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| 1 | 北京PM_(2.5)化学物种的质量平衡特征显示文摘以北京 2个采样点连续采集的样品对PM2 5中的元素、水溶性离子和含碳组分进行分析 .车公庄和清华园PM2 5中有机物的含量分别为 2 7 8%和 30 9% ,是含量最丰富的物种 ,其次是二次无机粒子、土壤尘、元素碳和微量元素 .PM2 5中约有 2 4 %的质量未能鉴别成分 ,相关性分析表明 ,含碳物种的估算所引起的偏差可能是主要的原因 .采暖期重污染周和春季沙尘周PM2 5的化学物种构成悬殊 ,反映了季节性变化的源排放和特殊气象条件的综合作用 . | 杨复沫 贺克斌 马永亮 张强 Cadle S H Chan T Mulawa P A | 2004 | 环境化学2004，23，3： | 63 |
| 2 | 基于人工智能干预措施的临床试验方案指南:SPIRIT-AI扩展显示文摘《干预试验方案报告标准》(Standard Protocol Items:Recommendations for Interventional Trials,SPIRIT)2013通过为试验最小条目集的确定提供基于证据的建议,旨在改善临床试验方案报告的完整性。该指南有助于促进新干预措施的透明评估。近年来,人们越来越认识到,涉及人工智能(artificial interlligence,AI)的干预措施需要经过严格的前瞻性临床研究评估,以证明其对健康结局的影响。《人工智能干预试验方案报告标准(Standard Protocol Items:Recommendations for Interventional Trials-Artificial Intelligence,SPIRIT-AI)扩展》是一份新的评估AI干预措施的临床试验方案的报告指南。它与配套的《人工智能试验报告统一标准》(Consolidated Standards of Reporting Trials-Artificial Intelligence,CONSORT-AI)是同步编制的。这两项指南的编制通过分阶段的文献回顾和专家咨询等过程达成共识,产生26项候选条目。由国际多方利益相关小组在两阶段德尔菲调查(103个利益相关者)中对这些条目进行了咨询,并在共识会议上达成一致意见(31个利益相关者),通过34个试点参与进行了改进和优化。SPI RI T-AI扩展包括15项对AI干预的临床试验方案非常重要的新条目。除SPIRIT 2013的核心条目外,这些新条目也应定期报告。SPIRIT-AI建议研究人员提供关于AI干预的清晰描述,包括使用AI所需的说明和操作技能、AI干预集成环境的设置、输入和输出数据处理的注意事项、人-AI交互和错误案例分析。SPI RI T-AI将有助于提高AI干预临床试验方案的透明度和完整性,也有助于编辑、同行评审以及普通读者理解、解释和严格评估临床试验的设计和偏倚风险。 | 熊云云(译) 李子孝(译) 丁玲玲(译) 谷鸿秋(译) 王春娟(译) 王春雪(译) 赵性泉(译) 王拥军(译) CRUZ RIVERA S LIU X CHAN A | 2020 | 中国卒中杂志2020，15，11： | 20 |
| 3 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 4 | 八角莲的愈伤组织和组培根及野生根状茎的鬼臼毒素含量比较研究显示文摘比较研究了峨眉山野生八角莲根、组培愈伤组织及其诱导根的鬼臼毒素含量,为八角莲的快速繁殖和利用生物技术生产鬼臼毒素提供科学依据.高效液相色谱技术(HPLC)显示组织培养的八角莲愈伤组织和诱导根中均含有鬼臼毒素,分别为0.117%和0.148%,野生品的根中其含量为0.600%.通过组织培养可在不破坏自然资源的前提下快速生产鬼臼毒素,从而为开发鬼臼毒素类抗癌药物提供大量原料. | 潘琦 陈绍瑗 姜维梅 Gilbert Y S Chan 傅承新 | 2006 | 浙江大学学报(农业与生命科学版)2006，32，1： | 13 |
| 5 | Potential role of metabolomics in diagnosis and surveillance of gastric cancer显示文摘Gastric cancer is one of the deadliest cancers worldwide, and is especially prevalent in Asian countries. With such high morbidity and mortality, early diagnosis is essential to achieving curative intent treatment and long term survival. Metabolomics is a new field of study that analyzes metabolites from biofluids and tissue samples. While metabolomics is still in its infancy, there are numerous potential applications in oncology, specifically early diagnosis. Only a few studies in the literature have examined metabolomics' role in gastric cancer. Various fatty acid, carbohydrate, nucleic acid, and amino acid metabolites have been identified that distinguish gastric cancer from normal tissue and benign gastric disease. However, findings from these few studies are at times conflicting. Most studies demonstrate some relationship of cancer cells to the Warburg Effect, in that glycolysis predominates with conversion of pyruvate to lactate. This is one of the most consistent findings across the literature. There is less consistency in metabolomic signature with respect to nucleic acids, lipids and amino acids. In spite of this, metabolomics holds some promise for cancer surveillance but further studies are necessary to achieve consistency and validation before it can be widely employed as a clinical tool. | Angela W Chan Richdeep S Gill Daniel Schiller Michael B Sawyer | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 6 | A review on human influenza A H5N1 infections in Hong Kong显示文摘Avian influenza A H5N1 remains the most threatening virus that may cause another devastating pandemic in the foreseeable future. In 1997, Hong Kong was the first place to detect human infections due to this virus originated from birds. The experience and lessons learnt provide important information for controlling further outbreaks caused by avian influenza viruses. | CHAN Paul K S | 2009 | Science China(Life Sciences)2009，52，5： | 7 |
