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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | CDX2 as a marker for intestinal differentiation: Its utility and limitations显示文摘CDX2 is a nuclear homeobox transcription factor that belongs to the caudalrelated family of CDX homeobox genes. The gene encoding CDX2 is a nonclustered hexapeptide located on chromosome 13q12-13. Homeobox genes play an essential role in the control of normal embryonic development. CDX2 is crucial for axial patterning of the alimentary tract during embryonic development and is involved in the processes of intestinal cell proliferation, differentiation, adhesion, and apoptosis. It is considered specif ic for enterocytes and has been used for the diagnosis of primary and metastatic colorectal adenocarcinoma. CDX2 expression has been reported to be organ specif ic and is normally expressed throughout embryonic and postnatal life within the nuclei of epithelial cells of the alimentary tract from the proximal duodenum to the distal rectum. In this review, the authors elaborate on the diagnostic utility of CDX2 in gastrointestinal tumors and other neoplasms with intestinal differentiation. Limitations with its use as the sole predictor of a gastrointestinal origin of metastatic carcinomas are also discussed. | Reda S Saad Zeina Ghorab Mahmoud A Khalifa | 2011 | World Journal of Gastrointestinal Surgery2011，3，11： | 11 |
| 3 | 腹腔镜治疗多囊卵巢综合征显示文摘 | Saad A K Amer TC Li 杨硕(翻译) 马彩虹(审校) | 2010 | 中国微创外科杂志2010，10，3： | 6 |
| 4 | Endoscopic ultrasound guided drainage of pancreatic fluid collections: Assessment of the procedure, technical details and review of the literature显示文摘Endoscopic ultrasound(EUS) guided drainage of pancreatic fluid collections(PFC) has become increasingly popular and become first line management option in many centers. Use of therapeutic echoendoscopes has greatly increased the applicability of EUS guided transmural drainage. Drainage is indicated in symptomatic PFCs, PFC related infection, bleed, luminal obstruction, fistulization and biliary obstruction. EUS guided transmural drainage of PFCs is preferred in patients with non bulging lesions, portal hypertension, bleeding tendency and in those whom conventional drainage has failed. In the present decade significant progress has been made in minimally invasive endoscopic techniques. There are newer stent designs, access devices and techniques for more efficient drainage of PFCs. In this review, we discuss the EUS guided drainage of PFCs in acute pancreatitis. | Rajesh Puri Ragesh Babu Thandassery Abdulrahman A Alfadda Saad Al Kaabi | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，4： | 5 |
| 5 | Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma显示文摘AIM:To investigate cell cycle proteins in chronic hepatitis C virus infection in order to analyze their role in the process of hepatocyte transformation and to characterize their prognostic properties. METHODS:Subjects of the current study included 50 cases of chronic hepatitis C(CHC) without cirrhosis,30 cases of CHC with liver cirrhosis(LC) ,and 30 cases of hepatitis C-related hepatocellular carcinoma(HCC) admitted to the Department of Hepato-Gastroenterology,Theodor Bilharz Research Institute(TBRI) ,Giza,Egypt.Fifteen wedge liver biopsies,taken during laparoscopic cholecystectomy,were also included as normal controls.Laboratory investigations including urine and stool analysis,liver function tests and prothrombin concentration;serologic markers for viral hepatitis and ultrasonography were done for all cases of the study together with immunohistochemical analysis using primary antibodies against Cyclin D1,Cyclin E,p21,p27 and Rb/p105 proteins. RESULTS:Normal wedge liver biopsies didn't express Cyclin E or Rb/p105 immunostaining but show positive staining for Cyclin D1,p21 and p27.Cyclin D1 expressed nuclear staining that was sequentially increased from CHC to LC(P<0.01) to HCC(P<0.001) cases;meanwhile,Cyclin E revealed nuclear positivity only in the case of HCCs patients that was directly correlated to Rb/p105 immuno-reactivity.The expression of p21 and p27 was significantly increased in CHC and LC cases compared to normal controls and HCCs with no significant difference between well-and poorlydifferentiated tumors.p21 showed only a nuclear pattern of staining,while,p27 presented with either cytoplasmic and/or nuclear reactivity in all studied cases.Correlation analysis revealed a direct relation between Cyclin D1 and p21 in CHC cases(P<0.001) ,between Cyclin D1 and Cyclin E in HCCs(P<0.01);however,an inverserelationship was detected between Cyclin D1 and p21 or p27(P<0.001) and between p21 and Rb/p105(P<0.05) in HCCs. CONCLUSION:Upregulation of Cyclin D1 in CHC plays a vital role in the development and differentiation of HCC;while,Cyclin E may be a useful marker for monitoring tumor behavior.p21 and p27 can be used as predictive markers for HCC.Furthermore,higher expression of Rb/p105 as well as inverse relation with p21 and histologic grades suggests its important role in hepatic carcinogenesis. | Azza E El Bassiouny Mona M Nosseir Mona K Zoheiry Noha A Ameen Ahmed M Abdel-Hadi Ibrahim M Ibrahim Suher Zada Abdel-Hakeem Saad El-Deen Nora E El-Bassiouni | 2010 | World Journal of Hepatology2010，2，1： | 3 |
