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| 1 | Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E显示文摘AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype.METHODS: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct sequencing.RESULTS: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/E.The comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.CONCLUSION: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E. | Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
| 2 | Exercise regulates Akt and glycogen synthase kinase-3 activities in human skeletal muscle显示文摘 | Sakamoto K Amolds D E Ekberg I | 2004 | Biochem Biophys Res Commun2004，319，2： | 1 |
| 3 | Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo 显示文摘 | Hisatomi T Sakamoto T Murata T Yamanaka I Oshima Y Hata Y | 2001 | Am J Pathol2001，158，4： | 1 |
| 4 | Difficulty of the differential diagnosis of basal cell adenoma and basal cell adenocarcinoma of parotid gland by magnetic resonance imaging: case reports and literature review显示文摘 | Kojima I Sakamoto M Watanabe M | 2012 | Oral Radiology2012，28，1： | 1 |
| 5 | Indocyanine green-assisted peeling of the epiretinal membrane in proliferative vitreoretinopathy显示文摘 | Sakamoto H Yamanaka I Kubota T | | 0，，： | 1 |
| 6 | Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formation显示文摘 | MATSUDA K I SAKAMOTO H MORI H | 2008 | Neuroscience Letters2008，441，1： | 1 |
| 7 | Characterization of genetic divergence among species with in the genus Fasciola by PCR-SSCP 显示文摘 | Itagaki T Tsutsumi K I Sakamoto T | 1995 | Japanese Journal of Parasitology1995，44，3： | 1 |
| 8 | Xanthone glucosides of Swertia japonica Makino and a related plant:structure of a new glucoside,isoswertianolin and structure revision of swertianolin and norswertianolin显示文摘 | Sakamoto I Tanaka T Tanaka O | 1982 | Chem Pharm Bull1982，30，11： | 1 |
| 9 | Penetrating atherosclerotic ulcer of the aorta:imaging features and disease concept显示文摘 | Hayashi H Matsuoka Y Sakamoto I | 2000 | Radio Graphics2000，20，4： | 1 |
| 10 | Serum sialic acid concentration and atherosclerotic risk factors显示文摘 | Sakamoto K Yoshimoto S | 1994 | J Atheroscler Thromb1994，1，2： | 1 |
| 11 | Ionic and os- motic effects of NaCl-induced inactivation of photosystemsⅠand Ⅱ in Synechococcus sp 显示文摘 | Allakaberdiev S I Sakamoto A Nishiyama Y | 2000 | Plant Physiology2000，123，3： | 1 |
| 12 | 显示文摘 | Takeda M Sakamoto J I Imai Y | 1999 | Composites Science and Technology1999，59，： | 1 |
| 13 | Chlorella strains from hot springs tolerant to high temperature and high CO2显示文摘 | Sakamoto Y Kishimoto N Chihara M Karube I | 1995 | Energy Convers Mgmt1995，36，： | 1 |
| 14 | Evidence that reactive oxygen species do not mediate NF-kappa B activation显示文摘 | Hayakawa M Miyashita H Sakamoto I | 2003 | EMBO J2003，22，： | 1 |
| 15 | Cine-magnetic resonance imaging of Cor triatriatum显示文摘 | Sakamoto I Matsunaga N Hayashi K | 1994 | Chest1994，106，5： | 1 |
| 16 | New technique for medial canthoplasty that incorporates modified v-w epicanthoplasty显示文摘 | Sakamoto Y Nakajima H Tamada I | 2012 | Arch Facial Plast Surg2012，14，1： | 1 |
| 17 | Visceral and peripheral arterial pseudoaneurysms显示文摘 | Sueyoshi E Sakamoto I Nakashima K | 2005 | Am J Roentgenol2005，185，3： | 1 |
| 18 | Complications associated with tran-scatheter arterial embolization for hepatic tumors显示文摘 | Aso N Nagaoki K | 1998 | Radingraphics1998，18，3： | 1 |
| 19 | Analysis of generating motion for five axis machining centers显示文摘 | SAKAMOTO S INASAKI I | 1993 | Transactions of the Japan Society of Mechanical Engineers1993，59，561： | 1 |
| 20 | Penatrating atherosclerosic ulcer of the aorta:imaing features and disease concept显示文摘 | Hayashi H Matsuoka Y Sakamoto I | 2000 | Radiographics2000，20，4： | 1 |
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