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| 1 | Pleiotropy within gene variants associated with nonalcoholic fatty liver disease and traits of the hematopoietic system显示文摘Genome-wide association studies of complex diseases,including nonalcoholic fatty liver disease(NAFLD),have demonstrated that a large number of variants are implicated in the susceptibility of multiple traits—a phenomenon known as pleiotropy that is increasingly being explored through phenome-wide association studies.We focused on the analysis of pleiotropy within variants associated with hematologic traits and NAFLD.We used information retrieved from large public National Health and Nutrition Examination Surveys,Genome-wide association studies,and phenome-wide association studies based on the general population and explored whether variants associated with NAFLD also present associations with blood cell-related traits.Next,we applied systems biology approaches to assess the potential biological connection/s between genes that predispose affected individuals to NAFLD and nonalcoholic steatohepatitis,and genes that modulate hematological-related traits—specifically platelet count.We reasoned that this analysis would allow the identification of potential molecular mediators that link NAFLD with platelets.Genes associated with platelet count are most highly expressed in the liver,followed by the pancreas,heart,and muscle.Conversely,genes associated with NAFLD presented high expression levels in the brain,lung,spleen,and colon.Functional mapping,gene prioritization,and functional analysis of the most significant loci(P<1×10-8)revealed that loci involved in the genetic modulation of platelet count presented significant enrichment in metabolic and energy balance pathways.In conclusion,variants in genes influencing NAFLD exhibit pleiotropic associations with hematologic traits,particularly platelet count.Likewise,significant enrichment of related genes with variants influencing platelet traits was noted in metabolic-related pathways.Hence,this approach yields novel mechanistic insights into NAFLD pathogenesis. | Carlos Jose Pirola Adrian Salatino Silvia Sookoian | 2021 | World Journal of Gastroenterology2021，27，4： | 2 |
| 2 | The relevance of thermal annealing to the evolution of coal char gasification reactivity显示文摘 | SENNECA O RUSSO P SALATINO P | 1997 | Carbon1997，35，1： | 1 |
| 3 | Epicutieular waxes from caatinga and cerrado species and their efficiency against water loss显示文摘 | Oliveira A F M Meirelles S T Salatino A | 2003 | Anais da Academia Brasileira de Ciencias2003，75，4： | 1 |
| 4 | Patterns and kinetics of pyrolysis of tobacco under inert and oxidative conditions显示文摘 | Osvalda Senneca Riccardo Chirone Piero Salatino Leonardo Nappi | 2006 | Journal of Analytical and Applied Pyrolysis2006，，1： | 1 |
| 5 | Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type Ⅰ insulin-like growth factor receptor in mammary tumor cells显示文摘 | Balana ME Labriola L Salatino M | | 0，，01： | 1 |
| 6 | Effect of ursolic acid from epicuticular waxes of Jacaranda decurrens on Schizaphis graminum 显示文摘 | Varanda E M Ztlniga G E Salatino A | 1992 | Journal of Natural Products1992，55，6： | 1 |
| 7 | Fluidized bed combustion of pelletized biomass andwaste-derived fuels 显示文摘 | Chirone R Salatino P Scala F Solimene R UrciuoloM | 2008 | Combustion and Flame2008，155，12： | 1 |
| 8 | Fluidized bed combustion of a biomasschar (Robinia pseudoacacia) 显示文摘 | Scala F Salatino P | 2000 | Energy Fuels2000，14，4： | 1 |
| 9 | Microstructural changes and loss of gasification reactivity of chars upon heat treatment显示文摘 | Senneca O Salatino P Masi S | 1998 | Fuel1998，77，13： | 1 |
| 10 | Microstructural changes and loss of gasification reactivity of chars upon heat treatment显示文摘 | SENNECA O SALATINO P MASI S | 1998 | Fuel1998，77，13： | 1 |
| 11 | Assessment of Thermodeactivation During Gasification of a Bituminous Coal Char显示文摘 | Salatino P Senneca O Masi S | 1999 | Energy Fuels1999，13，11： | 1 |
| 12 | Transient fluidization and segregation of binary mixtures of particles显示文摘 | Marzocchella A Salatino P Pastena V D | 2000 | Particle Technology and Fluidization2000，46，11： | 1 |
| 13 | Phylogenetic Inference in Velloziaceae Using Chloroplast TrnL-F Sequences 显示文摘 | Maria Luiza F Salatino | 2001 | Systematic Botany2001，26，1： | 1 |
| 14 | Segregation of fluidized binary mixtures of granular solids显示文摘 | Olivieri G Marzocchella A Salatino P | 2004 | AIChE Journal2004，50，12： | 1 |
| 15 | Char- wall interaction and properties of slag waste in entrained- flow gasification of coal显示文摘 | MONTAGNARO F BRACHI P SALATINO P | 2011 | Energy & Fuels2011，25，8： | 1 |
| 16 | Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation显示文摘 | Salatino M Beguelin W Peters MG | 2006 | Oncogene2006，25，59： | 1 |
| 17 | A fast heating-rate thermogravimetric study of the pyrolysis of scrap tyres显示文摘 | Senneca O Salatino P Chirone R | 1999 | Fuel1999，78，13： | 1 |
| 18 | Effect of ursolic acid from epicuticular waxes of Jacaranda decurrens on Schizaphis graminum显示文摘 | Varanda E M Zūniga G E Salatino A | 1992 | J Nat Prod1992，55，6： | 1 |
| 19 | A fast heating - rate thermogravimetric study of the pyrolysis of scrap tyres 显示文摘 | O Senneca P Salatino R Chirone | 1999 | Fuel1999，78，： | 1 |
| 20 | Progrestins induce transcriptional activation of signal transducer and activator of transcription 3(Stat3)via a Jak-and Src-dependent mechaniam in breast cancer cell显示文摘 | Proietti C Salatino M Rosemblit C | 2005 | Mol cell Biol2005，25，： | 1 |
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