|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pathogenesis and clinical management of Helicobacter pylori gastric infection显示文摘Helicobacter pylori(H.pylori)is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide.However,its prevalence varies among different geographic areas,and is influenced by several factors.The infection can be acquired by means of oral-oral or fecal-oral transmission,and the pathogen possesses various mechanisms that improve its capacity of mobility,adherence and manipulation of the gastric microenvironment,making possible the colonization of an organ with a highly acidic lumen.In addition,H.pylori presents a large variety of virulence factors that improve its pathogenicity,of which we highlight cytotoxin associated antigen A,vacuolating cytotoxin,duodenal ulcer promoting gene A protein,outer inflammatory protein and gamma-glutamyl transpeptidase.The host immune system,mainly by means of a Th1-polarized response,also plays a crucial role in the infection course.Although most H.pylori-positive individuals remain asymptomatic,the infection predisposes the development of various clinical conditions as peptic ulcers,gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas.Invasive and non-invasive diagnostic methods,each of them with their related advantages and limitations,have been applied in H.pylori detection.Moreover,bacterial resistance to antimicrobial therapy is a major challenge in the treatment of this infection,and new therapy alternatives are being tested to improve H.pylori eradication.Last but not least,the development of effective vaccines against H.pylori infection have been the aim of several research studies. | Breno Bittencourt de Brito Filipe Ant?nio Fran?a da Silva Aline Silva Soares Vinícius Afonso Pereira Maria Luísa Cordeiro Santos Mariana Miranda Sampaio Pedro Henrique Moreira Neves Fabrício Freire de Melo | 2019 | World Journal of Gastroenterology2019，25，37： | 84 |
| 2 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 3 | Role of a probiotic (Saccharomyces boulardii) in management and prevention of diarrhoea显示文摘瞄准:估计酵母属 boulardii 的功效和安全(S。boulardii ) 在在减少腹泻的事件的频率在的尖锐水的腹泻和它的角色随后二个月。方法:从 2 瞬间的孩子到 12 岁,在 S 根据包括标准和随机的 ised 与尖锐腹泻被选择。boulardii 组(与 ORS,营养的支持和 S 一起对待。boulardii, 250 mg 出价) 并且在控制组(仅仅与 ORS 和营养的支持一起对待) 。直接疗法阶段是 5 d,每个孩子以后被跟随二个月。象药的安全一样的凳子的频率和一致性在每访问上被估计。二个组的比较以痢疾的事件的数字被做在随后二个月。结果:在每个组有五十个病人。象吝啬的年龄和凳子的平均频率那样的基线特征在 S 是可比较的。boulardii 和控制在试用在包括的时候组织。由 d 3 它分别地并且由 d 每 d 归结为 2.7 和 4.2 张凳子 6 它归结为 1.6 (S。boulardii 组) 并且 3.3 (控制组) 。腹泻的持续时间是在 S 的 3.6 d。而它是在控制组的 4.8 d, boulardii 组织(P = 0.001 ) 。在下列二个月内, S。有的 boulardii 组一显著地, 0.54 个事件的低频率作为与在控制的 1.08 个事件相比组织。这药很好被接受并且容忍。在治疗时期期间没有副作用的报告。结论:S。boulardii 显著地减少尖锐腹泻的频率和持续时间。凳子的一致性也改善。这药是容忍得好的。 | AG Billoo MA Memon SA Khaskheli G Murtaza Khalid Iqbal M Saeed Shekhani Ahson Q Siddiqi | 2006 | World Journal of Gastroenterology2006，12，28： | 22 |
