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| 1 | Hepatitis B virus therapy:What's the future holding for us?显示文摘Hepatitis B is one of the leading causes of liver cancer worldwide and unfortunately the number of people affected with hepatitis B virus(HBV) infection is still on the rise. Although the HBV has been known to cause fatal illness since decades but the population effected by this lethal virus have still only a few options for its management. The major treatment strategies include interferons and nucleos(t)ide analogues. These agents have so far produced unsatisfactory results in terms of complete virus eradication. Interferons cannot be used for long term therapy because of their potential side effects. Prolong treatment with nucleos(t)ide analogues has also been reported to cause serious side effects besides the increasing resistance by the virus. The need for new innovative solutions for treatment of HBV has been realized by global research institutes and pharmaceutical industry. Present review focuses in detail on the new ideas that are being transformed into therapeutic tools for use as future therapies in HBV infection. Modern drug designing and screening methods have made the drug discovery process shorter and more reliable. HBV therapeutics will take a new turn in coming years owing to these intelligent drug designing and screening methods. Future therapy of HBV is aiming to include the use of vaccines(both prophylactic and therapeutic), immunomodulators such as antibodies, non-nucleoside antivirals such as RNAi and inhibitors of viral life cycle. | Sobia Manzoor Muhammad Saalim Muhammad Imran Saleha Resham Javed Ashraf | 2015 | World Journal of Gastroenterology2015，21，44： | 9 |
| 2 | Crohn's disease with gastroduodenal involvement: Diagnostic approach显示文摘Crohn's disease(CD) is a chronic idiopathic inflammatory disease of gastrointestinal tract characterizedby segmental and transmural involvement of gastrointestinal tract. Ileocolonic and colonic/anorectal is a most common and account for 40% of cases and involvement of small intestine is about 30%. Isolated involvement of stomach is an extremely unusual presentation of the disease accounting for less than 0.07% of all gastrointestinal CD. To date there are only a few documented case reports of adults with isolated gastric CD and no reports in the pediatric population. The diagnosis is difficult to establish in such cases with atypical presentation. In the absence of any other source of disease and in the presence of nonspecific upper gastrointestinal endoscopy and histological findings, serological testing can play a vital role in the diagnosis of atypical CD. Recent studies have suggested that perinuclear anti-neutrophil cytoplasmic antibody and anti-Saccharomycescervisia antibody may be used as additional diagnostic tools. The effectiveness of infliximab in isolated gastric CD is limited to only a few case reports of adult patients and the long-term outcome is unknown. | Sachin B Ingle Baban D Adgaonkar Nawab P Jamadar Saleha Siddiqui Chitra R Hinge | 2015 | World Journal of Clinical Cases2015，3，6： | 5 |
| 3 | Increased incidence of adrenal gland injury in blunt ab- dominal trauma: a computed tomography-based study from Pakistan显示文摘ObjectiveTo 在由计算断层摄影术( CT )与钝腹的损伤介绍的病人决定肾的损害的频率 .MethodsDuring 6 ;从2011年1月1日的月时期到2011年6月30日, 82 紧急情况 CT 考试在主要腹的损伤的背景被执行并且回顾地为 7 个病人全部的肾上腺 injuries.ResultsA 考察了作为有肾上腺损害( 6 男性和 1 女性)被识别。二个病人孤立肾上腺损害。在有 nonisolated 损害的另外的 5 个病人,对肝(1 个案例) 的损害,怒气(1 个案例) , retroperitoneum (2 个案例) 和肠系膜(4 个案例) 被识别。有肝损害( 29 %)的外套 24 案例,有脾的损害(13%)的 11 个案例,有 mesenteric 损害(65%)的 54 个案例,有 retroperitoneal 损害的 14 个盒子(17%)和有肾的损害的 9 个盒子是 identified.ConclusionAdrenal 腺损害从在主要腹的损伤以后经历了 CT 的 82 个病人的一个总数在 7 个病人(11.7%)被识别。大多数这些盒子是 nonisolated 损害。我们的经验比由另外的报告建议显示肾的损害源于损伤是更普通的。在肾的损害的发生的上升能被归因于损害的模式。 | Muhammad Usman Aziz Saleha Shahzad Muhammad Ayiub Mansoor | 2014 | Chinese Journal of Traumatology2014，17，1： | 3 |
