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| 1 | Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis显示文摘AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations(variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis.METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%CI.RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality(OR = 1.62, 95%CI: 1.11-2.36, P = 0.01). Portal vein thrombosis was associated with an increased risk of ascites(OR = 2.52, 95%CI: 1.63-3.89, P < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy. CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed. | Jonathan G Stine Puja M Shah Scott L Cornella Sean R Rudnick Marwan S Ghabril George J Stukenborg Patrick G Northup | 2015 | World Journal of Hepatology2015，7，27： | 42 |
| 2 | Hemodynamic monitoring during liver transplantation:A state of the art review显示文摘Orthotopic liver transplantation can be marked by significant hemodynamic instability requiring the use of a variety of hemodynamic monitors to aide in intraoperative management. Invasive blood pressure monitoring is essential,but the accuracy of peripheral readings in comparison to central measurements has been questioned. When discrepancies exist,central mean arterial pressure,usually measured at the femoral artery,is considered more indicative of adequateperfusion than those measured peripherally. The traditional pulmonary artery catheter is less frequently used due to its invasive nature and known limitations in measuring preload but still plays an important role in measuring cardiac output(CO) when required and in the management of portopulmonary hypertension. Pulse wave analysis is a newer technology that uses computer algorithms to calculate CO,stroke volume variation(SVV) and pulse pressure variation(PPV). Although SVV and PPV have been found to be accurate predicators of fluid responsiveness,CO measurements are not reliable during liver transplantation. Transesophageal echocardiography is finding an increasing role in the realtime monitoring of preload status,cardiac contractility and the diagnosis of a variety of pathologies. It is limited by the expertise required,limited transgastric views during key portions of the operation,the potential for esophageal varix rupture and difficulty in obtaining quantitative measures of CO in the absence of tricuspid regurgitation. | Mona Rezai Rudnick Lorenzo De Marchi Jeffrey S Plotkin | 2015 | World Journal of Hepatology2015，7，10： | 15 |
| 3 | Current state of endohepatology: Diagnosis and treatment of portal hypertension and its complications with endoscopic ultrasound显示文摘The diagnosis and management of cirrhosis and portal hypertension(PH)with its complications including variceal hemorrhage,ascites,and hepatic encephalopathy continues to evolve.Although there are established“standards of care”in liver biopsy and measurement of PH,gastric varices remain an area without a universally accepted therapeutic approach.The concept of“Endo Hepatology”has been used to describe of the applications of endoscopic ultrasound(EUS)to these challenges.EUS-liver biopsy(EUS-LB)offers an alternative to percutaneous and transjuglar liver biopsy without compromising safety or efficacy,and with added advantages including the potential to reduce sampling error by allowing biopsies in both hepatic lobes.Furthermore,EUS-LB can be performed during the same procedure as EUS-guided portal pressure gradient(PPG)measurements,allowing for the collection of valuable diagnostic and prognostic data.EUS-guided PPG measurements provide an appealing alternative to the transjugular approach,with proposed advantages including the ability to