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| 1 | GLOBAL STABILITY AND HOPF BIFURCATION OF AN SIS EPIDEMIC MODEL WITH TIME DELAYS显示文摘An SIS epidemic model with a discrete delay has been investigated in this article. By means of Liapunov functional, some sufficient conditions of global stability to endemic equilibrium and disease free equilibrium have been obtained. The influence of time delay on the stability of equilibria is displayed. The switch of stability and the Hopf bifurcation from the endemic equilibrium have been discussed. | YUAN Sanling MA Zhien (Department of Applied Mathematics, Xi’an Jiaotong University, Xi’an 710049, China) | 2001 | Journal of Systems Science & Complexity2001，14，3： | 7 |
| 2 | STUDY ON AN SIS EPIDEMIC MODEL WITH TIME VARIANT DELAY显示文摘In this paper,we study an SIS epidemic model with a time variant delay.By means of Liapunov functional,some sufficient conditions of global stability to endemic equilibrium and disease free equilibrium have been obtained.The influence of time delay on the stability of equilibria is displayed. | YUAN Sanling MA Zhien (Department of Applied Mathematics, Xi ’an Jiaotong University, Xi ’an 710049, China] | 2002 | Journal of Systems Science & Complexity2002，15，3： | 4 |
| 3 | Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca^(2+) ions and L-tryptophan显示文摘The human calcium-sensing receptor(CaSR)is a class C G protein-coupled receptor(GPCR)responsible for maintaining Ca^(2+)homeostasis in the blood.The general consensus is that extracellular Ca^(2+)is the principal agonist of CaSR.Aliphatic and aromatic L-amino acids,such as L-Phe and L-Trp,increase the sensitivity of CaSR towards Ca^(2+)and are considered allosteric activators.Crystal structures of the extracellular domain(ECD)of CaSR dimer have demonstrated Ca^(2+)and L-Trp binding sites and conformational changes of the ECD upon Ca^(2+)/L-Trp binding.However,it remains to be understood at the structural level how Ca^(2+)/L-Trp binding to the ECD leads to conformational changes in transmembrane domains(TMDs)and consequent CaSR activation.Here,we determined the structures of full-length human CaSR in the inactive state,Ca^(2+)-or L-Trp-bound states,and Ca^(2+)/L-Trp-bound active state using single-particle cryo-electron microscopy.Structural studies demonstrate that L-Trp binding induces the closure of the Venus flytrap(VFT)domain of CaSR,bringing the receptor into an intermediate active state.Ca^(2+)binding relays the conformational changes from the VFT domains to the TMDs,consequently inducing close contact between the two TMDs of dimeric CaSR,activating the receptor.Importantly,our structural and functional studies reveal that Ca^(2+)ions and L-Trp activate CaSR cooperatively.Amino acids are not able to activate CaSR alone,but can promote the receptor activation in the presence of Ca^(2+).Our data provide complementary insights into the activation of class C GPCRs and may aid in the development of novel drugs targeting CaSR. | Shenglong Ling Pan Shi Sanling Liu Xianyu Meng Yingxin Zhou Wenjing Sun Shenghai Chang Xing Zhang Longhua Zhang Chaowei Shi Demeng Sun Lei Liu Changlin Tian | 2021 | Cell Research2021，31，4： | 3 |
| 4 | A pest control model with state-dependent impulses显示文摘 | Xuehui Ji Sanling Yuan Lansun Chen | 2015 | International Journal of Biomathematics2015，8，1： | 2 |
| 5 | Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis显示文摘Dear Editor,Plants utilize K^+ions to maintain hydrostatic pressure,drive irreversible cell expansion for growth,and facilitate reversible changes in guard cell volume that cause stomatal opening or closing.KAT1 is a voltage-dependent potassium channel from Arabidopsis thaliana that is mainly expressed in guard cells.KAT1 allows the influx of K+,leading to the swelling and opening of the stoma,and therefore plays a key role in regulating the aperture of stomatal pores on the surface of plant leaves. | Siyu Li Fan Yang Demeng Sun Yong Zhang Mengge Zhang Sanling Liu Peng Zhou Chaowei Shi Longhua Zhang Changlin Tian | 2020 | Cell Research2020，30，11： | 2 |