| 4 | Malnutrition and liver disease in a developing country显示文摘Malnutrition is a highly prevalent and under recognized condition in developing countries of South Asia.The presence of malnutrition causes a severe impact on patients with liver cirrhosis.The etiology of cirrhosis differs in the South Asian region compared to the West,with hepatitis B and C still being the leading causes and the prevalence of nonalcoholic fatty liver disease increasing over time.Comorbid malnutrition worsens outcomes for cirrhosis patients.Urgent attention to address malnutrition is needed to improve patient outcomes.The etiology and pathophysiology of malnutrition in liver diseases is multifactorial,as reduction in liver function affects both macronutrients and micronutrients.A need for nutritional status assessment for liver disease patients exists in all parts of the world.There are many widely studied tools in use to perform a thorough nutritional assessment,of which some tools are low cost and do not require extensive training.These tools can be studied and evaluated for use in the resource limited setting of a country like Pakistan.Treatment guidelines for proper nutrition maintenance in chronic liver disease exist for all parts of the world,but the knowledge and practice of nutritional counseling in Pakistan is poor,both amongst patients and physicians.Emphasis on assessment for nutritional status at the initial visit with recording of vital signs is needed.Simultaneously,treating physicians need to be made aware of the misconceptions surrounding nutritional restrictions in cirrhosis so that patient education is done correctly based on proper scientific evidence. | Asra tus Saleha Siddiqui Om Parkash Syeda Amrah Hashmi | 2021 | World Journal of Gastroenterology2021，27，30： | 3 |
| 5 | Effects of Sialic Acid from Edible Bird Nest on Cell Viability Associated with Brain Cognitive Performance in Mice显示文摘Background:Edible bird nest(EBN)is a natural food product rich in glycoprotein such as sialic acid,which has been reported to improve brain functions.The EBN is widely consumed due to its higher nutritional contents and antioxidant status;however,an interaction of EBN on brain cell metabolic activity and viability are still unclear.Objective:The objectives of this study were to identify the effect of sialic acid from EBN on the cell viability and to determine the appropriate concentration of sialic acid on cognitive performance in mice.Materials and Methods:The viability of pheochromocytoma and neuroblastoma cell lines were tested using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay.For in vivo study,7-week-old female BALB/c mice were randomly assigned into four treatment groups and were treated with sialic acid for 21 days.At day 22,all mice were tested on cognitive performance by Y-maze test.Results:Treatment concentration of sialic acid extract and sialic acid standard at 60μg/mL(0.6 ppm)increased cell viability and showed no cytotoxicity effects in pheochromocytoma and neuroblastoma cell lines.In addition,an administration of higher dose of sialic acid at 0.6 ppm in animals improved Y-maze test performance,which they showed significantly higher number of entries and time spent in the novel arm.Conclusion:Thus,the current study shows that the sialic acid extract at 0.6 ppm improved brain cognitive performance in mice associated with an increased viability of pheochromocytoma and neuroblastoma cell lines. | Siti Khadijah Abdul Khalid Aswir Abd Rashed Saleha Abdul Aziz Hafandi Ahmad | 2019 | World Journal of Traditional Chinese Medicine2019，5，4： | 3 |
| 6 | Papillary carcinoma of breast: Minireview显示文摘The term 'intracystic papillary ductal carcinoma in situ ' constitutes only 0.5% to 1% of all breast cancers.It is usually seen in postmenopausal age group.Herein,we are presenting a minireview about this unusual breast malignancy usually difficult to diagnose on clinical grounds and highlighting modalities of diagnosis and management. | Sachin B Ingle Hemant G Murdeshwar Saleha Siddiqui | 2016 | World Journal of Clinical Cases2016，4，1： | 2 |