| 4 | Compensation trends of the angulation of first molars:retrospective study of 1403 malocclusion cases显示文摘We investigated the compensatory trends of mesiodistal angulation of first molars in malocclusion cases. We compared differences in the angulation of first molars in different developmental stages, malocclusion classifications and skeletal patterns. The medical records and lateral cephalogrammes of 1 403 malocclusion cases taken before treatment were measured to evaluate compensation of molar angulation in relation to the skeletal jaw. The cases were stratified by age, Angle classification and skeletal patterns. Differences in the mesiodistal angulation of the first molars were compared among the stratifications. We observed three main phenomena. First,angulation of the upper first molar varied significantly with age and tipped most distally in cases aged,12 years and least distally in cases aged.16 years. The lower first molar did not show such differences. Second, in Angle Class II or skeletal Class II cases, the upper first molar was the most distally tipped, the lower first molar was the most mesially tipped, and opposite angulation compensation was observed in Class III cases. Third, in high-angle cases, the upper and lower first molars were the most distally tipped, and opposite angulation compensation was observed in low-angle cases. These data suggest that the angulation of the molars compensated for various growth patterns and malocclusion types. Hence, awareness of molar angulation compensation would help to adjust occlusal relationships, control anchorage and increase the chances of long-term stability. | Hong Su Bing Han Sa Li Bin Na Wen Ma Tian-Min Xu | 2014 | International Journal of Oral Science2014，6，3： | 22 |
| 5 | 基因工程FGF19类似物aldafermin治疗非酒精性脂肪性肝炎的效果和安全性显示文摘aldafermin是一种成纤维细胞生长因子19的工程类似物,可抑制胆汁酸的合成并调节代谢稳态。该研究报告了一项对非酒精性脂肪性肝炎(NASH)患者进行的一系列肝脏活检的为期24周的2期临床试验结果。 | HARRISON SA NEFF G GUY CD 张瑞华 温晓玉 | 2021 | 临床肝胆病杂志2021，37，3： | 22 |
| 6 | Expression of B7 costimulation molecules by colorectal cancer cells reduces tumorigenicity and induces anti-tumor immunity显示文摘METHODSB7genewastransfectedintomousecoloncancercellineCMT93.ThetransfectantswereselectedinDMEMcontaining800mg/LG418,andB7mole... | HU Jin Yue, WANG Sa, ZHU Jian Gao, ZHOU Guo Hua and SUN Qu Bing | 1999 | World Journal of Gastroenterology1999，5，2： | 20 |
| 7 | 献血前水的摄入可减弱献血不良反应显示文摘最近的数据表明,初次献血者的维持正在变得困难,只有不到一半的初次献血者会再次献血.事实上众多初次献血者不参加再次献血可能有多种原因,其中献血晕厥及相关不良反应是重要诱因.最近的一项前瞻性研究表明即使有轻度献血不良反应(晕厥、头昏、无力),第二年重复献血也会下降50%. | Hauson SA France CR 杨晓芬 赵凤绵 武江 | 2005 | 国外医学(输血及血液学分册)2005，28，1： | 20 |
