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136篇 您的检索式:作者名="SABAPATHY"
    题名 作者 年代 出处 被引量
1Understanding p53 functions through p53 antibodies显示文摘TP53 is the most frequently mutated gene across all cancer types. Our understanding of its functions has evolved since its discovery four decades ago. Initially thought to be an oncogene, it was later realized to be a critical tumour suppressor. A significant amount of our knowledge about p53 functions have come from the use of antibodies against its various forms. The early anti-p53 antibodies contributed to the recognition of p53 accumulation as a common feature of cancer cells and to our understanding of p53 DNA-binding and transcription activities. They led to the concept that conformational changes can facilitate p53’s activity as a growth inhibitory protein. The ensuing p53 conformational-specific antibodies further underlined p53’s conformational flexibility, collectively forming the basis for current efforts to generate therapeutic molecules capable of altering the conformation of mutant p53. A subsequent barrage of antibodies against post-translational modifications on p53 has clarified p53’s roles further, especially with respect to the mechanistic details and context-dependence of its activity. More recently, the generation of p53 mutation-specific antibodies have highlighted the possibility to go beyond the general framework of our comprehension of mutant p53-and promises to provide insights into the specific properties of individual p53 mutants. This review summarizes our current knowledge of p53 functions derived through the major classes of anti-p53 antibodies, which could be a paradigm for understanding other molecular events in health and disease.Kanaga Sabapathy David P.Lane 2019Journal of Molecular Cell Biology2019,11,4:15
2Reconstruction of finger tip amputations with advan- cement flap and free nail bed graft 显示文摘Raja sabapathy S Yenkatramani H Bharathi R 2002J Hand Surg Br2002,27,2:1
3The Prediction of Burn - through during In - service Welding of Gas Pipelines 显示文摘Sabapathy P N Wahab M A Painter M J 2000International Journal of Pressure Vessels and Piping2000,77,11:1
4Role of the JNK pathway in human diseases显示文摘Sabapathy K 2012Prog Mol Biol Transl Sci2012,106,:1
5Functional and edible uses of soy protein products显示文摘Singh P Kumar R Sabapathy S N 2008Comprehensive Reviews in Food Science and Food Safety2008,7,1:1
6The prediction of burn-through during in-service welding of gas pipelines显示文摘Sabapathy P N Wahab M A Painter M J 2000International Journal of Pressure Vessels and Piping2000,77,11:1
7Characterization of chemically treated bacterial (acetobacter xylinum)biopolymer: Some thermo-mechanical properties 显示文摘George J Ramana K V Sabapathy S N 2005Jntemational Journal of Biological Macromolecules2005,37,4:1
8Analytical and Experimental Studies on Fatigue Life Predic- tion of Steel and Composite Multi - leaf Spring for Light Passenger Ve- hicles Using Life Data Analysis显示文摘Mouleeswaran SENTHIL KUMAR Sabapathy VIJAYAR ANGAN 2007Materials Science2007,13,2:1
9Trp53-dependent DNA-repair is affected by the codon 72 polymorphism显示文摘SiddiqueM Sabapathy K 2006Oncogene2006,25,25:1
10Characterization of chemically treated bacterial (Acetobacter xylinum) biopolymer: Some thermo-meehanieal properties 显示文摘George J Ramana K V Sabapathy S N 2005International Journal of Biological Macromolecules2005,37,:1
11Reconstruction of the thumb amputation at the carpometacarpal joint level by groin flap and second toe transfer显示文摘Sabapathy SR Venkatramani H Bhardwaj P 2013Injury2013,44,3:1
12Characterization of chemically treated bacterial (Acetobacter xylinum) biopolymer:Some thermo-mechanical properties显示文摘George J Ramana K V Sabapathy S N 2005Int er J Biolog Macromol2005,37,4:1
13Secondary proeedures in replantation显示文摘Sabapathy SR Bhardwaj P 2013Semin Plast Surg2013,27,4:1
14eplantation显示文摘Sabapathy SR 2013Semin Plast Surg2013,27,4:1
15The Prediction of Bum-through During In-service Welding of Gas Pipelines 显示文摘SABAPATHY P N WAHAB M A PAINTER M J 2002International Journal of Pressure Ves- sels and Piping2002,,79:1
16The Prediction of Bum - through During In - service Welding of Gas Pipelines 显示文摘Sabapathy PN Wahab MA Painter MJ 2000Int J Pressure Vessels and Piping2000,77,:1
17An apoptotic signaling pathway in the interferon antiviral response mediated by RNase L and c-Jun NH2-terminal kinase 显示文摘Li G Xiang Y Sabapathy K 2004J Biol Chem2004,279,2:1
18Comparison of the roles of serratiopeptidase and dexamethasone in the control of inflammation and trismus following impacted third molar surgery 显示文摘Murugesan K Sreekumar K Sabapathy B 2012Indian J Dent Res2012,23,6:1
19Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2 显示文摘SABAPATHY K JOCHUM W HOCHEDINGER K 1999Mech Dev1999,89,:1
20Numerical Methods to Predict Failure During the In-service Welding of Gas Pipelines 显示文摘SABAPATHY P N WAHAB M A PAINTER M J 2001Journal of Strain Analysis2001,36,6:1
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