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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Production and characterisation of alginate microparticles incorporating Aero- monas hydrophila designed for fish oral vaccination 显示文摘 | Rodrigues A P Hirsch D Figueiredo H C P | 2006 | Process Biochem2006，41，： | 1 |
| 3 | Experimental research on the critical temperature of compressed steel elements with restrained thermal elongation 显示文摘 | Correia Rodrigues J P Cabrita Neves I Valente J C | 2000 | Fire Safety Journal2000，35，2： | 1 |
| 4 | Three-Dimensional Modeling of Vertical-Horizontal Rolling Process显示文摘 | XIONG Shang-wu Rodrigues J M C Martins P A F | 2003 | Finite Elements in Analysis and Design2003，39，： | 1 |
| 5 | Mechanical properties of HSLA bainitic steel subjected to controlled rolling with accelerated cooling显示文摘 | RODRIGUES P C M PERELOMA E V SANTOS D B | 2000 | Materials Science and Engineering: A2000，283，： | 1 |
| 6 | Spatial and temporal variation of phytoplankton in two subtropical Brazilian reservoirs 显示文摘 | BORGES P A F TRAIN S RODRIGUES L C | 2008 | Hydrobiologia2008，607，： | 1 |
| 7 | Study of preantral follicle population in situ and after mechanical isolation from caprine ovaries at different reproduction stages显示文摘 | LUCCI C M AMORIM C A RODRIGUES A P R | 1999 | Animal Reproduction science1999，56，： | 1 |
| 8 | New Delhimetallo-blactamase(NDM-1)in enterobacteriaceae:treatmentoptions with earbapenems compromised显示文摘 | Deshpande P Rodrigues C Shetty A | 2010 | Associat PhysicIndia2010，58，： | 1 |
| 9 | From Delay-tolerant Networks to Vehicular Delay-tolerant Networks显示文摘 | Pereira P R Casaca A Rodrigues J J P C | 2012 | IEEE Communications Surveys &Tutorials2012，2012，： | 1 |
| 10 | Formation of ultra- fine ferrite mierostructure in warm rolled and annealed C-Mn steel显示文摘 | Santos D B Bruzszek R K Rodrigues P C M | 2003 | Materials Science and Engineering: A2003，346，12： | 1 |
| 11 | Ahybrid NFC-Bluetooth secure protocol for credit transferamong mobile phones显示文摘 | Monteiro D M Rodrigues J J P C Lloret J | 2014 | Security and CommunicationNetworks2014，7，2： | 1 |
| 12 | Three-dimensional modelling of the vertical- horizontal rolling process 显示文摘 | XIONG Shang-wu Rodrigues J M C Martins P A F | 2003 | Finite Elements in Analysis and Design2003，39，11： | 1 |
| 13 | GeoSpray:A Geographic Routing Protocol for Vehicular Delay-tolerant Networks显示文摘 | Soares V N G J Rodrigues J J P C Farahmand F | 2014 | Information Fusion2014，15，： | 1 |
| 14 | Effects of Deficit Irrigation Strategies on Cluster Microclimate for Improving Fruit Composition of Moscatel field-grown Grapevines显示文摘 | Dos Santos T P Lopes C M Rodrigues M L | 2007 | Scientia Horticuhurae2007，112，3： | 1 |
| 15 | Identification and organ expression of peroxisome proliferator activated receptors in brown trout (Salmo trutta fario )显示文摘 | Batista-Pinto C Rodrigues P Rocha E | 2005 | Biochim Biophys Acta2005，1731，： | 1 |
| 16 | Solvent prop-erties governing protein partitioning in polymer/polymer a-queous two-phase systems显示文摘 | Madeira P P Reis C A Rodrigues A E | 2011 | Chromatogr A2011，1018，10： | 1 |
| 17 | Mechanical Properties of an HSLA Bainitic Steel Subjected to Controlled Rolling with Accelerated Cooling显示文摘 | Rodrigues P C M Pereloma E V Santoc D B | 2000 | Materials Science and Engineering2000，283，12： | 1 |
| 18 | Mechanical preperities of an HSLA bainitic steel subjected to controlled rolling with accelerated cooling显示文摘 | Rodrigues P C M Pereloma E V Stantos D B | 2000 | Materials Science and Engineering A2000，283，： | 1 |
| 19 | Species identi- fication of Aspergillus section Flavi isolates from Portuguese al- monds using phenotypic, including MALDI-TOF ICMS, and molecular approaches 显示文摘 | Rodrigues P Santos C Venancio A Lima N | 2011 | Journal of applied microbiology2011，111，4： | 1 |
| 20 | Boost current multilevel inverter and its application on single-phase grid-connected photovoltaic systems显示文摘 | Barbosa P G Braga H A C Rodrigues M C B | 2006 | IEEE Transactions on Power Electronics2006，21，4： | 1 |
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