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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Predictors of mortality after transjugular portosystemic shunt显示文摘AIM:To investigate if echocardiographic and hemodynamic determinations obtained at the time of transjugular intrahepatic portosystemic shunt(TIPS)can provide prognostic information that will enhance risk stratification of patients.METHODS:We reviewed medical records of 467 patients who underwent TIPS between July 2003 and December 2011 at our institution.We recorded information regarding patient demographics,underlying liver disease,indication for TIPS,baseline laboratory values,hemodynamic determinations at the time of TIPS,and echocardiographic measurements both before and after TIPS.We recorded patient comorbidities that may affect hemodynamic and echocardiographic determinations.We also calculated Model for Endstage Liver Disease(MELD)score and Child Turcotte Pugh(CTP)class.The following pre-and post-TIPS echocardiographic determinations were recorded:Left ventricular ejection fraction,right ventricular(RV)systolic pressure,subjective RV dilation,and subjective RV function.We recorded the following hemodynamic measurements:Right atrial(RA)pressure before and after TIPS,inferior vena cava pressure before and after TIPS,free hepatic vein pressure,portal vein pressure before and after TIPS,and hepatic venous pressure gradient(HVPG).RESULTS:We reviewed 418 patients with portal hypertension undergoing TIPS.RA pressure increased by a mean ± SD of 4.8 ± 3.9 mmH g(P < 0.001),HVPG decreased by 6.8 ± 3.5 mmH g(P < 0.001).In multivariate linear regression analysis,a higher MELD score,lower platelet count,splenectomy and a higher portal vein pressure were independent predictors of higher RA pressure(R = 0.55).Three variables predicted 3-mo mortality after TIPS in a multivariate analysis:Age,MELD score,and CTP grade C.Change in the RA pressure after TIPS predicted long-term mortality(per 1 mm Hg change,HR = 1.03,95%CI:1.01-1.06,P < 0.012).CONCLUSION:RA pressure increased immediately after TIPS particularly in patients with worse liver function,portal hypertension,emergent TIPS placement and history of splenectomy.The increase in RA pressure after TIPS was associated with increased mortality.Age,splenectomy,MELD score and CTP grade were independent predictors of long-term mortality after TIPS. | Mona Ascha Sami Abuqayyas Ibrahim Hanouneh Laith Alkukhun Mark Sands Raed A Dweik Adriano R Tonelli | 2016 | World Journal of Hepatology2016，8，11： | 13 |
| 3 | Deep learning with convolutional neural networks for identification of liver masses and hepatocellular carcinoma: A systematic review显示文摘BACKGROUND Artificial intelligence,such as convolutional neural networks(CNNs),has been used in the interpretation of images and the diagnosis of hepatocellular cancer(HCC)and liver masses.CNN,a machine-learning algorithm similar to deep learning,has demonstrated its capability to recognise specific features that can detect pathological lesions.AIM To assess the use of CNNs in examining HCC and liver masses images in the diagnosis of cancer and evaluating the accuracy level of CNNs and their performance.METHODS The databases PubMed,EMBASE,and the Web of Science and research books were systematically searched using related keywords.Studies analysing pathological anatomy,cellular,and radiological images on HCC or liver masses using CNNs were identified according to the study protocol to detect cancer,differentiating cancer from other lesions,or staging the lesion.The data were extracted as per a predefined extraction.The accuracy level and performance of the CNNs in detecting cancer or early stages of cancer were analysed.The primary outcomes of the study were analysing the type of cancer or liver mass and identifying the type of images that showed optimum accuracy in cancer detection.RESULTS A total of 11 studies that met the selection criteria and were consistent with the aims of the study were identified.The studies demonstrated the ability to differentiate liver masses or differentiate HCC from other lesions(n=6),HCC from cirrhosis or development of new tumours(n=3),and HCC nuclei grading or segmentation(n=2).The CNNs showed satisfactory levels of accuracy.The studies aimed at detecting lesions(n=4),classification(n=5),and segmentation(n=2).Several methods were used to assess the accuracy of CNN models used.CONCLUSION The role of CNNs in analysing images and as tools in early detection of HCC or liver masses has been demonstrated in these studies.While a few limitations have been identified in these studies,overall there was an optimal level of accuracy of the CNNs used in segmentation and classification of liver cancers images. | Samy A Azer | 2019 | World Journal of Gastrointestinal Oncology2019，11，12： | 10 |
