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| 1 | Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus(Linn) F.Muell in streptozotocin—induced diabetic rats显示文摘Objective:To evaluate antidiabetic and antioxidant potential of Hybanthus enneaspermus in different models.Methods:The oral glucose tolerance test(OGTT) and normoglycemic effect of alcoholic extract of Hybanthus enneaspermus(AHE) were evaluated at a dose of 125,250 and 500mg/kg p.o.while hypoglycemic activity and effect on body weight were tested at 250 and 500 mg/kg p.o.per day for 21 days in Streptozotocin(STZ) induced diabetic rats.Further,glucose uptake by hemidiaphram was also evaluated.The total polyphenolic and flavonoid were determined and their correlation with various antioxidant assays was also determined.Results:The results showed high level of phenolic content in AHE.AHE also exhibited higher total antioxidant capacity,good reducing power and a significant scavenger of reactive oxygen species like DPPH radical,nitric oxide,hydrogen peroxide and deoxyribose.Furthermore there was a significant increase in the body weight and decrease in the blood glucose level on treatment with the AHE.AHE increased glucose uptake on isolated rat hemi-diaphragm compared to control group.Conclusions:AHE reduce blood glucose level in STZ-induced diabetic model.It does not show significant effect in normoglycemic study but showes significant effect in OGT.AHE has significant antioxidant activity,which may be attributed to high phenolic content. | Patel DK Kumar R Prasad SK Sairam K Hemalatha S | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 22 |
| 2 | 雌激素减少与代谢综合征关系的实验研究显示文摘目的:探讨雌激素减少与代谢综合征的相关性。方法:在基因库中搜索已知的对脂肪组织有影响的10个基因,筛选其启动子中可能存在的雌激素调控因子的基因。以不同月龄、不同基因型的卵泡刺激素受体敲除(FORKO)雌鼠为动物模型,测量其腹内白色脂肪组织(WAT)重量、体重,计算腹内WAT与体重的比率;口服葡萄糖(2g/kg),测快速血糖(0,30,60,120min)行葡萄糖耐量实验;用组织学方法观察脂肪细胞、肝脏细胞的形态;用放射免疫法测定血清瘦素。结杲:①在7个肥胖相关基因中找到了可能的雌激素调控位点;②FORKO雌鼠于3月龄时出现肥胖,腹内WAT的重量明显高于野生型(P〈0.05);③FORKO雌鼠随月龄的增长葡萄糖耐量逐渐减低(P〈0.05);④FORKO雌鼠腹内WAT细胞在3月龄时体积较小,表现为增生(P〈0.05),而在8个月时表现为肥大(P〈0.05);⑤FORKO雌鼠于8月龄时WAT细胞、棕色脂肪(BAT)细胞及肝细胞内均有大量脂酯颗粒堆积;⑥月龄3~5个月的FORKO雌鼠空腹的血清瘦素水平均明显高于野生雌鼠(P〈0.05)。结论:FORKO雌鼠因雌激素减少而表现出腹型肥胖、高血糖、高瘦素和胰岛素抵抗等代谢紊乱,提示雌激素减少可导致代谢综合征。 | 王敏 王磊 任续功 单祥鸣 吴丽娜 吕春梅 袁广梅 M.Ram Sairam Natalia Danilovich | 2006 | 山东大学学报(医学版)2006，44，5： | 12 |
| 3 | Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats显示文摘Objective:To investigate antidiabetic potential of alcoholic leaves extract of Alangium lamarekii (A.lamarckii) on streptozotocin-nicotinamide induced type 2 diabetic rats.Methods:Oral glucose tolerance test was done by inducing hyperglycemic state via administration of glucose in water(2 g/kg).Single dose of alcoholic leaves extract of.4.lamarckii(250 and 500 mg/kg,p.o.) were administered to normoglycemic,hyperglycemic rats.Type 2 diabetes was induced by single intraperitoneal injection of nicotinamide(110 mg/kg) followed by streptozotocin(65 mg/kg).The study also included estimations of blood plasma glucose,lipid profile,liver glycogen,body weight and antioxidant status in normal and diabetic rats.Results:Admistration of alcoholic extract of A.lamarekii at two dosage 250 and 500 rag/kg,p.o.did not showed any significant change in blood glucose level of normoglycemic rats(P>0.05).whereas,oral glucose tolerance test depicted reduction in blood glucose level(P<0.05).The streptozotocin-nicotinamide induced diabetic rats, significantly decreased the blood plasma glucose level(P<0.001) comparable to glibenclamide (10 mg/kg),restored the lipid profile and showed improvement in liver glycogen,body weight and antioxidant status in diabetic rats.Conclusions:Present finding demonstrated the significant antidiabetic activity of alcoholic leaves extract of.4.lamarekii. | Rajesh Kumar Dinesh Kumar Pate Satyendra Kuldip Prasad Kirshnamurthy Sairam Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 8 |
| 4 | Inhibitory effect of two Indian medicinal plants on aldose reductase of rat lens in vitro显示文摘Objective:To assesse the inhibitor) effect of alcoholic extract of two Indian medicinal plants namely Ceasalpinia digyna Rottler and.Alangium lamarckii Thwaits on aldose reductase(AR) of rat lens.Methods:Rats lens were enucleated through posterior approach and their homogenate was prepared and centrifuged to obtain a clear supernatant for the determination of AR activity and protein content.Results:The alcoholic extract of Ceasalpirda digyna and Alangium lamarckii had a potent inhibitory effect on the lens AR enzyme.The IC50 values of alcoholic extract of the selected plants were calculated and were(46.29±11.17) and(106.00±5.11)μg/mL,respectively. Quercetin was used as a positive control and its IC50 value was(2.95±1.53)μg/mL.Conclusions:Thus,it is concluded that alcoholic extracts of the selected plant exhibit significant inhibitory effects on AR in the rat lens in vitro. | Rajesh Kumar Dinesh Kumar Patel Damiki Laloo Krishnamurthy Sairam Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 4 |