| 8 | Transplantation of human bone marrow-derived mesenchymal stem cells transfected with ectodysplasin for regeneration of sweat glands显示文摘有严重完整厚度的灼伤损害的背景病人受不了他们的无能因为完全的 destructed 汗腺不能被改革,通过排汗维持身体温度。因为他们的容易的纯化和 multipotency,骨头导出髓的间充质的干细胞(BM-MSCs ) 为房间治疗代表理想的干细胞来源。在这研究,我们试图导致人的 BM-MSCs 通过 ectodysplasin (EDA ) 为汗腺新生区分进汗腺房间基因 transfection。EDA 和 EDA 受体(EDAR ) 的动态表示第一在胚胎学的开发期间在汗腺形成被观察的方法。在有 EDA 表示向量的 transfection 以后,人的 BM-MSCs 被移植进灼伤动物模型的受伤区域。汗腺的新生被排汗测试和 immunohistochemical 分析识别。结果 EDA 和 EDAR 的内长的表示在人的胎儿的皮肤与汗腺开发相关。在 EDA transfection 以后, BM-MSC 获得了 sweat-gland-cell 显型,由流动 cytometry 分析由他们汗腺标记的表示证实了。染色的 Immunohistochemical 揭示了一显著地到在烫伤的爪的汗腺的新生的 EDA-transfected BM-MSCs 的贡献。为为与 EDA-transfected BM-MSCs 对待的爪的排汗测试的积极的率比与 BM-MSCs 或 EDA 表示向量(P 0.05 ) 对待的那些显著地高。我们的结果在汗腺的发展证实了 EDA 的重要角色的结论。有 EDA 的 BM-MSCs transfected 显著地改进了汗腺新生。这研究为受伤皮肤和它的附器的修理和新生建议修改 EDA 的 MSC 的潜在的申请。 | CAI Sa PAN Yu HAN Bing SUN Tong-zhu SHENG Zhi-yong FU Xiao-bing | 2011 | Chinese Medical Journal2011，，15： | 18 |
| 9 | Treatment of urethral strictures using lingual mucosas urethroplasty: experience of 92 cases显示文摘复杂尿道的苛评的背景 Urethroplasty 是一个困难的过程,并且没有在出版文学描述的广泛地接受的标准途径。我们为在 2006 年 8 月和 2009 年 4 月之间的尿道的 strictures.Methods 的修理用语言的 mucosa 接枝(LMG ) 评估了 urethroplasty 的功效和安全,尿道的苛评的 92 个盒子(长度从 2.5 厘米到 18 厘米,平均数 6.5 厘米) 用 LMG 被对待。92 个病人, 38 与长片断的尿道的苛评(9-18 厘米) 经历了与包皮拍动相结合的双 LMG 或 LMG 或口腔的 mucosal 接枝 urethroplasty.Results 后续手术后地被获得 3-33 月(平均数 17.2 月) 。复杂并发症发生在 8 个病人,包括在 4 个病人的尿管;周期性的苛评 post-operatively 在 3-4 月在 4 个病人发展了。留下的病人 voided 井手术后地,与在 14.3 ml/s 和 54.6 ml/s (平均数 28.4 ml/s ) 之间的山峰流动 .Conclusions 舌头是为前面的 mucosal 苛评的修理的接枝材料的优秀来源。双 LMG 替换 urethroplasty 能成功地对待更长的、更复杂的尿道的苛评。 | XU Yue-min FU Qiang SA Ying-long ZHANG Jiong JIN Chong-rui SI Jie-min SONG Lu-jie | 2010 | Chinese Medical Journal2010，，4： | 13 |
| 10 | Major regulatory mechanisms involved in sperm motility显示文摘涉及鞭子部件以及在 flagellar 运动的规定的汇编和函数的基因库和分子的机制充分没被理解,特别在人。为精子无法移动,一些能被避免并且改正有几个原因,而其它与基因缺点有关并且值得完整的调查把诊断给病人。这评论在科学的联机数据库 PubMed, ScienceDirect,和网上在广泛的文学搜索以后被执行。这里,我们考察为精子活动性负责的规章的小径的参与,显示为精子无法移动的可能的原因。这些包括了钙小径,营地依赖者蛋白质 kinase 小径, kinases 和磷酸酶的重要性,反应的氧种类的功能,并且房间体积和 osmolarity 的规定怎么也是基本部件。我们然后讨论与特定的词法畸形联系的主要基因缺点。最后,我们稍微讨论某预防措施和治疗途径避免与未特别指出的精子无法移动被联系的条件的开发。我们在不久的将来相信那,与更强大的技术,精子无法移动的基因原因和活动性将是的精子的规章的机制的发展更好理解,因此启用执行完整的诊断并且揭开新治疗。 | Rute Pereira Rosalia Sa Alberto Barros Mario Sousa | 2017 | Asian Journal of Andrology2017，19，1： | 12 |
| 11 | Effect of Alkali Stress on Soluble Sugar, Antioxidant Enzymes and Yield of Oat显示文摘Alkali stress can cause severe crop damage and reduce production. However, physiological processes involved in alkali stress in oat seedlings are not well understood. In this study, physiological responses and yield of oat to alkali stress were studied using the alkali-tolerant oat genotype Vao-9 and the alkali-sensitive oat genotype Baiyan 5. The results were: (i) low concentrations of alkali stress (25 and 50 mmol L-1) significantly reduced the yield and grain weight while increased the oat grain number per spike. A negative correlation between yield and malondialdehyde (MDA) content at the jointing and grain filling stages and positive correlations between yield on one hand and superoxide dismutase (SOD), and peroxidase (POD) activities on the other at the jointing stage were observed. There was a positive correlation between MDA and soluble sugar at the grain