| 4 | Inflammatory bowel disease: An evaluation of health information on the internet显示文摘AIM To evaluate the quality and accuracy of websites written to the public on inflammatory bowel disease(IBD)(Crohn's disease and ulcerative colitis) and assess their readability level.METHODS Google?, Bing?, and Yahoo? search engines were searched independently by three researchers in December 2014. Only English-language websites were selected on the basis of predetermined inclusion and exclusion criteria. Researchers independently evaluated the quality of each website by using the DISCERN and the HONcode instruments. The readability levels were calculated using two formulas; the Flesch-Kincaid Grade Level Index, and the Coleman-Liau Readability Index. The agreement between the evaluators was calculated using Cohen kappa coefficient.RESULTS Eighty-four websites were finally identified. Scores varied from a minimum DISCERN score of 18 to a maximum of 68 [mean ± SD, 42.2 ± 10.7; median = 41.5, interquartile range, interquartile range (IQR) = 15.8] and a minimum score of HONcode of 0.14 and a maximum of 0.95 (mean ± SD, 0.16 ± 0.19; median = 0.45, IQR = 0.29). Most of these websites were reviewed in 2014 and 2015 (n = 51). The creators of these websites were: universities and research centers(n = 25, 30%), foundations and associations (n = 15, 18%), commercial and pharmaceutical companies(n =25, 30%), charities and volunteer work(n = 9, 10%), and non-university educational bodies (n = 10, 12%). The Flesch-Kincaid Grade Level readability score(mean ± SD) was 11.9 ± 2.4 and the Coleman-Liau Readability Index score was 12.6 ± 1.5. Significant correlation was found between the two readability scores (R2 = 0.509, P = 0.001). The overall agreement between evaluators measured by Cohen kappa coefficient was in the range of 0.804-0.876; rated as 'Good'.CONCLUSION The DISCERN and the HONcode scores of websites varied and the readability levels of most websites were above the public readability level. The study highlights the areas that need further improvement and development in patient education online materials about IBD. | Samy A Azer Thekra I AlOlayan Malak A AlGhamdi Malak A AlSanea | 2017 | World Journal of Gastroenterology2017，23，9： | 4 |
| 5 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 6 | Application of the three-dimensional finite-difference time-domain method to the analysis of planar microstrip circuits 显示文摘 | Sheen D M Sami M A Abouzahra M D | 1990 | IEEE Transactions on MTT1990，38，7： | 1 |
| 7 | Effect of rare earth substitutions on some physical properties of Mn-Zn ferrite studied by positron annihilation lifetime spectroscopy 显示文摘 | Samy A M Mostafa N Gomaa E | 2006 | Applied Surface Science2006，252，： | 1 |
| 8 | Infectious diarrhea : newpathogens and new challenges in developed and developing areas显示文摘 | Steiner TS Samie A Guerrant RL | 2006 | Clin Infec Dis2006，43，40： | 1 |
| 9 | Novel bio-inspired approach for fault-tolerant VLSI systems 显示文摘 | Samie M Dragffy G Tyrrell A M | 2012 | IEEE Transactions on Very Large Scale Integration (VLSI) Systems2012，21，10： | 1 |
| 10 | Application of the three-dimensional finite-difference time-domain method to the analysis of planar microstrip circuits 显示文摘 | Sheed D M Sami M A | 1990 | IEEE Transactions on Microwave Theory and Techniques1990，38，7： | 1 |
| 11 | Non-Interactive Zero-Knowledge Proof Systems显示文摘 | De Samis A Mieali S Persiano G | 1991 | GSIAM Journal on Computing1991，20，6： | 1 |
| 12 | Shape classification basedon singular value decomposition transform 显示文摘 | Thawar A Sami B | 2009 | Journal ofChongqing University of Posts and Telecommunications:Natural Science Edition2009，21，2： | 1 |
| 13 | Anterior deep bite malocclusion treated with connecticut intrusion arch: biomeehanical consideration 显示文摘 | Sana S Bansal A Sami L | 2014 | J Clin Diagn Res2014，8，5： | 1 |
| 14 | Microsporidiosis in South Africa : PCR detection in stool samples of HIV-positive and HIV-negative individuals and school children in Vhembe district, Limpopo Province 显示文摘 | Samie A Obi CL Tzipori S | 2007 | Trans R Soc Trop Med Hyg2007，101，6： | 1 |
| 15 | LTE Heterogeneous Network: A Case Study显示文摘 | Aubida A Jasim Sami A Mawjoud | 2013 | International Journal of Computer Applications2013，61，8： | 1 |
| 16 | Heterologous expression of lignin peroxiedase of Phanerochaete chrysosporium in Aspergillus niger显示文摘 | A S Mohamed S Sami G Ali | 1999 | Biotechnology Letters1999，21，： | 1 |
| 17 | Effect of topical anti-inflammatory drugs on corneal and limbal wound healing显示文摘 | Barba KR Samy A Lai C | 2000 | J Cataract Refract Surg2000，26，6： | 1 |
| 18 | Using Feature Generation from API Calls for Malware Detection 显示文摘 | SALELU Z SAMI A GHIASI M | 2014 | Computer Fraud & Security2014，2014，9： | 1 |
| 19 | Transparent silica gel-PMMA composites显示文摘 | Pope E J A A Sami M Mackenzie J D | 1989 | J Mater Res1989，，4： | 1 |
| 20 | Laparoseopie management of eryptorehidism in adults 显示文摘 | Kucheria R Sabai A Sami TA | 2005 | Eur Urol2005，48，3： | 1 |
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