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| 1 | 非运动症状负担、情绪和步态障碍是导致帕金森病非痴呆患者生活质量下降的最重要因素显示文摘帕金森病存在多种运动和非运动症状表现,其中非运动症状对于帕金森病患者生活质量的影响更为严重。改善帕金森病非运动症状,有助于提高患者的生活质量。既往帕金森病非运动症状研究多为单中心小样本研究,所涉及的非运动症状类型较为局限,无法全面反映非运动症状对帕金森病患者生活质量的影响。为此,该研究通过分析COPPADIS-2015研究队列来关注帕金森病患者非运动症状对其生活质量的影响。该队列是西班牙全国范围内为期5年的多中心综合观察性随访队列研究。 | 张煜(编译) Santos Garcia D de Deus Fonticoba T Suarez Castro E | 2020 | 中华医学杂志2020，100，27： | 3 |
| 2 | The application of gas chromatography to environmental analysis显示文摘 | Santos F J Galceran M T | 2002 | Trends in analytical chemistry2002，21，： | 2 |
| 3 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 4 | Lipoprotein lipase gene polymorphism in non-insulin-dependent diabetics: preliminary study显示文摘 | PEREZ F LAFAYETTE T SANTOS J L | 1997 | Rev Med Chil1997，125，11： | 2 |
| 5 | Comparative study of propylene polymerization using Me2Si(Rind)2ZrCl2/SiO2-SMAO/AlR3 and Me2Si(RInd)2ZrCl2/MAO(R=Me, H)显示文摘 | Franceschini F C da R Tavares T T dos Santos J H Z | 2007 | Polymer2007，48，7： | 1 |
| 6 | Geog raphic differences in the allele frequencies of the human Y-linked tetranucleotide polymorphism DYS19 显示文摘 | Grelsaikhan T Munkhtuja B | 1996 | Hum Genet1996，97，3： | 1 |
| 7 | Vertebrate predation on Holm Oak,Quercus ilex,acorns in a fragmented habitat:effect on seedling recruitment显示文摘 | Santos T and Telleria J L | 1997 | Forest Ecology and Management1997，98，： | 1 |
| 8 | Liquid chromatography multi-stage mass spectrometry for the analysis of 5-hydroxymethylfurfural in foods显示文摘 | ERIKA T MOYANO E SANTOS F J | 2008 | Journal of Chromatography A2008，1185，2： | 1 |
| 9 | Shape optimization of three- dimensional shell structures with the shape parameterization of a CAD system 显示文摘 | Linby T Santos J L T | 1999 | Structural Optimization1999，18，： | 1 |
| 10 | A liquid crystal microlens obtained with a non-uniform electric field显示文摘 | NOSE T SANTO S | 1989 | Liquid Crystals1989，5，5： | 1 |
| 11 | Infusing Social Networks With Culture显示文摘 | SANTOS E E PAN L WILKINSON J T | 2014 | Ieee T Syst Man Cy-S2014，44，1： | 1 |
| 12 | The effect of a minor constituent of essential oil from Cit- rus aurantium: the role of β-myrcene in preventing peptic ulcer disease 显示文摘 | Bonamin F Moraes T M Dos Santos R C | 2014 | Chem Biol Interact2014，5，212： | 1 |
| 13 | Rapid control of foot - and - mouth disease outbreaks:is RNAi a possible solution 显示文摘 | Grubman M J de Los Santos T | 2005 | Trends in Immunology2005，26，2： | 1 |
| 14 | Response of antioxidant enzymes in freshwater fish populations (Leuciscus alburnides complex)to inorginanic pollu- tants exposure显示文摘 | Lopes P A Pinheiro T Santos M C | 2001 | Sci Total Environ2001，280，13： | 1 |
| 15 | Bird conservation in fragmented Mediterranean forests of Spain: effects of geographical location, habitat and landscape degradation 显示文摘 | Santos T Telleria J L Carbonell R | 2002 | Biological Conserv- ation2002，105，： | 1 |
| 16 | Determination of chlorophenols by solid-phase micro- extraction and liquid chromatography with electro chemical detection显示文摘 | SARRION M N SANTOS F J GALCERAN M T | 2002 | Journal of Chromatography A2002，947，15： | 1 |
| 17 | On quasi-orthodox semigroups with inverse transversals显示文摘 | BLYTH T S ALMEIDA SANTOS M H | 1997 | Proc Edinburgh Math Soc1997，40，3： | 1 |
| 18 | Expression of alpha-hemoglobin stabilizing protein gene during human erythropoiesis显示文摘 | DOS SANTOS C O DUARTE A S SAAD S T | 2004 | Exp Hematol2004，32，2： | 1 |
| 19 | Firing distance estimation through the analysis of the gunshot residue deposit pattern around the bullet entrance hole by inductively coupled plasma-mass spectrometry:an experimental study显示文摘 | Santos A Magalh?es T Vieira DN | | 0，，01： | 1 |
| 20 | Influence of knee position on the postural stability index regis- tered by the Biodex Stability System 显示文摘 | PEREIRA H M DE CAMPOS T F SANTOS M B | 2008 | Gait Posture2008，28，4： | 1 |
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