-β response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7 显示文摘 | Weiss G Maaetoft-Udsen K Stifter SA | 2012 | J Immunol2012，9，6： | 1 |
| 12 | Clinical evaluation of inten- sity-modulated radiotherapy for head and neck cancers 显示文摘 | Bhide SA Newbold KL Harrington K J | 2012 | Br J Radial2012，85，1013： | 1 |
| 13 | Cisplatin-induced apoptotic cell death in Mongolian gerbil cochlea显示文摘 | Alam SA Ikeda K Oshima T | | 0，，： | 1 |
| 14 | Circadian rhythm genetics: from flies to mice to humans显示文摘 | Wager-Smith K Kay SA | 2000 | Nat Genet2000，26，1： | 1 |
| 15 | Comparison of cone beam computed tomography imaging with physical measures 显示文摘 | Stratemann SA Huang JC Maki K | 2008 | Dentomaxillofac Radiol2008，37，： | 1 |
| 16 | Yes-Associated Protein (YAP) is a critical mediator of c-Jun-dependent apoptosis 显示文摘 | Danovi SA Rossi M Gudmundsdottir K | 2008 | Cell Death Differ2008，15，1： | 1 |
| 17 | Efficacy and safety of re- combinant activated factor VII for acute intracerebral hemor- rhage 显示文摘 | Mayer SA Brun NC Begtrup K | 2008 | N Engl J Med2008，358，20： | 1 |
| 18 | Body mass index and body weight perception as risk factors for internalizing and externalizing problem behavior among adolescents 显示文摘 | Ter Bogt TF van Dorsselaer SA Monshouwer K | 2006 | J Adolesc Health2006，39，1： | 1 |
| 19 | Treatment of unstable thoracolumbar burst fractures by indirect reduction and posterior stabilization: short-segment versus long-segment stabilization 显示文摘 | Sapkas G Kateros K Papadakis SA | 2010 | Open Orthop J2010，4，2： | 1 |
| 20 | Loss of asthma following inhaled eortieosteroid withdrawal is associ- ated with increased sputum interleukin-8 and neutrophils 显示文摘 | Maneechotesuwan K Essilfie-Quaye S Kharitonov SA | 2007 | Chest2007，132，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员