filling stage; (ii) soluble sugar content was increased at the jointing and grain filling stages and decreased at the heading stage by alkali stress; (iii) alkali stress increased the SOD activity during the heading and grain filling stages, and increased the POD activity at the heading stage. As compared to the control, the increase of MDA contents in alkali-treated oat was observed, during the jointing, heading and grain filling stages; (iv) under alkali stress, the oat genotype Vao-9 showed higher antioxidant enzyme activity and lower soluble sugar contents during the heading stage, and lower MDA contents than those in the oat genotype Baiyan 5 under alkali stress. The result suggested that the high ROS scavenging capacity and soluble sugar levels might play roles in oat response to alkali stress. | BAI Jian-hui LIU Jing-hui ZHANG Na YANG Jun-heng SA Ru-la WU Lan | 2013 | Journal of Integrative Agriculture2013，12，8： | 12 |
| 12 | 慢性术后或创伤后疼痛显示文摘组织创伤后的慢性疼痛较为常见,并可能对病人的生理功能和生活质量产生持久的影响。但目前对慢性术后或创伤后疼痛(Chronic postsurgical or post traumatic pain,CPSP或CPTP)的认识尚不足,因而相关治疗也较为欠缺,并且世界卫生组织(WHO)之前的国际疾病分类ICD-10版本也没有收录此类诊断。本文介绍了ICD-11中关于慢性术后或创伤后疼痛的新分类。慢性术后或创伤后疼痛是指在组织损伤后发生、发展或加剧,并且在愈合后持续存在(即手术或组织创伤后持续至少3个月)的疼痛。新分类区分了在外科手术的可控过程中所产生的组织创伤和意外创伤或伤害形式,包含了最常见的疼痛类型。新分类为在初始组织创伤恢复后仍然存在,并且需要特殊治疗和管理的慢性疼痛提供了诊断编码。ICD-11新增的慢性术后或创伤后疼痛的编码将有望促进对这些疼痛状态的识别、诊断和治疗。更为重要的是,这将使慢性术后或创伤后疼痛能够体现在统计数据中,并有助于促进对此类疼痛综合征的研究。 | 冯艺(译) 许军军(译) 林夏清(译) 吴莹(审校) 宋学军(审校) 万有(审校) 樊碧发(审校) 韩济生(审校) Schug SA | 2021 | 中国疼痛医学杂志2021，27，4： | 12 |
| 13 | Density Effects on Plant Height Growth and Inequality in Sunflower Populations显示文摘在竞争和人口表明的非竞争的葵花(向日葵 annuusL ) 之间的比较在植物高度生长, height-to-crownwidth 比率,和一张人口上读了密度的效果“ s 高度不平等。在现在的学习,高度的 non-destructivemeasurements 和葵花植物的投射王冠区域与 1, 4,16,和 64 plants/m2 的起始的密度在平单音的特定的看台从出现在七次被带去水果成熟。人口的吝啬的高度与增加种群密度增加了然后减少;uncrowded 人口的高度不平等在看台生长期间减少了,而拥挤的人口的高度不平等首先减少了然后在看台开发期间增加了。内部在在 uncrowded 人口以内的相对高度生长率和高度之间的单个关系在人口生长期间变得显著地否定,而这些关系首先是否定的然后在拥挤的人口的发展期间变得积极。在 uncrowded 人口,静电干扰内部单个关系 betweenheight-to-crown 宽度比率和体积是积极的,而为拥挤的人口这些关系与为光增加竞争变得否定。数据建议到轻竞争的植物高度和 height-to-crown 宽度比率的塑料回答将与增加竞争变得更强烈紧张。现在的学习的结果为尺寸依赖者的重要性强烈争论个人级的塑料回答由于在在人口高度不平等产生变化的尺寸不对称的轻竞争。 | Sa Xiao Shu-Yan Chen Lu-Qiang Zhao Gang Wang | 2006 | Journal of Integrative Plant Biology2006，48，5： | 11 |
| 14 | 口服消炎痛和布洛芬治疗早产儿动脉导管未闭的比较显示文摘目的静脉注射消炎痛是早产儿动脉导管未闭的常规治疗方法,但治疗过程中常出现一些副作用,如少尿、消化道出血、脑血流灌注减少。近年来,静脉注射布洛芬已用于治疗早产儿动脉导管未闭。布洛芬治疗不会减少脑血流灌注,也不会影响胃肠道和肾脏的血流动力学。伊朗目前尚无消炎痛和布洛芬的静脉制剂供应。该研究旨在比较这两种药的口服制剂治疗早产儿动脉导管未闭的疗效和安全性。方法36例胎龄小于34周经超声心动图确诊患有动脉导管未闭的早产儿被随机分为两组,每组18人。一组给予消炎痛口服,每次0.2mg/kg,24h给药1次,共3次。另一组给予布洛芬口服,共3次,间隔时间为24h,首剂为10mg/kg,随后两次各5mg/kg。用药后观察导管闭合率、副作用、并发症及临床过程。结果用药后布洛芬组18例患儿动脉导管都闭合(100%),而消炎痛组18例中有15例患儿动脉导管闭合(83.3%)(P〉0.05)。两组疗效差异统计学无显著性意义。治疗前后两组的血清尿素氮和肌酐含量差异也无显著性意义。消炎痛组发生了3例(16.6%)坏死性小肠结肠炎,布洛芬组则无,差异有显著性意义(P〈0.05)。治疗1个月后两组成活率均为94%(17/18)。消炎痛组1例死于坏死性小肠结肠炎,布洛芬组1例死于败血症。结论口服布洛芬治疗早产儿动脉导管未闭和口服消炎痛治疗一样有效,而且坏死性小肠结肠炎的发生率较口服消炎痛治疗低。 | Saed Hossein FAKHRAEE Zohreh BADIEE Saied MOJTAHEDZADEH Mohammad KAZEMIAN Roya KELISHADI Shahid Beheshti | 2007 | 中国当代儿科杂志2007，9，5： | 11 |