| 7 | 联合应用沙利度胺和脂质体阿霉素治疗复发性卵巢上皮性癌和腹膜癌的初步研究显示文摘目的:评价联合应用沙利度胺与脂质体阿霉素治疗复发性卵巢上皮性癌和腹膜癌的疗效和毒副作用。方法:将9例经手术和术后泰素+卡铂化疗后复发患者纳入本研究。每4周予以脂质体阿霉素30~50mg/m^2化疗,共3~8个疗程;同时每日予以沙利度胺100~300mg,其剂量从100mg/d开始,此后每2周增加50~100mg。通过体检、影像学检查和测定CA125水平评价治疗效果。结果:9例患者的中位年龄为56岁(35~81岁),FIGO分期为ⅢB~Ⅳ期。本次化疗的中位疗程数是6个疗程。中位随访时间为18.5个月。最常见的不良反应为疲劳(55.6%)和神经系统症状(55.6%)。3例患者出现Ⅲ度副反应,1例为无力、1例过敏性皮疹和1例末梢神经感觉异常。根据RECIST标准评价有病灶的6例患者疗效,2例部分缓解,2例治疗中疾病无进展,1例病情进展,1例失访。另有2例CA125升高的患者,在联合化疗3~4个疗程后CA125水平降低50%以上。1例二次肿瘤细胞减灭术后化疗的患者治疗后随访36个月无肿瘤复发迹象。在随访的8例患者中,中位疾病无进展时间为6.5个月(0~36个月);中位总的生存时间为20.5个月(8~36个月)。结论:联合应用沙利度胺与脂质体阿霉素治疗复发性卵巢上皮性癌具有可接受的毒副作用,同时具有一定的治疗效果。 | 郭红燕 Nelson N. Teng John K. Chan Amreen Husain Deirdre Stieglitz Jonathon S Bereck | 2008 | 现代妇产科进展2008，17，2： | 5 |
| 8 | Anti-rods/rings autoantibody generation in hepatitis Cpatients during interferon-α/ribavirin therapy显示文摘Chronic inflammation associated with hepatitis C virus(HCV) infection can lead to disabling liver diseases with progression to liver cirrhosis and hepatocellular carcinoma. Despite the recent availability of more effective and less toxic therapeutic options, in most parts of the world the standard treatment consists of a weekly injection of pegylated interferon α(IFN-α) together with a daily dose of ribavirin. HCV patients frequently present circulating non-organ-specific autoantibodies demonstrating a variety of staining patterns in the indirect immunofluorescence assay for antinuclear antibodies(ANA). Between 20% to 40% of HCV patients treated with IFN-α and ribavirin develop autoantibodies showing a peculiar ANA pattern characterized as rods and rings(RR) structures. The aim of this article is to review the recent reports regarding RR structures and anti-rods/rings(antiRR) autoantibody production by HCV patients after IFN-α/ribavirin treatment. Anti-RR autoantibodies first appear around the sixth month of treatment and reach a plateau around the twelfth month. After treatment completion, anti-RR titers decrease/disappear in half the patients and remain steady in the other half. Some studies have observed a higher frequency of anti-RR antibodies in relapsers, i.e., patients in which circulating virus reappears after initially successful therapy. The main target of anti-RR autoantibodies in HCV patients is inosine-5'-monophosphate dehydrogenase 2(IMPDH2), the rate-limiting enzyme involved in the guanosine triphosphate biosynthesis pathway. Ribavirin is a direct IMPDH2 inhibitor and is able to induce the formation of RR structures in vitro and in vivo. In conclusion, these observations led to the hypothesis that anti-RR autoantibody production is a human model of immunologic tolerance breakdown that allows us to explore the humoral autoimmune response from the beginning of the putative triggering event: exposure to ribavirin and interferon. | Gerson Dierley Keppeke S John Calise Edward KL Chan Luis Eduardo C Andrade | 2016 | World Journal of Gastroenterology2016，22，6： | 4 |