| 5 | Hybridization between salt resistant and salt susceptible genotypes of mungbean(Vigna radiata L.Wilczek)and purity testing of the hybrids using SSRs markers显示文摘Six cultivated and two wild genotypes of mungbean(Vigna radiata L. Wilczek) possessing variation for phenotypic and genotypic response for salt tolerance were hybridized. Hybridization results showed successful pod set and significant variations in cross-compatibility of investigated genotypes. Genotypes PLM 380 and PLM 562 showed promising combining ability with all genotypes. Results revealed significant crossing compatibility between V. radiata and V. sublobata. The cross ability ranged from 1.99 to 5.12%(average 3.08%). Molecular analysis confirmed the hybrids purity. All F_1 seeds were bold, green/shiny green and germinated between 3 to 5 days. Hybrid plants were normal, fertile and healthier over their respective progenitors. Uniform flowering and maturity of the hybrids showed absence of any defect or alteration in plant habit and life cycle of the hybrids. The hybrid plants showed increase in yield characteristics as no. of pods, pod length, 100 seeds weight, and yield per plant. Number of pods containing F_2 seeds ranged from 5–8 per cluster. The F_2 seeds were collected and stored for further research. Present study suggests that salt resistant wild relatives or cultivars of mungbean can be explored by breeding as a source of useful traits/genes providing salt tolerance. This may help in development of best mungbean variety for saline prone areas. Micro-satellite markers linked to the trait/genes may assist breeding by early selection of the genotypes compared to the phenotypic screening. | Sehrawat Nirmala Yadav Mukesh Bhat Kangila Venkataraman Sairam Raj Kumar Jaiwal Pawan Kumar | 2016 | Journal of Integrative Agriculture2016，15，3： | 3 |
| 6 | Differences in antioxidant activity in response to salinity stress in tolerant and susceptible wheat genotypes显示文摘 | R. K. Sairam G. C. Srivastava S. Agarwal R. C. Meena | 2005 | Biologia Plantarum2005，，1： | 2 |
| 7 | Differential response of wheat genotypes to long term salinity stress in relation to oxidative stress, antioxidant activity and osmolyte concentration显示文摘 | Sairam R K Rao K V Srivastava G C | 2002 | Plant Science2002，163，： | 1 |
| 8 | Thermal, viscoelastic, solution and membrane properties of sodium alginate/hydroxyethylcellulose blends显示文摘 | Naidu B V K Sairam M Raju K V S N | 2005 | Carbohydrate Polymers2005，61，1： | 1 |
| 9 | Role of ABA, salicylic acid,Calcium and hydrogen peroxide on antioxidant enzymes induction in wheat seedlings显示文摘 | AGARWAL S SAIRAM R K SRIVASTAVA G C | 2005 | Plant Sci- ence2005，169，3： | 1 |
| 10 | Oxidative stress and antioxidant activity as the basis of senescence in maize leaves显示文摘 | Dagmar P Sairam R K Srivastava G C | 2001 | Plant Science2001，161，： | 1 |
| 11 | Oxidative stress and antioxidative system in plants 显示文摘 | Arora A Sairam R K Srivastava G C | 2002 | Current Science India2002，82，10： | 1 |
| 12 | Oxidative stress and antioxi-dants in wheat genotypes : Possible mechanism of water stresstolerance 显示文摘 | SAIRAM R Kf SAXENA D C | 2002 | Journal of Agronomy and Crop Science2002，184，1： | 1 |
| 13 | Oxidative stress and antioxidant activity as the basis of senescence in maize leaves 显示文摘 | Prochazkova D Sairam R K Srivastava G C | 2001 | Plant Sci2001，161，： | 1 |
| 14 | Case report; paravesical suture granuloma resembling bladder carcinoma on CT scanning显示文摘 | Carroll KM Sairam K Olliff SP | 1996 | Br J Radiol1996，69，821： | 1 |
| 15 | Novel dense poly(vinyl alcohol)-TiO2 mixed matrix membranes for pervaporation separation of water-isopropanol mixtures at 30 ℃显示文摘 | Sairam M Patil M B Veerapur R S | 2006 | J Membr Sci2006，281，12： | 1 |
| 16 | Changes in activities of antioxidant enzymes in sunflower leaves of different age显示文摘 | Sairam R K Singh D V Srivastava G C | 2003 | Biol Plant2003，47，1： | 1 |
| 17 | Characterization of the 5' flanking region and potential control elements of the ovinefollitropin receptor gene显示文摘 | Sairam M R and Subbarayan V S | 1997 | Molecular Reproduction and Devlopment1997，48，4： | 1 |
| 18 | Effects of homobrassinolide application on plant metabolism and grain yield under irrigated and moisture-stress conditions of two wheat varieties显示文摘 | SAIRAM R K | 1994 | Plant Growth Regul1994，14，2： | 1 |
| 19 | A study on the effect of genotypes, plant growth regulators and sugars in promoting plant regeneration via organogenesis from soybean cotyledonary nodao callus显示文摘 | Sairam R V Franklin G Hassel R | 2003 | Plant cell tissue organ cult2003，75，1： | 1 |
| 20 | Changes in antioxidant activity in sub cellular fractions of tolerant and susceptible wheat genotypes in re- sponse to long-term salt stress显示文摘 | Sairam R K Srivastava G C | 2002 | Plant Science2002，162，6： | 1 |
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