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| 1 | Study on the sensitivity to cadmium of marine fish Salaria basilisca(Pisces: Blennidae)显示文摘The present study tested the sensitivity of Salaria basilisca to water-cadmium (Cd) contamination. For this purpose, liver somatic index (LSI), Cd concentrations and the activities of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured in the liver of S. basilisca exposed to Cd-contaminated water (2 mg Cd/L as CdCl2) for 14 and 28 d. The results showed that the LSI decreased significantly after 14 and 28 d of Cd-exposure. Cd bioaccumulation in the liver resulted in an increasing uptake up to 42 μg/g dry weight after 28 d of exposure. Activities of CAT and SOD were significantly increased with increasing exposure time. A significant increase in GSH-Px activity, under Cd influence, was observed during 14-day exposure period (p < 0.0001). However, a significant decrease (p < 0.05) in this activity with respect to control fish was registered after 28 d of Cd-exposure. These results showed that Cd accumulation in the liver of S. basilisca could induce oxidative stress as demonstrated by changes in the antioxidant enzyme activities. Results also emphasized that S. basilisca may considered as a sensitive species to Cd exposure. | Imed Messaoudi Sana Barhoumi Khaled Sd Abdelhamid Kerken | 2009 | Journal of Environmental Sciences2009，21，11： | 7 |
| 2 | Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers显示文摘AIM:To investigate the polymorphic simple sequencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-SSRⅠ),which is known to affect theefficiency of gene transcription as a putative target of themismatch repair(MMR)machinery in colorectal tumors.METHODS:The CA-SSRⅠgenotype was analyzed ina total of 86 primary colorectal tumors,selected upontheir microsatellite instability(MSI)status[42 with highfrequency MSI(MSI-H)and 44 microsatellite stable(MSS)]and their respective normal tissue.The effect of the CA-SSRⅠgenotype on the expression of the EGFR gene wasevaluated in 18 specimens using quantitative real-timereverse transcription PCR and immunohistochemistry.RESULTS:Mutations in CA-SSRⅠwere detected in 86%(36 of 42)of MSI-H colorectal tumors and 0%(0 of 44)ofMSS tumors,indicating the EGFR gene as a novel putativespecific target of the defective MMR system(P<0.001).Impaired expression of EGFR was detected in most ofthe colorectal tumors analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noassociation was apparent between EGFR expression andCA-SSRⅠstatus in tumors or normal tissues.CONCLUSION:Our results suggest that CA-SSRⅠsequence does not contribute to the regulation of EGFRtranscription in colon,and should thus not be consideredas a promising predictive marker for response to EGFRinhibitors in patients with colorectal cancer. | Marie-Pierre Buisine Agnès Wacrenier Christophe Mariette Emmanuelle Leteurtre Fabienne Escande Sana Aissi Amandine Ketele Annette Leclercq Nicole Porchet Thécla Lesuffleur | 2008 | World Journal of Gastroenterology2008，14，7： | 3 |
| 3 | Price Sensitive Demand with Random Sales Price--A Newsboy Problem 显示文摘 | Sana S S | 2012 | International Journal of Systems Science2012，，3： | 1 |
| 4 | A production-inventory model for a deteriorating item with trended demand and shortages显示文摘 | Sana S Goyal S K Chaudhuri K S | 2004 | European Journal of Operational Research2004，157，： | 1 |
| 5 | A deterministic EOQ model with delays in payments and price-discount offers显示文摘 | Sana S S Chaudhuri K S | 2008 | European Journal of Operational Research2008，184，2： | 1 |
| 6 | An EOQ Model for Perishable Item with Stock- Dependent Demand and Price Discount Rate 显示文摘 | Sana S S | 2010 | American Journal of Mathematical and Management Sciences2010，30，34： | 1 |
| 7 | Anterior deep bite malocclusion treated with connecticut intrusion arch: biomeehanical consideration 显示文摘 | Sana S Bansal A Sami L | 2014 | J Clin Diagn Res2014，8，5： | 1 |
| 8 | Demand influenced by enterprises' initiatives--a multi-item EOQ model of deteriorating and ameliorating items 显示文摘 | SANA S S | 2010 | Mathematieal and Computer Modeling2010，52，1： | 1 |
| 9 | A stock-review EOQ model with stock-dependent demand, quadratic deterioration rate 显示文摘 | Sana S Chaudhuri K S | 2004 | Advanced Modeling and Optimization2004，14，6： | 1 |
| 10 | Maximising profits for an EPQ model with unreliable machine and rework of random defective items 显示文摘 | PAL B SANA S S CHAUDHURI K | 2013 | International Journal of Systems Science2013，44，3： | 1 |
| 11 | Demand influenced by enterprises' initiatives- A multi-item EOQ model of deterio- rating and ameliorating items显示文摘 | Sana S S | 2010 | Mathematical and Computer modeling2010，52，： | 1 |
| 12 | Vaccination with non-toxic mutant TSST-1 protects Staphylococcus aureus infection 显示文摘 | HU D L KATSUHIKO O SANAE S | 2003 | Journal of Infectious Diseases2003，188，9： | 1 |
| 13 | A production-inventory model for a deteriorating item with trended demand and shortages显示文摘 | Sana S Goyal S K Chaudhuri K S | 2004 | European Journal of Operational Research2004，157，2： | 1 |
| 14 | Agrobacterium tumefaciens media- ted genetic transformation of Ocimum gratissimum:A medicinally important crop显示文摘 | SANA K NAVEERA F POOJA S | 2015 | Industrial Crops and Products2015，71，： | 1 |
| 15 | Comparative epidemiology of black rot and Alternaria black spot of cabbage in the agreste of Pernambuco 显示文摘 | Azevedo Simone S Michereff Sana J Mariano | 2002 | Fitopatologia Brasileira2002，27，1： | 1 |
| 16 | Isolation of key methanogens for global methane emission from rice paddy fields: a novel isolate afiliated with the clone cluster rice duster 显示文摘 | Sanae S Hiroyuki I Yu J S | 2007 | Applied and Envir- onmenta Microbiology2007，73，13： | 1 |
| 17 | A deterministic EOQ model with delays ill payments and price- discount offers显示文摘 | Sana S S Chaudhuri K S | 2008 | European Journal of Operational Research2008，184，： | 1 |
| 18 | A deterministic EOQ model with delays in payments and price-discount offers 显示文摘 | Sana S S Chaudhuri K S | 2008 | European Journal of Operational Research2008，184，2： | 1 |
| 19 | A deterministic EOQ model with delays in payments and price-discount offers显示文摘 | Sana S S Chaudhuri K S | 2008 | European Journal of Operational Research2008，184，： | 1 |
| 20 | A production - inventory model in an imperfect production process显示文摘 | Sana S S | 2010 | European Journal of Operational Research2010，200，2： | 1 |
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