| 9 | Moving Force Identification - Time Domain Method显示文摘 | Law S S Chan T H T Zeng Q H | 1997 | Journal of Sound and Vibration1997，201，1： | 4 |
| 10 | Mutations around interferon sensitivity-determining region:A pilot resistance report of hepatitis C virus 1b in a Hong Kong population显示文摘AIM: To explore mutations around the interferon sensitivity-determining region (ISDR) which are associated with the resistance of hepatitis C virus 1b (HCV-1b) to interferon-α treatment. METHODS: Thirty-seven HCV-1b samples were ob- tained from Hong Kong patients who had completed the combined interferon-α/ribavirin treatment for more than one year with available response data. Nineteen of them were sustained virological responders, while 18 were non-responders. The amino acid sequences of the extended ISDR (eISDR) covering 64 amino acids upstream and 67 amino acids downstream from the previously reported ISDR were analyzed. RESULTS: One amino acid variation (I2268V, P = 0.023) was significantly correlated with treatment outcomein this pilot study with a limited number of patients, while two amino acid variations (R2260H, P = 0.05 and S2278T, P = 0.05) were weakly associated with treatment outcome. The extent of amino acid variations within the ISDR or eISDR was not correlated with treatment outcome as previously reported. CONCLUSION: Three amino acid mutations near but outside of ISDR may associate with interferon treatment resistance of HCV-1b patients in Hong Kong. | Xiao-Ming Zhou Paul KS Chan John S Tam | 2011 | World Journal of Gastroenterology2011，17，48： | 3 |
| 11 | 心脏病及非心脏病患者降低舒张压的效果:收缩压干预试验结果分析显示文摘收缩压和舒张压低于何种阈值时心血管事件增多仍然不明确。应用收缩压干预试验(systolic blood pressure intervention trial,SPRINT)的数据,研究者评估了1519例心血管病患者和7574位非心血管病者的收缩压和舒张压与心血管事件之间的关系。 | 刘青 叶鹏 Khan NA Rabkin SW Zhao Y McAlister FA Park JE Guan M Chan S Humphries KH | 2018 | 中华高血压杂志2018，26，6： | 3 |
| 12 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 13 | A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings显示文摘The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. | LUI Simon S Y SHAM Pak CHAN Raymond C K CHEUNG Eric F C | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 14 | Effect of fiber pretreatment condition on the interfacial strength and mechanical properties of wood fiber/PP composites显示文摘 | Wu J S Yu D M Chan C M | 2000 | J Appl Polym Sci2000，76，7： | 2 |
| 15 | Pointwise equilibrating polynomial element for nonlinear analysis of frames 显示文摘 | Chan S L Zhou H Z | 1994 | J Struct Engng ASCE1994，120，6： | 2 |
| 16 | Soluble E-cadherin is a valid prognostic marker in gastric carcinoma显示文摘 | Chan A O Lam S K Chu K M | 2001 | Gut2001，48，6： | 2 |
| 17 | Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure显示文摘 | Ip M S Lam B Chan L Y | 2000 | Am J Respir Crit Care Med2000，162，6： | 2 |
| 18 | ESD reliability and protection schemes in SOI CMOS output buffers显示文摘 | Chan M S Yuen S S Ma Z J | 1995 | IEEE Trans Elec Dev1995，42，10： | 2 |
| 19 | Weighted essentially nonoscillatory scheme显示文摘 | Liu X D Osher S Chan T | 1994 | J Comput phys1994，115，： | 2 |
| 20 | An overview of energy sources for electric vehicles显示文摘 | Chau K T Wong Y S Chan C C | 1999 | Energy Conversion and Management1999，40，10： | 2 |
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