| 15 | Treatment strategies for mass burn casualties显示文摘因为很多严重受伤的病人在一短时间以内被送,背景集体灼伤伤亡总是是对一个医疗队的大挑战。通常,高死亡正在逼近。从牺牲品的成功的治疗获得的经验可能在在武装 conflict.Methods 指导集体伤亡的照顾是有用的在单个批的 35 个灼伤牺牲品,坐飞机不停地被转移并且从一个远省的高速公路,被承认 48 个小时损害以后。所有病人与吝啬的年龄是男性的(22.4 ? 蟠 ?( | CHAI Jia-ke SHENG Zhi-yong YANG Hong-ming HAO Dai-feng SHEN Chuan-an JIA Xiao-ming LI Feng JING Sa LI Li-gen SONG Hui-feng JIA Chi-yu TUO Xiao-ye SUN Tian-jun HU Quan | 2009 | Chinese Medical Journal2009，，5： | 10 |
| 16 | Changes in plant community diversity and aboveground biomass along with altitude within an alpine meadow on the Three-River source region显示文摘The grassland is an important component of terrestrial ecosystems and plays a significant role in biodiversity and ecosystem functions.In the present study,the changes of plant species diversity and aboveground biomass productivity were examined along with the altitude in natural alpine grassland in the source region of three rivers on the Qinghai-Tibetan Plateau.Eleven experimental locations were selected with altitudes ranging from 3862 to 4450 m above sea level(a.s.l.).The results indicated that Kobresia pygmaea meadow,Kobresia humilis meadow and Salix cupularis shrub meadow had higher indices of diversity and aboveground biomass.The distribution of species diversity,richness and aboveground biomass showed similarly unimodal patterns across the altitude gradient with the highest indices appeared at mid-altitudes locations.The changing trend of species diversity,richness and evenness also showed significant unimodal patterns with total aboveground biomass,and the highest species diversity occurred at intermediate level of productivities.This research would provide a valuable reference for the protection of grassland biodiversity and maintaining of the grazing ecosystem function in the source region of the Three Rivers. | SA WenJun AN LiZhe SA Wei | 2012 | Chinese Science Bulletin2012，57，27： | 10 |
| 17 | Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells显示文摘 | Fu JD Li J Tweedie D Yu HM Chen L Wang R Riordon DR Brugh SA Wang SQ Boheler KR Yang HT | 2006 | 中国生物学文摘2006，20，7： | 9 |
| 18 | 结直肠癌的检出与治疗进展显示文摘近年在结直肠癌的检出与治疗中出现了一些强调联合应用多种检查方法的新技术和新观念,包括内镜超声显像、癌胚抗原与单克隆抗体等。对早期病例可采取更保守的手术,某些病例可加用术后放疗和自身肿瘤疫苗免疫疗法。随访则强调适当的措施与频度,强调早期发现复发和转移,以便采取能治愈的措施。 | Curley SA & Roh MS 卢光增 | 1991 | 国外医学(肿瘤学分册)1991，18，1： | 9 |
| 19 | Neurologic complications after liver transplantation显示文摘Neurologic complications are relatively common after solid organ transplantation and affect 15%-30%of liver transplant recipients.Etiology is often related to immunosuppressant neurotoxicity and opportunistic infections.Most common complications include seizures and encephalopathy,and occurrence of central pontine myelinolysis is relatively specific for liver transplant recipients.Delayed allograft function may precipitate hepatic encephalopathy and