directly measure portal vein pressure.In addition,EUS-guided treatment of gastric varices(GV)offers several possible advantages to current therapies.EUS-guided treatment of GV allows detailed assessment of the vascular anatomy,similar efficacy and safety to current therapies,and allows the evaluation of treatment effect through doppler ultrasound visualization.The appropriate selection of patients for these procedures is paramount to ensuring generation of useful clinical data and patient safety. | Sean R Rudnick Jason D Conway Mark W Russo | 2021 | World Journal of Hepatology2021，13，8： | 4 |
| 4 | Marginal pricing and supplement cost allocation in transmission open access 显示文摘 | RUDNICK H PALMA R FERNANDEZ J E | 1995 | IEEE Trans on Power Systems1995，10，5： | 2 |
| 5 | Undersea gliders for 6cean research 显示文摘 | Rudnick L Davis R Eriksen D | 2004 | Marine Tech Soc2004，38，2： | 1 |
| 6 | Congestion management and transmission rights in centralized electric markets显示文摘 | H Rudnick | 2004 | IEEE Transactions on Power Systems2004，19，2： | 1 |
| 7 | A ttenuation and dispersion of elastic waves in a cylindrical bar显示文摘 | ZAMANEK J RUDNICK I | 1961 | Journal of A Coustic Society of America1961，33，： | 1 |
| 8 | Rare earth element patterns in Archean high-grade metadsediments and tectonic significance显示文摘 | Taylor S R Rudnick R L Mclennan S M | 1986 | Geochim Cosmochim Acta1986，50，： | 1 |
| 9 | Tracking the budget of Nb and Ta in the continental crust显示文摘 | Barth M G McDonough W F Rudnick R L | 2000 | Chemical Ge- ology2000，165，34： | 1 |
| 10 | Pathogenosis of contrast-induced ne- phropathy experimental and clinical observations with emphasis on the role of osmolality 显示文摘 | Rudnick MR Goldfarb S | 2003 | Rev Cardiovasc Med2003，4，5： | 1 |
| 11 | Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 sig- naling显示文摘 | Fillmore C M Gupta P B Rudnick J A | 2010 | Proc Natl Acad Sci USA2010，107，21： | 1 |
| 12 | 丝裂原调控子CDC2 0在EGR1基因敲出鼠模型中诱导表达的研究(英文)显示文摘目的 确认肝再生过程中参与调控肝细胞有丝分裂的EGR1靶向基因CDC2 0 ,并对其作用进行评价。方法 通过cDNA微阵列分析 ,比较切肝后 4 8h野生鼠和EGR1基因敲出鼠的肝组织基因表达。使用RT -PCR法测定再生肝组织中野生鼠和EGR1基因敲出鼠的CDC2 0基因表达谱 ,并将其切肝后 4 8h的结果与同一时间点的EGR1蛋白质表达水平进行比较。结果 切肝后前 12h肝组织CDC2 0基因的表达水平无变化 ,但于 36h开始上升并于 4 8h达到顶峰 ,这个表达曲线恰好与肝再生过程中EGR1蛋白质的表达特点一致。此外 ,与EGR1基因敲出鼠相比 ,野生鼠切肝后 4 8h的CDC2 0基因表达水平明显升高 (P <0 .0 2 )。结论 EGR1基因敲出鼠的肝细胞有丝分裂进程受损与肝再生过程中CDC2 0基因表达水平降低有关 ;提示 :受EGR1调控的CDC2 0基因的表达在肝再生过程中肝细胞有丝分裂进程中起重要作用。 | 廖允军 王成友 张阳德 David Rudnick | 2004 | 中国现代医学杂志2004，14，5： | 1 |
| 13 | Radiocontrast media associated nephrotoxicity 显示文摘 | Berns J Rudnick M | 2002 | Kidney2002，24，： | 1 |
| 14 | Rare earth element patterns in Archean high-grade metadsediments and tectonic signifi- cance 显示文摘 | Taylor S R Rudnick R L Mclennan S M | 1986 | Geochim Cosmochim Acta1986，50，： | 1 |
| 15 | Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia显示文摘 | Marchette NJ Garcia R Rudnick A | 1969 | Am J Trop Med Hyg1969，18，3： | 1 |
| 16 | Nephrotoxicity of iodixanol versus ioversol in patients with chronic kidney disease:the Visipaque Angiography/Interventions with Laboratory Outcomes in Renal Insufficiency (VALOR) Trial显示文摘 | Rudnick MR Davidson C Laskey W | 2008 | Am Heart J2008，156，4： | 1 |
| 17 | 显示文摘 | MARSHALL D J RUDNICK K A MCCARTHY S G | 2006 | Vaccine2006，24，3： | 1 |
| 18 | Inter-leukin-18 enhances Th1 immunity and tumor protec-tion of a DNA vaccine显示文摘 | Rudnick K A McCarthy S G | 2006 | Vaccine2006，24，： | 1 |
| 19 | Radiocontrast media associated nephrotoxicity显示文摘 | Betas J Rudnick M | 1992 | Kidney1992，24，： | 1 |
| 20 | Recycling lower continental crust in the North China craton显示文摘 | Gao S Rudnick R L Yuan H L | 2004 | Nature2004，，432： | 1 |
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