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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | The effects of niobium and nickel on the corrosion resistance of the zinc phosphate layers显示文摘 | Banczek E P Rodrigues P R P Costa I | 2008 | Surface and Coatings Technology2008，202，10： | 1 |
| 3 | Abscisic acid inhibits type 2C protein phosphatases via the PYR/ PYL family of START proteins显示文摘 | PARK S Y FUNG P NISHIMURA N JENSEN D R FFUJII ZHAO Y LUMBA S SANTIAGO J RODRIGUES A CHOW T F | 2009 | Science2009，324，： | 1 |
| 4 | Crk I and Crk Ⅱ funtion as key signaling integrators for migration and invasion of cancer cells显示文摘 | Rodrigues S P Fathers K E Chan G | 2005 | Mol Cancer Res2005，3，4： | 1 |
| 5 | Production and characterisation of alginate microparticles incorporating Aero- monas hydrophila designed for fish oral vaccination 显示文摘 | Rodrigues A P Hirsch D Figueiredo H C P | 2006 | Process Biochem2006，41，： | 1 |
| 6 | Globalization and the synchronization of transport terminals显示文摘 | RODRIGUE J P | 1999 | Journal of Transport Geography1999，，7： | 1 |
| 7 | Experimental research on the critical temperature of compressed steel elements with restrained thermal elongation 显示文摘 | Correia Rodrigues J P Cabrita Neves I Valente J C | 2000 | Fire Safety Journal2000，35，2： | 1 |
| 8 | Three-Dimensional Modeling of Vertical-Horizontal Rolling Process显示文摘 | XIONG Shang-wu Rodrigues J M C Martins P A F | 2003 | Finite Elements in Analysis and Design2003，39，： | 1 |
| 9 | Characterization of a bovine collagen-hydroxyapatite composite scaffold for bone tissue engineering显示文摘 | Rodrigues CV Serricella P Linhares AB | 2003 | Biomaterials2003，24，27： | 1 |
| 10 | Regulatory volume de- crease in Trypanosoma cruzi involves amino acid efflux and changes in intracellular calcium 显示文摘 | Rohloff P Rodrigues CO Docampo R | 2003 | Mol Biochem Parasitol2003，126，2： | 1 |
| 11 | An expeditiousmethod for the determ ination of organochlorine pesticides resi-dues in estuarine sediments using microwave assisted pre-ex-traction an d automa ted headspace solid phase microextractioncoupled to gas chromatography-mass spectrometry显示文摘 | Carvalho P N Rodrigues P N R Alves F | 2008 | Talan-ta2008，76，5： | 1 |
| 12 | Optimization of the production of biodiesel from soybean oil by ultrasound assisted methanolysis显示文摘 | SANTOS F F P RODRIGUES S FERNANDES F A N | | 0，，： | 1 |
| 13 | The waves of containeriza- tion: shifts in global maritime transportation显示文摘 | Guerrero D Rodrigue J P | 2014 | Journal of Transport Geography2014，34，： | 1 |
| 14 | Mechanical properties of HSLA bainitic steel subjected to controlled rolling with accelerated cooling显示文摘 | RODRIGUES P C M PERELOMA E V SANTOS D B | 2000 | Materials Science and Engineering: A2000，283，： | 1 |
| 15 | The transport geography of logistics and freight distribution 显示文摘 | HESSE M RODRIGUE J P | 2004 | Journal of Transport Geography2004，，12： | 1 |
| 16 | In vitro reconstitution of an abscisic acid signalling pathway显示文摘 | FUJII H CHINNUSAMY V RODRIGUES A RUBIO S AATONI R PARK S Y CUTLER S R SHEEN J ROTRIGUES P L ZHU J K | 2009 | Nature2009，462，： | 1 |
| 17 | Spatial and temporal variation of phytoplankton in two subtropical Brazilian reservoirs 显示文摘 | BORGES P A F TRAIN S RODRIGUES L C | 2008 | Hydrobiologia2008，607，： | 1 |
| 18 | Development of a Mois- ture Absorber for Packaging of Fresh Mushrooms (Aga- ricus Bisporous) 显示文摘 | Mahajan P V Rodrigues F A S | 2008 | Postharvest Biology and Technolo- gy2008，48，3： | 1 |
| 19 | Study of preantral follicle population in situ and after mechanical isolation from caprine ovaries at different reproduction stages显示文摘 | LUCCI C M AMORIM C A RODRIGUES A P R | 1999 | Animal Reproduction science1999，56，： | 1 |
| 20 | Parabolic shape of a tapered fused coupler-comparison with experiment显示文摘 | RODRIGUES J M P MACLEAN T S M GAZEY B K | 1987 | Applied Optics1987，26，9： | 1 |
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