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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | 多形性黄色瘤型星形细胞瘤:自然病史和长期随访显示文摘作者回顾性研究74例多形性黄色瘤型星形细胞瘤(PXA)组织学问变特征和BRAFV600E突变的预后意义。患者平均诊断年龄21.5岁,包括31例儿童和43例成人,随访中位时间为7.6年。间变特征(PXA—AF)定义为核分裂指数≥5个/10HPF和(或)伴有坏死,共有33例。作者将其中60例进行免疫组化和(或)分子分析,发现其中39例BRAFV600E突变,且这39例IDH1(R132H)均为阴性。 | Ida C M Rodriguez F J Burger P C 李晓玲 王行富 | 2015 | 临床与实验病理学杂志2015，31，11： | 9 |
| 3 | Gains from corporate headquarters relocations: evidence from the stock market 显示文摘 | Ghosh C Rodriguez M Sirmans C F | 1995 | Journal of Urban Economics1995，38，： | 1 |
| 4 | Influence of testing methodology on the tigecycline activity profile against presumably tigecycline-non-susceptible Acinetobacter spp显示文摘 | Casal M Rodriguez F Johnson B | 2009 | JAntimicrob Chemother2009，64，1： | 1 |
| 5 | Pancreatic tuberculosis: CT findings显示文摘 | Pombo F Diaz Candamio M J Rodriguez E | 1998 | Abdom Imaging1998，23，4： | 1 |
| 6 | Analysis of the influence of pH and pressure on the elimination of boron in reverse osmosis 显示文摘 | D Prats M F Chillon - Arias M Rodriguez - Pastor | 2000 | Desalination2000，128，3： | 1 |
| 7 | Physical characterization of hydroxyapatite porous scaffolds for tissue engineering 显示文摘 | Teixeira S Rodriguez M A Pena P De Aza A H De Aza S Ferraz M P Monteiro F J | 2009 | Materials Science & Engineering C-Biomimetic and Supramolecular Systems2009，29，5： | 1 |
| 8 | Mi- croRNA 30c expression level is an independent predictor of clinical benefit of endocrine therapy in advanced es- trogen receptor positive breast cancer显示文摘 | Rodriguez Gonzalez F Sieuwerts AM Smid M | 2011 | Breast Cancer Res Treat2011，127，1： | 1 |
| 9 | influence of testing merhodol- ogy on the tigecline activity profile against presumably tigecline- non-susceptible Aeinetobaeter spp 显示文摘 | Casal M Rodriguez F Johnson B | 2009 | J Antimicrob Chemother2009，64，1： | 1 |
| 10 | Isolation and characterization of pediocin L50, a new bacteriocin from Pediococcus acidilactici with a broad inhibitory spectrum 显示文摘 | CINTAS S Y RODRIGUEZ J M FERNANDEZ M F | 1995 | Appl Enviom Mierobiol1995，61，： | 1 |
| 11 | 显示文摘 | Almansa C Molina S M Rodriguez R F | 2004 | Microporous and Mesoporous Materials2004，76，3： | 1 |
| 12 | Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses Asthma-like responses via nitric oxide synthase 2 activity显示文摘 | RODRIGUEZ D ALEXANDRE C K ELIANA L F M | 2003 | The Journal of Immunology2003，171，： | 1 |
| 13 | Genetic manipulation of lignin reduces recalcitrance and improves ethanol production from switchgrass 显示文摘 | Fu C Mielenz JR Xiao X Ge Y hamilton CY Rodriguez M Chen F Foston M Ragauskas A Bouton J Dixon RA Wang ZY | 2011 | Proc Natl Acad Sci USA2011，108，9： | 1 |
| 14 | Carbon nanotubes provide self extinguishing grade to silicone-based foams显示文摘 | VERI)EJO R BARROS()-BUJANS F RODRIGUEZ PEREZ M A | 2008 | Journal of Materials Chemistry2008，18，33： | 1 |
| 15 | Reproductive cycle of Manila clam Ruditapes philippinarum (Adams and Reeve 1850) ,in Ria of Vigo ( NW Spain ) 显示文摘 | Rodriguez M E Pazo J P Cortes F F | 1992 | Scientian Marina1992，56，1： | 1 |
| 16 | Value of indirect hem agglutination and coagglutiation test for serotyping Haemophilus parasuis显示文摘 | Del Rio M L Gut ierrez B C Rodriguez Ferri E F | 2003 | Clin Microbio 12003，41，2： | 1 |
| 17 | Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm显示文摘 | Arenzana-Seisdedos F Turpin P Rodriguez M | 1997 | J Cell Sci1997，110，3： | 1 |
| 18 | Parametrical optimisation of ultrasonic motors显示文摘 | Pons J L Rodriguez H Fernandez J F Villegas M Seco F | 2003 | Sensors and Actuators A2003，107，： | 1 |
| 19 | Characterization of a novolac resin substituting phenol by ammonium lignosul- fonate as filler or extender显示文摘 | Perez J M Rodriguez F Alonso M V | 2007 | BioResources2007，2，2： | 1 |
| 20 | Prepa- ration of activated carbon by chemical activation with ZnCl2 显示文摘 | Caturla F Molina - sabio M Rodriguez - Reinoso F | 1991 | Carbon1991，29，7： | 1 |
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