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| 1 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 2 | Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice显示文摘AIM: To study whether matrix metalloproteinase-9 (MMP-9) is a key factor in epithelial damage in the dextran sodium sulphate (DSS) model of colitis in mice.METHODS: MMP-9-deficient and wild-type (wt) mice were given 5% DSS in drinking water for 5 d followed by recovery up to 7 d. On d 5 and 12 after induction of colitis, gelatinases, MMP-2 and MMP-9, were measured in homogenates of colonic tissue by zymography and Western blot, whereas tissue inhibitor of metalloproteinases (TIMPs) were measured by reverse zymography. The gelatinolytic activity was also determined in supernatants of polymorphonuclear leukocytes (PMN) isolated from mice blood. Moreover, intestinal epithelial cells were stimulated with TNF-α to study whether these cells were able to produce MMPs. Finally, colonic mucosal lesions were measured by microscopic examination. RESULTS: On d 5 of colitis, the activity of MMP-9 was increased in homogenates of colonic tissues (0.24 ± 0.1 vs 21.3 ± 6.4, P < 0.05) and PMN from peripheral blood in wt (0.5 ± 0.1 vs 10.4 ± 0.7, P < 0.05), but not in MMP-9-deficient animals. The MMP-9 activity was also up-regulated by TNF-α in epithelial intestinal cells (2.5 ± 0.5 vs 14.7 ± 3.0, P < 0.05). Although colitis also led to increase of TIMP-1 activity, the MMP-9/TIMP-1 balance remained elevated. Finally, in the MMP-9-deficient colitic mice both the extent and severity of intestinal epithelialinjury were significantly attenuated when compared with wt mice. CONCLUSION: We conclude that DSS induced colitis is markedly attenuated in animals lacking MMP-9. This suggests that intestinal injury induced by DSS is modu-lated by MMP-9 and that inhibition of this gelatinase may reduce inflammation. | Alfredo Santana Carlos Medina Maria Cristina Paz-Cabrera Federico Díaz-Gonzalez Esther Farré Antonio Salas Marek W Radomski Enrique Quintero | 2006 | World Journal of Gastroenterology2006，12，40： | 9 |
| 3 | Nonlinear dynamics,delay times,and embedding windows显示文摘 | Kim H S Eykholt R Salas J D | | 0，，1： | 2 |
| 4 | Nonlinear dynamics, delay times, and embedding windows显示文摘 | Kim H S Eykholt R Salas J D | 1999 | Physica D1999，127，： | 2 |
| 5 | Enhanced Cooperative Absorption and Upconversion in Yb^3+ Doped YAG Nanophosphors显示文摘 | Diaz-Torres L A Rosa E D Salas P | 2005 | Optical Matersials2005，27，： | 1 |
| 6 | Drought occurrence probabilities and risk of dependent hydrologic processes显示文摘 | Chung C Salas J D | 2000 | Journal of Hydrologic Engineering2000，5，3： | 1 |
| 7 | Nonlinear dynamics, delay times, and embedding windows 显示文摘 | Kim H S Eykholt R Salas J D | 1999 | Physics D: Nonlinear Phenomenons1999，127，： | 1 |
| 8 | Nolinear dynamics delay times and embedding windows显示文摘 | KIM H S EYKHOLT R SALAS J D | 1999 | Physica D1999，127，： | 1 |
| 9 | Secondary forest age and tropical forest biomass estimation using thematic mapper imagery显示文摘 | NELSON R F KIMES D S SALAS W A | 2000 | Bioscience2000，50，5： | 1 |
| 10 | Effects of the HMG-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthasein vascular endothelial ceils 显示文摘 | HERNANDEZ PERERA O PEREZ SALA D NAVARRO AN- TOLIN J | 1998 | J Clin Invest1998，101，： | 1 |
| 11 | Superoxide production by marine microalgae 显示文摘 | MARSHALL J A SALAS M D ODA T | 2005 | Marine Biology2005，147，： | 1 |
| 12 | Effects of iron on extracellular and intracellular growth of Penicillium marneffei 显示文摘 | Taramelli D Brambilla S Sala G | 2000 | Infect Immun2000，68，3： | 1 |
| 13 | Multiple genetic and epigenetic in-teracting mechanisms contribute to clonally selection of drug-re-sistant tumors:current views and new therapeutic prospective显示文摘 | Roberti A La Sala D Cinti C | 2006 | J Cell Physiol2006，207，3： | 1 |
| 14 | Double - blind, placebo - controlled trial comparing effects of supplementation with two different combinations of micronutrients delivered as sprinkles on growth, anemia, and iron deficiency in Cambodian infants 显示文摘 | Giovannini M Sala D Usuelli M | 2006 | J Pediatr Gastroenterol Nutr2006，42，3： | 1 |
| 15 | Reliability of neurophysiological monitoring of the lumbosacral nervous system during tethered cord release显示文摘 | Chang D Krzan M | 2000 | Childs Nerv Syst2000，16，： | 1 |
| 16 | Nonlinear dynamics,delay times,and embedding windows显示文摘 | KIM H S EYKHOLT R SALAS J D | 1999 | Physica D(S0167-2789)1999，127，： | 1 |
| 17 | Prevalence of tem-poromandibular joint disk displacement in infants andyoung children显示文摘 | Paesani D Salas E Martinez A | 1999 | Oral Surg Oral Med Oral Pathol OralRadiol Endod1999，87，1： | 1 |
| 18 | Factors influencing carbon fixation and water use by mediterranean sclerophyll during summer drought 显示文摘 | TENHUNEN J D SERRA SALA A HARLEY P C | 1990 | Oecologia1990，82，： | 1 |
| 19 | Characterizing the severity and risk of drought in the Poudre River显示文摘 | Salas J D Chongjin F Cancelliere A | 2005 | Journal of Water Resources Planning and Management2005，131，5： | 1 |
| 20 | Protein S defidency: a database of mutations-summary of the first upclate显示文摘 | Gandrille S Borgel D Sala N | 2000 | Thromb Haemost2000，84，5： | 1 |
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