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| 1 | Portal hypertension: Imaging of portosystemic collateral pathways and associated image-guided therapy显示文摘Portal hypertension is a common clinical syndrome, defined by a pathologic increase in the portal venous pressure. Increased resistance to portal blood flow, the primary factor in the pathophysiology of portal hypertension, is in part due to morphological changes occurring in chronic liver diseases. This results in rerouting of blood flow away from the liver through collateral pathways to low-pressure systemic veins. Through a variety of computed tomographic, sonographic, magnetic resonance imaging and angiographic examples, this article discusses the appearances and prevalence of both common and less common portosystemic collateral channels in the thorax and abdomen. A brief overview of established interventional radiologic techniques for treatment of portal hypertension will also be provided. Awareness of the various imaging manifestations of portal hypertension can be helpful for assessing overall prognosis and planning proper management. | Murad Feroz Bandali Anirudh Mirakhur Edward Wolfgang Lee Mollie Clarke Ferris David James Sadler Robin Ritchie Gray Jason Kam Wong | 2017 | World Journal of Gastroenterology2017，23，10： | 14 |
| 2 | β-酪蛋白与婴幼儿生长和发育显示文摘母乳是婴幼儿的首选营养源。世界卫生组织(WHO)建议婴儿出生后头6个月应完全以母乳喂养。此外,应坚持母乳辅以适当的固体食物喂养至少两年[1]。然而,并非所有婴儿均可得到母乳喂养,一些婴儿也无法获得捐赠母乳。在这种情况下需要用婴幼儿配方奶代替母乳。牛奶含有相对价廉的蛋白质与营养素且来源丰富,因此大多数婴幼儿配方奶均产自牛奶。但是,牛奶与母乳的蛋白质成分差异颇大。如,母乳主要含乳清蛋白,酪蛋白∶乳清蛋白约为40∶60(泌乳早期10∶90,泌乳后期50∶50),而牛奶的酪蛋白∶乳清蛋白则高达80∶20[2]。 | Michele J. Sadler Nicholas Smith | 2014 | 临床儿科杂志2014，32，2： | 7 |
| 3 | 1,10-邻菲啉衍生物钌配合物的合成、表征及与DNA和BSA的相互作用显示文摘通过2-(4-吡啶)-咪唑[4,5-f]-1,10-邻菲啉(L_1)与[Ru(η~6-cymene)(μ-Cl) Cl]_2反应合成了3种新型芳基钌配合物,并利用新配体2-(4-咪唑基苯基)咪唑[4,5-f]-1,10-邻菲啉(L_2)与RuCl_3反应合成了配合物4.利用核磁共振波谱、质谱等对配合物进行了表征.通过紫外光谱和圆二色谱研究了配合物在缓冲溶液中的稳定性及与CT-DNA的相互作用,利用荧光光谱研究了配合物与牛血清蛋白的作用,用乌氏黏度计测试了配合物对DNA黏度的影响,并通过荧光光谱、凝胶电泳研究了配合物4在不同pH条件下的荧光响应及与pBR322 DNA的作用.结果表明,配合物通过嵌入的方式与DNA作用,并对DNA的二级结构产生影响;配合物1~4均可与牛血清蛋白的一个位点发生相互作用并使其发生静态荧光猝灭.配合物4在光照条件下有活性氧生成,可以使pBR322 DNA断裂并在酸性溶液中荧光增强. | 赵雅晨 李季 张培培 刘姝娴 魏代娜 苏志 钱勇 王飞利 Peter John Sadler 刘红科 | 2019 | 高等学校化学学报2019，40，1： | 4 |
| 4 | 1H nuclear magnetic resonance spectroscopy-basedmetabonomic study in patients with cirrhosis and hepaticencephalopathy显示文摘AIM: To identify plasma metabolites used as biomarkers in order to distinguish cirrhotics from controls and encephalopathics.METHODS: A clinical study involving stable cirrhotic patients with and without overt hepatic encephalopathy was designed. A control group of healthy volunteers was used. Plasma from those patients was analysed using 1H- nuclear magnetic resonance spectroscopy. We used the Carr Purcell Meiboom Gill sequence to process the sample spectra at ambient probe temperature. We used a gated secondary irradiation field for water signal suppression. Samples were calibrated and referenced using the sodium trimethyl silyl propionate peak at 0.00 ppm. For each sample 128 transients(FID's) were acquired into 32 K complex data points over a spectral width of 6 KHz. 30 degree pulses were applied with an acquisition time of 4.0 s in order to achieve better resolution, followed by a recovery delay of 12 s, to allow for complete relaxation and recovery of the magnetisation. A metabolic profile was created for stable cirrhotic patients without signs of overt hepatic encephalopathy and encephalopathic patients as well as healthy controls. Stepwise discriminant analysis was then used and discriminant factors were created to differentiate between the three groups.RESULTS: Eighteen stabled cirrhotic patients, eighteen patients with overt hepatic encephalopathy and seventeen healthy volunteers were recruited. Patients with cirrhosis had significantly impaired ketone body metabolism, urea synthesis and gluconeogenesis. This was demonstrated by higher concentrations of acetoacetate(0.23 ± 0.02 vs 0.05 ± 0.00, P < 0.01), and b-hydroxybutarate(0.58 ± 0.14 vs 0.08 ± 0.00, P < 0.01), lower concentrations of glutamine(0.44 ± 0.08 vs 0.63 ± 0.03, P < 0.05), histidine(0.16 ± 0.01 vs 0.36 ± 0.04, P < 0.01) and arginine(0.08 ± 0.01 vs 0.14 ± 0.02, P < 0.03) and higher concentrations of glutamate(1.36 ± 0.25 vs 0.58 ± 0.04, P < 0.01), lactate(1.53 ± 0.11 vs 0.42 ± 0.05, P < 0.01), pyruvate(0.11 ± 0.02 vs 0.03 ± 0.00, P < 0.01) threonine(0.39 ± 0.02 vs 0.08 ± 0.01, P < 0.01) and aspartate(0.37 ± 0.03 vs 0.03 ± 0.01). A five metabolite signature by stepwise discriminant analysis could separate between controls and cirrhotic patients with an accuracy of 98%. In patients with encephalopathy we observed further derangement of ketone body metabolism, impaired production of glycerol and myoinositol, reversal of Fischer's ratio and impaired glutamine production as demonstrated by lower b-hydroxybutyrate(0.58 ± 0.14 vs 0.16 ± 0.02, P < 0.0002), higher acetoacetate(0.23 ± 0.02 vs 0.41 ± 0.16, P < 0.05), leucine(0.33 ± 0.02 vs 0.49 ± 0.05, P < 0.005) and isoleucine(0.12 ± 0.02 vs 0.27 ± 0.02, P < 0.0004) and lower glutamine(0.44 ± 0.08 vs 0.36 ± 0.04, P < 0.013), glycerol(0.53 ± 0.03 vs 0.19 ± 0.02, P < 0.000) and myoinositol(0.36 ± 0.04 vs 0.18 ± 0.02, P < 0.010) concentrations. A four metabolite signature by stepwise discriminant analysis could separate between encephalopathic and cirrhotic patients with an accuracy of 87%.CONCLUSION: Patients with cirrhosis and patients with hepatic encephalopathy exhibit distinct metabolic abnormalities and the use of metabonomics can select biomarkers for these diseases. | Konstantinos John Dabos John Andrew Parkinson Ian Howard Sadler John Nicholas Plevris Peter Clive Hayes | 2015 | World Journal of Hepatology2015，7，12： | 3 |
| 5 | Formative assessment and the design of instructional systems显示文摘 | D. Royce Sadler | 1989 | Instructional Science1989，，2： | 3 |
| 6 | Micromachined spiral inductor using UV-LIGA techniaues显示文摘 | Sadler DJ | 2001 | IEEE Transactions2001，37，4： | 2 |
| 7 | Phase Ⅰ/Ⅱ trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma显示文摘 | Berenson JR Yang HH Sadler K | | 0，，： | 2 |
| 8 | Fine-tuning of the innate immune response by microRNAs显示文摘 | Gantier M P Sadler A J Williams B R | 2007 | lmmunol Cell Biol2007，，6： | 1 |
| 9 | Micromachined semi-encapsulaed spiral inductors for MEMS applications 显示文摘 | ZHANG W AHN C H | 1997 | IEEE Transactions on Magnetics1997，33，5： | 1 |
| 10 | A Survey of Dynamic Spectrum Access显示文摘 | ZHAO Qing SADLER Brian M | 2007 | Signal Processing Magazine IEEE2007，24，03： | 1 |
| 11 | Metabolism,disposition and excretion of melamine in male Fischer 344 rats 显示文摘 | Mast R W Jeffcoat A R Sadler B M | 1983 | Food Chem Toxicol1983，21，6： | 1 |
| 12 | Oxidation of biological substrates by chromium(Ⅵ) part1 mechanism of the oxidation of L-Ascorbic acid in aqueous solution显示文摘 | DIXON D A SADLER N P DASGUPTU T P | 1993 | J Chem Soc Dolton Trans1993，，23： | 1 |
| 13 | Mechanisms of floc destruction during anaerobic and aerobic digestion and the effect on conditioning and dewatering of biosolids 显示文摘 | John T Novak Mary E Sadler | 2003 | Water Res2003，37，13： | 1 |
| 14 | Hierarchical digital modulation classification using cumulants 显示文摘 | Swami A Sadler B M | 2000 | IEEE Trans on communication (S0090-6778)2000，48，3： | 1 |
| 15 | Metabolism, dis position and excretion of melamine in male Fischer 344 rats显示文摘 | Mast R W Jeffcoat A R Sadler B M etal | 1983 | FoodChemToxicol1983，21，6： | 1 |
| 16 | The 2009 Proposed Rule for Prospective ESRD Payment: Perspectives from a Not- for-profit Small Dialysis Organization 显示文摘 | Sadler J | 2010 | American Journal of Kidney Disease2010，55，2： | 1 |
| 17 | Mechanisms of neural tube closure and defects显示文摘 | Sadler TW | 1998 | Merit Retard Dev Disabil Res Rev1998，4，： | 1 |
| 18 | Cerebral asymmetries in inspection time? 显示文摘 | Sadler A J Deary I J | 1996 | Neuropsychologia1996，34，4： | 1 |
| 19 | Hierarchical Digital Modulation Classification Using Cumulants 显示文摘 | Swami A Sadler B M | 2000 | IEEE Transactions on Communications2000，48，03： | 1 |
| 20 | A survey of dynamic spectrum access显示文摘 | Zhao Qing Sadler B M | 2007 | IEEE Signal Processing Magazine2007，24，3： | 1 |
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