| 7 | Primary signet ring cell carcinoma of the appendix: A rare case report显示文摘Primary adenocarcinoma of the appendix is a rare malignancythat constitutes < 0.5% of all gastroin-testinalneoplasms. Moreover, primary signet ring cell carcinomaof the appendix is an exceedingly rare entity. In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastasesand unresectable peritoneal dissemination occurring in a 45-year-old female patient. She was clinically misdiagnosed as torsion of ovarian cyst. She underwent appendicectomy and unilateral salpingooophorectomy.Histopathology revealed signet ring cell carcinoma and a right hemicolectomy was done. She then received palliative systemic chemotherapy with 12 cycles of oxaliplatin, 5-fluorouracil, and leucovorin(FOLFOX-4). The patient is doing well till today on follow up without progression of disease 10 mo after beginning chemotherapy. | Ram V Kulkarni Sachin B Ingle Saleha Siddiqui | 2015 | World Journal of Clinical Cases2015，3，6： | 2 |
| 8 | Extremely unusual case of gastrointestinal trichobezoar显示文摘Trichobezoars(hair ball) are usually located in the stomach, but may extend through the pylorus into the duodenum and small bowel(Rapunzel syndrome). Rapunzel syndrome remains uncommon; with fewer than 40 cases reported. To the best of our knowledge, this case may be the first well-documented case with a length of 75 cm. They are almost always associated with trichotillomania and trichophagia or other psychiatric disorders. In the literature several treatment options are proposed, including removal by conventional laparotomy, laparoscopy and endoscopy. Herein, we are reporting an interesting case of an 18-year mentally retarded girl with history of trichotillomania and trichophagia who presented to our emergency department with a history of central abdominal pain associated with vomiting and constipation for five days. An examination showed a trichobezoar requiring emergent surgical intervention, and indicating the need for psychiatric treatment. The trichobezoar was treated successfully by laparoscopy. | Sopan N Jatal Nawab P Jamadar Bhagwat Jadhav Saleha Siddiqui Sachin B Ingle | 2015 | World Journal of Clinical Cases2015，3，5： | 2 |
| 9 | Retained austenite in dual-phase silicon steels and its effect on mechanical properties显示文摘 | SALEHA M H PRIESTNERB R | 2001 | Journal of Materials Processing Technology2001，113，： | 1 |
| 10 | MRI features of intraductal papilloma of the breast: sheep in wolf's clothing?显示文摘 | KurzKD RoyS SalehA | 2011 | Acta Radiol2011，52，3： | 1 |
| 11 | Retained Austenite in Dual-Phase Silicon Steels and Its Effect on Mechanical Properties 显示文摘 | Saleha M H Priestnerb R | 2001 | Journal of Materials Processing Technology2001，113，1： | 1 |
| 12 | DNA damage in leukocytes of mice treated with copper sulfate 显示文摘 | SALEHA BANU B ISHAQ M DANADEVI K | 2004 | Food Chem Toxicol2004，42，12： | 1 |
| 13 | Genotoxic effect of monocrotophos to sentinel species using comet assay显示文摘 | SALEHA B B DANADEVI K RAHMAN M F | 2001 | Food and Chemical Toxicology2001，39，4： | 1 |
| 14 | Hypertension and its physio-psychosocial risks factors in elderly people:a cross-sectional study in north-eastern region of Bangladesh显示文摘Hypertension has been increasingly cited mortality cause in developing countries including Bangladesh,[1–4]and generally associated with coronary artery disease,stroke,heart failure,atrial fibrillation,peripheral vascular disease,vision loss and chronic kidney disease. | Gowranga Kumar Paul Mohammad Meshbahur Rahman Mohammad Hamiduzzaman Zaki Farhana Somaresh Kumar Mondal Saleha Akter Shayla Naznin | 2021 | Journal of Geriatric Cardiology2021，18，1： | 1 |
| 15 | Frequency-Dependent Nonlinear Models and Frequency-Independent of TWT Amplifiers显示文摘 | SalehA AM | 1981 | IEEE Transactions on Communications1981，1981，： | 1 |
| 16 | Genotoxic effect of monocrotophos to sentinel species using comet assay显示文摘 | Saleha Banu B Danadevi K Rahman M F | 2001 | Food Chem Toxicol2001，39，4： | 1 |
| 17 | Occurrence of Campylobacter and Salmonella in Ducks and Duck Eggs in Selangor,Malaysia显示文摘 | NOR FAIZA S SALEHA A A JALILA A | 2013 | Trop Biomed2013，30，1： | 1 |
| 18 | Surgical manag ement of ectopic pregnancy 显示文摘 | Tulandi T SalehA | 1999 | Clin Obstet Gynecol1999，42，1： | 1 |
| 19 | AconservedXIAP-in-teractionmotifincaspase-9andSmac/DIABLOregulatescaspaseactivityandapoptosis显示文摘 | SrinivasulaSM HegdeR SalehA etal | 2001 | Nature2001，410，6824： | 1 |
| 20 | Genotoxic effect of monocrotophos to sentinel species using comet assay 显示文摘 | Saleha Banu B Danadevi K Rahman M F | 2001 | Food and Chemical Toxicology2001，39，4： | 1 |
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