neurotoxicity of calcineurin inhibitors typically manifests with tremor,headaches and encephalopathy.Reduction of neurotoxic immunosuppressants or conversion to an alternative medication usually result in clinical improvement.Standard preventive and diagnostic protocols have helped to reduce the prevalence of opportunistic central nervous system(CNS)infections,but viral and fungal CNS infections still affect 1%of liver transplant recipients,and the morbidity and mortality in the affected patients remain fairly high.Critical illness myopathy may also affect up to 7%of liver transplant recipients.Liver insufficiency is also associated with various neurologic disorders which may improve or resolve after successful liver transplantation.Accurate diagnosis and timely intervention are essential to improve outcomes,while advances in clinical management and extended post-transplant survival are increasingly shifting the focus to chronic post-transplant complications which are often encountered in a community hospital and an outpatient setting. | Saa A Zivkovi | 2013 | World Journal of Hepatology2013，5，8： | 9 |
| 20 | Antihyperglycemic and antioxidant effects of Solanum xanthocarpum leaves(field grown & in vitro raised) extracts on alloxan induced diabetic rats显示文摘Objective:To investigate antidiabetic efficacy of the extract of field grown and in vitro raised leaves of Solanum xanthocarpum(S.xanthocarpum) against alloxan induced diabetic rats. Methods:The antidiabetic activity of the crude methanol extracts of the field grown and in vitro raised leaves of S.xanthocarpum at different concentrations(100-200 mg/kg bw) was tested against alloxan induced diabetic rats.The antidiabetic efficacy was validated through various biochemical parameters and the antioxidant effect was also determined.The phytochemical analyses of field grown S.xanthocarpum and in vitro rasied 5.xanthocarpum leaves were done by estimating their chlorophyll,carotenoids,total sugar,protein,amino acid and minerals contents. Results:The results revealed that the methanol extracts of both the leaves(field grown and in vitro raised) of S.xanthocarpum was efficient anti hyperglycemic agents at a concentration of 200 mg/kg bw and posses potent antioxidant activity.However,the extracts of in vitro rasied S.xanthocarpum raised leaves exhibit higher efficacy than the field grown leaves in all tested concentrations.Proximal composition and mineral analysis of S.xanthocarpum revealed higher concentration of contents in in vitro rasied S.xanthocarpum than field grown S.xanthocarpum. Conclusions:From the results it can be concluded that the leaves extracts of S.xanthocarpum can be a potential candidate in treating the hyperglycemic conditions and suits to be an agent to reduce oxidative stress. | K Poongothai P Ponmurugan K Syed Zameer Ahmed B Senthil Kumar SA Sheriff | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 9 |
您所在的机构暂未开通此部分的功能，请联系管理员