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| 1 | Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease显示文摘AIM To determine levels of cytokines incolonic mucosa of asymptomatic first degreerelatives of Crohn’s disease patients.METHODS Cytokines(Interleukin(IL)1-Beta,IL-2,IL-5 and IL-8)were measured using ELISAin biopsy samples of normal looking colonicmucosa of first degree relatives of Crohn’sdisease patients(n = 9)and from normalcontrols(n = 10)with no family history ofCrohn’s disease.RESULTS Asymptomatic first degree relativesof patients with Crohn’s disease had significantlyhigher levels of basal intestinal mucosalcytokines(IL-2,IL-5 and IL-8)than normalcontrols.Whether these increased cytokinelevels serve as phenotypic markers for a geneticpredisposition to developing Crohns diseaselater on,or whether they indicate early(pre-clinical)damage has yet to be further defined.CONCLUSION Asymptomatic first degreerelatives of Crohn’s disease patients have higherlevels of cytokines in their normal-lookingintestinal mucosa compared to normal controls,This supports the hypothesis that increasedcytokines may be a cause or an early event inthe inflammatory cascade of Crohns disease andare not merely a result of the inflammatoryprocess. | Indaram AVK Nandi S Weissman S Lam S Bailey B Blumstein M Greenberg R Bank S | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 2 | Global solvability for damped abstract nonlinear hyperbolic systems显示文摘 | BANKS H T GILLIAM D S SHUBOV V I | 1997 | Differential and Integral Equations1997，，10： | 2 |
| 3 | Pathophysiology of severe asthma显示文摘 | Busse WW Banks Schlegel S Wenzel SE | | 0，，： | 2 |
| 4 | Mechanism of lovastatin-induced apotosis in intesnalepithelial cells显示文摘 | Banke Agarwal Balazs Halmos Aleksander S | 2002 | Carcinogenesis2002，23，3： | 2 |
| 5 | Should multi-gene panel testing replace limited BRCA1/2 testing? A review of genetic testing for hereditary breast and ovarian cancers显示文摘Clinical testing of patients for hereditary breast and ovarian cancer syndromes began in the mid-1990s with the identification of the BRCA1 and BRCA2 genes.Since then,mutations in dozens of other genes have been correlated to increased breast,ovarian,and other cancer risk.The following decades of data collection and patient advocacy allowed for improvements in medical,legal,social,and ethical advances in genetic testing.Technological advances have made it possible to sequence multiple genes at once in a panel to give patients a more thorough evaluation of their personal cancer risk.Panel testing increases the detection of mutations that lead to increased risk of breast,ovarian,and other cancers and can better guide individualized screening measures compared to limited BRCA testing alone.At the same time,multi-gene panel testing is more time-and cost-efficient.While the clinical application of panel testing is in its infancy,many problems arise such as lack of guidelines for management of newly identified gene mutations,high rates of variants of uncertain significance,and limited ability to screen for some cancers.Through on-going concerted efforts of pooled data collection and analysis,it is likely that the benefits of multi-gene panel testing will outweigh the risks in the near future. | Nimmi S Kapoor Kimberly C Banks | 2016 | World Journal of Surgical Procedures2016，6，1： | 2 |
| 6 | 显示文摘 | CLAESSENS S DEMIRGUC-KUNT A HUIZINGA H: How does Foreign Entry Affect the Domestic Banking Market? | 2001 | Journal of Banking and Finance2001，25，： | 1 |
| 7 | Acute pancreatitis : nonsurgical management显示文摘 | Tenner S Banks PA | 1997 | World J Surg1997，21，2： | 1 |
| 8 | Laboratory studies with nine amidinohydrazones,a promising new class of bait eoxieants for control of red imported fire ants显示文摘 | Williams D F Lofgren C S Banks W A | 1980 | Journal of Economic Entomology1980，73，： | 1 |
| 9 | Growth of Listeria monocytogenes at refrigeration temperatures显示文摘 | WALKER S J ARCHER P BANKS J G | 1990 | J Appl Bacteriol1990，68，： | 1 |
| 10 | Acute pancreatitis: nonsurgical management显示文摘 | Tenner S Banks PA | 1997 | World J Surg1997，21，： | 1 |
| 11 | Evaluation of factors that have reduced mortality from acute pancreatitis over the past 20 years 显示文摘 | Bank S Singh P Pooran N | 2002 | J Clin Gastroenterol2002，35，1： | 1 |
| 12 | Cytokines ( IL - 6 , IL - 8 ,TNF) :early and reliable predictors of severe acute pancreatitis 显示文摘 | Pooran N Indaram A Singh P Bank S | 2003 | J Clin Gas2troenterol2003，37，3： | 1 |
| 13 | Antidiabetic actions of a non-agonist PPARγligand blocking CdkS-mediated phosphorylation 显示文摘 | Choi J H Banks A S Kamenecka T M | 2011 | Nature2011，477，7365： | 1 |
| 14 | Indoor air pollution : effects on cultural and historical materials显示文摘 | Baer N S Banks P N | 1985 | Int J Museum Manag Curatorship1985，4，： | 1 |
| 15 | Efficacy ofpositive airway pressure and oral appliance in mild tomoderate obstructive sleep apnea显示文摘 | Barnes M McEvoy R D Banks S | 2004 | Am J Respir CritCare Med2004，170，6： | 1 |
| 16 | Evaluation off actors that have reduced mortality from acute pancreatitis over the past 20year显示文摘 | Bank S Singh P Pooran N | | 0，，01： | 1 |
| 17 | A model specification for FRP composites for civil engineering structures显示文摘 | Lawrence C Bank T.Russell Gentry Benjamin P Thompson Jeffrey S Russell | 2003 | Construction and Building Materials2003，，6： | 1 |
| 18 | Multiperiodic repetitive control system:A Lyapunov stability analysis for MIMO systems显示文摘 | OWENS D H LI L M BANKS S P | 2004 | International Journal of Control2004，77，5： | 1 |
| 19 | The use of cell cul- ture of subchromosomal introgressions of barley yellow cwarf virus resistance from Thinopyrum intermedium to wheat 显示文摘 | Banks P M Larkin P J Bariana H S | 1995 | Genome1995，38，： | 1 |
| 20 | An experimental study of damage accumulation in balanced CFRP laminates due to repeated impact显示文摘 | David-West O S Nash D H Banks W M | 2008 | Composite Structures2008，83，3： | 1 |
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