| 6 | Endometriosis in the uterine wall cesarean section scar显示文摘 | Kafkasli A Franklin RR Sanls D | 1996 | Gynecol Obstet Invest1996，42，3： | 1 |
| 7 | High-anxious individuals show increased chronic stress burden,decreased protective immunity,and increased cancer progression in a mouse model of squamous cell carcinoma显示文摘 | Dhabhar FS Sanl AN Holmes TH | | 0，，04： | 1 |
| 8 | Superparamagnetic Iron Oxide Nanoparticles(SPIONs): Development, Surface Modification and Applications in Chemotherapy 显示文摘 | Mahmoudi M Sanl S Wang B | 2011 | Advanced Drug Delivery Reviews2011，63，： | 1 |
| 9 | FPGEN : A fast, scala- ble and programmable traffic generator for the performance evaluation of high - speed computer networks 显示文摘 | Sanl M Schmidt E G Gttran H C | 2011 | Performance Evaluation2011，68，12： | 1 |
| 10 | The threshold of a stochastic SIVS epidemic model with nonlinaer saturated incidence显示文摘 | ZHAO Dianli ZHANG Tiansi YUAN Sanling | 2016 | Physica A Statistical Mechanics and its Applications2016，443，： | 1 |
| 11 | Relationship of onset of cigarette smoking during college to alcohol use, dieting concerns, and depressed mood: results from the Young Women's Health Survey显示文摘 | Sanles KK Pomerleau CS Snedecor SM | 2004 | Addict Behav2004，29，5： | 1 |
| 12 | The use of lipid emulsions for sterol supplementation of spat of the Pacif ic oyster,Crassostrea gigas显示文摘 | Soudant P Sanles M V Quere C | 2000 | Aquaculture2000，184，31： | 1 |
| 13 | Optimizing performance and reli- ability on heterogeneous parallel systems : approximation algorithms and heuristics显示文摘 | E Jeannot E Sanle D Trystram | 2012 | Journal of Parallel and Distributed Computing (JPDC)2012，72，2： | 1 |
| 14 | Stochastic dynamics of the delayed chemostat with Levy noises显示文摘This paper formulates and studies a delayed ehemostat with Levy noises.Existence of the glohally positive solution is proved first by establishing suitable Lyapunov functions,and a further result on exact Lyapunov exponent shows the growth of the total concentration in the ehemostat.Then,we prove existence of the uniquely ergodic stationary distribution for a subsystem of the nutrient,based on this,a unique threshold is identified,which completely determines persistence or not of the microorganism in the ehemostat.Besides,recurrence is studied under special conditions in case that the microorganism persists.Results indicate that all the noises have negative effects on persistence of the microorganism,and the time delay has almost no effects on the sample Lyapunov exponent and the threshold value of the ehemostat. | Dinnli Zhao Sanling Yuan Haidong Liu | 2019 | International Journal of Biomathematics2019，12，5： | 1 |
| 15 | Pro-thrombotic and pro-oxidant effects of diet-induced hyperhomocysteinemia 显示文摘 | Sanls DL Arnold EK Bell CW | 2007 | Thromb Res2007，120，1： | 1 |
| 16 | Separation of acetic acid-water mixtures through acrylonitrile grafted poly(vinyl alcohol) membranes by pervaporation显示文摘 | Alghezawi N Sanl O Aras L | 2005 | Chemical Engineering and Processing2005，44，： | 1 |
| 17 | Competition between two microorganisms in the ehemostat with general variable yields and general growth rates 显示文摘 | Luo Jianmei Yuan Sanling Zhang Weiguo | 2008 | International Journal of Bi-amathematics2008，1，4： | 1 |
| 18 | Bifurcation analysis in a predator–prey system with time delay显示文摘 | Yongli Song Sanling Yuan | 2005 | Nonlinear Analysis: Real World Applications2005，，2： | 1 |
| 19 | The protective ef- fects of intratympanic dexamethasone and vitamin E on cisplatin-induced ototoxicity are demonstrated in rats显示文摘 | Paksoy M Ayduran E Sanl A | 2011 | MedOncol2011，28，2： | 1 |
| 20 | The use of lipid emulsions for sterol supplementation of spat of the Pacific oyster, Crassostrea gigas 显示文摘 | SOUDANT P SANLES M V QUERE C | 2000 | Aquaculture2000，184，34： | 1 |
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