| 6 | Visual and refractive outcomes of posterior chamber phakic IOL in stable keratoconus显示文摘We evaluated the visual and refractive outcomes after phakic visian toric implantable collamer lens(ICL) insertion in stable keratoconus(KC). This retrospective study investigated toric ICL implantation in 14 eyes of 8 patients with stable KC. After 6 mo, the mean uncorrected distance visual acuity improved significantly from 0.77 to 0.15 logMAR. The mean best corrected distance visual acuity(BCDVA) improved from 0.18±0.1 to 0.15±0.1 logMAR. Fifty percent of eyes maintained their preoperative BCDVA; 42.8% gained one line. There was no statistical difference in high order or coma aberration. The mean refractive manifest spherical equivalent(MSE), mean refractive manifest spherical error, mean manifest astigmatism decreased significantly postoperatively. At 6 mo postoperatively, our achieved mean spherical equivalent was approximately 74%. No intraoperative or postoperative complications occurred. Toric ICL implantation was effective, predictable and safe to correct refractive error and improve visual acuity in patients with stable KC. | Sherif H Emerah Moataz M Sabry Hisham A Saad Waleed A Ghobashy | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 2 |
| 7 | Malignant struma ovarii: an unusual presentation显示文摘 | Checrallah A Medlej R Saade C | 2001 | Thyroid2001，11，9： | 2 |
| 8 | Towards hepatitis C virus elimination:Egyptian experience,achievements and limitations显示文摘Worldwide, more than one million people die each year from hepatitis C virus(HCV) related diseases, and over 300 million people are chronically infected with hepatitis B or C. Egypt used to be on the top of the countries with heavy HCV burden. Some countries are making advances in elimination of HCV, yet multiple factors preventing progress; remain for the majority. These factors include lack of global funding sources for treatment, late diagnosis, poor data, and inadequate screening. Treatment of HCV in Egypt has become one of the top national priorities since 2007. Egypt started a national treatment program intending to provide cure for Egyptian HCV-infected patients. Mass HCV treatment program had started using Pegylated interferon and ribavirin between 2007 and 2014. Yet, with the development of highly-effective direct acting antivirals(DAAs) for HCV, elimination of viral hepatitis has become a real possibility. The Egyptian National Committee for the Control of Viral Hepatitis did its best to provide Egyptian HCV patients with DAAs. Egypt adopted a strategy that represents a model of care that could help other countries with high HCV prevalence rate in their battle against HCV. This review covers the effects of HCV management in Egyptian real life settings and the outcome of different treatment protocols. Also, it deals with the current and future strategies for HCV prevention and screening as well as the challenges facing HCV elimination and the prospect of future eradication of HCV. | Dalia Omran Mohamed Alboraie Rania A Zayed Mohamed-Naguib Wifi Mervat Naguib Mohamed Eltabbakh Mohamed Abdellah Ahmed Fouad Sherief Sahar Maklad Heba Hamdy Eldemellawy Omar Khalid Saad Doaa Mohamed Khamiss Mohamed El Kassas | 2018 | World Journal of Gastroenterology2018，24，38： | 2 |
| 9 | Dynamic thick restarting of the Davidson, and the implicitly restarted Arnoldi methods 显示文摘 | Stathopoulos A Saad Y Wu K | 1998 | SIAM Journal on Scientific Computing1998，19，1： | 1 |
| 10 | Effect of temperature on physical and mechanical properties of concrete containing silica fume显示文摘 | Saad M Abo-EI-Enein S A | 1996 | Cement and Concrete Research1996，26，5： | 1 |
| 11 | A SiC14-ZnC12 induced general, mild and efficient one-pot, three- component synthesis of fl-amido ketone libraries 显示文摘 | Tarek A Salama Saad S Elmorsy Abdel-Galel M Khalil | 2007 | Tetrahedmn Letters2007，48，： | 1 |
| 12 | Phragmalin limonoids from Chukrasia tabularis 显示文摘 | NAKATANI M ABDELGALEIL S A M SAAD M M G | 2004 | Phytochemistry2004，65，20： | 1 |
| 13 | Molecular tools for discovering the secrets of Diatoms 显示文摘 | Saade A Bowler C | 2009 | Bioscience2009，59，9： | 1 |
| 14 | How to design a fuzzy adaptive controller based on observers for uncertain affine nonlinear systems显示文摘 | Boulkroune A Tadjine M Saad M M | 2008 | Fuzzy Sets and Systems2008，159，8： | 1 |
| 15 | Use of support vector machines for dis- ease risk prediction in genome - wide association studies : Concerns and opportunities显示文摘 | Mittag F Saad M Jahn A | 2012 | Human Mutation2012，33，12： | 1 |
| 16 | A binaphthol-substituted tetrathiafulvalene with axial ehirality and its enantiopure TCNQF4 charge-transfer salts显示文摘 | Saad A Jeannin O Fourmigue M | 2011 | New J Chem2011，35，： | 1 |
| 17 | Hollow fiber liquid-phase microextraction coupled with gas chromatography-flame ionization detection for the profiling of fatty acids in vegetable oils显示文摘 | SIANG G H MAKAHLEH A SAAD B | 2010 | Journal of Chromatography A2010，1217，52： | 1 |
| 18 | Pediocin N5p from Pediococcus pentosaceus:adsorption on bacterial strains 显示文摘 | de Nadra M C M de Lamelas D S de Saad A M S | 1998 | International Journal of Food Microbiology1998，39，： | 1 |
| 19 | Effect of lateral hypothal amus lesions on the water and salt intake, and sodium and urine excretion induced by activation of the median preoptie nucleus in conscious rats 显示文摘 | da Silva R K Saad W A Renzi A | 1995 | J Auton Nerv Syst1995，53，23： | 1 |
| 20 | Expression of alpha-hemoglobin stabilizing protein gene during human erythropoiesis显示文摘 | DOS SANTOS C O DUARTE A S SAAD S T | 2004 | Exp Hematol2004，32，2： | 1 |
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