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| 1 | Adenoma and advanced neoplasia detection rates increase from 45 years of age显示文摘BACKGROUND Colonoscopy is considered a valid primary screening tool for colorectal cancer(CRC). The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate(ADR). Due to the fact that screening programs usually start from the age of 50, very few data are available on the risk of adenoma between 40 and 49 years. However, the incidence of CRC is increasing in young populations and it is not uncommon in routine practice to detect adenomas or even advanced neoplasia during colonoscopy in patients under 50 years.AIM To compare the ADR and advanced neoplasia detection rate(ANDR) according to age in a large series of patients during routine colonoscopy.METHODS All consecutive patients who were scheduled for colonoscopy were included.Exclusion criteria were as follows: patients scheduled for partial colonoscopy or interventional colonoscopy(for stent insertion or stenosis dilation).Colonoscopies were performed in our unit by a team of 30 gastroenterologists in2016. We determined the ADR and ANDR in each age group in the whole population and in the population with an average risk of CRC(excluding patients with personal or family history of advanced adenoma or cancer).RESULTS6027 colonoscopies were performed in patients with a median age of 57 years(range, 15-96). The ADR and ANDR were 28.6% and 9.7%, respectively, in the whole population. When comparing patients aged 40-44(n = 382) and 45-49 years (n = 515), a strong increase in all parameters from 45 years was observed, with the ADR rising from 9.7% in patients aged 40-44 to 21.2% between 45 and 49(P <0.001) and the ANDR increasing from 3.1% in patients aged 40-44 to 6.4% in those aged 45-49 years(P < 0.03). With regard to patients aged 50-54(n = 849), a statistically significant increase in the ADR and ANDR was not observed between patients aged 45-49 and those aged 50-54 years. In the population with an average risk of CRC, the ADR and ANDR were still significantly higher in patients aged 45-49 compared with those aged 40-44 years.CONCLUSION This study shows a significant two-fold increase in the ADR and ANDR in patients aged 45 years and over. | David Karsenti Gaelle Tharsis Pascal Burtin Franck Venezia Gilles Tordjman Agnès Gillet Joelle Samama Karine Nahon-Uzan Philippe Cattan Maryan Cavicchi | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 2 | The coagulopathy of massive transfusion显示文摘 | Hardy JF de Moerloose P Samama CM | 2005 | Vox Sang2005，89，3： | 1 |
| 3 | Laboratory diagnosis of the thrombophilic state in cancer patients 显示文摘 | Gouin- Thibault I Samama MM | 1999 | Semin Thromb He- most1999，25，2： | 1 |
| 4 | Near-patient testing of haemostasis in the operating theatre: an approach to appropriate use of blood in surgery显示文摘 | Samama CM Ozier Y | 2003 | Vox Sang2003，84，4： | 1 |
| 5 | An epidemiologic study of risk factors for deep vein thrombosisin in medical outpatients: the Sirius study显示文摘 | Samama MM | 2000 | Arch Intern Med2000，160，22： | 1 |
| 6 | New antithromboticdrugs:American College of Chest Physicians evidence-basedclinical practice guidelines(8th edition)显示文摘 | WEITZ JI HIRSH J SAMAMA MM | 2008 | Chest2008，133，6： | 1 |
| 7 | New antithrombotic drugs : American College of Chest Physicians evidence-based clin- ical practice guidelines (8th edition) 显示文摘 | Weitz JI Hirsh J Samama MM | 2008 | Chest2008，133，6： | 1 |
| 8 | New antithrombitic drugs:Anti-thrombotic therapy and prevention of thrombosis,9th ed:American college of chest physicians evidence-based clinical practice guidelines显示文摘 | Weitz JI Eikelboom JW Samama MM | 2012 | Chest2012，141，2： | 1 |
| 9 | Laboratory assessmentof rivaroxaban: a review显示文摘 | Samama MM Contant G Spiro TE | 2013 | Thromb J2013，11，1： | 1 |
| 10 | In vitro study of the anticoagulant effects of edoxaban and its effect on thrombin generation in comparison to fondaparinux显示文摘 | Samama MM Mendell J Guinet C | | 0，，4： | 1 |
| 11 | A silent killer:exploring the berden of vie in medical Patlents显示文摘 | Samama MM | 2004 | VTE Experts meeting:Belgium2004，23，12： | 1 |
| 12 | Laparoscopic splenectomy for idiopathic thrombocytopenic purpura显示文摘 | Delaitre B Blezel E Samama G | 2002 | Surgical Laparoscopy Endoscopy and Percutaneous Techniques2002，12，6： | 1 |
| 13 | Massive transfusion: an overview of themain characteristics and potential risks associated with substances used forcorrection of a coagulopathy显示文摘 | Seghatchian J Samama M M | 2012 | Transfus Apher Sci2012，47，2： | 1 |
| 14 | Intraoperative cholangiography during laparoscopic cholecystectomy显示文摘 | Samama G | 2004 | J Chir2004，141，3： | 1 |
| 15 | New antithrombotic drugs:american college of chest physicians evidence-based clinical practice guidelines (8th ed)显示文摘 | Weitz J I Hirsh J Samama M M | 2008 | Chest2008，133，6： | 1 |
| 16 | New antithrombotic drugs:Antithrombotic Therapy and Prevention of Thrombosis,9th ed:American College of Chest Physicians Evidence-Based Clinical Practice Guidelines显示文摘 | Weitz JI Eikelboom JW Samama MM | 2012 | Chest2012，141，21： | 1 |
| 17 | Mechanisms for the antithrombotic activity in man of low molecular weight heparins(LMWH)显示文摘 | Baral L Gerotziafas GT | 1994 | Haemostasis1994，24，2： | 1 |
| 18 | In vitro effect on heptest of low molecular weight heparn显示文摘 | Bara L Mardiguian J Samama M | 1990 | Thromb Res1990，57，： | 1 |
| 19 | A direct antifibrinolytic agent in major orthopedic surgery显示文摘 | Samama CM | 2004 | Orthopedics2004，27，6： | 1 |
| 20 | The mechanism of action of rivaroxaban-an oral,direct Factor Xa inhibitor-compared with other anticoagulants显示文摘 | Samama MM | 2011 | Thromb Res2011，127，6： | 1 |
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